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135 条记录 (耗时 0.073 秒)

    Catalytic depolymerization of polymers containing electrophilic linkages using nucleophilic reagents
    111.
    发明授权
    Catalytic depolymerization of polymers containing electrophilic linkages using nucleophilic reagents 失效
    使用亲核试剂催化解聚包含亲电键的聚合物

    公开(公告)号：US07544800B2

    公开(公告)日：2009-06-09

    申请号：US11208268

    申请日：2005-08-18

    申请人： James Lupton Hedrick ,  Gregory Walker Nyce ,  Robert M. Waymouth

    发明人： James Lupton Hedrick ,  Gregory Walker Nyce ,  Robert M. Waymouth

    IPC分类号： C07F1/00

    CPC分类号： C07D233/16 ,  C07C59/285 ,  C07C67/03 ,  C07C68/06 ,  C07D233/02 ,  C07D233/04 ,  C07D233/06 ,  C07D233/54 ,  C07D307/33 ,  C07F1/00 ,  C07C69/82 ,  C07C69/96

    摘要： A method is provided for carrying out depolymerization of a polymer containing electrophilic linkages in the presence of a catalyst and a nucleophilic reagent, wherein production of undesirable byproducts resulting from polymer degradation is minimized. The reaction can be carried out at a temperature of 80° C. or less, and generally involves the use of an organic, nonmetallic catalyst, thereby ensuring that the depolymerization product(s) are substantially free of metal contaminants. In an exemplary depolymerization method, the catalyst is a carbene compound such as an N-heterocyclic carbene, or is a precursor to a carbene compound. The method provides an important alternative to current recycling techniques such as those used in the degradation of polyesters, polyamides, and the like.

    摘要翻译： 提供了一种在催化剂和亲核试剂的存在下进行含有亲电键的聚合物解聚的方法，其中由聚合物降解产生的不需要的副产物的产生最小化。 反应可以在80℃或更低的温度下进行，通常涉及使用有机非金属催化剂，从而确保解聚产物基本上不含金属污染物。 在示例性的解聚方法中，催化剂是卡宾化合物如N-杂环卡宾，或是卡宾化合物的前体。 该方法提供了当前回收技术的重要替代方法，例如用于降解聚酯，聚酰胺等的那些。

    Process for preparing a patterned continuous polymeric brush on a substrate surface
    113.
    发明授权
    Process for preparing a patterned continuous polymeric brush on a substrate surface 失效
    在衬底表面上制备图案化连续聚合物刷的方法

    公开(公告)号：US06423465B1

    公开(公告)日：2002-07-23

    申请号：US09493450

    申请日：2000-01-28

    申请人： Craig Jon Hawker ,  James Lupton Hedrick ,  William Dinan Hinsberg, III ,  Marc Husemann ,  Michael Morrison

    发明人： Craig Jon Hawker ,  James Lupton Hedrick ,  William Dinan Hinsberg, III ,  Marc Husemann ,  Michael Morrison

    IPC分类号： G03F711

    CPC分类号： G03F7/168 ,  G03F7/0392 ,  G03F7/165

    摘要： A method is disclosed for preparing a patterned continuous polymeric brush on a substrate surface. The method generally involves functionalization of the substrate surface followed by surface-initiated polymerization at the initiation sites so provided, e.g., using a living free radical polymerization technique or the like, whereby a covalently bound continuous polymeric brush results, with acid-labile groups present throughout. An acid is then applied to the continuous polymer brush in a predetermined pattern, under conditions that result in removal of the acid-labile groups in at least one first region of the continuous polymer brush but not in at least one second region of the continuous polymer brush. In a preferred embodiment, the acid is a photogenerated acid resulting from imagewise irradiation of a photoacid generator applied as a film or coating to the surface-bound polymer brush.

    摘要翻译： 公开了一种用于在衬底表面上制备图案化的连续聚合物刷的方法。 该方法通常涉及基材表面的官能化，然后在例如使用活性自由基聚合技术等提供的起始位点进行表面引发聚合，由此产生共价键连续的聚合物刷，其中存在酸不稳定基团 始终。 然后在预定的图案中，在导致连续聚合物刷的至少一个第一区域中除去酸不稳定基团但不在连续聚合物的至少一个第二区域中的条件下，将酸施加到连续聚合物刷上 刷。 在一个优选的实施方案中，酸是由作为膜或涂层施加到表面结合聚合物刷的光致酸产生体的成像照射产生的光生酸。

    Method of preparing cyclic carbonates, cyclic carbamates, cyclic ureas, cyclic thiocarbonates, cyclic thiocarbamates, and cyclic dithiocarbonates
    117.
    发明授权
    Method of preparing cyclic carbonates, cyclic carbamates, cyclic ureas, cyclic thiocarbonates, cyclic thiocarbamates, and cyclic dithiocarbonates 有权
    环状碳酸酯，环状氨基甲酸酯，环状脲，环状硫代碳酸酯，环状硫代氨基甲酸酯和环状二硫代碳酸酯的制备方法

    公开(公告)号：US08476428B2

    公开(公告)日：2013-07-02

    申请号：US13451225

    申请日：2012-04-19

    申请人： James Lupton Hedrick ,  Alshakim Nelson ,  Daniel Paul Sanders

    发明人： James Lupton Hedrick ,  Alshakim Nelson ,  Daniel Paul Sanders

    IPC分类号： C07D319/06 ,  C07D265/06

    CPC分类号： C07D319/06 ,  C07D239/10 ,  C07D265/10 ,  C07D327/06 ,  C07D339/08 ,  Y02P20/582

    摘要： A method of preparing a cyclic monomer, comprising: forming a first mixture comprising a precursor compound, bis(pentafluorophenyl)carbonate, and a catalyst; wherein the precursor compound has a structure comprising a) two or more carbons, and b) two functional groups selected from the group consisting of primary amine, secondary amine, thiol group, hydroxyl group, and combinations thereof; and agitating the first mixture at a temperature effective to form a second mixture comprising the cyclic monomer, the cyclic monomer selected from the group consisting of a cyclic carbonate, a cyclic carbamate, a cyclic urea, a cyclic thiocarbonate, a cyclic thiocarbamate, and a cyclic dithiocarbonate.

    摘要翻译： 一种制备环状单体的方法，包括：形成包含前体化合物，双（五氟苯基）碳酸酯和催化剂的第一混合物; 其中所述前体化合物具有包含a）两个或更多个碳的结构，和b）选自伯胺，仲胺，硫醇基，羟基及其组合的两个官能团; 并在有效形成包含环状单体的第二混合物的温度下搅拌第一混合物，所述环状单体选自环状碳酸酯，环状氨基甲酸酯，环状脲，环状硫代碳酸酯，环状硫代氨基甲酸酯和 环状二硫代碳酸酯。

    Biodegradable block polymers for drug delivery, and methods related thereto
    118.
    发明授权
    Biodegradable block polymers for drug delivery, and methods related thereto 有权
    用于药物递送的可生物降解性嵌段聚合物及其相关方法

    公开(公告)号：US08470891B2

    公开(公告)日：2013-06-25

    申请号：US12646024

    申请日：2009-12-23

    申请人： James Lupton Hedrick ,  Alshakim Nelson ,  Chuan Yang ,  Yi Yan Yang

    发明人： James Lupton Hedrick ,  Alshakim Nelson ,  Chuan Yang ,  Yi Yan Yang

    IPC分类号： A61K47/34 ,  A61K9/127 ,  A61K48/00 ,  A61K38/00

    CPC分类号： C12N5/0068 ,  A61K9/1075 ,  A61K47/34 ,  A61K47/549 ,  A61K47/6801 ,  A61K47/6907 ,  C08G63/664 ,  C08G64/183 ,  C08G2261/126 ,  C08L71/02 ,  C08L2203/02 ,  C08L2205/05 ,  C12N2533/30 ,  Y02P20/582 ,  C08L69/00

    摘要： A biodegradable block copolymer is disclosed, comprising a hydrophilic block derived from a polyether alcohol; and a hydrophobic block comprising a first repeat unit derived by ring opening polymerization of a first cyclic carbonyl monomer initiated by the polyether alcohol, the first repeat unit comprising a side chain moiety comprising a functional group selected from the group consisting of i) urea groups and ii) mixtures of urea groups and carboxylic acid groups. No side chain of the hydrophobic block comprises a covalently bound biologically active material. The block copolymer self-assembles in water forming micelles suitable for sequestering a biologically active material by a non-covalent interaction, and the block copolymer is 60% biodegraded within 180 days in accordance with ASTM D6400.

    摘要翻译： 公开了一种可生物降解的嵌段共聚物，其包含衍生自聚醚醇的亲水性嵌段; 和疏水嵌段，其包含通过由所述聚醚醇引发的第一环状羰基单体的开环聚合得到的第一重复单元，所述第一重复单元包含侧链部分，所述侧链部分包含选自以下的官能团：i）脲基团和 ii）脲基和羧酸基团的混合物。 疏水嵌段的侧链不包括共价结合的生物活性材料。 嵌段共聚物在水形成胶束中自组装，适合于通过非共价相互作用螯合生物活性材料，并且嵌段共聚物根据ASTM D6400在180天内生物降解60％。