公开(公告)号：US20220387365A1

公开(公告)日：2022-12-08

申请号：US17775851

申请日：2020-11-09

申请人： BeyondSpring Pharmaceuticals, Inc.

发明人： Chengjiang He ,  Lan Huang ,  James R. Tonra

IPC分类号： A61K31/198 ,  A61K39/395 ,  A61K45/06 ,  A61K31/496 ,  A61P35/00 ,  A61K31/405 ,  A61K31/4172 ,  A61K31/7034 ,  A61K31/235 ,  A61K31/24 ,  C07C235/84 ,  C07D209/20 ,  C07C323/59 ,  C07D233/64 ,  C07H15/18 ,  C07C69/94 ,  C07C251/48

摘要： Disclosed herein are tucaresol derivative compound and composition containing the same. Also disclosed herein are methods of enhancing immune response in a subject by administering the tucaresol derivative compound or by co-administering the tucaresol derivative compound and one or more additional agents. Also disclosed herein are use of the tucaresol derivative compound and composition containing the same in the manufacture of a medicament for treating cancer or enhancing immune response in a subject.

公开(公告)号：US11471791B2

公开(公告)日：2022-10-18

申请号：US15779714

申请日：2016-11-08

申请人： HINDUSTAN PETROLEUM CORPORATION LIMITED

发明人： Raman Ravishankar ,  Chinthalapati Sivakesava Raju ,  Jitalaxmi Bharali ,  Sheshachala Srinivasa Narasimha ,  Peddy Venkat Chalapathi Rao ,  Nettem Venkateswarlu Choudary

IPC分类号： B01D17/04 ,  B09C1/08 ,  C02F1/68 ,  C07C233/47 ,  C07C323/59 ,  E02B15/04 ,  E02B15/10 ,  C02F101/32 ,  C02F103/00 ,  C02F103/08

摘要： A process is provided for separating hydrophobic material from a mixture of hydrophobic and hydrophilic material using peptide-based amphiphilic organogelators.

公开(公告)号：US10961187B2

公开(公告)日：2021-03-30

申请号：US16443793

申请日：2019-06-17

申请人： Promentis Pharmaceuticals, Inc.

发明人： Michael Neary ,  James Nieman ,  Steven Tanis ,  Daniel Lawton ,  Garry Smith

IPC分类号： C07C327/34 ,  C07C323/60 ,  C07D277/14 ,  C07C327/26 ,  C07D277/08 ,  C07C327/32 ,  C07C329/06 ,  C07C323/59 ,  C07C323/58 ,  C07C323/57 ,  C07D241/08 ,  C07D327/04 ,  A61K31/265 ,  A61K31/165 ,  A61K31/426 ,  A61K31/513

摘要： Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

公开(公告)号：US10660967B2

公开(公告)日：2020-05-26

申请号：US15790498

申请日：2017-10-23

申请人： Augusta University Research Institute, Inc.

发明人： Siva Panda

IPC分类号： C07C69/96 ,  C07C229/08 ,  C07C229/18 ,  C07C229/36 ,  C07C233/25 ,  C07C233/47 ,  C07C233/51 ,  A61K47/54 ,  A61K9/00 ,  C07D209/20 ,  C07C323/58 ,  C07C323/59 ,  C07C323/52 ,  C07C237/06 ,  C07C243/14 ,  C07D209/28 ,  C07C271/22

摘要： Curcumin-based conjugates and methods of use thereof are provided. Pharmaceutical compositions including an effective amount of one or more curcumin conjugates are also provided. In particular embodiments, the compositions are formulated for oral delivery. The conjugates and pharmaceutical compositions thereof can be administered to a subject in need thereof to treat a host of diseases and disorders including but not limited to, cancer, inflammation, and microbial growth.

公开(公告)号：US10358414B2

公开(公告)日：2019-07-23

申请号：US15481728

申请日：2017-04-07

申请人： Promentis Pharmaceuticals, Inc.

发明人： Michael Neary ,  James Nieman ,  Steven Tanis ,  Daniel Lawton ,  Garry Smith

IPC分类号： C07D277/08 ,  C07D241/08 ,  C07C323/60 ,  C07C327/26 ,  C07C329/06 ,  C07C327/34 ,  C07D327/04 ,  C07C323/57 ,  C07C323/58 ,  C07C323/59 ,  C07C327/32 ,  C07D277/14 ,  A61K31/265 ,  A61K31/165 ,  A61K31/426 ,  A61K31/513

摘要： Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers′ disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

公开(公告)号：US10314802B2

公开(公告)日：2019-06-11

申请号：US15665922

申请日：2017-08-01

申请人： Signum Biosciences, Inc.

发明人： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

IPC分类号： A61K31/197 ,  A61K9/00 ,  C07C323/59 ,  C07C335/08 ,  C07C243/34 ,  C07C321/18 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24 ,  C07D207/16 ,  C07D243/34

摘要： Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

公开(公告)号：US20190090488A1

公开(公告)日：2019-03-28

申请号：US16203690

申请日：2018-11-29

申请人： Dow AgroSciences LLC

发明人： Ronald J. Heemstra ,  Ronald Ross, JR. ,  Kyle A. DeKorver ,  Kaitlyn Gray ,  Daniel I. Knueppel ,  Peter Vednor ,  Timothy P. Martin ,  Joseph D. Eckelbarger ,  John F. Daeuble, SR. ,  Ricky Hunter ,  David A. Demeter ,  Tony K. Trullinger ,  Erich W. Baum ,  Zoltan L. Benko ,  Nakyen Choy ,  Gary D. Crouse ,  Fangzheng Li ,  Jeffrey Nissen ,  Monica B. Olson ,  Michelle Riener ,  Thomas C. Sparks ,  Frank J. Wessels ,  Maurice C. Yap

IPC分类号： A01N53/00 ,  C07C233/63 ,  C07D209/49 ,  C07C237/22 ,  C07C233/65 ,  C07C323/41 ,  C07C259/10 ,  C07D215/227 ,  C07D261/12 ,  C07D263/26 ,  C07C311/08 ,  C07D207/273 ,  C07C255/57 ,  C07D333/48 ,  C07D307/33 ,  C07C271/28 ,  C07C317/50 ,  C07C317/28 ,  C07C255/60 ,  C07D277/30 ,  C07D241/20 ,  C07C381/10 ,  C07D307/52 ,  C07D231/56 ,  C07C317/40 ,  C07D233/36 ,  C07C323/59 ,  C07D215/38 ,  C07D235/30 ,  C07C237/42 ,  C07D207/452 ,  C07C255/29 ,  C07D205/04 ,  C07D213/84 ,  C07C311/46 ,  C07D213/56 ,  C07C271/66 ,  C07C255/46 ,  C07C323/42 ,  C07D487/04 ,  C07D333/60 ,  C07D253/07 ,  C07D233/80 ,  C07D277/36 ,  C07D213/89 ,  C07C331/12 ,  C07C317/14

摘要： This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

公开(公告)号：US10219516B2

公开(公告)日：2019-03-05

申请号：US15679415

申请日：2017-08-17

申请人： Dow AgroSciences LLC

发明人： Ronald J. Heemstra ,  Ronald Ross, Jr. ,  Kyle A. DeKorver ,  Kaitlyn Gray ,  Daniel I. Knueppel ,  Peter Vednor ,  Timothy P. Martin ,  Joseph D. Eckelbarger ,  John F. Daeuble, Sr. ,  Ricky Hunter ,  David A. Demeter ,  Tony K. Trullinger ,  Erich W. Baum ,  Zoltan L. Benko ,  Nakyen Choy ,  Gary D. Crouse ,  Fangzheng Li ,  Jeffrey Nissen ,  Monica B. Olson ,  Michelle Riener ,  Thomas C. Sparks ,  Frank J. Wessels ,  Maurice C. Yap

IPC分类号： A01N53/00 ,  C07D487/04 ,  C07D333/60 ,  C07D333/48 ,  C07D333/36 ,  C07D331/04 ,  C07D309/14 ,  C07D307/52 ,  C07D307/33 ,  C07C255/46 ,  C07C255/57 ,  C07C255/60 ,  C07C259/10 ,  C07D213/84 ,  C07D213/89 ,  C07D215/227 ,  C07C271/28 ,  C07C271/66 ,  C07D215/38 ,  C07D231/56 ,  C07D233/36 ,  C07C311/08 ,  C07C311/46 ,  C07D235/30 ,  C07C317/28 ,  C07C317/40 ,  C07C317/50 ,  C07C323/41 ,  C07C323/42 ,  C07C323/59 ,  C07C331/12 ,  C07C381/10 ,  C07D205/04 ,  C07C237/42 ,  C07D207/452 ,  C07C255/29 ,  C07D209/49 ,  C07D207/273 ,  C07D233/80 ,  C07D261/12 ,  C07D263/26 ,  C07D277/36 ,  C07C237/22 ,  C07D213/56 ,  C07D277/30 ,  C07C233/63 ,  C07C233/65 ,  C07C317/14 ,  C07D241/20 ,  C07D253/07

摘要： This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

公开(公告)号：US20180362456A1

公开(公告)日：2018-12-20

申请号：US16060359

申请日：2016-12-06

申请人： EMS S/A

发明人： Giancarlo SANTUS ,  Silvana MASIERO ,  Leticia Khater COVESI

IPC分类号： C07C323/58 ,  C07D207/28 ,  C07C323/59 ,  C07D475/04 ,  A61K8/46 ,  A61K8/49 ,  A61Q19/08 ,  A61P39/06

摘要： The present invention describes new derivatives of S-allylcysteine with antioxidant and antiaging activity. Said derivatives can be used alone or in a combined formulation with other compounds with known activity.

公开(公告)号：US20180194151A1

公开(公告)日：2018-07-12

申请号：US15742067

申请日：2016-09-13

申请人： SANKO CO., LTD.

发明人： Yoshimi Ishibashi ,  Ryoichi Kinishi ,  Yoshito Nakagawa

IPC分类号： B41M5/333 ,  C07C237/40 ,  C07C323/59 ,  C07C275/42 ,  C07C311/51 ,  C07C311/19

CPC分类号： B41M5/3333 ,  B41M5/333 ,  C07C237/40 ,  C07C275/28 ,  C07C275/42 ,  C07C311/19 ,  C07C311/42 ,  C07C311/51 ,  C07C311/58 ,  C07C323/59 ,  C07C335/16

摘要： A heat-sensitive recording material includes a heat-sensitive recording layer containing a basic dye and a developer and provided on a supporting body, in which the developer is at least one type of an N-substituted amino acid derivative represented by the following General Formula: (R—X)m—Y—(Z)m  (1) (In Formula (1), R represents an alkyl group or an aryl group which may have a substituent. X is a group bonded to the N-terminus of Y, and represents —OCO—, —SO2NHCO—, —NHCO—, —NHCS—, or —SO2—. Y represents an amino acid residue or a peptide residue. Z represents a group bonded to the C-terminus of Y and represents an OH group or an OR″ group. When Y is an amino acid residue other than a cystine residue or when Y is a peptide residue not having a cystine residue, m=1, and when Y is a peptide residue having n cystine residues, m=n+1 and n is 1 or 2.)