公开(公告)号：US20050148474A1

公开(公告)日：2005-07-07

申请号：US11058368

申请日：2005-02-16

申请人： Mineyuki Yokoyama ,  Shoko Yamaguchi ,  Toshii Iida ,  Kiyotaka Kojima ,  Koji Kobayashi ,  Osamu Tanaka

发明人： Mineyuki Yokoyama ,  Shoko Yamaguchi ,  Toshii Iida ,  Kiyotaka Kojima ,  Koji Kobayashi ,  Osamu Tanaka

IPC分类号： A01N37/42 ,  A01N37/00

CPC分类号： A01N37/42

摘要： An object of the present invention is to determine novel means of activating plants; more particularly, means or controlling plant growth, such as means of promoting growth, means of controlling dormancy, means of imparting tolerance against stress for plants (dryness, high or low temperatures, osmotic pressure, etc.), and means of preventing aging. The present inventors have found that the above object can be achieved by providing plant activators containing, as an active ingredient, C4-C24 ketol fatty acids, in particular, 9-hydroxy-10-oxo-12(Z),15(Z)-octadecadienoic acid.

摘要翻译： 本发明的目的是确定活化植物的新方法; 更具体地说，是指或控制植物生长，例如促进生长的手段，控制休眠的手段，赋予植物胁迫耐受性的手段（干燥，高温或低温，渗透压等）以及防止老化的手段。 本发明人已经发现，上述目的可以通过提供含有作为有效成分的C 4 -C 24脂肪醇脂肪酸的植物活化剂来实现，特别是9 - 羟基-10-氧代-12（Z），15（Z） - 十八碳二烯酸。

公开(公告)号：US20050009808A1

公开(公告)日：2005-01-13

申请号：US10495370

申请日：2002-11-13

申请人： Takuya Hiruma ,  Koji Kobayashi ,  Shinji Inomata

发明人： Takuya Hiruma ,  Koji Kobayashi ,  Shinji Inomata

IPC分类号： A61K8/49 ,  A61K31/403 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/55 ,  A61P1/02 ,  A61P1/04 ,  A61P17/00 ,  A61P17/16 ,  A61P19/02 ,  A61P19/04 ,  A61P19/08 ,  A61P19/10 ,  A61P25/00 ,  A61P27/02 ,  A61P29/00 ,  A61P35/04 ,  A61P43/00 ,  A61Q19/00 ,  A61Q19/08 ,  C07D209/52 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D405/14 ,  C07D451/06 ,  C07D453/06 ,  C07D471/08 ,  C07D453/02 ,  A61K31/4745

CPC分类号： A61Q19/08 ,  A61K8/0212 ,  A61K8/492 ,  A61K31/403 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/55 ,  A61K2800/782 ,  A61Q1/02 ,  A61Q19/00 ,  C07D209/52 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D405/14 ,  C07D451/06 ,  C07D453/06 ,  C07D471/08

摘要： An azabicyclo compound (I) or a salt thereof in accordance with the present invention has an excellent inhibiting action on matrix metalloproteases (MMPs) activity, and is useful for pharmaceutical, cosmetic and skin external compositions. wherein R is H, alkyl, heteroalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, acyl, COOR1, carbamoyl or SO2R2 (wherein R1 and R2 each are alkyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl); X is methylene, ethylene or propylene; and is a single bond or a double bond.

摘要翻译： 根据本发明的氮杂二环化合物（I）或其盐对基质金属蛋白酶（MMPs）活性具有优异的抑制作用，并且可用于药物，化妆品和皮肤外用组合物。 其中R是H，烷基，杂烷基，芳基，杂芳基，芳基烷基，杂芳基烷基，酰基，COOR 1，氨基甲酰基或SO 2 R 2（其中R 1和R 2各自是烷基，杂烷基，芳基，杂芳基 ，芳基烷基或杂芳基烷基）; X是亚甲基，亚乙基或亚丙基; 并且是单键或双键。

公开(公告)号：US06580227B2

公开(公告)日：2003-06-17

申请号：US10112725

申请日：2002-04-02

申请人： Koji Kobayashi

发明人： Koji Kobayashi

IPC分类号： H05B3700

CPC分类号： H01J11/32 ,  H01J11/12 ,  H01J11/24 ,  H01J2211/245 ,  H01J2211/323

摘要： A mesh barrier rib structure to separate display cells is provided, and each of the display cells is completely separated from the adjacent cells. Bus electrodes are provided to overlap transparent electrodes. The bus electrodes are for example made of a layered body including a white Ag thin film and a black RuO2 thin film. The transparent electrode and the bus electrode form a scan electrode, while the transparent electrode and the bus electrode form a common electrode. The bus electrodes are provided in the closest positions to the surface discharge gap between the transparent electrodes. Therefore, priming discharge is generated in the vicinity of the discharge gap, and light emission can be restrained in the priming period.

摘要翻译： 提供了用于分离显示单元的网状隔壁结构，并且每个显示单元与相邻单元完全分离。 提供总线电极以重叠透明电极。 总线电极例如由包括白色Ag薄膜和黑色RuO 2薄膜的层状体制成。 透明电极和总线电极形成扫描电极，而透明电极和总线电极形成公共电极。 总线电极设置在与透明电极之间的表面放电间隙最接近的位置。 因此，在放电间隙附近产生引发放电，能够在启动期间抑制发光。

公开(公告)号：US06468734B2

公开(公告)日：2002-10-22

申请号：US09753518

申请日：2001-01-04

申请人： Koji Kobayashi ,  Yuji Setoguchi ,  Kiyoshi Kuriyama

发明人： Koji Kobayashi ,  Yuji Setoguchi ,  Kiyoshi Kuriyama

IPC分类号： G01N3350

CPC分类号： G01N33/6869 ,  G01N33/96 ,  Y10S435/809 ,  Y10S435/81 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S435/971 ,  Y10S435/973 ,  Y10S435/974 ,  Y10S436/81

摘要： An object is to obtain a container for measurement of cell functions which is simplified in operation, less risky and capable of measuring the cell functions very accurately. A container for measurement of cell functions, for use in the determination of a physiologically active substance produced by blood cells, is constituted such that an amount of material capable of inducing production of the physiologically active substance, when extracted by collecting water of a volume equal to a liquid volume to be subjected to measurement, is controlled at a level insufficient to induce production of the physiologically active substance from the blood cells. A container for measurement of cell functions in which a material capable of inducing production of a physiologically active substance in blood when contacted with the blood is accommodated in such a condition as being contactable with blood, and in which an amount of the material capable of inducing production of the physiologically active substance in the container before use is limited to a level insufficient to influence a measured value of the physiologically active substance.

摘要翻译： 本发明的目的是获得用于测量细胞功能的容器，其操作简单，风险较小并且能够非常精确地测量细胞功能。1。一种用于测量细胞功能的容器，用于测定由 血细胞被构成为使得能够诱导生理生物活性物质的物质的量通过收集与待测量的液体体积相同的体积的水进行提取时被控制在不足以诱导生产 来自血细胞的生理活性物质。 用于测量细胞功能的容器，其中当与血液接触时能够诱导在血液中产生生理活性物质的物质的容器被容纳在与血液接触的状态下，并且其中能够诱导的物质的量 在使用前将容器中的生理活性物质的产生限制在不足以影响生理活性物质的测定值的水平。

公开(公告)号：US06458548B2

公开(公告)日：2002-10-01

申请号：US09068027

申请日：1998-04-01

申请人： Koji Kobayashi ,  Yuji Setoguchi ,  Kiyoshi Kuriyama

发明人： Koji Kobayashi ,  Yuji Setoguchi ,  Kiyoshi Kuriyama

IPC分类号： G01N3353

CPC分类号： G01N33/6869 ,  G01N33/96 ,  Y10S435/809 ,  Y10S435/81 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S435/971 ,  Y10S435/973 ,  Y10S435/974 ,  Y10S436/81

摘要： A container for measurement of cell functions, for use in the determination of a physiologically active substance produced by blood cells, is constituted such that an amount of material capable of inducing production of the physiologically active substance, when extracted by collecting water of a volume equal to a liquid volume to be subjected to measurement, is controlled at a level insufficient to induce production of the physiologically active substance from the blood cells. A container for measurement of cell functions in which a material capable of inducing production of a physiologically active substance in blood when contacted with the blood is accommodated in such a condition as being contactable with blood, and in which an amount of the material capable of inducing production of the physiologically active substance in the container before use is limited to a level insufficient to influence a measured value of the physiologically active substance.

摘要翻译： 用于测定由血细胞产生的生理活性物质的细胞功能测定用容器构成为能够诱导生成生理活性物质的物质的量，当通过收集体积相等的水提取时 对于要进行测量的液体体积被控制在不足以诱导从血细胞产生生理活性物质的水平。 用于测量细胞功能的容器，其中当与血液接触时能够诱导在血液中产生生理活性物质的物质的容器被容纳在与血液接触的状态下，并且其中能够诱导的物质的量 在使用前将容器中的生理活性物质的产生限制在不足以影响生理活性物质的测定值的水平。

公开(公告)号：US06195460B1

公开(公告)日：2001-02-27

申请号：US09297537

申请日：1999-04-30

申请人： Koji Kobayashi ,  Hiroshi Nakajima ,  Takafumi Aoki ,  Masayuki Kawamata ,  Tatsuo Higuchi

发明人： Koji Kobayashi ,  Hiroshi Nakajima ,  Takafumi Aoki ,  Masayuki Kawamata ,  Tatsuo Higuchi

IPC分类号： G06K946

CPC分类号： G06K9/522

摘要： Collation Fourier image data (FIG. 1D) FB generated by performing the two-dimensional discrete Fourier transform (DFT) for the image data (FIG. 1C) of a collation pattern is synthesized with registration Fourier image data (FIG. 1B) generated by performing the two-dimensional DFT for the image data of a registration pattern. After amplitude suppression processing is performed for the resultant data, two-dimensional DFT is performed. A correlation peak is extracted from a correlation component area which appears in the synthesized Fourier image data (FIG. 1E) for which the two-dimensional DFT has been performed. A predetermined area including this correlation peak is then masked (FIG. 1F). The two-dimensional DFT is performed for the masked synthesized Fourier image data, and amplitude restoration processing is performed for the data. The resultant data is re-synthesized with the registration Fourier image data FA, and the two-dimensional IDFT is performed for the synthesized data. With this processing, image data containing a difference pattern like the one shown in FIG. 1G or a moving pattern can be obtained.

摘要翻译： 通过对核对图案的图像数据（图1C）执行二维离散付里叶变换（DFT）生成的核对付里叶图像数据（图1D），由登记付里叶图象数据（图1B）合成， 对注册图案的图像数据执行二维DFT。 在对所得数据进行幅度压缩处理之后，执行二维DFT。 从出现在执行了二维DFT的合成付里叶图像数据（图1E）中的相关分量区域提取相关峰值。 然后掩蔽包括该相关峰的预定区域（图1F）。 对被掩蔽的合成付里叶图像数据执行二维DFT，并且对数据执行幅度恢复处理。 所得到的数据与登记付里叶图象数据FA重新合成，并且对合成数据执行二维IDFT。 通过该处理，包含类似于图1所示的差异模式的图像数据。 可以获得1G或移动图案。

公开(公告)号：US6057337A

公开(公告)日：2000-05-02

申请号：US239960

申请日：1999-01-29

申请人： Koji Kobayashi ,  Hirotada Fukunishi ,  Kenichi Umishio ,  Akihiro Ishino

发明人： Koji Kobayashi ,  Hirotada Fukunishi ,  Kenichi Umishio ,  Akihiro Ishino

IPC分类号： C07D211/22 ,  C07D211/26 ,  C07D401/12 ,  C07D521/00 ,  A61K7/06

CPC分类号： C07D231/12 ,  C07D211/22 ,  C07D211/26 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12

摘要： A 1,2-di-substituted piperidine derivative or a salt thereof expressed by the following Formula (I): ##STR1## wherein one of A and B is a hydrocarbon group of C.sub.1-30 expressed by R.sup.1 and the other is --(CH.sub.2)n-NR.sup.2 R.sup.3 ; Y is --CO--, --CONR.sup.5 -- or --COO--; Z is --O--, --OCO--, --OCONR.sup.6 -- or --NR.sup.6 --; R.sup.2 and R.sup.3 individually represent a hydrogen a lower alkyl, a phenyl or a benzyl group, or together represent a heterocycle having 3-7 members; --NR.sup.5 --(CH.sub.2)n-NR.sup.2 R.sup.3 and --NR.sup.6 --(CH.sub.2)n-NR.sup.2 R.sup.3 of --(Y).sub.1 --A and --Z--B may be the following Group W: ##STR2## wherein ring E is a heterocycle of 6 or 7 members including two nitrogen atoms and R.sup.2 is a hydrogen, a lower alkyl, a phenyl or a benzyl group; R.sup.4 is a hydrogen, a halogen, a lower alkyl, a lower acyl, a nitro, a cyano, a lower alkoxycarbonyl, a carbamoyl, a lower alkylcarbamoyl, a lower alkylamino, a lower acylamino, a lower alkoxy or a lower acyloxy group; each of R.sup.5 and R.sup.6 is a hydrogen, a lower alkyl, a lower acyl, a lower alkylcarbamoyl group, or a part of said ring E; l is 0 or 1; m is an integer of 2-5; and n is an integer of 0-5. The 1,2-di-substituted piperidine derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in human.

摘要翻译： 由下式（I）表示的1,2-二取代的哌啶衍生物或其盐：其中A和B中的一个为由R1表示的C1-30的烃基，另一个为 - （CH 2）n - NR2R3; Y是-CO - ， - CONR 5 - 或-COO-; Z是-O - ， - OCO - ， - OCONR 6 - 或-NR 6 - ; R2和R3各自表示氢，低级烷基，苯基或苄基，或一起表示具有3-7个成员的杂环; - （Y）1-A和-ZB的-NR 5 - （CH 2）n -NR 2 R 3和-NR 6 - （CH 2）n -NR 2 R 3可以是以下W组：其中环E是6或7个成员的杂环，包括两个 氮原子，R 2为氢，低级烷基，苯基或苄基; R4是氢，卤素，低级烷基，低级酰基，硝基，氰基，低级烷氧基羰基，氨基甲酰基，低级烷基氨基甲酰基，低级烷基氨基，低级酰基氨基，低级烷氧基或低级酰氧基。 R5和R6各自为氢，低级烷基，低级酰基，低级烷基氨基甲酰基或所述环E的一部分; l为0或1; m为2-5的整数; n为0-5的整数。 1,2-二取代的哌啶衍生物或其盐具有优异的毛发生长和再生长促进效果，其可用于哺乳动物，特别是人的护发，改善或预防脱发。

公开(公告)号：US5596186A

公开(公告)日：1997-01-21

申请号：US354731

申请日：1994-12-06

申请人： Koji Kobayashi

发明人： Koji Kobayashi

IPC分类号： E21B49/00 ,  G01B11/16 ,  H01L27/146 ,  H01L31/107 ,  H01J40/14

CPC分类号： G01B11/16 ,  E21B49/006 ,  H01L27/14643 ,  H01L31/107

摘要： A silicon avalanche photodiode for ultraviolet light detection having a p.sup.+ -layer, an n-layer, an n.sup.- -layer and an n.sup.+ -silicon substrate in the order from the entrance side of the ultraviolet light, wherein the p.sup.+ -layer has a thickness at least equal to 0.7/.alpha. in which .alpha. is the absorption coefficient of silicon to the ultraviolet light. Also, a divided silicon avalanche photodiode provided with a photosensor array comprising plural light-receiving areas arranged in a matrix and having a guard ring only at the external periphery of the photosensor array.

摘要翻译： 一种用于紫外光检测的硅雪崩光电二极管，其具有从紫外光入射侧开始的顺序具有p +层，n层，n层和n + - 硅基板，其中p +层具有厚度 至少等于0.7 /α，其中α是硅对紫外光的吸收系数。 另外，分开的硅雪崩光电二极管设置有光电传感器阵列，该光电传感器阵列包括排列成矩阵的多个光接收区域，并且仅在光电传感器阵列的外围具有保护环。

公开(公告)号：US5525398A

公开(公告)日：1996-06-11

申请号：US854892

申请日：1992-03-20

申请人： Mitsuru Takai ,  Koji Kobayashi ,  Jiro Yoshinari

发明人： Mitsuru Takai ,  Koji Kobayashi ,  Jiro Yoshinari

IPC分类号： G11B5/64 ,  G11B5/65 ,  G11B5/66 ,  G11B5/73 ,  G11B5/733 ,  G11B5/85 ,  B32B3/10 ,  B32B7/02

CPC分类号： G11B5/85 ,  G11B5/66 ,  Y10S428/90 ,  Y10T428/24355 ,  Y10T428/24942 ,  Y10T428/265

摘要： A perpendicular magnetic recording medium has a magnetic layer comprised of two stacked sublayers each in the form of ferromagnetic metal thin film consisting of columnar crystal grains wherein the angle .theta. between the average growth direction of the columnar crystal grains and a normal to the substrate is .theta..gtoreq.45.degree. for the lower sublayer and .theta..ltoreq.30.degree. for the upper sublayer, and the mean maximum diameter of columnar crystal grains of the lower sublayer is not smaller than the mean maximum diameter of columnar crystal grains of the upper sublayer. An apparatus suitable for the evaporation of the magnetic layer is arranged as shown in the Figure. Magnetic flux associated with the upper sublayer finds an escape to the lower sublayer, preventing formation of a closed loop of magnetic flux within the columnar crystal grains of the upper sublayer. The lower sublayer is magnetized, thus contributing to an improvement in reproduction output.

摘要翻译： 垂直磁记录介质具有由两个堆叠的子层组成的磁性层，每个层叠子层由柱状晶粒构成的强磁性金属薄膜形式，其中柱状晶粒的平均生长方向与基板的法线之间的角度θ为θ > / = 45°，下层的θ= 30°，下层的柱状晶粒的平均最大直径不小于上层的柱状晶粒的平均最大直径 。 如图所示，配置适合于磁性层蒸发的装置。 与上部子层相关联的磁通量向下部子层发现逃逸，从而防止在上部子层的柱状晶粒内形成磁通的闭环。 下部子层被磁化，因此有助于再现输出的改善。

公开(公告)号：US5453886A

公开(公告)日：1995-09-26

申请号：US181160

申请日：1994-01-13

申请人： Koji Kobayashi ,  Mitsuru Takai

发明人： Koji Kobayashi ,  Mitsuru Takai

IPC分类号： C23C14/22 ,  G11B5/66 ,  G11B5/85 ,  G11B5/00

CPC分类号： C23C14/226 ,  G11B5/66 ,  G11B5/85 ,  Y10S428/90 ,  Y10S428/928 ,  Y10T428/12465 ,  Y10T428/12646 ,  Y10T428/12861 ,  Y10T428/12931 ,  Y10T428/24942 ,  Y10T428/24975

摘要： A magnetic recording medium for digital recording has a magnetic layer on a non-magnetic substrate. The magnetic layer includes a lower layer of ferromagnetic metal thin film nearer to the substrate surface and an upper layer of ferromagnetic metal thin film, each ferromagnetic metal thin film being composed of columnar grains deposited by oblique evaporation process. The average growth directions of columnar grains in the lower and upper layers intersect each other from opposite sides of a normal to the substrate surface. Digital recording is carried out by means of a magnetic head in relative motion toward or opposite to the growth direction of columnar grains in the upper layer.

摘要翻译： 用于数字记录的磁记录介质在非磁性基板上具有磁性层。 磁性层包括更靠近基板表面的铁磁性金属薄膜的下层和强磁性金属薄膜的上层，每个强磁性金属薄膜由通过倾斜蒸发工艺沉积的柱状晶体组成。 下层和上层的柱状晶粒的平均生长方向从基板表面的法线的相对侧彼此相交。 数字记录通过与上层的柱状颗粒的生长方向相对运动或相反运动的磁头进行。