公开(公告)号：US20150272885A1

公开(公告)日：2015-10-01

申请号：US14350674

申请日：2012-10-12

Applicant: STC.UNM ,  SANDIA CORPORATION

Inventor： Carlee Erin Ashley ,  C. Jeffrey Brinker ,  Eric C. Carnes ,  Mohammad Houman Fekrazad ,  Linda A. Felton ,  Oscar Negrete ,  David Patrick Padilla ,  Brian S. Wilkinson ,  Dan C. Wilkinson ,  Cheryl L. Willman

IPC: A61K9/127 ,  A61K45/06 ,  A61K31/704 ,  A61K31/513 ,  A61K31/713 ,  A61K38/17

CPC classification number: A61K48/0008 ,  A61K9/0014 ,  A61K9/107 ,  A61K9/1271 ,  A61K9/5078 ,  A61K31/192 ,  A61K31/465 ,  A61K31/506 ,  A61K31/513 ,  A61K31/704 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K33/24 ,  A61K38/00 ,  A61K38/17 ,  A61K38/45 ,  A61K38/47 ,  A61K45/06 ,  A61K47/6923 ,  A61K49/0082 ,  A61K49/0423 ,  B82Y5/00 ,  C07K7/06 ,  C07K2319/00 ,  C12N15/113 ,  C12N15/1131 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2810/40 ,  C12Y204/02036 ,  C12Y302/02022 ,  A61K2300/00

Abstract: The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.

Abstract translation: 本发明涉及用于特异性靶向肝细胞和其它癌细胞的原细胞，其包含具有支持的脂质双层的纳米多孔二氧化硅核心; 至少一种促进癌细胞死亡的药物（例如传统的小分子，大分子货物（例如siRNA或蛋白质毒素如蓖麻毒素A链或白喉毒素A链）和/或组蛋白包装的质粒DNA 设置在纳米多孔硅芯内（优选超螺旋以更有效地将DNA包装到原细胞中），其任选地用核定位序列修饰以帮助定位癌细胞核内的原细胞，以及表达参与治疗的肽的能力 （凋亡/细胞死亡）或作为报告物，靶向肽靶向待治疗的组织中的癌细胞，使得原细胞与靶细胞的结合是特异性和增强的，并且促进内体逃逸的融合肽 原细胞和包封的DNA。根据本发明的原细胞可用于治疗癌症，特别是包括肝细胞（肝）癌症 选择性结合肝细胞组织或在癌症诊断中起作用的新型结合肽（c-MET肽），包括癌症治疗和药物发现。

公开(公告)号：US20150246126A1

公开(公告)日：2015-09-03

申请号：US14426543

申请日：2013-09-06

Applicant: Graham TIMMINS ,  Seong Won CHOI ,  STC.UNM

Inventor： Graham Timmins ,  Seong Won Choi

IPC: A61K41/00 ,  A61K31/4409

CPC classification number: A61K41/0052 ,  A61K31/4409

Abstract: The invention provides method of treating a subject suffering from, or at risk of developing, a Mycobacterium infection by administering to the subject a therapeutically-effective amount of isotopically labeled isoniazid and/or ethionamide, or an analog, derivative or prodrug thereof, and exposing the subject to a magnetic field.

Abstract translation: 本发明提供了通过向受试者施用治疗有效量的同位素标记的异烟肼和/或乙硫异烟胺或其类似物，衍生物或前药，以及暴露于受试者的方法，治疗患有或有发展为分枝杆菌感染风险的受试者 受到磁场的影响。

公开(公告)号：US09116219B1

公开(公告)日：2015-08-25

申请号：US13655295

申请日：2012-10-18

Applicant: STC.UNM

Inventor： Stefan Posse

IPC: G01V3/00 ,  G01R33/56

CPC classification number: G01R33/5608 ,  G01R33/4806 ,  G01R33/4822 ,  G01R33/5616

Abstract: A system and methods for high-speed functional magnetic resonance imaging using multi-slab echo-volumar imaging (EVI), specifically a combination of multi-slab excitation and single-shot 3D encoding with parallel imaging to reduce geometrical image distortion and blurring, and to increase blood oxygenation level-dependent (BOLD) sensitivity compared to conventional echo-planar imaging (EPI).

Abstract translation: 一种使用多板回波 - 体积成像（EVI）的高速功能磁共振成像的系统和方法，特别是多平板激发和单次3D编码与并行成像的组合，以减少几何图像失真和模糊，以及 与常规回波平面成像（EPI）相比，增加血氧水平依赖性（BOLD）灵敏度。

公开(公告)号：US20150011494A1

公开(公告)日：2015-01-08

申请号：US14449599

申请日：2014-08-01

Applicant: STC.UNM

Inventor： David L. Vander Jagt ,  Lorraine M. Deck ,  Steve F. Abcouwer ,  Robert A. Orlando ,  Robert E. Royer ,  Waylon M. Weber ,  Ekaterina V. Bobrovnikova-Marjon ,  Lucy A. Hunsaker

IPC: C07C49/255 ,  C07D213/50 ,  G01N33/50 ,  C07C49/235 ,  A61K45/06 ,  A61K31/121 ,  A61K31/444

CPC classification number: C07C49/255 ,  A61K31/12 ,  A61K31/121 ,  A61K31/137 ,  A61K31/235 ,  A61K31/277 ,  A61K31/282 ,  A61K31/336 ,  A61K31/337 ,  A61K31/444 ,  A61K31/704 ,  A61K45/06 ,  C07C49/235 ,  C07D213/50 ,  G01N33/5023 ,  G01N33/5058 ,  G01N2500/10 ,  A61K2300/00

Abstract: Curcumin analogues and methods are provided for treatment of disease.

Abstract translation: 提供姜黄素类似物和方法用于治疗疾病。

公开(公告)号：US20150004594A1

公开(公告)日：2015-01-01

申请号：US14121488

申请日：2014-09-11

Applicant: STC.UNM

Inventor： Scott S. Sibbett

IPC: G01N33/543

CPC classification number: G01N33/54386 ,  G01N33/558 ,  G01N33/56988 ,  G01N2333/005

Abstract: The present invention provides a semi-quantitative lateral flow assay device and method for generating semi-quantitative data from a lateral flow assay. The device comprises a thin, porous hydrophilic substrate wherein the substrate includes a star-shaped or other geometry taken in plan view having a liquid sample-receiving central region and multiple arms that extend or radiate out from the central region. Each arm includes a reaction zone formed by the presence of an analyte-capturing agent wherein the reaction zone of each arm is located at a different distance from the central region such that the analyte in the sample is captured accumulates in different quantities at at least some of the reaction zones of the arms in a manner that can be analyzed to yield semi-quantitative data from lateral flow assays. The reaction zones on the arms can be analyzed visually and/or by software analysis of a digital image based on color saturation, grayscale, or other characteristics of the reactions zones due to the presence of different amounts of analyte to produce semi-quantitative data of the total loading of a virus or other agent of interest of a patient's blood.

Abstract translation: 本发明提供了一种半定量侧流测定装置和用于从侧流测定产生半定量数据的方法。 该装置包括薄的多孔亲水基底，其中基底包括在平面图中取得的星形或其他几何形状，具有液体样品接收中心区域和从中心区域延伸或辐射出的多个臂。 每个臂包括通过存在分析物 - 捕获剂形成的反应区，其中每个臂的反应区位于与中心区不同的距离处，使得捕获的样品中的分析物在至少一些 的臂的反应区域以可以分析的方式产生来自侧向流动测定的半定量数据。 可以通过视觉和/或通过基于颜色饱和度，灰度或反应区域的其他特征的数字图像的软件分析来分析臂上的反应区域，这是由于存在不同量的分析物以产生半定量数据 患者血液感兴趣的病毒或其他药剂的总负荷。

公开(公告)号：US08921569B2

公开(公告)日：2014-12-30

申请号：US13760605

申请日：2013-02-06

Applicant: STC.UNM ,  Johns Hopkins University

Inventor： Graham Timmins ,  Sharon Master ,  Vojo P Deretic ,  William Bishai

IPC: C07D213/86 ,  A61K9/00 ,  C07D213/81 ,  C07D213/83 ,  A61K31/44 ,  A61K31/4409

CPC classification number: C07D213/81 ,  A61K9/0019 ,  A61K9/0073 ,  A61K31/44 ,  A61K31/4409 ,  C07D213/83 ,  C07D213/86

Abstract: The present invention relates to the use of isotopically labeled derivatives of isoniazid, ethionamide and related compounds as effective therapy for the treatment of mycobacterial diseases, including Mycobacterium tuberculosis.

Abstract translation: 本发明涉及异烟肼，乙硫异烟胺和相关化合物的同位素标记衍生物在治疗分枝杆菌疾病（包括结核分枝杆菌）中的有效疗法。

公开(公告)号：US20140295486A1

公开(公告)日：2014-10-02

申请号：US14226572

申请日：2014-03-26

Applicant: STC.UNM

Inventor： Laurel Sillerud ,  Todd M. Alam ,  Andrew F. McDowell

IPC: G01R33/32

CPC classification number: G01R33/32 ,  B82Y15/00 ,  G01N24/08 ,  G01N33/54326 ,  G01N33/553 ,  G01R33/281 ,  G01R33/302 ,  G01R33/34007 ,  G01R33/34046 ,  G01R33/34092 ,  G01R33/341 ,  G01R33/465 ,  G01R33/5601

Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

Abstract translation: 生物检测器包括用于接收含有一个或多个待纳入检测体的磁性纳米颗粒标记的生物体的流体的导管，以及一个用于建立其中设置导管的低磁场的永磁体或电磁体。 微线圈靠近导管设置，以允许通过NMR光谱法检测流体中是否存在一个或多个磁性标记的生物体的频率。

公开(公告)号：US20140290311A1

公开(公告)日：2014-10-02

申请号：US13960659

申请日：2013-08-06

Applicant: STC.UNM

Inventor： Ravinder K. Jain ,  Mani Hossein-Zadeh

IPC: C03B37/15

CPC classification number: G02B6/02052 ,  G02B6/262 ,  G02B2006/12038 ,  G02B2006/12109 ,  G02B2006/12159 ,  G02B2006/12169 ,  H01S3/0627 ,  H01S3/1608 ,  H01S3/173

Abstract: An optical resonator made from an elongated fiber having a proximal and distal end. A sphere is created on the distal end by locating the distal end in cylindrically symmetrical heating zone along a centerline. For some embodiments, the distal end is rapidly cooled by allowing it to retract away from the heating zone along the centerline during the formation and solidification of the molten microsphere. The resulting optical resonator has an intrinsic quality factor greater than 106 over the 2.0 to 3.2 μm MIR wavelength range.

Abstract translation: 由具有近端和远端的细长纤维制成的光学谐振器。 通过将远端沿着中心线定位在圆柱对称的加热区域中，在远端产生球体。 对于一些实施例，远端在熔融微球体的形成和凝固过程中允许其沿着中心线从加热区域缩回而快速冷却。 所得光学谐振器在2.0至3.2μmMIR波长范围内具有大于106的固有品质因数。

公开(公告)号：US20140234981A1

公开(公告)日：2014-08-21

申请号：US14347713

申请日：2012-09-28

Applicant: STC.UNM

Inventor： Payman Zarkesh-Ha ,  Steven R.J. Brueck ,  Jeremy Edwards

IPC: G01N27/414

CPC classification number: C12Q1/6869 ,  C12Q1/6806 ,  C12Q1/6874 ,  G01N27/414 ,  G01N27/4145 ,  Y10T436/143333 ,  C12Q2531/125 ,  C12Q2535/122

Abstract: Devices that include a substrate; a source region and a drain region formed within the substrate and having a channel region provided therebetween; a first insulating layer formed over the channel region; a first floating gate formed over the first insulating layer, the first floating gate configured to respond to an analyte in a target material; and a second gate formed over the first floating gate, the second gate capacatively coupled but not electrically connected to the first floating gate.

Abstract translation: 包括基板的装置; 源极区域和漏极区域，形成在所述衬底内并且在其间设置有沟道区域; 形成在所述沟道区上的第一绝缘层; 形成在所述第一绝缘层上的第一浮动栅极，所述第一浮置栅极被配置为响应目标材料中的分析物; 以及形成在所述第一浮动栅极上的第二栅极，所述第二栅极电容耦合但不电连接到所述第一浮动栅极。

公开(公告)号：US08803259B2

公开(公告)日：2014-08-12

申请号：US13764558

申请日：2013-02-11

Applicant: STC.UNM

Inventor： Jingkuang Chen

IPC: H01L21/00

CPC classification number: B06B1/06 ,  A61B1/041 ,  A61B8/12 ,  A61B8/4472 ,  A61B8/4488 ,  A61B8/4494 ,  B06B1/0292 ,  B81B2201/0271 ,  B81C1/00095 ,  B81C3/008 ,  G01S15/8929 ,  Y10T29/42

Abstract: Systems, apparatus, and associated methods of forming the systems and/or apparatus may include imaging devices that may comprise multiple arrays of ultrasonic transducer elements for use in a variety of applications. These multiple arrays of ultrasonic transducer elements can be arranged to form a three-dimensional imaging device. Non-coplanar arrays of ultrasonic transducer elements can be coupled together. These imaging devices may be used as medical imaging devices. Additional apparatus, systems, and methods are disclosed.

Abstract translation: 形成系统和/或装置的系统，装置和相关联的方法可以包括可以包括用于各种应用的超声换能器元件的多个阵列的成像装置。 这些多个超声波换能器阵列阵列可被布置成形成三维成像装置。 非共面阵列的超声换能器元件可以耦合在一起。 这些成像装置可以用作医疗成像装置。 公开了附加装置，系统和方法。