公开(公告)号：US11832871B2

公开(公告)日：2023-12-05

申请号：US17352817

申请日：2021-06-21

Applicant: Board of Regents of the University of Nebraska

Inventor： Shane Farritor ,  Tom Frederick ,  Joe Bartels

IPC: A61B18/18 ,  A61B18/14 ,  A61B34/30 ,  A61B18/00

CPC classification number: A61B18/1445 ,  A61B34/30 ,  A61B2018/0063 ,  A61B2018/00345 ,  A61B2018/00595 ,  A61B2018/1455 ,  A61B2034/301

Abstract: The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices, and more specifically including end effectors that can be incorporated into such devices. Certain end effector embodiments include various vessel cautery devices that have rotational movement as well as cautery and cutting functions while maintaining a relatively compact structure. Other end effector embodiments include various end effector devices that have more than one end effector.

公开(公告)号：US11819299B2

公开(公告)日：2023-11-21

申请号：US18058904

申请日：2022-11-28

Applicant: Board of Regents of the University of Nebraska

Inventor： Jack Mondry ,  Shane Farritor ,  Eric Markvicka ,  Thomas Frederick ,  Joe Bartels

IPC: A61B34/20 ,  A61B34/30 ,  B25J9/00 ,  A61B90/00 ,  A61B17/00 ,  A61B17/29

CPC classification number: A61B34/30 ,  A61B17/00234 ,  A61B34/20 ,  A61B90/361 ,  B25J9/0084 ,  B25J9/0087 ,  A61B2017/2906 ,  A61B2034/2048 ,  A61B2034/2051 ,  A61B2034/302

Abstract: Disclosed herein are various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Also disclosed are various medical devices for in vivo medical procedures. Included herein, for example, is a surgical robotic device having an elongate device body, a right robotic arm coupled to a right shoulder assembly, and a left robotic arm coupled to a left shoulder assembly.

公开(公告)号：US20230302196A1

公开(公告)日：2023-09-28

申请号：US18015094

申请日：2021-07-20

Applicant: Board of Regents of the University of Nebraska

Inventor： Jingwei XIE ,  Shixuan CHEN

IPC: A61L27/26 ,  A61L27/56 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54

CPC classification number: A61L27/26 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/418 ,  A61L2400/12 ,  A61L2430/02 ,  A61L2430/06

Abstract: Nanofiber structures are provided as well as methods of use thereof and methods of making.

公开(公告)号：US11752221B2

公开(公告)日：2023-09-12

申请号：US16024643

申请日：2018-06-29

Applicant: Massachusetts Institute of Technology ,  Board of Regents of the University of Nebraska

Inventor： Jeremiah A. Johnson ,  Hung Vanthanh Nguyen ,  Andrzej Rajca

IPC: A61K49/12 ,  A61K49/00 ,  A61K49/20 ,  A61K49/18 ,  B82Y5/00

CPC classification number: A61K49/124 ,  A61K49/0032 ,  A61K49/0054 ,  A61K49/0093 ,  A61K49/186 ,  A61K49/1881 ,  A61K49/20 ,  A61K2123/00 ,  B82Y5/00

Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare nitroxide-functionalized brush-arm star polymer organic radical contrast agent (BASP-ORCA) as well as compositions and uses thereof. Various embodiments show that BASP-ORCA display unprecedented per-nitroxide and per-molecule transverse relaxivities for organic radical contrast agents, exceptional stability, high water solubility, low in vitro and in vivo toxicity, and long blood compartment half-life. These materials have the potential to be adopted for tumor imaging using clinical high-field 1H MRI techniques.

公开(公告)号：US20230253611A1

公开(公告)日：2023-08-10

申请号：US18105348

申请日：2023-02-03

Applicant: NUtech Ventures ,  Board of Regents of the University of Nebraska

Inventor： Michael SEALY ,  Xuejing SHEN ,  Tao SUN ,  Li TAN ,  Alexey KRASNOSLOBODTSEV ,  Wai-Ning MEI ,  Renat SABIRIANOV

IPC: H01M10/054 ,  H01M4/46 ,  H01M4/38 ,  H01M4/583 ,  H01M10/0566

CPC classification number: H01M10/054 ,  H01M4/463 ,  H01M4/38 ,  H01M4/583 ,  H01M10/0566 ,  H01M2004/027

Abstract: Aspects disclosed herein include an electrochemical cell comprising: an anode comprising: a first surface comprising aluminum metal or an aluminum alloy; a liquid metal on the first surface, the liquid metal being in liquid state during operation of the battery and the liquid metal having a different composition than that of the first surface; and aluminum-rich dendrites extending from the first surface and in contact with an electrolyte; a positive electrode; and the electrolyte between the positive electrode and the negative electrode, the electrolyte being capable of conducting ions.

公开(公告)号：US20230250085A1

公开(公告)日：2023-08-10

申请号：US18301693

申请日：2023-04-17

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Amarnath Natarajan

IPC: C07D403/04 ,  A61P35/04

CPC classification number: C07D403/04 ,  A61P35/04 ,  A61K9/0053

Abstract: Provided herein are compounds having a structure of formula (I) and methods of using the disclosed compounds to inhibit IKKβ activity.

公开(公告)号：US11607464B2

公开(公告)日：2023-03-21

申请号：US16967527

申请日：2019-04-04

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Janina Baranowska-Kortylewicz ,  Zbigniew Kortylewicz

IPC: A61K51/04 ,  A61P35/00 ,  A61K31/4184 ,  A61B6/03 ,  A61N5/10 ,  C07D235/32

Abstract: Compositions and methods for treating, detecting, and diagnosing cancer are disclosed.

公开(公告)号：US11574704B2

公开(公告)日：2023-02-07

申请号：US16746347

申请日：2020-01-17

Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services ,  British Columbia Cancer Agency Branch ,  Arizona Board of Regents on Behalf of the University of Arizona ,  Universitat de Barcelona ,  Hospital Clinic de Barcelona ,  The Cleveland Clinic Foundation ,  Board of Regents of the University of Nebraska ,  Oregon Health & Science University ,  Julius-Maximilians—University of Würzburg ,  Oslo University Hospital HF

Inventor： Louis M. Staudt ,  George W. Wright ,  David William Scott ,  Joseph M. Connors ,  Randy D. Gascoyne ,  Lisa Rimsza ,  Elias Campo Guerri ,  Raymond Tubbs ,  Timothy C. Greiner ,  James Robert Cook ,  Kai Fu ,  Paul Michael Williams ,  Chih-Jian Lih ,  Elaine S. Jaffe ,  Rita M. Braziel ,  Andreas Rosenwald ,  Erlend B. Smeland ,  Wing C. Chan ,  German Ott ,  Jan Delabie ,  Dennis Weisenburger

IPC: G01N33/48 ,  G16B25/10 ,  G16B25/00 ,  G16B5/00 ,  C12Q1/6886

Abstract: The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.

公开(公告)号：US11555208B2

公开(公告)日：2023-01-17

申请号：US15890561

申请日：2018-02-07

Applicant: Board of Regents of the University of Nebraska ,  Tokai University Educational System

Inventor： Channabasavaiah B. Gurumurthy ,  Hiromi Miura ,  Masato Ohtsuka

IPC: C12N15/90 ,  C12N15/10 ,  A01K67/027 ,  C12N9/22 ,  C12N15/11 ,  C12N15/85 ,  C12N9/96

Abstract: Disclosed are compositions, methods, and kits for modifying DNA within cells as well as compositions and methods for modifying gene expression in a cell. In particular, the invention generally relates to compositions, methods, and kits for DNA editing using single-stranded DNA. Compositions and methods for modifying gene expression using artificial microRNAs (amiRNA) are also contemplated.

公开(公告)号：US11504196B2

公开(公告)日：2022-11-22

申请号：US17236489

申请日：2021-04-21

Applicant: Board of Regents of the University of Nebraska

Inventor： Joseph Palmowski ,  Shane Farritor

IPC: B25J17/02 ,  A61B34/30 ,  B25J9/12 ,  B25J9/10

Abstract: Disclosed herein are various robotic surgical devices and systems that include first and second elongate bodies, first and second driveshafts disposed through the second elongate body, and an in-line shoulder joint with a robotic arm coupled thereto. In certain implementations, the in-line shoulder joint has a differential yoke and a dual shaft disposed within the yoke lumen.