公开(公告)号：US06753966B2

公开(公告)日：2004-06-22

申请号：US09803131

申请日：2001-03-09

Applicant: Charles W. Von Rosenberg

Inventor： Charles W. Von Rosenberg

IPC: G01N2100

CPC classification number: G01J3/02 ,  G01J3/0213 ,  G01J3/0218 ,  G01J3/0227 ,  G01J3/0232 ,  G01J3/0256 ,  G01J3/0262 ,  G01J3/28 ,  G01J3/502 ,  G01J2003/2866 ,  G01N21/3563 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/8507 ,  G01N33/10

Abstract: The present invention relates to spectral analysis systems and methods for determining physical and chemical properties of a sample by measuring the optical characteristics of light emitted from the sample. In one embodiment, a probe head for use with a spectrometer includes a reflector for illuminating a sample volume disposed circumferentially about the light source of the probe head. In another embodiment, a probe head includes an optical blocking element for forcing the optical path between the light source and an optical pick-up optically connected to the spectrometer into the sample. The probe head also includes a reference shutter for selectively blocking light emitted from the sample from reaching the optical pick-up to facilitate calibration of the spectrometer.

Abstract translation: 本发明涉及通过测量从样品发射的光的光学特性来确定样品的物理和化学性质的光谱分析系统和方法。 在一个实施例中，用于光谱仪的探针头包括用于照亮围绕探头的光源周向设置的样品体积的反射器。 在另一个实施例中，探头包括用于迫使光源和光学连接到光谱仪的光学拾取器之间的光路进入样品的光学阻挡元件。 探头还包括用于选择性地阻挡从样品发射的光到达光学拾波器以便于校准光谱仪的参考快门。

公开(公告)号：US20040042009A1

公开(公告)日：2004-03-04

申请号：US10653306

申请日：2003-09-02

Inventor： David E. Aspnes ,  Jon Opsal

IPC: G01J004/00

CPC classification number: G01J3/02 ,  G01J3/0229 ,  G01J3/0232 ,  G01N21/211 ,  G01N2021/213

Abstract: An ellipsometer, and a method of ellipsometry, for analyzing a sample using a broad range of wavelengths, includes a light source for generating a beam of polychromatic light having a range of wavelengths of light for interacting with the sample. A polarizer polarizes the light beam before the light beam interacts with the sample. A rotating compensator induces phase retardations of a polarization state of the light beam wherein the range of wavelengths and the compensator are selected such that at least a first phase retardation value is induced that is within a primary range of effective retardations of substantially 135null to 225null, and at least a second phase retardation value is induced that is outside of the primary range. An analyzer interacts with the light beam after the light beam interacts with the sample. A detector measures the intensity of light after interacting with the analyzer as a function of compensator angle and of wavelength, preferably at all wavelengths simultaneously. A processor determines the polarization state of the beam as it impinges the analyzer from the light intensities measured by the detector.

Abstract translation: 用于使用宽波长范围分析样品的椭偏仪的椭偏仪和椭偏仪的方法包括用于产生具有用于与样品相互作用的光波长范围的多色光束的光源。 在光束与样品相互作用之前，偏振器使光束偏振。 旋转补偿器引起光束的偏振状态的相位延迟，其中选择波长范围和补偿器，使得至少引入第一相位延迟值，该值在大致135°至225°的有效延迟的主要范围内 °，并且引起超出初级范围的至少第二相位延迟值。 在光束与样品相互作用后，分析仪与光束相互作用。 检测器测量与分析仪相互作用后的光强度，作为补偿器角度和波长的函数，优选同时在所有波长处。 处理器确定当光束从由检测器测量的光强度撞击分析仪时的偏振状态。

公开(公告)号：US20040017566A1

公开(公告)日：2004-01-29

申请号：US10460255

申请日：2003-06-13

Applicant: C.R.F. SOCIETA CONSORTILE PER AZIONI

Inventor： Marco Pizzi

IPC: G01J003/42 ,  G01J003/28

CPC classification number: G01J3/02 ,  G01J3/0232 ,  G01J3/04

Abstract: Described herein is a spectrophotometer having an inlet slit associated to which is at least one electrostatic-film shutter.

Abstract translation: 本文描述的分光光度计具有与至少一个静电膜快门相关联的入口狭缝。

公开(公告)号：US06667803B1

公开(公告)日：2003-12-23

申请号：US09584990

申请日：2000-06-01

Applicant: Larry D. Flessland ,  Sergey I. Gritsenko ,  Mark S. Lewandowski ,  Dean E. Myers

Inventor： Larry D. Flessland ,  Sergey I. Gritsenko ,  Mark S. Lewandowski ,  Dean E. Myers

IPC: G01J342

CPC classification number: G01N21/3151 ,  A61B5/0059 ,  A61B2560/0223 ,  A61B2560/0233 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0291 ,  G01J3/28 ,  G01J2003/2866 ,  G01N21/255 ,  G01N21/274 ,  G01N21/3563 ,  G02B6/3825 ,  G02B6/3885 ,  G02B6/4249 ,  G02B6/4298

Abstract: A spectrophotometric instrument including light signal sources, a detector, a processor/controller, a probe and a calibration device. The light signal sources include a source of measurement light signals having measurement light wavelengths and a source of a calibration light signal at a calibration detection wavelength which is different than the measurement light wavelengths. The probe has one or more send fibers coupled to the measurement and calibration light signal sources for transmitting the measurement light signals and the calibration light signal into tissue, and one or more receive fibers for receiving light including the measurement light signals and the calibration light signal. The calibration device is adapted to receive the probe and has an optical filter for transmitting the measurement light signals but not the calibration light signal. The detector is coupled to the receive fibers to generate electrical signals representative of the light received at the receive fibers. The processor/controller is coupled to the detector and initiates a calibration procedure when the calibration light signal is not detected.

Abstract translation: 包括光信号源，检测器，处理器/控制器，探针和校准装置的分光光度仪器。 光信号源包括具有测量光波长的测量光信号源和与测量光波长不同的校准检测波长的校准光信号源。 探头具有耦合到测量和校准光信号源的一个或多个发送光纤，用于将测量光信号和校准光信号传输到组织中，以及一个或多个接收光纤，用于接收包括测量光信号和校准光信号的光 。 校准装置适于接收探头并且具有用于传送测量光信号而不是校准光信号的滤光器。 检测器耦合到接收光纤以产生代表在接收光纤处接收的光的电信号。 当未检测到校准光信号时，处理器/控制器耦合到检测器并启动校准程序。

公开(公告)号：US20030191368A1

公开(公告)日：2003-10-09

申请号：US10393028

申请日：2003-03-20

Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

Inventor： Thomas D. Wang ,  Michael S. Feld ,  Yang Wang ,  Jacques Van Dam ,  Stephen F. Fulghum

IPC: A61B001/06 ,  A61B006/00

CPC classification number: G01J3/4406 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/043 ,  A61B1/05 ,  A61B1/07 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/415 ,  A61B5/418 ,  G01J3/02 ,  G01J3/0232 ,  G01J3/10 ,  G01N21/6456 ,  G01N2021/6417 ,  G01N2021/6421 ,  G01N2021/6484

Abstract: The present invention relates to a fluorescence endoscope imaging system. The system uses first and second light sources to provide fluorescence and reflectance images of tissue being examined. An imaging device mounted at the distal end of the device is used to collect both images.

Abstract translation: 本发明涉及一种荧光内窥镜成像系统。 该系统使用第一和第二光源来提供正在检查的组织的荧光和反射图像。 安装在设备远端的成像装置用于收集两个图像。

公开(公告)号：US20030130709A1

公开(公告)日：2003-07-10

申请号：US10180802

申请日：2002-06-26

Inventor： Constance Haber D.C. ,  Allan Gardiner

IPC: A61N005/00

CPC classification number: G01J3/02 ,  A61B5/0488 ,  A61B5/0531 ,  A61B5/4519 ,  A61B5/4528 ,  A61N5/0619 ,  A61N2005/0663 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/10 ,  G01J2003/1213

Abstract: This invention provides methods for treating a variety of disorders using electromagnetic radiation directed at excitable tissues, including nerves, muscles and blood vessels. By controlling the wavelength, the wavelength bandpass, pulse duration, intensity, pulse frequency, and/or variations of those characteristics over time, and by selecting sites of exposure to electromagnetic radiation, improvements in the function of different tissues and organs can be provided. By monitoring physiological variables such as muscle tone and activity, temperature gradients, surface electromyography, blood flow and others, the practitioner can optimize a therapeutic regimen suited for the individual patient.

Abstract translation: 本发明提供了使用针对可兴奋组织（包括神经，肌肉和血管）的电磁辐射来治疗多种疾病的方法。 通过控制波长，波长带通，脉冲持续时间，强度，脉冲频率和/或这些特性随时间的变化，并且通过选择暴露于电磁辐射的部位，可以提供不同组织和器官的功能的改善。 通过监测诸如肌肉紧张度和活动，温度梯度，表面肌电描记术，血流量等生理变量，医师可以优化适合于个体患者的治疗方案。

公开(公告)号：US06583865B2

公开(公告)日：2003-06-24

申请号：US09932844

申请日：2001-08-17

Applicant: David A. Basiji ,  William E. Ortyn

Inventor： David A. Basiji ,  William E. Ortyn

IPC: G01J314

CPC classification number: G06K9/00127 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0232 ,  G01J3/14 ,  G01J3/2823 ,  G01J3/2889 ,  G01N15/14 ,  G01N21/6458 ,  G01N2015/1497

Abstract: Light from an object moving through an imaging system is collected, dispersed, and imaged onto a time delay integration (TDI) detector that is inclined relative to an axis of motion of the object, producing a pixilated output signal. In one embodiment, the movement of the image object over the TDI detector is asynchronous with the movement of the output signal producing an output signal that is a composite of the image of the object at varying focal point along the focal plane. In another embodiment, light from the object is periodically incident on the inclined TDI detector, producing a plurality of spaced apart images and corresponding output signals that propagate across the TDI detector. The inclined plane enables images of FISH probes or other components within an object to be produced at different focal points, so that the 3D spatial relationship between the FISH probes or components can be resolved.

公开(公告)号：US06472657B1

公开(公告)日：2002-10-29

申请号：US09594663

申请日：2000-06-15

Applicant: Paul C. Miles ,  Eldon L. Porter ,  Thomas L. Prast ,  Duane A. Sunnarborg

Inventor： Paul C. Miles ,  Eldon L. Porter ,  Thomas L. Prast ,  Duane A. Sunnarborg

IPC: G01D534

CPC classification number: G01J3/02 ,  G01J3/0232 ,  G01J3/027

Abstract: A fast mechanical shutter, based on rotating chopper wheels, has been designed and implemented to shutter the entrance slit of a spectrograph. This device enables an exposure time of 9 &mgr;s to be achieved for a 0.8 mm wide spectrograph entrance slit, achieves 100% transmission in the open state, and an essentially infinite extinction ratio. The device further incorporates chopper wheel position sensing electronics to permit the synchronous triggering of a laser source.

Abstract translation: 基于旋转斩波轮的快速机械快门已经被设计和实现，以便遮蔽光谱仪的入口狭缝。 该装置能够实现0.8mm宽的光谱仪入口狭缝的曝光时间为9μs，在打开状态下实现100％透射，并且基本上具有无限大的消光比。 该装置还包括切割轮位置检测电子器件，以允许激光源的同步触发。

公开(公告)号：US20020018205A1

公开(公告)日：2002-02-14

申请号：US09944831

申请日：2001-08-31

Inventor： David E. Aspnes ,  Jon Opsal

IPC: G01J004/00

CPC classification number: G01J3/02 ,  G01J3/0229 ,  G01J3/0232 ,  G01N21/211 ,  G01N2021/213

Abstract: An ellipsometer, and a method of ellipsometry, for analyzing a sample using a broad range of wavelengths, includes a light source for generating a beam of polychromatic light having a range of wavelengths of light for interacting with the sample. A polarizer polarizes the light beam before the light beam interacts with the sample. A rotating compensator induces phase retardations of a polarization state of the light beam wherein the range of wavelengths and the compensator are selected such that at least a first phase retardation value is induced that is within a primary range of effective retardations of substantially 135null to 225null, and at least a second phase retardation value is induced that is outside of the primary range. An analyzer interacts with the light beam after the light beam interacts with the sample. A detector measures the intensity of light after interacting with the analyzer as a function of compensator angle and of wavelength, preferably at all wavelengths simultaneously. A processor determines the polarization state of the beam as it impinges the analyzer from the light intensities measured by the detector.

公开(公告)号：US06191860B1

公开(公告)日：2001-02-20

申请号：US09370131

申请日：1999-08-06

Applicant: Leonid Klinger ,  Ilya Fine

Inventor： Leonid Klinger ,  Ilya Fine

IPC: G01J351

CPC classification number: G01J3/02 ,  G01J3/0213 ,  G01J3/0232

Abstract: An attenuating optical shutter for high speed spectral analysis of an optical radiation band so as to derive N wavelength-dependent portions thereof. The attenuating optical shutter incorporates an optical shutter body including N shutter segments, each selectably switchable between a first substantially transparent and a second substantially opaque optical state, and a multi-zone attenuator comprising N optical attenuating zones each having a different predetermined wavelength-dependent attenuation characteristic. Each of the shutter segments is optically interconnected with a respective one of the N optical attenuating zones of the multi-zone attenuator thus forming N respective cells of the attenuating optical shutter. Such an attenuating optical shutter finds particular application in a spectrometer. A method for determining the spectral function of a sample using the attenuating optical shutter is also described.

Abstract translation: 一种用于光辐射带的高速光谱分析的衰减光学快门，以便导出其与N个波长相关的部分。 衰减光学快门结合有光学快门主体，其包括N个快门段，每个快门段可选地在第一基本上透明和第二基本上不透明的光学状态之间切换，以及包括N个光衰减区域的多区域衰减器，每个光衰减区域具有不同的预定波长相关衰减 特性。 每个快门段与多区衰减器的N个光衰减区域中的相应一个光学互连，从而形成衰减光学快门的N个相应单元。 这种衰减光学快门在光谱仪中发现具体应用。 还描述了使用衰减光学快门来确定样品的光谱功能的方法。