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公开(公告)号：US08982340B2
公开(公告)日：2015-03-17
申请号：US13947113
申请日：2013-07-22
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Yair Peled , Moshe Tur
IPC: G01M11/00
CPC classification number: G01M11/3172 , G01M11/39
Abstract: A method for conducting fast Brillouin optical time domain analysis for dynamic sensing of optical fibers is provided herein. The method includes the following stages: injecting a pump pulse signal into a first end of an optical fiber and a probe signal into a second end of the optical fiber, wherein the probe and the pump pulse signals exhibit a frequency difference between them that is appropriate for an occurrence of a Brillouin effect; alternating the frequency of either the probe or the pulse signals, so as the alternated signal exhibits a series of signal sections, each signal section having a predefined common duration and a different frequency; measuring the Brillouin probe gain for each one of the alternating frequencies; and extracting physical properties of the optical fiber throughout its length at sample points associated with the sampled time and the frequencies, based on the measured Brillouin probe gain.
Abstract translation: 本文提供了一种用于进行光纤动态感测的快速布里渊光时域分析的方法。 该方法包括以下步骤：将泵浦脉冲信号注入到光纤的第一端并将探测信号注入光纤的第二端，其中探针和泵浦脉冲信号在它们之间表现出适当的频率差 发生布里渊效应; 交替的探针或脉冲信号的频率，以便交替的信号表现出一系列信号部分，每个信号部分具有预定的公共持续时间和不同的频率; 测量每个交变频率的布里渊探针增益; 并且基于所测量的布里渊探针增益，在与采样时间和频率相关联的采样点处，在整个长度上提取光纤的物理特性。
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172.发明申请COMPOSITES COMPRISING COLLAGEN EXTRACTED FROM SARCOPHYTON SP. CORAL 有权包括从SARCOPHYTON SP提取的胶原蛋白的复合材料 珊瑚公开(公告)号：US20150013299A1
公开(公告)日：2015-01-15
申请号：US14376891
申请日：2013-02-07
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Rami Haj-Ali , Yehuda Benayahu , Dafna Benayahu , Aviad Sason-Levi , Mirit Sharabi
IPC: A61L27/36 , D04B1/14 , D04C1/02 , D03D15/00 , A61L27/54 , D01G13/00 , D06M13/00 , A61L27/48 , A61L27/24 , D02G3/02 , D01G1/00
CPC classification number: A61L27/3637 , A61L27/24 , A61L27/3687 , A61L27/446 , A61L27/48 , A61L27/54 , A61L2430/20 , A61L2430/34 , D01G1/00 , D01G13/00 , D02G3/02 , D03D15/00 , D04B1/14 , D04C1/02 , D06M13/00 , D10B2211/06 , C08L89/06
Abstract: Isolated composites are disclosed comprising collagen fibers isolated from a Sarcophyton sp. coral. An exemplary composite comprises as a first component a bundle of collagen fibers, the collagen fibers being isolated from a Sarcophyton sp. coral, and a second component selected from the group consisting of a polysaccharide, a polypeptide, polylipid, a synthetic polymer, a metal and a mineral, wherein the bundle of collagen fibers comprise woven fibers, twisted fibers, braided fibers, knitted fibers, tied fibers, or sutured fibers. Uses thereof and method of generating are also disclosed.
Abstract translation: 公开了分离的复合物，其包含从Sarcophyton sp。分离的胶原纤维。 珊瑚。 示例性复合材料包括作为第一组分的胶原纤维束，胶原纤维与Sarcophyton sp。分离。 珊瑚和选自多糖，多肽，多脂，合成聚合物，金属和矿物质的第二组分，其中所述胶原纤维束包含编织纤维，扭曲纤维，编织纤维，针织纤维，捆扎 纤维或缝合纤维。 还公开了其用途和生成方法。
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公开(公告)号：US20140378635A1
公开(公告)日：2014-12-25
申请号：US14289186
申请日：2014-05-28
Inventor： Moshe Kol , Konstantin Press , Matthew W. Holtcamp
IPC: C08F110/06 , C07F7/00
CPC classification number: C08F110/06 , C07F7/003 , C08F4/60189 , C08F4/64189 , C08F4/659 , C08F4/65912 , C08F2500/15 , C08F2500/20
Abstract: Catalysts comprising salenol ligands are disclosed herein. Also, catalyst systems comprising the catalyst and an activator; methods to prepare the ligands, catalysts and catalyst systems; processes to polymerize olefins using the catalysts and/or catalyst systems; and the olefin polymers prepared according to the processes.
Abstract translation: 包含salenol配体的催化剂在本文中公开。 而且，包含催化剂和活化剂的催化剂体系; 制备配体，催化剂和催化剂体系的方法; 使用催化剂和/或催化剂体系聚合烯烃的方法; 和根据该方法制备的烯烃聚合物。
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公开(公告)号：US08900574B2
公开(公告)日：2014-12-02
申请号：US14164286
申请日：2014-01-27
Inventor： Avinoam Kadouri , Avihay Bar-Ilan , Eldad Melamed , Daniel Offen , Ofer Sadan , Merav Bahat-Stromza
CPC classification number: A61K38/185 , A61K35/12 , A61K35/28 , C12N5/0618 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0669 , C12N2500/84 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2506/1353
Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.
Abstract translation: 公开了一种分离的人细胞，其包含至少一种间充质干细胞表型和分泌性脑源性神经营养因子（BDNF），其中BDNF的基础分泌比间充质干细胞中BDNF的基础分泌高至少五倍 。 还公开了生产方法及其用途。
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175.发明申请公开(公告)号：US20140255972A1
公开(公告)日：2014-09-11
申请号：US14280612
申请日：2014-05-18
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Reuven TIROSH , Fernando Patolsky , Hagit Peretz-Soroka
IPC: G01N33/50
CPC classification number: G01N33/5091 , G01N33/5005 , G01N33/5023 , G01N33/5038 , G01N33/5094 , G01N33/84 , G06F19/12
Abstract: A method of measuring a metabolic activity (MA) of a cell is provided. The method comprising independently measuring in an extracellular environment of the cell, time-dependent acidification profiles due to secretion of:(i) non-volatile soluble metabolic products; (ii) non-volatile soluble metabolic products and volatile soluble metabolic products; and (iii) volatile soluble metabolic products; wherein at least one of the time dependent acidification profiles is indicative of the metabolic activity of the cell. Also provided are clinical methods which make use of the assay.
Abstract translation: 提供了测量细胞的代谢活性（MA）的方法。 该方法包括在细胞的细胞外环境中独立测量，由于分泌以下因素而导致的时间依赖性酸化曲线：（i）非挥发性可溶性代谢产物; （ii）不挥发性可溶性代谢产物和挥发性可溶性代谢产物; 和（iii）挥发性可溶性代谢产物; 其中至少一个时间依赖性酸化曲线指示细胞的代谢活性。 还提供了利用该测定法的临床方法。
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Patent Agency Ranking
176.发明申请CONJUGATE OF A POLYMER, AN ANTI-ANGIOGENESIS AGENT AND A TARGETING MOIETY, AND USES THEREOF IN THE TREATMENT OF BONE RELATED ANGIOGENESIS CONDITIONS 审中-公开聚合物，抗血管发生剂和靶向药物的联合使用及其在治疗骨髓相关血管生成条件中的应用公开(公告)号：US20140212357A1
公开(公告)日：2014-07-31
申请号：US14242901
申请日：2014-04-02
Inventor： RONIT SATCHI-FAINARO , EHUD SEGAL , JINDRICH KOPECEK , PAVLA KOPECKOVA , HUAIZHONG PAN
CPC classification number: A61K47/58 , A61K31/787 , A61K49/0043 , A61K49/0054
Abstract: Conjugates of hydroxypropyl methacrylamide (HPMA)-derived copolymers having attached thereto TNP-470 and a high load (e.g., higher than 3 mol %) of alendronate (ALN), and processes of preparing same are disclosed.Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and an oligoaspartate bone targeting agent, and processes of preparing same, are further disclosed.Pharmaceutical compositions containing these conjugates and uses thereof in the treatment and monitoring of bone related disorders are also disclosed.
Abstract translation: 公开了具有附着于其上的羟丙基甲基丙烯酰胺（HPMA）衍生的共聚物TNP-470和高负载量（例如高于3mol％）的阿仑膦酸盐（ALN）的结合物及其制备方法。 另外还公开了附着有抗血管生成剂和寡天冬氨酸骨靶向剂的聚合物或共聚物的共轭物及其制备方法。 还公开了含有这些缀合物的药物组合物及其在骨相关疾病的治疗和监测中的用途。
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177.发明授权Method of regenerating connective tissue with a scaffold of coral-derived collagen 有权用珊瑚衍生胶原支架再生结缔组织的方法公开(公告)号：US08747484B2
公开(公告)日：2014-06-10
申请号：US13944917
申请日：2013-07-18
Inventor： Yehuda Benayahu , Dafna Benayahu , Yoel Kashman , Amira Rudi , Yoram Lanir , Ido Sella , Einat Raz
IPC: A61F2/02
Abstract: A method is disclosed for regenerating connective tissue by administering a scaffold comprising collagen fibers extracted from a soft coral. The length of the soft coral collagen fibers following stretching by about 15% is identical to the length of the fibers prior to stretching.
Abstract translation: 公开了通过施用包含从软珊瑚提取的胶原纤维的支架来再生结缔组织的方法。 拉伸后软珊瑚胶原纤维的长度约15％与拉伸前纤维的长度相同。
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178.发明申请ISOLATED CELLS AND POPULATIONS COMPRISING SAME FOR THE TREATMENT OF CNS DISEASES 有权分离细胞和包含相同的人类用于治疗CNS疾病公开(公告)号：US20140154222A1
公开(公告)日：2014-06-05
申请号：US14173846
申请日：2014-02-06
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Daniel OFFEN , Merav Bahat-Stromza , Eldad Melamed
IPC: C12N5/077
CPC classification number: C12N5/0669 , C12N5/0622 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/40 , C12N2506/1353
Abstract: An isolated human cell and populations thereof is provided comprising at least one astrocytic phenotype and at least one mesenchymal stem cell phenotype, wherein the mesenchymal stem cell phenotype is not an astrocytic phenotype.
Abstract translation: 提供分离的人细胞及其群体，其包含至少一种星形细胞表型和至少一种间充质干细胞表型，其中间质干细胞表型不是星形细胞表型。
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公开(公告)号：US20140044949A1
公开(公告)日：2014-02-13
申请号：US14061771
申请日：2013-10-24
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Ehud GAZIT , Meital Reches
IPC: D01F4/00
CPC classification number: D01F4/00 , C07K5/06078 , C07K5/06191 , C08J5/18 , C08J2300/16 , D01D5/00 , D01F1/10 , D01F6/68 , Y10T428/253 , Y10T428/298 , Y10T442/60 , Y10T442/614
Abstract: A method of forming a fiber made of peptide nanostructures is disclosed. The method comprises: providing peptide nanostructures in solution, and fiberizing the solution thereby forming at least one fiber of the peptide nanostructures. Also disclosed are methods of forming films and other articles using the peptide nanostructures.
Abstract translation: 公开了一种形成由肽纳米结构制成的纤维的方法。 该方法包括：在溶液中提供肽纳米结构，并使溶液纤维化，从而形成肽纳米结构的至少一种纤维。 还公开了使用肽纳米结构形成膜和其它制品的方法。
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公开(公告)号：US20140039138A1
公开(公告)日：2014-02-06
申请号：US13921532
申请日：2013-06-19
Inventor： Garth R. Giesbrecht , Gregory S. Day , Matthew W. Holtcamp , Moshe Kol , David A. Cano , Eric D. Whetmore , Konstantin Press
IPC: C08F4/6592
CPC classification number: C08F4/65925 , C08F4/659 , C08F4/65912 , C08F210/16 , C08F210/14 , C08F2500/03 , C08F4/64189 , C08F110/06
Abstract: Catalysts comprising salan ligands with carbazole moieties. Also, catalyst systems comprising the catalyst and an activator; methods to prepare the ligands, catalysts and catalyst systems; processes to polymerize olefins using the catalysts and/or catalyst systems; and the olefin polymers prepared according to the processes.
Abstract translation: 包含具有咔唑部分的沙兰配体的催化剂。 而且，包含催化剂和活化剂的催化剂体系; 制备配体，催化剂和催化剂体系的方法; 使用催化剂和/或催化剂体系聚合烯烃的方法; 和根据该方法制备的烯烃聚合物。
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