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141.发明申请公开(公告)号：US20180356392A1
公开(公告)日：2018-12-13
申请号：US15996898
申请日：2018-06-04
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Michael Rein
CPC classification number: G01N33/49 , G01N21/17 , G01N21/51 , G01N21/94 , G01N33/491 , G01N2015/045 , G01N2015/0693 , G01N2035/0406 , G01N2035/1018 , G01N2201/066
Abstract: A method for determining properties of a laboratory sample contained in a laboratory sample container is presented. The method comprises measuring projections of the laboratory sample container comprising the laboratory sample by irradiating light to the laboratory sample container at different projection angle and determining the properties by tomographic reconstruction based on the projections.
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142.发明申请公开(公告)号：US20180348140A1
公开(公告)日：2018-12-06
申请号：US16044897
申请日：2018-07-25
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Stefan Quint , Klaus Bauer-Espindola
IPC: G01N21/66 , G01N35/00 , G01N35/10 , G01N27/416 , G01N27/327
CPC classification number: C12Q1/00 , G01N33/5438 , G01N33/582
Abstract: Described is an electrochemiluminescence method of detecting an analyte in a liquid sample using a measuring cell having a working electrode for detecting the analyte using an electrochemiluminescence measurement cycle, involving a. carrying out the measurement cycle in a calibration process using a liquid sample without analyte and performing a first electrochemical impedance spectroscopy, EIS, at a given point of the measurement cycle, the first EIS being performed using the working electrode, b. carrying out the measurement cycle in an analysis process using the liquid sample containing the analyte and performing a second EIS at the given point of the measurement cycle, the second EIS being performed using the working electrode, c. comparing the result of the first EIS and the second EIS, providing an indication indicating if the comparison results show a deviation between the first EIS and the second EIS exceed a predefined threshold.
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公开(公告)号：US20180340952A1
公开(公告)日：2018-11-29
申请号：US16052709
申请日：2018-08-02
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Marcel Kaeppeli , Tobias Huber , Pius Hermann , Matthias Edelmann
Abstract: A transport device for a laboratory sample distribution system is presented. The transport device comprises a plurality of actuator modules. Each actuator module comprises a plurality of electro-magnetic actuators. A plurality of base plate modules arranged in a pattern is provided. The base plate modules are coupled to each other and aligned by support elements. The number of base plate modules at least equals the number of actuator modules and each base plate module is configured to support one of the plurality of actuator modules. A laboratory sample distribution system and to a laboratory automation system comprising a laboratory sample distribution system are also presented.
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144.发明授权公开(公告)号：US10132805B2
公开(公告)日：2018-11-20
申请号：US14524700
申请日：2014-10-27
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Georg Kurz , Eloisa Lopez-Calle
IPC: G01N31/00 , G01N33/53 , G01N33/543 , G01N21/27 , G01N33/52 , G01N21/78 , G01N21/82 , G01D18/00 , G01N21/63 , G01N33/573 , G01N33/68 , G01N33/92 , G06F19/18 , G16H50/30
Abstract: A method for determining the amount of specific analyte of a sample which may show interferences by photometric assays, wherein the analyte is quantified from the change in the optical signal of the reaction mixture after the interaction of the analyte with analyte specific reagents. Multiple calibration curves are generated for multiple wavelengths for the specific analyte. An interference test is performed simultaneously to the determination of the specific analyte, for quantifying the amount of interfering substances present in the sample. The amount of each interfering substances is compared to predetermined cut-off values. The optical signal for the specific analyte is measured in the reaction mixture at multiple wavelengths over the complete reaction time, and a calibration curve is selected depending on the interfering substances. The amount of specific analyte is quantified by comparison with the selected calibration curve for the chosen wavelengths.
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公开(公告)号：US20180313850A1
公开(公告)日：2018-11-01
申请号：US16027890
申请日：2018-07-05
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dirk Block , Julian Braz , Hans-Peter Brunner , James Creeden , Hans-Joerg Loyda , Ursula-Henrike Wienhues-Thelen , Christian Zaugg
IPC: G01N33/68
CPC classification number: G01N33/6887 , G01N33/6893 , G01N2333/47 , G01N2333/58 , G01N2800/325 , G01N2800/52
Abstract: The present invention relates to a method for guiding heart failure treatment in a subject suffering from heart failure. The method is based on the determination of the amount of a BNP-type peptide and a cardiac troponin in a sample from said subject. Further envisaged by the present invention are kits and devices adapted to carry out the present invention. The present invention also relates to a system for guiding heart failure treatment in a subject suffering from heart failure as disclosed herein and to reagents and kits used in performing the methods disclosed herein.
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Patent Agency Ranking
146.发明申请公开(公告)号：US20180291354A1
公开(公告)日：2018-10-11
申请号：US16014355
申请日：2018-06-21
Inventor： Peter Kratzsch , Mara Boenitz-Dulat , Daniela Beck , Thomas Streidl , Stacy Hunt DuVall
CPC classification number: C12N9/0006 , C12Q1/32 , C12Q1/54 , C12Y101/0103
Abstract: The present disclosure relates to a mutant 3-hydroxybutyrate dehydrogenase (3-HBDH) with improved performance relative to the wild-type 3-HBDH, a nucleic acid encoding the mutant 3-HBDH, a cell having the mutant 3-HBDH or the nucleic acid, and/or a method of determining the amount or concentration of 3-hydroxybutyrate in a sample. Also disclosed is the use of the mutant 3-HBDH for determining the amount or concentration of 3-hydroxybutyrate in a sample, and a device for determining the amount or concentration of 3-hydroxybutyrate in a sample.
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公开(公告)号：US10094817B2
公开(公告)日：2018-10-09
申请号：US14611611
申请日：2015-02-02
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Siegfried Dick , Markus Fischer
Abstract: A process for the production of at least one analytical device is disclosed. The analytical device comprises at least one capillary element. The process comprises providing at least one carrier layer; providing at least one spacer layer; applying the spacer layer on top of the carrier layer; providing at least one cover layer; and applying the cover layer on top of the spacer layer. The process further comprises at least one cutting step. At least one capillary channel of the capillary element is cut out from the spacer layer. The cutting step is performed by using at least two cutting tools. The cutting tools complement one another to form a contour of the capillary channel.
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公开(公告)号：US10086373B2
公开(公告)日：2018-10-02
申请号：US15352698
申请日：2016-11-16
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Boehm , Sascha Lutz , Juergen Spinke , Thorsten Brueckner
Abstract: An automatic analyzer cartridge, spinnable around a rotational axis, has a support structure with a front face perpendicular to the rotational axis, a fluidic structure for processing a biological sample into the processed biological sample, a measurement structure with at least one detection zone on the front face, and a rotatable lid covering the front face. The rotatable lid is rotatable about the rotational axis relative to the support structure from a first position relative to the support structure to a second position relative to the support structure. The rotatable lid has a sample inlet opening and a detection zone opening. In the first position, a sample inlet is aligned with the sample inlet opening and the measurement structure is covered by the rotatable lid. In the second position, the sample inlet is covered by the rotatable lid and the measurement structure is aligned with the detection zone opening.
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公开(公告)号：US20180265288A1
公开(公告)日：2018-09-20
申请号：US15921816
申请日：2018-03-15
Applicant: Roche Diagnostics Operations, Inc.
Inventor： David Huber , Bruno Koch , Franz Lindegger , Marco Sangermano
CPC classification number: B65F1/1607 , B01L1/50 , B01L2300/12 , B65F1/1421 , B65F1/1436 , B65F1/1478 , G01N35/00 , G01N35/04 , G01N2035/00277 , G01N2035/0406 , G01N2035/0422 , G01N2035/103
Abstract: A secondary solid waste container for solid waste of an analyzer is disclosed. The secondary solid waste container comprises side walls and an impact absorbing member. The side walls comprise an upper end and a lower end. The impact absorbing member is connected to the side walls such that the impact absorbing member extends between the side walls and is spaced apart from the lower end with respect to a direction from the lower end to the upper end. The impact absorbing member is configured to absorb an impact from solid waste of the analyzer. An analyzer and a method for removing solid waste of an analyzer are also disclosed.
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公开(公告)号：US20180252651A1
公开(公告)日：2018-09-06
申请号：US15909295
申请日：2018-03-01
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Rik Harbers , Kurt Schildknecht
CPC classification number: G01N21/75 , G01J3/28 , G01J3/42 , G01N21/255
Abstract: An optical device for determining the presence and/or concentration of analytes in a sample is presented. The optical device comprises a detector and a detection unit comprising optical path components. The detection unit has wavelength-dependent responsivity. The optical device further comprises a light source for emitting light of different respective usable wavelength ranges. The light is guidable through the optical path to the detector to generate baseline signals and response signals relative to the baseline signal indicative of the presence and/or concentration of analytes in the optical path. The intensity of the light reaching the detector is adjusted inverse to the wavelength-dependent responsivity with respect to at least two respective usable wavelength ranges so that a reduction of the ratio between the maximum baseline signal at one of the selected usable wavelength ranges and the minimum baseline signal at another of the selected usable wavelength ranges is obtained.
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