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    FORMULATION PROCESS FOR CPMV NANOPARTICLES
    165.
    发明公开
    FORMULATION PROCESS FOR CPMV NANOPARTICLES 审中-公开

    公开(公告)号：US20240350422A1

    公开(公告)日：2024-10-24

    申请号：US18580090

    申请日：2022-07-25

    Applicant: The Regents of the University of California

    Inventor： Nicole F. Steinmetz ,  Matthew D. Shin

    IPC: A61K9/51 ,  A61K35/76

    CPC classification number: A61K9/5184 ,  A61K9/5192 ,  A61K35/76

    Abstract: Proteinaceous nanoparticles can be used to deliver large payloads of active ingredients, which is advantageous in medicine and agriculture. However, the conjugation of hydrophobic ligands to hydrophilic nanocarriers such as plant viral nanoparticles (plant VNPs) can result in aggregation by reducing overall solubility. Provided herein are improved methods for ligand conjugations, as well as the particles prepared by these methods. The disclosed methods promote efficient bioconjugation and prevent the aggregation that accompanies conventional bioconjugation methods, thus improving the stability, homogeneity, and translational potential of plant VNP conjugates in medicine and agriculture.

    ZERO PEEK ROBUSTNESS CHECKS FOR FEDERATED LEARNING
    168.
    发明公开
    ZERO PEEK ROBUSTNESS CHECKS FOR FEDERATED LEARNING 审中-公开

    公开(公告)号：US20240346379A1

    公开(公告)日：2024-10-17

    申请号：US18633905

    申请日：2024-04-12

    Applicant: The Regents of the University of California

    Inventor： Zahra Ghodsi ,  Mojan Javaheripi ,  Nojan Sheybani ,  Xinqiao Zhang ,  Farinaz Koushanfar

    IPC: G06N20/00

    CPC classification number: G06N20/00

    Abstract: A computing system determines a median of a first number of mean values received from a first number of clusters, where each cluster of the first number of clients includes a first plurality of clients. Also, a threshold is determined based on the median, where the threshold applies to model updates. The median and the threshold are broadcast to all clients. Next, one or more clients that fail to provide a proof attesting that their model update is within the threshold of the median are dropped. Then, a second plurality of clients, not including the one or more dropped clients, participate in a final round of secure aggregation. Next, a final aggregate result is obtained, where the final aggregate result is based on the final round of secure aggregation. Then, one or more actions are performed based on the final aggregate result.

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