公开(公告)号：US20170233702A1

公开(公告)日：2017-08-17

申请号：US15498493

申请日：2017-04-27

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rony SEGER ,  Alexander PLOTNIKOV

IPC: C12N9/12

CPC classification number: C12N9/12 ,  A61K38/00 ,  A61K38/12 ,  A61K47/64 ,  C12N9/1205 ,  C12Y207/11 ,  C12Y207/11024

Abstract: An isolated peptide being no longer than 20 amino acids comprising a sequence at least 95% homologous to the sequence GQLNHILGILGX1PX2QED (SEQ ID NO: 4), wherein X1 and X2 are any amino acid, the peptide being capable of preventing extracellular signal-regulated kinase1/2 (ERK) translocation into the nucleus.

公开(公告)号：US20170210823A1

公开(公告)日：2017-07-27

申请号：US15328036

申请日：2014-07-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Moran GROSSMAN ,  Nir BEN-CHETRIT

IPC: C07K16/40 ,  A61K45/06 ,  A61K33/24 ,  A61K39/395

CPC classification number: C07K16/40 ,  A61K33/24 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76

Abstract: An article of manufacture is disclosed which comprises at least two active agents, wherein a first of the two active agents comprises an anti-cancer agent or an antifibrotic agent and a second of the at least two active agents downregulates the activity and/or expression of lysyl-oxidase like protein-2 (LOXL-2) and which is capable of altering the structure of the extracellular matrix.

公开(公告)号：US09696310B2

公开(公告)日：2017-07-04

申请号：US14738894

申请日：2015-06-14

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David Margulies ,  Leila Motiei ,  Linor Unger

IPC: C07D417/14 ,  G01N33/573 ,  C07D417/06 ,  C09K11/06 ,  G01N33/58 ,  C07F9/6541 ,  C07K7/06 ,  G01N33/574

CPC classification number: G01N33/573 ,  C07D417/06 ,  C07D417/14 ,  C07F9/6541 ,  C07K7/06 ,  C09K11/06 ,  C09K2211/1029 ,  C09K2211/1037 ,  G01N33/574 ,  G01N33/582 ,  G01N2333/91177 ,  G01N2333/918 ,  G01N2333/96494

Abstract: The present invention is directed to fluorescent molecular sensor based on Thiazole Orange for protein detection. Interaction of the protein target with the molecular sensors of this invention results in a significant increase in the fluorescence emission. The generation of light output signal enables one to detect protein biomarkers associated with different diseases or detecting the protein of interest also in living cells.

公开(公告)号：US20170183665A1

公开(公告)日：2017-06-29

申请号：US15312734

申请日：2015-05-21

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ron MILO ,  Niv ANTONOVSKY ,  Elad NOOR ,  Arren BAR-EVEN ,  Yehudit ZOHAR ,  Lior ZELCBUCH ,  Shmuel GLEIZER ,  Shira AMRAM

IPC: C12N15/70 ,  C12N9/88 ,  C12N1/20 ,  C12N9/90 ,  C07K14/245 ,  C12N9/10 ,  C12N9/12 ,  C12N9/04

CPC classification number: C12N15/70 ,  C07K14/195 ,  C07K14/245 ,  C12N1/20 ,  C12N9/0006 ,  C12N9/1025 ,  C12N9/1205 ,  C12N9/88 ,  C12N9/90 ,  C12Y101/01049 ,  C12Y203/03009 ,  C12Y207/01011 ,  C12Y207/01019 ,  C12Y401/01039 ,  C12Y402/01011 ,  C12Y504/02

Abstract: A microorganism which is genetically modified so that it produces a first essential biomass precursor by metabolizing CO2 using a recombinant carbon fixation enzyme is disclosed. The microorganism produces a second biomass precursor by metabolizing an organic carbon source and not by metabolizing CO2. The microorganism does not use the organic carbon source for producing the first essential biomass precursor.

公开(公告)号：US20170172979A1

公开(公告)日：2017-06-22

申请号：US15118196

申请日：2015-02-18

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Menachem RUBINSTEIN ,  Efrat DVASH-RIESENFELD

IPC: A61K31/366 ,  A61K31/381 ,  A61K31/41

CPC classification number: A61K31/366 ,  A61K31/166 ,  A61K31/192 ,  A61K31/381 ,  A61K31/404 ,  A61K31/41 ,  A61K31/426 ,  A61K31/47 ,  A61K2300/00

Abstract: The present invention relates to the alleviation of adverse side effects resulting from statin therapy. The present invention further relates to the use of an inhibitor of leukotriene C4 (LTC4) mediated activity for alleviating at least one side effects of statin therapy.

公开(公告)号：US20170141835A1

公开(公告)日：2017-05-18

申请号：US15346747

申请日：2016-11-09

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Avishay Gal-Yam ,  Barak Zackay ,  Eran Ofek

IPC: H04B7/08 ,  H04B17/20

CPC classification number: H04B7/0851 ,  H04B17/20 ,  H04B17/318 ,  H04B17/3912

Abstract: A method for detecting a dispersed pulse in a received signal that has been dispersed by a dispersive medium includes obtaining an input army of cells, each indicating an intensity of a frequency component of the signal at a representative time. A fast dispersion measure transform (FDMT) is applied to concurrently sum the cells of the input array that lie along different dispersion curves, each curve defined by a known non-linear functional form and being uniquely characterized by a time coordinate and by a value of the dispersion measure. Application of FDMT includes initially generating a plurality of sub-arrays, each representing a frequency sub-band and iteratively combining pairs of adjacent sub-arrays in accordance with an addition rule until all of the initially generated plurality of sub-arrays are combined into an output army of the sums, in which a cell of the output array that is indicative of a transmitted pulse is identified.

公开(公告)号：US20170128365A1

公开(公告)日：2017-05-11

申请号：US15319005

申请日：2015-06-15

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Jacob KLEIN ,  Ronit GOLDBERG ,  Jasmine SEROR ,  Weifeng LIN ,  Reut MASHIACH

IPC: A61K9/127 ,  A61K9/00 ,  A61K31/728

CPC classification number: A61K9/127 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/728 ,  A61K31/77 ,  A61K31/79 ,  A61K47/10 ,  A61K47/32 ,  A61K47/36 ,  B65D35/00 ,  B65D75/36

Abstract: A method of reducing a friction coefficient of a surface is disclosed herein, comprising attaching a water-soluble polymer to the surface, and contacting the water-soluble polymer with liposomes, thereby coating the surface with an amphiphilic lipid. Further disclosed herein are solutions comprising a water-soluble polymer attachable to the surface, liposomes, and an aqueous carrier, for reducing a friction coefficient of a surface, and methods utilizing same. Articles of manufacture comprising a substrate coated by a water-soluble polymer which is coated by an amphiphilic lipid are also described, as are uses and methods for treating a synovial joint disorder associated with increased articular friction.

公开(公告)号：US20170121668A1

公开(公告)日：2017-05-04

申请号：US14929363

申请日：2015-11-01

Applicant: Ariel-University Research and Development Company Ltd. ,  Yeda Research and Development Co. Ltd. ,  Indian Institute of Technology Bombay

Inventor： Mordechai SHEVES ,  Irishi N.N. NAMBOOTHIRI ,  Guy PATCHORNIK

IPC: C12N1/00 ,  C07K14/215

CPC classification number: C07K14/215 ,  C12N1/06 ,  C12N1/20

Abstract: A method of precipitating cell membrane fragments from a cell lysate is disclosed. The method comprises contacting the cell lysate with a hydrophobic chelator and a metal ion under conditions that allow precipitation of the cell membrane fragments. Kits for precipitating cell membrane fragments are also disclosed.

公开(公告)号：US20170105645A1

公开(公告)日：2017-04-20

申请号：US15292147

申请日：2016-10-13

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Elisha MOSES ,  Jodie Naim FEIL ,  Dominik FRECHE ,  Nava LEVIT-BINNUN

IPC: A61B5/0478 ,  A61N2/00 ,  A61B5/0408

CPC classification number: A61B5/0478 ,  A61B5/04085 ,  A61B5/0476 ,  A61B5/7217 ,  A61N2/004 ,  A61N2/006

Abstract: A system includes an array of electroencephalography (EEG) electrodes for placement on the head of a subject and a transcranial magnetic stimulation (TMS) device. A controller is configured to operate the array of EEG electrodes to acquire a plurality of EEG signals concurrently with operation of the TMS device to apply a TMS pulse to the head of the subject. The controller is further configured to select an initial set of EEG signals from the EEG signals and to fit an initial decreasing rational function of time to a TMS artifact component of each EEG signal of the initial set. The TMS artifact component of each remaining EEG signal is fit to a linear combination of the initial decreasing rational functions. Each EEG signal is corrected by removing from the EEG signal the function that is fit to the TMS artifact component of the EEG signal.

公开(公告)号：US20170087190A1

公开(公告)日：2017-03-30

申请号：US15379528

申请日：2016-12-15

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michael WALKER ,  Yoav SOEN ,  Revital SHARIVKIN

IPC: A61K35/39 ,  G01N33/569 ,  C12N5/071

CPC classification number: A61K35/39 ,  C12N5/0676 ,  C12N2501/415 ,  C12N2501/50 ,  C12N2501/505 ,  C12N2501/585 ,  C12N2501/599 ,  G01N33/56966 ,  G01N2333/70596 ,  G01N2333/71 ,  G01N2500/10

Abstract: Methods of isolating distinct specific cell types within mixed populations of cells. Methods of isolating specific cell types among pancreatic cells, particularly from human islets of Langerhans. Markers and combinations thereof for use in methods of isolating insulin producing islet beta cells for treatment of diabetes.