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公开(公告)号：US20180009754A1
公开(公告)日：2018-01-11
申请号：US15544837
申请日：2016-01-20
Applicant: MERIAL, INC.
Inventor： Alan Long , Dpuglas Edward Wilkinson
IPC: C07D213/74 , A61K45/06 , A61K31/496
CPC classification number: C07D213/74 , A61K31/496 , A61K45/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D487/04
Abstract: The present invention relates to novel anthelmintic compounds of formula (IA) below: wherein, Y is selected from the group consisting of —H, aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocyclyl, alkyl, haloalkyl, and alkoxyalkyl; and Z is selected from the group consisting of aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocyclyl, alkyl, haloalkyl, and alkoxyalkyl. Variables Ring A, Ring B, Ring C, X1, X6, and X8 are as defined herein. The invention also relates to parasiticidal compositions comprising the compounds, and methods and uses of the compounds for treating and preventing parasitic infections and infestations in animals.
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142.发明申请公开(公告)号：US20170360923A1
公开(公告)日：2017-12-21
申请号：US15624405
申请日：2017-06-15
Applicant: MERIAL INC. , SANOFI PASTEUR
Inventor： Guillaume Rigaut , Alexis Guy André Lucien Parisot , Karelle De Luca , Christine Michele Pierrette Andreoni , Lydie Remolue , Marie Garinot , Jean-François Cotte , Patricia Probeck-Quellec , Jean Haensler , Véronique Chambon , Philippe Talaga
Abstract: The present invention provides for novel immunological and vaccine formulations comprising a newly applied non-crosslinked polyacrylic acid polymer adjuvant. The adjuvants may be combined with a wide variety of immunogens to produce vaccines that are safe and effective when administered to a wide range of target animals. The immunogens may include, but are not limited to: inactivated pathogens, attenuated pathogens, subunits, recombinant expression vectors, plasmids or combinations thereof. The animals may include, but are not limited to: humans, murine, canines, felines, equines, porcines, ovines, caprines and bovines.
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公开(公告)号：US20170312852A1
公开(公告)日：2017-11-02
申请号：US15499127
申请日：2017-04-27
Applicant: MERIAL INC.
Inventor： Andy Brehm , Dennis Jerome Freeman , Ed Schindler , Julie Campbell
IPC: B23K26/12 , B23K37/047 , B23K28/00 , B41M5/24 , B23K26/362
CPC classification number: B23K26/127 , A01N1/0236 , A01N1/0257 , A01N1/0268 , B23K26/361 , B23K26/362 , B23K28/00 , B23K37/047 , B41M5/24 , B41M5/26 , B41M5/262
Abstract: The invention relates to a machine for labeling “blank-labeled” cryogenically-frozen vials or ampoules, which contain heat-labile biological materials, and to which a laser-light sensitive material had been applied prior to freezing. Accordingly, the machine has been designed to maintain the integrity of the biological materials throughout all phases of the labeling process. The machine generally comprises a master control system; a programmable user interface; a frame; cryogenic freezer assemblies, for keeping the vials at the required low temperatures; an infeed assembly, configured to receive and position blank-labeled cryogenic vials; a cryostatic labeling/quality control tunnel, wherein the vials are maintained at the required temperature, labeled by laser ablation, and checked for quality; and, an outfeed assembly. The machine further comprises a means for transporting the vials from the infeed assembly to the tunnel, and from the tunnel to the outfeed assembly. Vials labeled according to the instant disclosure are ultimately manually or automatically loaded into cryogenic shipping containers.
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公开(公告)号：US20170280688A1
公开(公告)日：2017-10-05
申请号：US15474300
申请日：2017-03-30
Applicant: MERIAL INC.
Inventor： Pierre-Emmanuel Deliou , Sebastien Lafon
CPC classification number: A01K29/005 , A01K11/004 , A01K11/008 , G06K7/10297 , G06K19/07749 , G06K19/07758 , G06K19/07773 , H01Q1/2225 , H01Q5/30
Abstract: A system and method are disclosed for tracking animals, which may include production animals as well as pets. The system and method may comprise a tag system that is attached to an animal that generally has at least a near-field-communication (NFC) tag. The tag system comprises at least an NFC tag and a radio-frequency identification (RFID) tag. For NFC tags, such tags may be read with a portable computing device, such as a mobile telephone running NFC reader application software. The phone may communicate with a communications network and ultimately a computer server in order to relay information received from a respective electronic tag. The electronic tags may be fastened, embedded, or ingested by an animal. The electronic tags may be part of a mechanical coupling. Each mechanical coupling may comprise a different structure depending on the whether the tags are fastened to, embedded in, or ingested by the animal.
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公开(公告)号：US09776986B2
公开(公告)日：2017-10-03
申请号：US14744166
申请日：2015-06-19
Applicant: MERIAL, INC.
Inventor： Charles Meng , Loïc Le Hir de Fallois
IPC: C07D209/08 , C07D401/12 , C07D209/10 , C07D401/04 , H03K5/04 , H03K7/00
CPC classification number: A61K31/404 , C07D209/08 , C07D209/10 , C07D401/04 , C07D401/12 , H03K5/04 , H03K7/00
Abstract: The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one indole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.
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Patent Agency Ranking
公开(公告)号：US20170246286A1
公开(公告)日：2017-08-31
申请号：US15594451
申请日：2017-05-12
Applicant: MERIAL INC.
Inventor： Russell F. Bey , Paulraj Kirubakaran Lawrence , Randy R. Simonson
IPC: A61K39/102 , C12N1/36 , C07K14/285
CPC classification number: A61K39/102 , A61K2039/522 , A61K2039/543 , A61K2039/552 , A61K2039/70 , C07K14/285 , C12N1/36
Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.
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公开(公告)号：US20170233438A1
公开(公告)日：2017-08-17
申请号：US15378219
申请日：2016-12-14
Applicant: MERIAL INC.
Inventor： Loic Le Hir de Fallois , Greg Pacofsky , Alan Long , Charles Q. Meng , Hyoung Ik Lee
CPC classification number: C07K11/02 , A01N43/72 , A61K38/15 , A61K45/06 , C07D273/00 , C07D413/14
Abstract: The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals, including humans. The compounds and compositions may be used for combating parasites in or on animals including mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in animals, including birds and mammals.
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148.发明授权公开(公告)号：US09713639B2
公开(公告)日：2017-07-25
申请号：US14716481
申请日：2015-05-19
Applicant: MERIAL, INC.
Inventor： Paulraj Lawrence , Russell Bey
IPC: A61K39/215 , A61K39/295 , A61K39/12 , A61K39/225 , C12N7/00 , A61K39/00
CPC classification number: A61K39/215 , A61K39/225 , A61K2039/5256 , A61K2039/552 , A61K2039/70 , C12N7/00 , C12N2710/14041 , C12N2770/20034
Abstract: The present invention encompasses porcine epidemic diarrhea virus (PEDV) vaccines or compositions. The vaccine or composition may be a vaccine or composition containing PEDV antigens. The invention also encompasses recombinant vectors encoding and expressing PEDV antigens, epitopes or immunogens which can be used to protect porcine animals against PEDV.
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公开(公告)号：US20170182141A1
公开(公告)日：2017-06-29
申请号：US15378165
申请日：2016-12-14
Applicant: MERIAL, INC.
Inventor： Keith Wilson , Paulraj Lawrence
CPC classification number: A61K39/0241 , A61K39/12 , A61K2039/5252 , A61K2039/545 , A61K2039/552 , A61K2039/55505 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2750/10011 , C12N2750/10034 , C12N2770/10034
Abstract: The present invention relates to compositions or vaccines for combating Mycoplasma hyopneumoniae (M hyo), Porcine Circovirus type 2 (PCV2), and Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infections in animals and for increasing the ability of pigs to gain weight and/or improve death loss, methods of vaccination against the infections, and kits for use with such methods and compositions.
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150.发明申请公开(公告)号：US20170181403A1
公开(公告)日：2017-06-29
申请号：US15378729
申请日：2016-12-14
Applicant: MERIAL, INC.
Inventor： Stephen Mario Imperiale-Hagerman
Abstract: The present invention builds and conveys to users in need thereof a Grass Growth Index (GGI) and a Nematode Suitability Index (NSI), to assist the determination of whether and when to administer parasiticides to grazing livestock, such as bovine, ovine and caprine animals. In particular, the invention relates to a computer-implemented method whereby GGI and NSI are calculated based upon both user-supplied information (e.g. grass/forage type and location data) and user-independent information (e.g. weather and environmental condition data associated with the location over time, and grass and nematode growth parameters). Importantly, the disclosed methods provide users with information as to when and where their herds of grazing animals may be at the greatest risk of parasite infestation.
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