公开(公告)号：US20120244186A1

公开(公告)日：2012-09-27

申请号：US13070197

申请日：2011-03-23

Applicant: Jyh-Yih CHEN ,  Chang-Jer Wu

Inventor： Jyh-Yih CHEN ,  Chang-Jer Wu

IPC: A61K39/12

CPC classification number: A61K39/12 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/55516 ,  C12N2770/24134 ,  Y02A50/39

Abstract: A method of enhancing a mammalian immune response to a virus is disclosed. The method comprises administering a composition comprising an effective amount of epinecidin (Epi)-1 and the virus to a mammal, wherein the virus has envelope protein and is infectious to the mammal. A vaccine kit and a method for preventing Japanese encephalitis virus (JEV) infection are also disclosed.

Abstract translation: 公开了增强对病毒的哺乳动物免疫应答的方法。 该方法包括向哺乳动物施用包含有效量的抗坏血酸（Epi）-1和病毒的组合物，其中所述病毒具有包膜蛋白并且对哺乳动物具有感染性。 还公开了疫苗试剂盒和预防日本脑炎病毒（JEV）感染的方法。

公开(公告)号：US20120149887A1

公开(公告)日：2012-06-14

申请号：US13159339

申请日：2011-06-13

Applicant: Masaaki Sawa ,  Chi-Huey Wong ,  Tsui-Ling Hsu ,  Sarah Hanson

Inventor： Masaaki Sawa ,  Chi-Huey Wong ,  Tsui-Ling Hsu ,  Sarah Hanson

IPC: C07H15/04 ,  C07H19/10

CPC classification number: G01N33/5005 ,  G01N33/5008 ,  G01N33/533 ,  G01N2400/00

Abstract: Methods for metabolic oligosaccharide engineering that incorporates derivatized alkyne-bearing sugar analogs as “tags” into cellular glycoconjugates are disclosed. Alkynyl derivatized Fuc and alkynyl derivatized ManNAc sugars are incorporated into cellular glycoconjugates. Chemical probes comprising an azide group and a visual or fluorogenic probe and used to label alkyne-derivatized sugar-tagged glycoconjugates are disclosed. Chemical probes bind covalently to the alkynyl group by Cu(I)-catalyzed [3+2] azide-alkyne cycloaddition and are visualized at the cell surface, intracellularly, or in a cellular extract. The labeled glycoconjugate is capable of detection by flow cytometry, SDS-PAGE, Western blot, ELISA, confocal microscopy, and mass spectrometry.

Abstract translation: 公开了将衍生的含炔烃类似物作为细胞糖缀合物的“标签”的代谢寡糖工程方法。 将炔基衍生的Fuc和炔基衍生的ManNAc糖掺入细胞糖缀合物中。 公开了包含叠氮基和视觉或荧光探针并用于标记炔衍生的糖标记的糖缀合物的化学探针。 化学探针通过Cu（I）催化的[3 + 2]叠氮炔环加成与炔基共价结合，并在细胞表面，细胞内或细胞提取物中显现。 标记的糖缀合物能够通过流式细胞术，SDS-PAGE，Western印迹，ELISA，共聚焦显微镜和质谱检测。

公开(公告)号：US08147880B2

公开(公告)日：2012-04-03

申请号：US12766895

申请日：2010-04-25

Applicant: Wen-Chin Yang

Inventor： Wen-Chin Yang

IPC: A61K36/00

CPC classification number: A61K36/28 ,  A61K31/7034 ,  Y10S514/866

Abstract: This invention relates to a method of treating type II diabetes with a polyacetylenic compound of the following formula: in which R1 is H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C20 cycloalkyl, C3-C20 cycloalkenyl, C1-C20 heterocycloalkyl, C1-C20 heterocycloalkenyl, aryl, or heteroaryl; R2 is H or a monosaccharide residue; R3 is H or C1-C10 alkyl; m is 2, 3, or 4; n is 0, 1, 2, or 3; o is 0, 1, 2, 3, or 4; and p is 1, 2, 3, or 4.

Abstract translation: 本发明涉及用下式的聚乙炔化合物治疗II型糖尿病的方法：其中R1是H，C1-C10烷基，C2-C10链烯基，C2-C10炔基，C3-C20环烷基，C3-C20环烯基 ，C 1 -C 20杂环烷基，C 1 -C 20杂环烯基，芳基或杂芳基; R2是H或单糖残基; R3是H或C1-C10烷基; m为2,3或4; n为0,1,2或3; o为0,1,2,3或4; 而p为1,2,3或4。

公开(公告)号：US20120046337A1

公开(公告)日：2012-02-23

申请号：US13033692

申请日：2011-02-24

Applicant: Pi-Hui Liang ,  Yi-Ling Lin ,  Chi-Huey Wong

Inventor： Pi-Hui Liang ,  Yi-Ling Lin ,  Chi-Huey Wong

IPC: A61K31/40 ,  A61P19/02 ,  C07D207/12

CPC classification number: A61K31/4015 ,  Y02A50/385 ,  Y02A50/389

Abstract: Novel 5-membered iminocyclitol derivatives were found to be a potent and selective inhibitors of the glycoprotein processing α- and β-glucosidase which were further found to be active antiviral agents against Japanese encephalitis virus, dengue virus serotype 2 (DEN-2), human SARS coronavirus and human β-hexosaminidase, a new target for development of osteoarthritis therapeutics.

Abstract translation: 发现新的5元亚氨基环醇衍生物是糖蛋白加工α-和β-葡萄糖苷酶的有效和选择性抑制剂，其进一步被发现是针对日本脑炎病毒，登革热病毒血清型2（DEN-2）的活性抗病毒剂， 人类SARS冠状病毒和人类 - 糖尿病病毒，是骨关节炎治疗发展的新靶点。

公开(公告)号：US20120039988A1

公开(公告)日：2012-02-16

申请号：US13201749

申请日：2010-02-19

Applicant: Han-Chung Wu ,  Chien-Yu Chiu

Inventor： Han-Chung Wu ,  Chien-Yu Chiu

IPC: A61K9/127 ,  A61K9/14 ,  C07K9/00 ,  A61P35/00 ,  A61K38/14 ,  C07H21/00 ,  A61K31/704 ,  C07K7/08 ,  A61K38/10

CPC classification number: C07K7/08

Abstract: Cancer-targeting peptides and uses thereof in cancer therapy.

Abstract translation: 癌症靶向肽及其在癌症治疗中的应用。

公开(公告)号：US08088887B2

公开(公告)日：2012-01-03

申请号：US11783926

申请日：2007-04-13

Applicant: Han-Chung Wu ,  Chin-Tarng Lin ,  Tong-Young Lee ,  Szu-Yao Kuo

Inventor： Han-Chung Wu ,  Chin-Tarng Lin ,  Tong-Young Lee ,  Szu-Yao Kuo

IPC: A61K38/00 ,  A61K38/18 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  C07K14/515 ,  A61P35/00

CPC classification number: A61K9/1271 ,  A61K47/62 ,  A61K47/6911 ,  G01N33/5082 ,  G01N33/57423

Abstract: The invention provides nucleic acids, peptides, and antibodies for use in applications including diagnosis and therapy. The peptides target neovasculature and were identified by in vivo phage display. One such peptide, SP5-52, recognized the neovasculature of multiple tumors in SCID mice, but did not target normal blood vessels. This peptide also binds to blood vessels of human lung cancer biopsy specimens. Liposomes comprising SP5-52 and doxorubicin enhanced the efficacy of the drug against multiple human cancer xenografts in SCID mice.

Abstract translation: 本发明提供用于包括诊断和治疗在内的应用的核酸，肽和抗体。 该肽靶向新血管生成，并通过体内噬菌体展示鉴定。 一种这样的肽SP5-52在SCID小鼠中识别出多个肿瘤的新血管，但不能靶向正常的血管。 该肽还结合人肺癌活检标本的血管。 包含SP5-52和多柔比星的脂质体增强了药物对SCID小鼠中多种人类癌症异种移植物的功效。

公开(公告)号：US20110321179A1

公开(公告)日：2011-12-29

申请号：US13166147

申请日：2011-06-22

Applicant: Che-Kun James SHEN ,  Lien-Szu Wu

Inventor： Che-Kun James SHEN ,  Lien-Szu Wu

IPC: A01K67/033 ,  A61K49/00 ,  C12N5/10 ,  C12N5/07

CPC classification number: A01K67/0276 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/0318 ,  C12N15/8509 ,  C12N2800/30

Abstract: A non-human animal model for amyotrophic lateral sclerosis (ALS) is disclosed. The animal model comprises a rodent whose spinal cord motor neurons have a loss of TAR-DNA binding protein-43 (TDP-43) function and phenotypes exhibit ALS-like symptoms. A method for identifying a candidate agent for treating, preventing and/or inhibiting ALS associated with a loss-of-function of TDP-43 is also disclosed.

Abstract translation: 公开了用于肌萎缩侧索硬化（ALS）的非人动物模型。 动物模型包括一只啮齿动物，其脊髓运动神经元具有TAR-DNA结合蛋白-43（TDP-43）功能的损失，表型表现出ALS样症状。 还公开了用于鉴定用于治疗，预防和/或抑制与TDP-43的功能丧失相关的ALS的候选药剂的方法。

公开(公告)号：US08080824B2

公开(公告)日：2011-12-20

申请号：US11560157

申请日：2006-11-15

Applicant: Kuei-Hsien Chen ,  Chien-Hung Lin ,  Chia-Wen Hsu ,  Li-Chyong Chen

Inventor： Kuei-Hsien Chen ,  Chien-Hung Lin ,  Chia-Wen Hsu ,  Li-Chyong Chen

IPC: H01L29/00

CPC classification number: H01L31/0352 ,  H01L31/18

Abstract: A semiconductor material structure includes at least one region capable of generating electrons and holes each having an associated mean kinetic energy during operation. A material layer in proximity to the region provides an associated potential energy larger than the mean kinetic energy associated with the generated electrons and the mean kinetic energy associated with the holes.

Abstract translation: 半导体材料结构包括至少一个能够产生电子和空穴的区域，每个区域在操作期间具有相关联的平均动能。 靠近该区域的材料层提供大于与产生的电子相关联的平均动能和与孔相关联的平均动能的相关势能。

公开(公告)号：US08071105B2

公开(公告)日：2011-12-06

申请号：US12244709

申请日：2008-10-02

Applicant: Shu-Mei Liang ,  Yen-Po Chen ,  Wen-Bin Yang ,  Chi-Huey Wong

Inventor： Shu-Mei Liang ,  Yen-Po Chen ,  Wen-Bin Yang ,  Chi-Huey Wong

IPC: A61K36/06

CPC classification number: A61K39/0002 ,  A61K2039/55588

Abstract: The present disclosure relates to the discovery of methods of isolating subfractions of an F3 Reishi extract, and of administration of these novel isolates to eukaryotic cells in order to induce certain immumodulatory, hematopoeitic and tumor-inhibiting phenotypic changes in those eukaryotic cells, mediated through particular toll-like receptor (TLR) and other transmembrane receptors. F3 subfractions F301 and F331 have demonstrated that F331 is capable of activating at least TLR-2 while F301 is capable of activating at least TLR-2, TLR-4, and TLR-5.

Abstract translation: 本公开涉及发现分离F3赖氏提取物的亚组分的方法，以及将这些新型分离物施用于真核细胞，以便诱导那些通过特异性介导的那些真核细胞中的某些免疫调节，造血细胞和肿瘤抑制表型变化 toll样受体（TLR）和其他跨膜受体。 F3亚分数F301和F331已经证明F331能够至少激活至少TLR-2，而F301能够至少激活TLR-2，TLR-4和TLR-5。

公开(公告)号：US20110284466A1

公开(公告)日：2011-11-24

申请号：US13112519

申请日：2011-05-20

Applicant: Chao-Jung Chen ,  Mei-Chun Tseng ,  Yet-Ran Chen

Inventor： Chao-Jung Chen ,  Mei-Chun Tseng ,  Yet-Ran Chen

IPC: B01D15/08 ,  C04B35/64 ,  B05D3/00 ,  B05D7/22 ,  B05D3/02

CPC classification number: G01N30/603 ,  B01D15/22 ,  G01N30/6078

Abstract: A durable on-column tunneled frit was developed for use in nanoflow UPLC systems. The frit was tunneled during sol-gel reaction. The tunneled-frit fabrication process is easy and reproducible in terms of back pressure and durability. This design creates low backpressure with high liquid flow, which is suitable for the nanoflowUPLC application. A short packing (2 cm C18 particle) tunneled-frit column was demonstrated to sustain 10,000 psi continuous liquid flow for over one week without any particle leakage or pressure instability. The tunneled-frit was also successfully applied to the fabrication of nanoUPLC trapping and analytical column system. It was demonstrated to have high separation efficiency and sensitivity for the analysis of tryptic peptides as well as improved detection sensitivity for phosphopeptide analysis.

Abstract translation: 开发了一种耐用的柱内隧道玻璃料，用于纳流低压UPLC系统。 玻璃料在溶胶 - 凝胶反应过程中被隧道化。 隧道式玻璃料制造工艺在背压和耐久性方面是容易的和可再现的。 该设计产生低液压，具有高液体流量，适用于纳米FLUP应用。 证明短填料（2cm C18颗粒）隧道玻璃料柱能够持续10,000psi连续液流超过一周，没有任何颗粒泄漏或压力不稳定性。 隧道玻璃料也成功应用于nanoUPLC捕集和分析柱系统的制造。 已被证明具有高分离效率和敏感性，用于分析胰蛋白酶肽，以及提高磷酸肽分析的检测灵敏度。