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公开(公告)号：US20090298710A1
公开(公告)日：2009-12-03
申请号：US12097118
申请日：2006-12-15
IPC分类号： C40B30/06
CPC分类号： G01N33/5088 , A61K47/555 , A61K47/66 , A61K47/6891 , B82Y5/00 , B82Y15/00 , C40B30/06
摘要： Screening of a library of particles in vivo and/or in vitro using Polyplex Iterative Combinatorial Optimization (PICO) allows for the design of particles for targeting a specific organ, tissue (e.g., cancer), or cell. Particles may, for example, include different targeting agents (e.g., aptamers or plurality of aptamers) on their surfaces, and the aptamer or aptamers may be evolved to provide better targeting of the particles. Libraries of particles are enriched in characteristics of particles that have been found to migrate to a tissue of interest, be taken up by cells, etc. The process may be repeated to engineer particles of a desired specificity or biological function.
摘要翻译： 使用Polyplex迭代组合优化（PICO）在体内和/或体外筛选粒子库允许设计用于靶向特定器官，组织（例如癌症）或细胞的颗粒。 例如，颗粒可以在其表面上包括不同的靶向剂（例如，适体或多个适配体），并且适配体或适体可以进化以提供更好的颗粒靶向。 已经发现已经发现迁移到感兴趣的组织，被细胞吸收的颗粒的特征的颗粒的富集等。可以重复该过程来设计具有所需特异性或生物学功能的颗粒。
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公开(公告)号：US20090274877A1
公开(公告)日：2009-11-05
申请号：US12402154
申请日：2009-03-11
申请人： Edwin Chan , Jeffrey M. Karp , Robert S. Langer
发明人： Edwin Chan , Jeffrey M. Karp , Robert S. Langer
CPC分类号： B32B33/00 , Y10T156/10 , Y10T428/2457
摘要： A material capable of promoting adhesion through transitioning reversibly between a first state and a second state when the material is exposed to or removed from a stimulus, wherein, the first state includes a first texture and the second state includes a second texture different from the first texture.
摘要翻译： 该材料能够通过在材料暴露于或从刺激中去除时在第一状态和第二状态之间可逆地转变而进行粘附，其中，第一状态包括第一纹理，第二状态包括与第一状态不同的第二纹理 质地。
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公开(公告)号：US20090203590A1
公开(公告)日：2009-08-13
申请号：US11915417
申请日：2006-05-30
CPC分类号： A61K31/00
摘要： The present invention is based on the discovery that Matrilin-1 has antiangiogenic and anticancer properties. The invention is directed to a method of treating a disease that responds to an inhibition of angiogenesis. Additionally, the invention can be applied to those at risk for developing a disease that responds to an inhibition of angiogenesis. The methods comprise administering to a mammal an effective angiogenesis-inhibiting amount of an Matrilin-1 consisting of Matrilin-1, Matrilin-1 fragment, analog, or derivative that is administered in a composition substantially free of other cartilage proteins.
摘要翻译： 本发明是基于Matrilin-1具有抗血管生成和抗癌特性的发现。 本发明涉及一种治疗对血管生成抑制作出反应的疾病的方法。 此外，本发明可以应用于那些处于风险中的那些发展对血管生成的抑制作用的疾病。 所述方法包括向哺乳动物施用有效的血管生成抑制量的由在基本上不含其它软骨蛋白的组合物中施用的Matrilin-1，Matrilin-1片段，类似物或衍生物组成的Matrilin-1。
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114.发明授权Controlled release polymer nanoparticle containing bound nucleic acid ligand for targeting 有权含有结合核酸配体的控制释放聚合物纳米粒子用于靶向公开(公告)号：US07550441B2
公开(公告)日：2009-06-23
申请号：US10860918
申请日：2004-06-04
IPC分类号： A61K31/7088 , A61K31/713 , A61K9/14 , C12Q1/00 , C12N11/00
CPC分类号： C12N15/87 , A61K9/1647 , A61K47/59 , A61K47/593 , A61K47/60 , A61K48/0041 , A61K48/0083 , Y10S530/817
摘要： The present invention relates to a conjugate that includes a nucleic acid ligand bound to a controlled release polymer system, a pharmaceutical composition that contains the conjugate, and methods of treatment using the conjugate. The controlled release polymer system includes an agent such as a therapeutic, diagnostic, prognostic, or prophylactic agent. The nucleic acid ligand that is bound to the controlled release polymer system, binds selectively to a target, such as a cell surface antigen, and thereby delivers the controlled release polymer system to the target.
摘要翻译： 本发明涉及包含与受控释放聚合物体系结合的核酸配体的缀合物，含有缀合物的药物组合物和使用该缀合物的治疗方法。 控释聚合物体系包括诸如治疗，诊断，预后或预防剂的试剂。 与受控释放聚合物体系结合的核酸配体选择性地结合到靶，例如细胞表面抗原，从而将受控释放的聚合物体系递送到靶。
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公开(公告)号：US20090074828A1
公开(公告)日：2009-03-19
申请号：US12098354
申请日：2008-04-04
申请人： Frank Alexis , Liangfang Zhang , Aleksandar F. Radovic-Moreno , Frank X. Gu , Pamela Basto , Etgar Levy-Nissenbaum , Juliana Chan , Robert S. Langer , Omid C. Farokhzad
发明人： Frank Alexis , Liangfang Zhang , Aleksandar F. Radovic-Moreno , Frank X. Gu , Pamela Basto , Etgar Levy-Nissenbaum , Juliana Chan , Robert S. Langer , Omid C. Farokhzad
IPC分类号： A61K9/14 , A61K47/42 , A61K31/135 , A61K31/337 , A61K38/16 , A61K31/4353 , A61K31/56 , A61K9/00 , C07K5/10 , A61P9/00
CPC分类号： A61K9/5123 , A61K9/5153 , A61K9/5192 , A61K47/62 , A61K47/6935 , A61K47/6937 , B82Y5/00
摘要： The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
摘要翻译： 本发明一般涉及聚合物和大分子，特别是涉及可用于颗粒如纳米颗粒的聚合物。 本发明的一个方面涉及一种开发具有所需性质的纳米颗粒的方法。 在一组实施方案中，该方法包括制备具有高度控制性质的纳米颗粒的文库，其可通过将两种或多种不同比例的大分子混合在一起形成。 一个或多个大分子可以是部分与生物相容性聚合物的聚合物缀合物。 在一些情况下，纳米颗粒可以含有药物。 本发明的其它方面涉及使用纳米颗粒文库的方法。
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公开(公告)号：US20090047256A1
公开(公告)日：2009-02-19
申请号：US11623041
申请日：2007-01-12
申请人： Christopher J. Bettinger , Joost P. Bruggeman , Lino Da Silva Ferreira , Jeffrey M. Karp , Robert S. Langer , Christiaan Nijst , Andreas Zumbuehl , Jason Burdick , Sonia J. Kim
发明人： Christopher J. Bettinger , Joost P. Bruggeman , Lino Da Silva Ferreira , Jeffrey M. Karp , Robert S. Langer , Christiaan Nijst , Andreas Zumbuehl , Jason Burdick , Sonia J. Kim
IPC分类号： A61K35/12 , C08G63/00 , C08G63/06 , C08G63/66 , C08G73/02 , A61K47/34 , A61N1/30 , A61K31/7088 , A61K31/715 , A61K38/02 , A61K35/00
CPC分类号： A61L31/06 , A61K35/12 , A61K35/48 , A61K45/06 , A61L27/18 , A61L27/38 , A61L27/58 , A61L31/148 , C08G63/6854 , C08J3/24 , C08J3/246 , C08J2367/00 , C08J2367/07 , C08K5/0025 , C12N11/08 , C08L67/00 , C08L67/07
摘要： The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.
摘要翻译： 本发明在各方面提供弹性可生物降解的聚合物。 在各种实施方案中，聚合物通过多官能醇或醚和双官能或更高级酸的反应形成以形成预聚物，其被交联以形成弹性可生物降解的聚合物。 在优选的实施方案中，通过用乙烯基官能化预聚物主链上的一个或多个OR基团进行交联，然后进行光聚合以形成弹性可生物降解的聚合物组合物或材料。 优选地，使用丙烯酸酯将一种或多种乙烯基加成到预聚物的主链上以形成丙烯酸酯化的预聚物。 在各种实施方案中，丙烯酸酯化的预聚物与一种或多种丙烯酸酯化的共聚物共聚。
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公开(公告)号：US20080248017A1
公开(公告)日：2008-10-09
申请号：US12125571
申请日：2008-05-22
IPC分类号： A61K38/43 , A61K47/30 , A61K47/32 , A61K38/45 , A61K31/715 , A61K39/00 , A61K38/18 , A61K39/395 , A61K38/46 , A61K38/44 , A61K31/56
CPC分类号： A61F6/08 , A61F6/142 , A61K9/0036 , A61K9/0056 , A61K31/565 , A61K31/57 , A61K38/09 , A61K45/06 , Y10S514/843 , A61K2300/00
摘要： The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.
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公开(公告)号：US20080182240A1
公开(公告)日：2008-07-31
申请号：US11676729
申请日：2007-02-20
CPC分类号： B01J19/0046
摘要： A microarray of polymeric biomaterials is provided. Specifically, a microarray of polymeric biomaterials that comprises a base with a cytophobic surface, and a plurality of discrete polymeric biomaterial elements bound to the cytophobic surface, is provided. Preferably said polymeric biomaterials comprise a synthetic polymer. Said polymeric biomaterials may also comprise other compounds covalently or non-covalently attached to said synthetic polymer. Methods of preparing the microarray of polymeric biomaterials of the present invention and uses of the microarray of polymeric biomaterials of the present invention are also provided.
摘要翻译： 提供了聚合物生物材料的微阵列。 具体地，提供了包含具有细胞疏松表面的基底的聚合物生物材料的微阵列和与细胞积极表面结合的多个离散的聚合物生物材料。 优选地，所述聚合物生物材料包含合成聚合物。 所述聚合物生物材料还可以包含与所述合成聚合物共价或非共价连接的其它化合物。 还提供了制备本发明的聚合物生物材料的微阵列的方法和本发明的聚合物生物材料的微阵列的用途。
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公开(公告)号：US06998115B2
公开(公告)日：2006-02-14
申请号：US09969431
申请日：2001-10-02
IPC分类号： A61K31/765 , C08G69/44 , C08G63/44 , C07C327/00
CPC分类号： A61K47/34 , A61K9/5146 , A61K31/711 , A61K31/713 , A61K47/59 , A61K47/593 , A61K47/6929 , B82Y5/00 , C08G63/685 , C08G73/02 , C08G73/0273 , C08G73/06 , C08G73/0611 , C08G73/0616 , C12N15/88
摘要： Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
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公开(公告)号：US06855329B1
公开(公告)日：2005-02-15
申请号：US09600502
申请日：1999-01-20
IPC分类号： A61K47/48 , A61L27/00 , A61L27/34 , A61L27/58 , A61L31/00 , A61L31/10 , A61L31/14 , A01N25/08 , A01N43/04 , A61F2/00 , C12Q1/68 , A01N61/90
CPC分类号： A61L31/148 , A61L27/34 , A61L27/58 , A61L31/10 , C08L89/00
摘要： The invention provides a biodegradable and biocompatible polymer article having a surface wherein a biologically active ligand is provided on said surface in a spatially controlled pattern. The pattern may be formed using a poly(dimethyl siloxane) mold. The biologically active ligand may be attached to the polymer article by a biotin-avidin-biotin linkage.
摘要翻译： 本发明提供了具有表面的可生物降解和生物相容的聚合物制品，其中在空间控制图案中在所述表面上提供生物活性配体。 图案可以使用聚（二甲基硅氧烷）模具形成。 生物活性配体可以通过生物素 - 抗生物素蛋白 - 生物素键连接到聚合物制品上。
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