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    Antibody combinations and use of same for treating cancer
    152.
    发明授权
    Antibody combinations and use of same for treating cancer 有权
    抗体组合及其用途用于治疗癌症

    公开(公告)号：US08883149B2

    公开(公告)日：2014-11-11

    申请号：US13063940

    申请日：2009-08-19

    Applicant: Michael Sela ,  Yosef Yarden ,  Bilha Schechter ,  Tsipi Ben-Kasus

    Inventor： Michael Sela ,  Yosef Yarden ,  Bilha Schechter ,  Tsipi Ben-Kasus

    IPC: A61K39/395 ,  A61P35/00 ,  C07K16/32 ,  G01N33/566 ,  A61K39/00

    CPC classification number: A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/32 ,  C07K2317/565

    Abstract: A method of identifying a combination of antibodies with a combined improved anti-tumor activity is provided. The method comprising: (a) identifying binding epitopes of anti ErbB-2 antibodies; and (b) selecting a combination of at least two antibodies of the anti ErbB-2 antibodies exhibiting binding to different epitopes on the ErbB-2, at least one of the different epitopes being localized to a dimerization site of the ErbB-2, the combination of antibodies being with the combined improved anti-tumor activity. Also provided are novel antibody combinations uncovered according to the present teachings.

    Abstract translation: 提供了鉴定具有组合改善的抗肿瘤活性的抗体组合的方法。 该方法包括：（a）鉴定抗ErbB-2抗体的结合表位; 和（b）选择表现出与ErbB-2上不同表位结合的抗ErbB-2抗体的至少两种抗体的组合，至少一种不同表位位于ErbB-2的二聚位点， 抗体与组合的改善的抗肿瘤活性的组合。 还提供了根据本发明揭示的新型抗体组合。

    Magnetic patterning method and system
    154.
    发明授权
    Magnetic patterning method and system 有权
    磁性图案化方法和系统

    公开(公告)号：US08859059B2

    公开(公告)日：2014-10-14

    申请号：US13127358

    申请日：2009-11-03

    Applicant: Ron Naaman ,  Amos Bardea ,  Alexander Yoffe

    Inventor： Ron Naaman ,  Amos Bardea ,  Alexander Yoffe

    IPC: B05D1/32

    CPC classification number: C12M23/06 ,  B81C1/00031 ,  B81C2201/0154 ,  B81C2201/0198 ,  C12M27/00 ,  H01F41/16

    Abstract: The present invention relates to a method and apparatus for patterning a substrate. The method comprises providing at least one magnetic pattern generator configured and operable to modulate the magnetic field to induce varying magnetic properties to a magnetic field according to a desired pattern; applying the modulated magnetic field in the vicinity of the substrate creating a certain pattern of regions of interaction to be obtained on top of the substrate; and; interacting the substrate with magnetic particles, while under the application of the modulated magnetic field, the magnetic particles being attracted to selected regions of interaction defined by the certain pattern while being substantially not attracted to regions outside the regions of interaction, thus creating on top of the substrate the certain pattern of regions interacted with the magnetic particles. The desired pattern corresponds to a certain pattern for a predetermined magnetic field profile and at a predetermined distance from the magnetic pattern generator, where the sample is to be located.

    Abstract translation: 本发明涉及一种用于图案化衬底的方法和装置。 该方法包括提供至少一个磁图案发生器，其被配置和可操作以根据期望的图案调制磁场以对磁场引起变化的磁特性; 将调制的磁场施加在衬底附近，产生在衬底的顶部上获得的相互作用区域的特定图案; 和; 在将基底与磁性颗粒相互作用的同时，在调制磁场的应用下，磁性颗粒被吸引到由特定图案限定的相互选择的相互作用区域，同时基本上不被吸引到相互作用区域之外的区域，从而在 基板的某些图案区域与磁性颗粒相互作用。 期望的图案对应于预定磁场分布的特定图案，并且距离磁图案发生器预定距离处，其中样本将被定位。

    Apparatus and method for removing sulfur dioxide from flue gases
    155.
    发明授权
    Apparatus and method for removing sulfur dioxide from flue gases 有权
    从烟道气中除去二氧化硫的设备和方法

    公开(公告)号：US08852540B2

    公开(公告)日：2014-10-07

    申请号：US14128287

    申请日：2012-06-21

    Applicant: Igor Lubomirsky ,  Valery Kaplan

    Inventor： Igor Lubomirsky ,  Valery Kaplan

    IPC: B01D53/50 ,  B01D53/74 ,  B01D53/14

    CPC classification number: B01D53/507 ,  B01D53/1425 ,  B01D53/502 ,  B01D53/504 ,  B01D2258/0283

    Abstract: An apparatus and method for removing sulfur dioxide from a flue gas is described. The apparatus has sequentially operable scrubbing zone and regeneration zone, which communicate with one another via a molten eutectic mixture of lithium, sodium and potassium carbonates. In the scrubbing zone, an ingress flue gas interacts with the molten carbonates, resulting in chemical absorbance of the sulfur dioxide and in discharge of reaction gases. In the regeneration zone, ether a chemical or electrochemical melt regeneration takes place resulting in formation of sulfur-containing vapor which is cooled down for converting the sulfur-containing vapor into a liquid and solid phase for a further collection and utilization.

    Abstract translation: 描述了从烟道气中除去二氧化硫的装置和方法。 该装置具有顺序可操作的洗涤区和再生区，其经由熔融的锂，碳酸钠和碳酸钾的共晶混合物相互连通。 在洗涤区中，入口烟气与熔融的碳酸盐相互作用，导致二氧化硫的化学吸收和排放反应气体。 在再生区中，乙醚发生化学或电化学熔融再生，导致形成含硫蒸汽，其被冷却以将含硫蒸气转化为液体和固相以进一步收集和利用。

    PROTEIN DETECTOR BASED ON MOLECULAR CONTROLLED SEMICONDUCTOR RESISTOR
    159.
    发明申请
    PROTEIN DETECTOR BASED ON MOLECULAR CONTROLLED SEMICONDUCTOR RESISTOR 有权
    基于分子控制半导体电阻的蛋白质检测器

    公开(公告)号：US20140170675A1

    公开(公告)日：2014-06-19

    申请号：US14124313

    申请日：2012-05-31

    Applicant: Ron Naaman ,  Eyal Capua ,  Danny Bavli ,  Maria Tkachev

    Inventor： Ron Naaman ,  Eyal Capua ,  Danny Bavli ,  Maria Tkachev

    IPC: G01N27/414

    CPC classification number: G01N27/4145

    Abstract: The invention provides a semiconductor device for the detection of an active site-containing protein or a ligand thereof in a solution, said device comprising at least one insulating or semi-insulating layer; at least one conducting semiconductor layer, two conducting pads on top of the upper layer making electrical contact with said at least one conducting semi-conductor layer, such that electrical current can flow between them at a finite distance from the surface of the device; a protective molecular layer fabricated on top of said upper layer and protecting said layer from corrosion; and said ligand or active site-containing protein linked to said protective molecular layer. Exposure of said ligand or active site-containing protein to a solution containing said active site-containing protein or ligand, respectively, causes a current change through the device when a constant electric potential is applied between the two conducting pads. The semi-conductor device can be seen as a molecularly controlled semiconductor resistor (MOCSER) protein sensor based on doped and undoped GaAs stack structure. The GaAs is protected against etching in aqueous environments by the protective molecular layer.

    Abstract translation: 本发明提供一种用于在溶液中检测含活性位点的蛋白质或其配体的半导体器件，所述器件包括至少一个绝缘或半绝缘层; 至少一个导电半导体层，在上层的顶部上的两个导电焊盘与所述至少一个导电半导体层电接触，使得电流可以在它们之间在与器件表面有限距离的位置之间流动; 在所述上层顶部制造的保护分子层，并保护所述层免受腐蚀; 和与所述保护性分子层连接的所述配体或含活性位点的蛋白质。 当在两个导电垫之间施加恒定的电位时，所述配体或含活性位点的蛋白质分别暴露于含有所述含活性位点的蛋白质或配体的溶液中，导致通过该装置的电流变化。 半导体器件可以看作是基于掺杂和未掺杂的GaAs堆叠结构的分子控制半导体电阻（MOCSER）蛋白质传感器。 在保护分子层的水溶液环境中保护GaAs不被腐蚀。

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