公开(公告)号：US06258564B1

公开(公告)日：2001-07-10

申请号：US09363787

申请日：1999-07-29

申请人： Makoto Kawai ,  Tadashi Okada ,  Fukiko Atsumi

发明人： Makoto Kawai ,  Tadashi Okada ,  Fukiko Atsumi

IPC分类号： C12N1502

CPC分类号： C07K14/705 ,  C07K16/28

摘要： The invention is related to antibodies which specifically react with connective tissue type-human mast cells, a production method of the antibodies, hybridomas which produce the antibodies, a production method of the hybridomas and antigen proteins recognized by the antibodies. After cord blood cells were cultured in the presence of SCF and IL-6, they were further cocultured with primary culture of human skin fibroblasts, and connective tissue type-human mast cells were thus obtained. A rat was immunized using the cells, hybridomas were prepared and selected by an ordinary method, and novel monoclonal antibodies were harvested from the culture supernatant of the selected hybridomas. The monoclonal antibodies specifically reacted with connective tissue type-human mast cells.

摘要翻译： 本发明涉及与结缔组织型 - 人肥大细胞特异性反应的抗体，抗体的制备方法，产生抗体的杂交瘤，由抗体识别的杂交瘤和抗原蛋白的制备方法。 在SCF和IL-6存在下培养脐带血细胞后，与人皮肤成纤维细胞的原代培养物进一步共培养，得到结缔组织型人类肥大细胞。 使用细胞免疫大鼠，通过常规方法制备杂交瘤并选择，并从所选择的杂交瘤的培养上清液中收获新的单克隆抗体。 单克隆抗体与结缔组织型 - 人类肥大细胞特异性反应。

公开(公告)号：US5798383A

公开(公告)日：1998-08-25

申请号：US836452

申请日：1997-05-08

申请人： Akiyoshi Kawai ,  Makoto Kawai ,  Rodney W. Stevens

发明人： Akiyoshi Kawai ,  Makoto Kawai ,  Rodney W. Stevens

IPC分类号： C07C275/26 ,  A01N47/28 ,  A61K20060101 ,  A61K31/17 ,  A61K31/275 ,  A61K31/34 ,  A61K31/38 ,  A61K31/435 ,  A61K31/44 ,  A61K31/47 ,  A61K31/557 ,  A61P29/00 ,  C07C20060101 ,  C07C67/02 ,  C07C69/66 ,  C07C69/76 ,  C07C273/18 ,  C07C275/64 ,  C07C309/23 ,  C07C309/27 ,  C07C313/02 ,  C07C317/22 ,  C07C317/42 ,  C07C323/18 ,  C07C323/43 ,  C07C323/47 ,  C07C323/65 ,  C07D213/24 ,  C07D213/26 ,  C07D213/30 ,  C07D213/32 ,  C07D213/60 ,  C07D213/63 ,  C07D215/12 ,  C07D215/14 ,  C07D215/16 ,  C07D215/20 ,  C07D307/38 ,  C07D307/52 ,  C07D307/56 ,  C07D307/58 ,  C07D307/78 ,  C07D307/79 ,  C07D307/81 ,  C07D307/82 ,  C07D307/83 ,  C07D333/06 ,  C07D333/26 ,  C07D333/32 ,  C07D333/54 ,  C07D333/62 ,  C07D333/64 ,  C12N20060101

CPC分类号： C07C275/64

摘要： The prevent invention provides a compound of formula (I): ##STR1## wherein Ar is (a) phenyl, naphthyl and biphenyl, each optionally substituted with C.sub.1-4 alkyl, C.sub.1-4 haloalkyl, C.sub.1-4 hydroxyalkyl, C.sub.1-4 alkoxy, C.sub.1-4 haloalkoxy, C.sub.2-4 alkoxyalkoxy, C.sub.1-4 alkylthio, hydroxy, halo, cyano, amino, C.sub.1-4 alkylamino, di (C.sub.2-8) alkylamino, C.sub.2-6 alkanoylamino, carboxy, C.sub.2-6 alkoxycarbonyl, or optionally substituted phenyl, phenoxy, phenylthio or phenylsulfinyl or (b) furyl, benzo�b!furyl, thienyl, benzo�b!thienyl, pyridyl or quinolyl, each optionally substituted with C.sub.1-4 alkyl, C.sub.1-4 haloalkyl, halo, C.sub.1-4 alkoxy, optionally-substituted phneyl, phenoxy or phenylthio, X is C.sub.1 -C.sub.4 alkylene, C.sub.2 -C.sub.4 alkenylene, --(CHR.sup.1).sub.m --Q.sup.1 --(CHR.sup.2).sub.n --, --O--(CHR.sup.1).sub.j --Q.sup.2 -- and --(CHR.sup.1)--O--N.dbd. in which the N.dbd. moiety is attached to the cycloalkene ring; and in which Q.sup.1 is O, S, SO, SO.sub.2, NR.sup.3, CH.dbd.N--O or CO, Q.sup.2 is O, S, SO, SO.sub.2 or NR.sup.3, and R.sup.1, R.sup.2 and R.sup.3 are each hydrogen or C.sub.1 -C.sub.4 alkyl, m and n are each an integer from 0 to 4 and j is an integer from 1 to 4; p is an integer of 1 or 2; Y is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 haloalkyl, C.sub.1-4 alkoxy, C.sub.2-4 alkoxyalkyl, C.sub.1-4 alkylthio, hydroxy, halo, cyano or amino; Z is hydrogen or C.sub.1-4 alkyl; and M is hydrogen, a pharmaceutically acceptable cation or a pharmaceutically acceptable metabolically cleavable group. Further the invention provides a pharmaceutical composition for treating a medical condition for which a 5-lipoxygenase inhibitor is needed in a mammalian subject which comprises a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. Preferably the medical condition is an inflammatory disease, allergy or cardiovascular diseases.

公开(公告)号：US5209446A

公开(公告)日：1993-05-11

申请号：US835389

申请日：1992-02-14

申请人： Makoto Kawai

发明人： Makoto Kawai

IPC分类号： F16M11/12 ,  F16M11/14 ,  G09F9/00 ,  H04M1/12 ,  H04N5/64

CPC分类号： F16M11/126 ,  F16M2200/022 ,  Y10S248/92 ,  Y10S248/923

摘要： A rotary stand having a base and a turntable connected in a slidable manner at their respective circular faces by a connecting member inserted into an axis and a spacer which has a projection fitted to the outer periphery of the axis inserted into an elongated hole of the turntable, so that the projection is restricted to turn within the elongated hole, while being permitted to turn only in a predetermined area within the guide groove of the base.

公开(公告)号：US5151254A

公开(公告)日：1992-09-29

申请号：US573753

申请日：1990-08-28

申请人： Hideki Arai ,  Makoto Kawai ,  Kenji Miyai

发明人： Hideki Arai ,  Makoto Kawai ,  Kenji Miyai

IPC分类号： F01N3/28 ,  F01N13/08

CPC分类号： F01N3/28 ,  F01N3/2807 ,  F01N13/08 ,  F01N2260/08 ,  F01N2510/06 ,  Y10S55/30

摘要： An exhaust gas cleaning device is disposed within an exhaust pipe connected to the exhaust port of an internal combustion engine. The exhaust gas cleaning device comprises an inner pipe disposed coaxially within the exhaust pipe with an annular space defined therebetween, the inner pipe being provided with a plurality of perforations, and laminated structures disposed upon the inner and outer surfaces of the inner pipe and including a catalyst for cleaning unburned components of the exhaust gas flowing within the exhaust pipe, each of the laminated structures being formed of a material which is not deleterious to the catalyst. The laminated structure includes a catalyst carrier layer formed by, in accordance with one method, fusibly injecting a catalyst including a solution onto an intermediate layer formed upon the inner and outer surfaces of the inner pipe and drying the same so as to remove the liquid component therefrom. The laminated structure may also be formed upon the inner surface of the exhaust pipe so as to improve the exhaust gas cleaning effect.

公开(公告)号：US4766326A

公开(公告)日：1988-08-23

申请号：US887622

申请日：1986-07-21

申请人： Chikahisa Hayashi ,  Makoto Kawai ,  Yoshikazu Hirose ,  Junichi Mizutani

发明人： Chikahisa Hayashi ,  Makoto Kawai ,  Yoshikazu Hirose ,  Junichi Mizutani

IPC分类号： B60R16/02 ,  B60R16/027 ,  B62D1/04 ,  H02G3/00

CPC分类号： B60R16/027 ,  B62D1/105

摘要： A communication structure provided in a steering wheel. The steering wheel includes having a steering shaft; a boss fixed to it. At least one spoke fixed to the boss. A pad is installed relatively rotatably to the steering shaft at a position more proximate to the driver than the boss. A column is positioned in relation to the pad so that at least one of the spoke and a boss plate is sandwiched therebetween. At least one set of magnetic communication units composed of a receiving unit and a transmitting unit is provided on the pad and said column, at least one of which consists of a core and a coil wound thereon.

摘要翻译： 设置在方向盘中的通信结构。 方向盘包括转向轴; 一个老板固定在它上面。 至少有一个辐条固定在老板身上。 在比凸台更靠近驾驶员的位置处，相对于转向轴可旋转地安装衬垫。 柱相对于垫定位，使得轮辐和凸台板中的至少一个夹在其间。 由接收单元和发送单元组成的至少一组磁通信单元设置在所述垫和所述列上，其中至少一组由卷绕在其上的芯和线圈组成。

公开(公告)号：US4618831A

公开(公告)日：1986-10-21

申请号：US775976

申请日：1985-09-13

申请人： Shunichiro Egami ,  Makoto Kawai

发明人： Shunichiro Egami ,  Makoto Kawai

IPC分类号： H03F3/68 ,  H01P5/16 ,  H01Q25/00 ,  H03F3/60

CPC分类号： H01P5/16 ,  H01Q25/00 ,  H03F3/602 ,  H03F2200/198

摘要： A first multi-port hybrid coupler is formed by n2.sup.n-1 (where n is an integer equal to or greater than 2) hybrid couplers alone, which are divided into n stages, each including 2.sup.n-1 hybrid couplers. A signal input to any one of N (=2.sup.n) input terminals of the first stage is distributed equally to N output terminals of the nth stage. The N output terminals of the nth stage of the first multi-port hybrid coupler are connected to N amplifiers at the input side thereof, respectively, and the N amplifiers are connected at the output side to a second multi-port hybrid coupler. The second multi-port hybrid coupler is identical in construction with the first multi-port hybrid coupler, but its input terminals and output terminals are reverse from those of the latter and the input terminals of the second multi-port hybrid coupler are connected to the N amplifiers in an order reverse from the order of arrangement of the output terminals of the first multi-port hybrid coupler.

摘要翻译： 第一多端口混合耦合器由n2n-1（其中n是等于或大于2的整数）单独的混合耦合器形成，其分为n级，每个级包括2n-1个混合耦合器。 输入到第一级的N（= 2n）个输入端中的任何一个的信号被均等地分配给第n级的N个输出端。 第一多端口混合耦合器的第n级的N个输出端分别在其输入侧连接到N个放大器，并且N个放大器在输出侧连接到第二多端口混合耦合器。 第二多端口混合耦合器在结构上与第一多端口混合耦合器相同，但是其输入端和输出端与后者相反，并且第二多端口混合耦合器的输入端连接到 N个放大器的顺序与第一多端口混合耦合器的输出端子的排列顺序相反。

公开(公告)号：US08927710B2

公开(公告)日：2015-01-06

申请号：US13378334

申请日：2010-06-14

申请人： Toshiyuki Akiyama ,  Kenji Takaya ,  Makoto Kawai ,  Yoshiyuki Taoda ,  Minako Mikamiyama ,  Kenji Morimoto ,  Chika Kageyama ,  Kenji Tomita ,  Hidenori Mikamiyama ,  Naoyuki Suzuki

发明人： Toshiyuki Akiyama ,  Kenji Takaya ,  Makoto Kawai ,  Yoshiyuki Taoda ,  Minako Mikamiyama ,  Kenji Morimoto ,  Chika Kageyama ,  Kenji Tomita ,  Hidenori Mikamiyama ,  Naoyuki Suzuki

IPC分类号： C07D471/04 ,  C07D401/06 ,  C07D413/06 ,  A61K31/53 ,  A61K31/4427 ,  A61K31/506 ,  A61K31/5377 ,  A61P31/16 ,  C07D498/14 ,  C07D471/14

CPC分类号： C07D471/04 ,  A61K31/53 ,  C07D471/14 ,  C07D487/14 ,  C07D487/20 ,  C07D498/14

摘要： This invention provides compounds having antiviral activities especially inhibiting activity for influenza virus, more preferably provides substituted 3-hydroxy-4-pyridone derivatives having cap-dependent endonuclease inhibitory activity.

摘要翻译： 本发明提供具有抗病毒活性的化合物，特别是抑制流感病毒的活性，更优选提供具有cap依赖性内切核酸酶抑制活性的取代的3-羟基-4-吡啶酮衍生物。

公开(公告)号：US08138177B2

公开(公告)日：2012-03-20

申请号：US11909763

申请日：2006-03-02

申请人： Kazuo Ando ,  Makoto Kawai ,  Tsutomu Masuda ,  Hirofumi Omura

发明人： Kazuo Ando ,  Makoto Kawai ,  Tsutomu Masuda ,  Hirofumi Omura

IPC分类号： A61K31/541 ,  A61K31/5377 ,  A61K31/454 ,  C07D413/02 ,  C07D211/32 ,  C07D471/02

CPC分类号： C07D471/04 ,  C07D235/26 ,  C07D401/06 ,  C07D403/12 ,  C07D405/06 ,  C07D413/12 ,  C07D417/12

摘要： This invention relates to compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein: A, B, R1, R2 and R3 are each as described herein, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by CB2 receptor binding activity such as, but not limited to, inflammatory pain, nociceptive pain, neuropathic pain, fibromyalgia, chronic low back pain, visceral pain, acute cerebral ischemia, pain, chronic pain, acute pain, post herpetic neuralgia, neuropathies, neuralgia, diabetic neuropathy, HIV-related neuropathy, nerve injury, rheumatoid arthritic pain, osteoarthritic pain, back pain, cancer pain, dental pain, fibromyalgia, neuritis, sciatica, inflammation, neurodegenerative disease, cough, broncho constriction, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), colitis, cerebrovascular ischemia, emesis such as cancer chemotherapy-induced emesis, rheumatoid arthritis, asthma, Crohn's disease, ulcerative colitis, asthma, dermatitis, seasonal allergic rhinitis, gastroesophageal reflux disease (GERD), constipation, diarrhea, functional gastrointestinal disorder, cutaneous T cell lymphoma, multiple sclerosis, osteoarthritis, psoriasis, systemic lupus erythematosus, diabetes, glaucoma, osteoporosis, glomerulonephritis, renal ischemia, nephritis, hepatitis, cerebral stroke, vasculitis, myocardial infarction, cerebral ischemia, reversible airway obstruction, adult respiratory disease syndrome, chronic obstructive pulmonary disease (COPD), cryptogenic fibrosing alveolitis or bronchitis.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中：A，B，R 1，R 2和R 3各自如本文所述，含有这些化合物的组合物和这些化合物在治疗 由CB2受体结合活性介导的病症，例如但不限于炎性疼痛，伤害性疼痛，神经性疼痛，纤维肌痛，慢性腰痛，内脏痛，急性脑缺血，疼痛，慢性疼痛，急性疼痛，疱疹后神经痛 ，神经病，神经痛，糖尿病性神经病，HIV相关神经病，神经损伤，类风湿性关节炎疼痛，骨关节炎疼痛，背痛，癌症疼痛，牙痛，纤维肌痛，神经炎，坐骨神经痛，炎症，神经变性疾病，咳嗽，支气管收缩，肠易激惹 综合征（IBS），炎性肠病（IBD），结肠炎，脑血管缺血，呕吐如癌症化疗诱发的呕吐，类风湿性关节炎，哮喘，克罗恩病，ul 结肠炎，哮喘，皮炎，季节性过敏性鼻炎，胃食管反流病（GERD），便秘，腹泻，功能性胃肠道疾病，皮肤T细胞淋巴瘤，多发性硬化症，骨关节炎，牛皮癣，系统性红斑狼疮，糖尿病，青光眼，骨质疏松症，肾小球性肾炎， 肾缺血，肾炎，肝炎，脑中风，血管炎，心肌梗死，脑缺血，可逆性气道阻塞，成人呼吸道疾病综合征，慢性阻塞性肺病（COPD），隐源性纤维化肺泡炎或支气管炎。

公开(公告)号：US08060107B2

公开(公告)日：2011-11-15

申请号：US11730245

申请日：2007-03-30

申请人： Yasuhisa Takizawa ,  Peter Davis ,  Makoto Kawai ,  Hisato Iwai ,  Akira Yamaguchi ,  Sadao Obana

发明人： Yasuhisa Takizawa ,  Peter Davis ,  Makoto Kawai ,  Hisato Iwai ,  Akira Yamaguchi ,  Sadao Obana

IPC分类号： H04W24/00

CPC分类号： H04W64/00 ,  G01S5/14

摘要： A radio apparatus forming a radio network system calculates a calculated distance, based on a tentative self-position and tentative positions of a plurality of radio apparatuses existing in the vicinity. The radio apparatus successively and autonomously corrects the tentative self-position so that the calculated distance comes closer to the measured distance, relying more heavily on the calculated distance than the measured distance between itself and each of the plurality of radio apparatuses, and determines the position of itself. Other radio apparatuses also successively correct the tentative self-positions by the same method as the radio apparatus, and determine the positions of themselves.

摘要翻译： 形成无线电网络系统的无线电设备基于存在于附近的多个无线电设备的临时自身位置和临时位置来计算计算出的距离。 无线电设备相继地并且自主地校正临时自身位置，使得所计算的距离更靠近测量的距离，更依赖于所计算的距离，而不是其测量的与多个无线电设备中的每一个之间的距离，并且确定位置 本身。 其他无线电设备也通过与无线电设备相同的方法连续校正临时自身位置，并且确定其自身的位置。

公开(公告)号：US20050258280A1

公开(公告)日：2005-11-24

申请号：US11118373

申请日：2005-05-02

申请人： Keiichi Goto ,  Makoto Kawai ,  Kenji Satoh

发明人： Keiichi Goto ,  Makoto Kawai ,  Kenji Satoh

IPC分类号： H05H1/46 ,  B05B1/18 ,  B05B3/04 ,  C23C8/36 ,  H01J37/32 ,  H01L21/3065

CPC分类号： H01J37/3244 ,  B05B1/185 ,  C23C8/36 ,  H01L21/3065

摘要： There is disclosed a shower plate 1, wherein the shower plate has a plurality of holes 3 for inserting the head of the fastening member and holes 4 for fitting the head are formed integrally along a concentric circle in the outside region of the gas feeding holes 2 on a side facing the supporting member, each hole for fitting extending in one direction of the concentric circle from each hole for insertion, each hole for fitting has a groove portion 4b through which the shank of the fastening member is to pass and a fitting portion 4a which is wider than the groove portion and in which the head of the fastening member is to be fitted, and the head of the fastening member fixed in the supporting member is inserted into the hole for insertion of the shower plate and the shower plate is turned so that the head of the fastening member is fitted in the fitting portion, and thereby the shower plate is supported by the supporting member without exposure of the fastening member. There can be provided a shower plate for a plasma processing apparatus, wherein effective diameter is large enough, contamination of a substrate to be treated can be prevented, it is easy to manufacture, and it is easy to fix to a supporting member.

摘要翻译： 公开了一种喷淋板1，其中喷淋板具有用于插入紧固部件的头部的多个孔3，用于安装头部的孔4沿气体供给孔2的外部区域中的同心圆一体地形成 在面对支撑构件的一侧，每个孔用于从每个孔插入同心圆的一个方向延伸，每个用于装配的孔具有凹槽部分4b，紧固构件的柄将穿过该槽部分4b和配件 部分4a，其宽于凹槽部分，并且紧固构件的头部将被装配在其中，并且固定在支撑构件中的紧固构件的头部插入到用于插入淋浴板和淋浴器的孔中 板的转动使得紧固件的头部装配在装配部分中，从而淋浴板由支撑件支撑而不暴露紧固件。 可以提供一种用于等离子体处理装置的喷淋板，其中有效直径足够大，可以防止待处理基板的污染，易于制造，并且易于固定到支撑构件。