公开(公告)号：US4746650A

公开(公告)日：1988-05-24

申请号：US747613

申请日：1985-06-21

申请人： Walter P. Cullen ,  Hiroshi Maeda ,  John C. Ruddock ,  Junsuke Tone

发明人： Walter P. Cullen ,  Hiroshi Maeda ,  John C. Ruddock ,  Junsuke Tone

IPC分类号： A23K20/195 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P31/04 ,  A61P33/02 ,  C07H17/04 ,  C07H19/01 ,  C12P17/18 ,  C12P19/44 ,  C12P19/60 ,  C12R1/03 ,  A61K31/71 ,  A23G3/00

CPC分类号： C07H19/01 ,  C12P19/44 ,  C12P19/60 ,  C12R1/03 ,  Y10S435/825

摘要： A new acidic polycyclic ether antibiotic UK-58,852 has the formula: ##STR1## wherein R and R.sup.1 are both hydrogen, and can be prepared by the submerged aerobic propagation in aqueous nutrient media of Actinomadura sp. ATCC 39697. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization in swine and ruminants. Two minor components, wherein R is H and R.sup.1 is CH.sub.3 and wherein R and R.sup.1 are both CH.sub.3, have also been isolated from the fermentation.

摘要翻译： 一种新的酸性多环醚抗生素UK-58,852具有以下分子式：其中R和R1都是氢，并且可以通过在放线菌属的水性营养培养基中浸没需氧繁殖来制备。 抗生素及其阳离子盐对各种微生物有活性，有效控制球虫病，肠炎，猪痢疾和腹膜炎，以及有效促进生长和/或提高猪和反刍动物饲料利用效率 。 从发酵中也分离出两个次要组分，其中R为H且R 1为CH 3，并且其中R和R 1均为CH 3。

公开(公告)号：US4625041A

公开(公告)日：1986-11-25

申请号：US770472

申请日：1985-08-29

申请人： Walter D. Celmer ,  Walter P. Cullen ,  Hiroshi Maeda ,  Junsuke Tone

发明人： Walter D. Celmer ,  Walter P. Cullen ,  Hiroshi Maeda ,  Junsuke Tone

IPC分类号： A23K20/195 ,  C07H19/01 ,  C12P19/44 ,  C12P19/60 ,  C07D309/10

CPC分类号： C07H19/01 ,  A23K20/195 ,  C12P19/445 ,  C12P19/60 ,  C12R1/465

摘要： A new acidic polycyclic ether antibiotic, CP-63,517, having the formula: ##STR1## and cationic salts thereof produced by submerged aerobic propagation of Streptomyces endus subsp. aureus, ATCC-39574, a new strain of microorganism isolated from a soil sample in Japan, a process for producing this antibiotic and methods for its use to improve feed utilization, promote growth of cattle and swine and to control coccidiosis.

摘要翻译： 一种新的酸性多环醚抗生素CP-63,517，具有下式：其中通过唾液链霉菌（Streptomyces endus subsp。）的浸没有氧繁殖产生的阳离子盐。 金黄色葡萄球菌ATCC-39574是从日本土壤样品中分离的新菌株，该抗生素的生产方法及其用于改善饲料利用，促进牛和猪生长以及控制球虫病的方法。

公开(公告)号：US4543334A

公开(公告)日：1985-09-24

申请号：US562784

申请日：1983-12-16

申请人： Walter D. Celmer ,  Walter P. Cullen ,  Hiroshi Maeda ,  Junsuke Tone

发明人： Walter D. Celmer ,  Walter P. Cullen ,  Hiroshi Maeda ,  Junsuke Tone

IPC分类号： C07H17/08 ,  C12P19/62 ,  C12N1/20 ,  C12R1/465

CPC分类号： C07H17/08 ,  C12P19/62 ,  C12R1/465 ,  Y10S435/886

摘要： An antibiotic complex, consisting of one major and two minor components, has been isolated from fermentation of a new Streptomyces culture. The components from the complex are three new macrolides which are active as antibacterial agents against certain gram-negative and gram-positive microorganisms.

摘要翻译： 由一种主要和两个次要组分组成的抗生素复合物已经从新的链霉菌培养物的发酵中分离出来。 来自该复合物的组分是三种新的大环内酯类，其作为针对某些革兰氏阴性和革兰氏阳性微生物的抗菌剂是有活性的。

公开(公告)号：US4163780A

公开(公告)日：1979-08-07

申请号：US891767

申请日：1978-03-30

申请人： Nakao Ishida ,  Fujio Suzuki ,  Hiroshi Maeda ,  Toshikatsu Fujii ,  Ituro Mizutani

发明人： Nakao Ishida ,  Fujio Suzuki ,  Hiroshi Maeda ,  Toshikatsu Fujii ,  Ituro Mizutani

IPC分类号： A61K36/07 ,  C12P1/02 ,  C12P21/00 ,  A61K35/00

CPC分类号： C12P21/005 ,  A61K36/07 ,  C12P1/02 ,  Y10S435/811 ,  Y10S514/889

摘要： KS-substance was obtained as raw material from the cultured mycelium of Daedalea dickinsii KSDD 6 (FERM-P No. 3993), Lentinus edodes KSLE 7 (FERM-P No. 3994) or Lentinus edodes KSLE 28 (FERM-P No. 4196), and by refining this substance a novel substance KS-2-A was obtained. This substance KS-2-A and also the KS-substance as the raw material both enhance the host defense function of the living body.

摘要翻译： 从Daedalea dickinsii KSDD 6（FERM-P 3993）培养的菌丝体，Lentinus edodes KSLE 7（FERM-P No.3994）或Lentinus edodes KSLE28（FERM-P编号4196）获得KS-物质 ），并且通过精制该物质，得到新的物质KS-2-A。 这种物质KS-2-A和KS-物质作为原料都能增强生物体的宿主防御功能。

公开(公告)号：US4131458A

公开(公告)日：1978-12-26

申请号：US843281

申请日：1977-10-18

申请人： Mitsunori Satoh ,  Masayuki Hijikata ,  Hiroshi Maeda ,  Ichiro Morimoto

发明人： Mitsunori Satoh ,  Masayuki Hijikata ,  Hiroshi Maeda ,  Ichiro Morimoto

IPC分类号： C22C5/06 ,  H01B1/02 ,  H01H1/023 ,  H01H1/0237 ,  H01H11/04

CPC分类号： H01H1/02372 ,  Y10S75/951

摘要： An electrical contact material consisting essentially of silver and a small amount of zinc oxide, tellurium oxide, and optionally indium oxide and tin oxide, these oxides being uniformly dispersed in the silver matrix.

摘要翻译： 基本上由银和少量氧化锌，氧化碲和氧化铟和氧化锡组成的电接触材料，这些氧化物均匀分散在银基质中。

公开(公告)号：US11036203B2

公开(公告)日：2021-06-15

申请号：US16352026

申请日：2019-03-13

申请人： Wataru Sugawara ,  Hiroshi Maeda ,  Yoshinobu Takeyama ,  Tsukasa Matsuoka ,  Yoichi Ito ,  Shingo Nagatsuka

发明人： Wataru Sugawara ,  Hiroshi Maeda ,  Yoshinobu Takeyama ,  Tsukasa Matsuoka ,  Yoichi Ito ,  Shingo Nagatsuka

IPC分类号： G05B19/4099 ,  B33Y50/02 ,  G01B11/24 ,  B29C64/393 ,  G06F30/20

摘要： A fabrication system for fabricating a three-dimensional object includes processing circuitry. The processing circuitry estimates, according to a fabrication condition and fabrication data, a three-dimensional object to be fabricated according to the fabrication data and corrects the fabrication data according to an estimation result of the three-dimensional object estimated by the processing circuitry.

公开(公告)号：US10946109B2

公开(公告)日：2021-03-16

申请号：US15488952

申请日：2017-04-17

申请人： Hiroshi Maeda

发明人： Hiroshi Maeda ,  Makoto Hashizume ,  Jun Fang ,  Hideaki Nakamura ,  Haibo Qin ,  Steffen Hackbarth ,  Masaharu Murata

IPC分类号： A61B1/04 ,  A61K49/00 ,  A61B1/313 ,  G01N21/33 ,  G01N21/64 ,  A61K41/00 ,  G01N33/574 ,  G01N33/58 ,  A61K47/58

摘要： The present invention provides a fluorescent molecular probe for efficient fluorescent detection (visualization) of tumors or for implementing fluorescent detection and photodynamic treatment, more specifically, the present invention provides a macromolecular fluorescent molecular probe for fluorescent detection of tumor, comprising a complex comprising a fluorescent molecule and a biocompatible macromolecule.

公开(公告)号：US10747203B2

公开(公告)日：2020-08-18

申请号：US16010693

申请日：2018-06-18

申请人： Reiji Yukumoto ,  Koji Kobayashi ,  Hiroshi Maeda ,  Yasuaki Yuji ,  Fei Yang

发明人： Reiji Yukumoto ,  Koji Kobayashi ,  Hiroshi Maeda ,  Yasuaki Yuji ,  Fei Yang

IPC分类号： G06F30/00 ,  G05B19/4099 ,  H04N1/409 ,  B33Y50/00 ,  B33Y50/02 ,  B29C64/386

摘要： A modeling process device for performing a three-dimensional object modeling process is provided. The modeling process device includes an accumulation unit configured to accumulate a plurality of three-dimensional object information sets each including corresponding surface shape information items for three-dimensional objects; a searching unit configured to, based on surface shape information of a three-dimensional object generated by a scanning unit that scans a surface of the three-dimensional object, search for a three-dimensional object information set used for modeling in the plurality of the three-dimensional object information sets accumulated in the accumulation unit; and an extraction unit configured to extract a modeling condition that has been used for modeling the three-dimensional object according to the surface shape information that has been generated by the scanning unit.

公开(公告)号：US20180264742A1

公开(公告)日：2018-09-20

申请号：US15983241

申请日：2018-05-18

申请人： Fei Yang ,  Reiji Yukumoto ,  Hiroshi Maeda ,  Koji Kobayashi ,  Yasuaki Yuji

发明人： Fei Yang ,  Reiji Yukumoto ,  Hiroshi Maeda ,  Koji Kobayashi ,  Yasuaki Yuji

IPC分类号： B29C64/393 ,  B29C64/118 ,  B33Y30/00 ,  B33Y50/02 ,  G06T17/10

CPC分类号： B29C64/393 ,  B29C64/118 ,  B29C67/00 ,  B33Y30/00 ,  B33Y50/00 ,  B33Y50/02 ,  G06F17/50 ,  G06T17/10

摘要： There is provision of an information processing device for processing three-dimensional information representing a three-dimensional shape of a solid object to be modeled by a solid object modeling device configured to model the solid object by depositing a plurality of layers each of which is formed by discharging the filamentary molding material on the flat surface. The information processing device is configured to acquire the three-dimensional information, generate a plurality of pieces of layer information corresponding to the respective layers of the filamentary molding materials, by slicing the three-dimensional information, generate deposition information used for depositing the filamentary molding material from the layer information, generate gap region information representing a gap region to be formed between the filamentary molding materials based on the deposition information, and generate discharging information for controlling discharge of the filamentary molding material, in accordance with the deposition information and the gap region information.

公开(公告)号：US09937152B2

公开(公告)日：2018-04-10

申请号：US15037723

申请日：2014-11-19

申请人： Hiroshi Maeda

发明人： Hiroshi Maeda ,  Hideaki Nakamura ,  Jun Fang

IPC分类号： C08F222/06 ,  C08F8/44 ,  C08F8/42 ,  C08F8/34 ,  C08F8/12 ,  C08F8/32 ,  C08F8/30 ,  A61K38/00 ,  C07K14/575 ,  A61K31/409 ,  A61K31/69 ,  A61K31/704 ,  C08F220/04 ,  A61K47/58

CPC分类号： A61K31/409 ,  A61K31/69 ,  A61K31/704 ,  A61K38/00 ,  A61K47/58 ,  C07K14/575 ,  C08F8/12 ,  C08F8/30 ,  C08F8/32 ,  C08F8/34 ,  C08F8/42 ,  C08F8/44 ,  C08F220/04 ,  C08F222/06 ,  C08F2800/10 ,  C08F222/08 ,  C08F212/08 ,  C08F222/02

摘要： The present invention provides a group of novel SMA derivatives and a covalent conjugate of the derivatives and an active substance. More specifically, the present invention provides: an SMA derivative which contains (i) a styrene-maleic acid copolymer (SMA) and (ii) a side chain (b) that contains a functional group (a) selected from among —NH2, —SH, —OH, —COOH, —NH—(C═NH)—NH2 and —C(CH2—OH)3 and introduced into a carboxyl group of a maleic acid residue of the SMA via an amide bond or an ester bond, and wherein when a plurality of side chain (b) is introduced into the SMA, the side chains (b) may be identical or different from each other; and a conjugate of this SMA derivative and an active substance.