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公开(公告)号：US11648226B2
公开(公告)日：2023-05-16
申请号：US17026671
申请日：2020-09-21
Inventor： Mark R. Kelley , Melissa L. Fishel
IPC: A61K31/201 , A61K31/165 , A61K31/343 , A61K31/501 , A61K31/519 , A61K31/7068 , A61K31/713 , A61K45/06 , A61K31/337 , A61K31/192 , A61P35/00 , A61K33/243 , A61K31/18 , A61K31/20 , A61K31/282
CPC classification number: A61K31/201 , A61K31/165 , A61K31/18 , A61K31/192 , A61K31/20 , A61K31/282 , A61K31/337 , A61K31/343 , A61K31/501 , A61K31/519 , A61K31/7068 , A61K31/713 , A61K33/243 , A61K45/06 , A61P35/00 , A61K31/201 , A61K2300/00 , A61K31/165 , A61K2300/00 , A61K31/343 , A61K2300/00 , A61K33/24 , A61K2300/00 , A61K31/501 , A61K2300/00 , A61K31/192 , A61K2300/00 , A61K31/519 , A61K2300/00 , A61K31/7068 , A61K2300/00 , A61K31/337 , A61K2300/00
Abstract: Combination therapies including a Apurinic/Apyrimidinic Endonuclease/reduction-oxidation (redox) Factor-1 (APE1/Ref-1) inhibitor specific to inhibit the redox function of APE1/Ref-1 are disclosed herein. The Combination therapies can be used for treating various cancers, as well as other angiogenesis-mediated diseases (e.g., retinal diseases, cardiovascular diseases).
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132.发明授权公开(公告)号：US11491147B2
公开(公告)日：2022-11-08
申请号：US16339042
申请日：2017-10-03
Inventor： Jian-Ting Zhang , Jian-Yuan Liu
IPC: A61K31/4439 , A61P35/00 , A61K31/137 , A61K31/4184 , A61K31/454 , A61K31/502 , A61K31/5025 , A61K31/55
Abstract: Various aspects and embodiments disclosed herein relate generally to the modelling, treatment, reduction of resistance to the treatment, prevention, and/or diagnosis of diseases characterized by the formation of cancers. Embodiments include methods of treating cancer, comprising the steps of: providing a patient diagnosed with cancer with a therapeutic regime that includes at least one therapeutically effective dose of at least one agent that reduces the activity of at least one DNA damage/repair pathway. Other embodiments include methods of treating cancer, comprising the steps of: treating a patient diagnosed with cancer with a combination of therapeutic agents that includes at least one therapeutically effective anti-cancer agent and at least one compound that reduces the activity of at least one DNA damage/repair pathway. Yet other embodiments include methods of reducing resistance to a genotoxic therapeutic, comprising the steps of: treating a patient at least one therapeutically effective dose of at least one agent that reduces at least one DNA damage/repair pathway.
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公开(公告)号：US11479752B2
公开(公告)日：2022-10-25
申请号：US16162921
申请日：2018-10-17
Inventor： Burcin Ekser
Abstract: Provided herein are synthetic, three-dimensional (3D) bioprinted tissue constructs comprising porcine cells and methods of producing and using the same. The synthetic 3D bioprinted tissue constructs are fabricated by bioprinting spheroids comprising porcine cells, including genetically engineered cells, on a microneedle mold and fusing the spheroids to form an engineered tissue construct. Also provided are methods of using scaffold-free 3D bioprinted tissue constructs for applications related to drug screening and toxicity screening.
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134.发明授权公开(公告)号：US11453699B2
公开(公告)日：2022-09-27
申请号：US16996473
申请日：2020-08-18
Inventor： William Leonard Scott , Martin James O'Donnell , Jack Geno Samaritoni
Abstract: Some embodiments include compounds that can inhibit the growth of bacterial and/or inhibit or reduce microbial infections caused by one or more microorganisms (e.g., Pseudomonas aeruginosa and Cryptococcus neoformans) and methods of using these compounds to treat microbial infection and outbreaks and/or to reduce the formation of biofilms. Other embodiments include synthesis of the compounds that can inhibit the growth of one or more microorganisms and/or inhibit or reduce microbial infections.
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公开(公告)号：US20220290696A1
公开(公告)日：2022-09-15
申请号：US17654321
申请日：2022-03-10
Inventor： Mark D. Rodefeld
IPC: F04F1/14 , A61M60/122 , A61M60/232 , A61M60/416 , F04D7/04 , F04D1/00
Abstract: Apparatus and methods for driving a circulatory assist device with motive power from a fluid motor. In one example a parallel plate Tesla-type of motor extracts power from the circulatory system of a biological unit to drive a non-positive displacement pump and increase blood pressure in the biological unit.
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Patent Agency Ranking
公开(公告)号：US20220264872A1
公开(公告)日：2022-08-25
申请号：US17666528
申请日：2022-02-07
Inventor： Keith L. March , Meijing Wang
IPC: A01N1/02 , A61K35/28 , C12N5/0775 , C12N5/00
Abstract: The present disclosure provides methods and compositions for treating tissue to preserve and/or rescue tissue from ischemic and/or reperfusion injury and methods for assessing ischemic and/or injuries in cardiac tissue. The disclosed compositions comprise at least a portion of mesenchymal stem cell-conditioned medium.
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公开(公告)号：US20220255056A1
公开(公告)日：2022-08-11
申请号：US17479881
申请日：2021-09-20
Inventor： Jian Xie
IPC: H01M4/1395 , H01M10/052 , H01M10/0566 , B82Y30/00 , H01M50/409 , H01M50/449
Abstract: A device for extending the life of a battery, including an electrode having a metal portion, wherein the metal portion is selected from the group including lithium, calcium, magnesium, sodium, potassium and combinations thereof, an electrolyte permeable membrane, and a metal dendrite seeding material disposed between the electrode and the membrane. The electrode, the membrane and the metal dendrite seeding material are positioned in an electrolyte matrix. At least one dendrite extends from the electrode toward the electrolyte permeable membrane combines with at least one dendrite extending from the dendrite seeding material.
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公开(公告)号：US20220249421A1
公开(公告)日：2022-08-11
申请号：US17718513
申请日：2022-04-12
Inventor： Mark R. Kelley
IPC: A61K31/201 , A61K31/203 , A61K31/454 , A61K31/198 , A61K31/7068 , A61K33/243 , A61K31/122 , A61K31/13 , A61K31/195 , A61K31/282 , A61K45/06 , A61K39/395
Abstract: Disclosed are novel methods for the therapeutic treatment of cancer and angiogenesis. The enzyme Ape1/Ref-1, via its redox function, enhances the DNA binding activity of transcription factors that are associated with the progression of cancer. The present disclosure describes the use of agents to selectively inhibit the redox function of Ape1/Ref-1 and thereby reduce tumor cell growth, survival, migration and metastasis. In addition, Ape1/Ref-1 inhibitory activity is shown to augment the therapeutic effects of other therapeutics and protect normal cells against toxicity. Further, Ape1/Ref-1 inhibition is shown to decrease angiogenesis, for use in the treatment of cancer as well other pathologic conditions of which altered angiogenesis is a component.
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公开(公告)号：US20220248690A1
公开(公告)日：2022-08-11
申请号：US17288748
申请日：2019-10-26
Inventor： Molly Duman Scheel
IPC: A01N63/60 , C12N15/113
Abstract: The present disclosure provides insecticides that can specifically target mosquitoes based on their sex. These sex-specific insecticides prevent maturation or development of larvae into adult insects using interfering RNA (iRNA). The present disclosure further provides compositions comprising sex-linked iRNA and methods of controlling, reducing, or treating an insect infestation with the iRNA or compositions described herein. The compositions and methods described herein can be used to sort mosquitoes based on sex.
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公开(公告)号：US11361407B2
公开(公告)日：2022-06-14
申请号：US16603807
申请日：2018-04-09
Inventor： Paul Richard Territo , Paul Salama , Juan Antonio Chong
Abstract: A computing device is provided having at least one processor (104) operative to facilitate motion correction in a medical image file (102). The at least one processor (104) is configured to generate at least one unified frame file (110) based on motion image data (204), depth map data (206) corresponding to the motion image data, and region of interest data (200). Further, at least one corrected image file derived from the medical image file (102) is generated by performing the motion correction based on the at least one unified frame file (110) using the processor (104). Subsequently, the at least one corrected image file is outputted for display to one or more display devices (122).
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