公开(公告)号：US20170261407A1

公开(公告)日：2017-09-14

申请号：US15347767

申请日：2016-11-09

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  MBD KOREA, CO., LTD.

Inventor： Hyo Jeong KUH ,  Ji Hoon KANG ,  Dong Wo LEE

IPC: G01N1/04 ,  C12M1/34 ,  C12M1/12

CPC classification number: G01N1/04 ,  C12M25/14 ,  C12M41/12 ,  G01N1/06 ,  G01N1/36 ,  G01N2001/366

Abstract: The present invention relates to a pillar assembly and an apparatus for producing a sample block comprising the same, and according to one aspect of the present invention, it is possible to change arrangement of pillars, and sample slices can be easily obtained from the sample block.

公开(公告)号：US20170197012A1

公开(公告)日：2017-07-13

申请号：US15449464

申请日：2017-03-03

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Heung Jae CHUN ,  Dae Hyeok YANG ,  Su Jung YOU ,  Hyun Joo KIM

IPC: A61L27/52 ,  A61L27/22 ,  A61L27/14 ,  A61L27/56

CPC classification number: A61L27/52 ,  A61L27/14 ,  A61L27/18 ,  A61L27/22 ,  A61L27/38 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/25 ,  C08L67/04 ,  C08L71/02

Abstract: There is provided a thermosensitive biodegradable hydrogel including MPEG-PCL to which a cell-adhesive peptide binds, and MPEG-PCL. The thermosensitive biodegradable hydrogel has excellent cellular adhesiveness while maintaining thermosensitivity of polymers intact, and is biodegradable in vivo after a predetermined period of time.

公开(公告)号：US09669103B2

公开(公告)日：2017-06-06

申请号：US15074443

申请日：2016-03-18

Applicant: KOREA NATIONAL UNIVERSITY OF TRANSPORTATION Industry-Academic Cooperation Foundation ,  THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Yong Kyu Lee ,  Sung Hoon Kang ,  Sang Joon Lee ,  In Kyu Park ,  Kwang Jae Cho ,  Mohammed Nurunnabi

IPC: C08B37/08 ,  C01G7/00 ,  C07H21/02 ,  C07H21/04 ,  A61K31/7032 ,  A61K47/48 ,  C12N15/113 ,  A61K31/713

CPC classification number: A61K31/713 ,  A61K47/6939 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2320/32

Abstract: Disclosed are a metal-nanoparticle-based liver-specific nucleic acid delivery system, a method of manufacturing the same, and a liver disease treatment composition containing the same. The liver-specific nucleic acid delivery system is coated with a bile acid-glycol chitosan polymer, so that it provides excellent liver-tissue specificity and high absorbance through digestive canals. Since the nucleic acid of the nucleic acid delivery system is coated with the bile acid-glycol chitosan polymer, it can be protected from decomposition of enzymes and the like inside a living organism. The liver-specific nucleic acid delivery system can be developed as an oral-administrating liver-disease treatment.

公开(公告)号：US20170056473A1

公开(公告)日：2017-03-02

申请号：US14928762

申请日：2015-10-30

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Tai Gyu KIM ,  Hyun Il CHO

IPC: A61K38/17 ,  C07K14/705

CPC classification number: A61K38/1774 ,  C07K14/7051 ,  C12N2710/16211 ,  C12N2710/16222 ,  C12N2740/16043

Abstract: The present invention relates to an EBV antigen specific T-cell receptor and the use thereof. Specifically, the present invention provides T cells specific for LMP1 of EBV using a T-cell receptor which is highly specific for specific epitopes derived from an EBV antigen, LMP1. In addition, the EBV antigen specific T-cell can be used in the prevention or treatment of EBV-associated diseases.

Abstract translation: 本发明涉及EBV抗原特异性T细胞受体及其用途。 具体地，本发明提供对使用对来自EBV抗原LMP1的特异性表位高度特异性的T细胞受体对EBV的LMP1特异性的T细胞。 此外，EBV抗原特异性T细胞可用于预防或治疗EBV相关疾病。

公开(公告)号：US20160310324A1

公开(公告)日：2016-10-27

申请号：US14417756

申请日：2014-12-02

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Joo Young Jung ,  Do Kun Yoon ,  Chang Uk Kim ,  Tae Suk Suh

IPC: A61F9/02

CPC classification number: A61F9/025 ,  A61F9/04 ,  A61N5/1017 ,  A61N2005/1094 ,  G21F3/00

Abstract: The present invention provides a shield apparatus for protecting eyeball structures in radiation therapy for a tumor in an eye portion, particularly an eyelid(eyelid) or the conjunctiva. The shield apparatus is a goggle-type patient-customized eyeball shield apparatus for use in radiation therapy, including a pair of lens frames connected by a center connection part, temples, and nose pads. The goggle-type patient-customized eyeball shield apparatus for use in radiation therapy includes the lens frames configured such that open tops are formed by cutting away the upper portions thereof, respectively, and lens grooves are formed along the inner circumferences thereof, respectively; lenses inserted into the respective lens grooves through the open tops; and shields each fastened onto the surface of each of the lenses via any one of a plurality of fastening holes passing through the lens, and configured to shield radiation to be applied to eyeballs. An advantage arises in that the vertical relationship between a radiation beam and a treated portion can be changed or maintained because the bending angles of the lens frames and temples of the shield apparatus and the locations of the shields can be immediately controlled in accordance with the shape of the face of a patient and the locations of the eyes and pupils of the patient.

Abstract translation: 本发明提供一种用于在眼部，特别是眼睑（眼睑）或结膜中的肿瘤的放射治疗中保护眼球结构的屏蔽装置。 屏蔽装置是用于放射治疗的护目镜式患者定制的眼球屏蔽装置，包括通过中心连接部分，寺庙和鼻垫连接的一对透镜框架。 用于放射治疗的护目镜型患者定制的眼球屏蔽装置包括分别通过切除其上部而形成开口顶部的透镜框，并且分别沿其内周形成透镜槽; 透镜通过开口顶部插入相应的透镜凹槽中; 以及通过穿过透镜的多个紧固孔中的任何一个固定在每个透镜的表面上的屏蔽，并且被构造成屏蔽要施加到眼球的辐射。 这样做的优点在于，可以改变或维持辐射束与处理部分之间的垂直关系，因为屏蔽装置的透镜框架和镜腿的弯曲角度和屏蔽件的位置可以根据形状立即被控制 患者的脸部和患者眼睛和瞳孔的位置。

公开(公告)号：US20160220567A1

公开(公告)日：2016-08-04

申请号：US14917548

申请日：2014-09-05

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Sung-Hwan Park ,  Mi-La Cho ,  MI-Kyung Park ,  Seong-Ki Kwok ,  Jennifer Lee ,  Jin-Sil Park ,  Sung-Min Kim ,  Mi-Ae Lim ,  Seong-Ye Baek ,  Dong-Gun Lee ,  Eun-Mi Park

IPC: A61K31/517

CPC classification number: A61K31/517

Abstract: The present invention relates to a composition for treating or preventing bone diseases comprising halofuginone as an active ingredient and, more specifically, to a composition for treating or preventing bone diseases, comprising, as an active ingredient, halofuginone having an osteoclast differentiation inhibitory efficacy and an osteoblast differentiation stimulatory activity. The composition for treating or preventing bone diseases, comprising halofuginone as an active ingredient, according to the present invention, reduces the expression of Th17 cells and increases the expression of Treg cells, thereby representing an effect of inhibiting osteoclast differentiation and being capable of also effectively inhibiting bone resorption by osteoclasts. Furthermore, the composition of the present invention will be able to be usefully utilized as a use for the treatment or prevention of bone diseases by being able to promote the differentiation and activity of osteoblast.

Abstract translation: 本发明涉及一种用于治疗或预防骨疾病的组合物，其包含卤代酮作为活性成分，更具体地，涉及用于治疗或预防骨疾病的组合物，其包含作为活性成分的具有破骨细胞分化抑制功效的卤伏酮和 成骨细胞分化刺激活性。 根据本发明的用于治疗或预防骨疾病的组合物，其包含卤代酮作为活性成分，减少Th17细胞的表达并增加Treg细胞的表达，从而代表抑制破骨细胞分化的效果并且还能够有效地 抑制破骨细胞的骨吸收。 此外，通过能够促进成骨细胞的分化和活性，本发明的组合物将能够有效地用作治疗或预防骨疾病的用途。

公开(公告)号：US20160193180A1

公开(公告)日：2016-07-07

申请号：US14913082

申请日：2014-08-22

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Mi-La CHO ,  Dong-Yun SHIN ,  Min-Jung PARK ,  Seon-Yeong LEE ,  Eun Ji YANG ,  Eun Kyung KIM ,  Hye-Jin SON ,  Eun-Jung LEE ,  Jae-Kyung KIM ,  Sung-Hee LEE

IPC: A61K31/365 ,  A61K36/75

CPC classification number: A61K31/365 ,  A61K36/75

Abstract: The daurinol compound according to the present invention exhibits excellent therapeutic effects on arthritis and inflammatory bowel diseases by having an excellent activity in inhibiting the generation of IL-17 and TNF-α, which are inflammatory cytokines causing inflammation, and can alleviate transplant rejection by inhibiting the proliferation of alloreactive T cells and increasing regulatory T cells; therefore, the daurinol compound according to the present invention can be used as a pharmaceutical composition capable of treating and preventing immune diseases. In addition, being a natural substance derived from the Mongolian medicinal plant Haplophyllum dauricum or Haplophyllum cappadocicum, the daurinol compound according to the present invention does not cause cytotoxicity and thus may be used as a composition for a functional health food capable of preventing and remedying immune diseases.

Abstract translation: 根据本发明的丹酚醇化合物通过在抑制作为引起炎症的炎性细胞因子的IL-17和TNF-α的产生中具有优异的活性而对关节炎和炎症性肠病具有优异的治疗效果，并且可以通过抑制 同种异体反应性T细胞的增殖和增加的调节性T细胞; 因此，根据本发明的丹酚醇化合物可以用作能够治疗和预防免疫疾病的药物组合物。 此外，作为来自蒙古药用植物Haplophyllum dauricum或Haplophyllum cappadocicum的天然物质，根据本发明的daurinol化合物不引起细胞毒性，因此可以用作能够预防和补救免疫的功能性保健食品的组合物 疾病

公开(公告)号：US20160089436A1

公开(公告)日：2016-03-31

申请号：US14670890

申请日：2015-03-27

Applicant: SNU R&DB FOUNDATION ,  Institute for Basic Science ,  The Catholic University of Korea Industry-Academic Cooperation Foundation

Inventor： Taeghwan Hyeon ,  Kun Na ,  Daishun Ling ,  Wooram Park

IPC: A61K41/00 ,  A61K49/12

CPC classification number: A61K41/0071 ,  A61K49/0036 ,  A61K49/0054 ,  A61K49/1857

Abstract: The present invention relates to a nanoformulated self-assembled pharmaceutical composition for photodynamic therapy. More particularly, the present invention is directed to a self-assembled pharmaceutical composition for photodynamic therapy comprising a photosensitizer, a ligand A which is separated at a specific pH range, and a ligand B of which surface charge changes at a specific pH range and a method for manufacturing the same.

Abstract translation: 本发明涉及用于光动力疗法的纳米结构的自组装药物组合物。 更具体地，本发明涉及一种用于光动力疗法的自组装药物组合物，其包含光敏剂，在特定pH范围分离的配体A和在特定pH范围内表面电荷变化的配体B和 制造方法

公开(公告)号：US20150279239A1

公开(公告)日：2015-10-01

申请号：US14667750

申请日：2015-03-25

Applicant: The Catholic University of Korea Industry-Academic Cooperation Foundation

Inventor： Dong Jin Chang ,  Choun-Ki Joo

IPC: G09B23/30

CPC classification number: G09B23/30

Abstract: The present invention relates to an ocular surgery training device, which includes an eye model having a hole at one side, and a catheter inserted into the hole, wherein a pressure sensor for measuring a pressure applied to the hole by the catheter is provided at one end of the catheter. The present invention may provide the ocular surgery training device which may enhance the skill of users in performing ocular surgery, thereby preventing complications.

Abstract translation: 本发明涉及一种眼部手术训练装置，其包括在一侧具有孔的眼睛模型和插入孔中的导管，其中用于测量由导管施加到孔的压力的压力传感器设置在一个 导管末端。 本发明可以提供眼部手术训练装置，其可以增强用户执行眼部手术的技能，从而防止并发症。

公开(公告)号：US20150241542A1

公开(公告)日：2015-08-27

申请号：US14629612

申请日：2015-02-24

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： BO YOUNG CHOE ,  KYU-HO SONG ,  SANG-YOUNG KIM ,  DO-WAN LEE

IPC: G01R33/58 ,  G01R33/46 ,  G01R33/28 ,  G01R33/56

CPC classification number: G01R33/58

Abstract: The present invention is to enhance efficiency of performance test and quality control, which is designed and manufactured to simultaneously acquire the performance test using one fused phantom. It is a phantom capable of simultaneously conducting a performance test on magnetic resonance imaging and a performance test on magnetic resonance spectroscopy within a predetermined error range by grasping a degree of performance capability of a human MRI system from a comprehensive result of image conditions and image parameters, in which the test elements of an ACR-MRI phantom used as a standard MRI phantom in the prior art are relocated, and inner containers configured in layers are inserted. It is a fusion phantom capable of performing a quantitative test and analysis by changing a type and concentration of a cerebral metabolite when a variety of images and spectra are acquire.The fusion phantom for testing performance of magnetic resonance imaging and magnetic resonance spectroscopy of the present invention can be generally used for multi-purpose performance test of magnetic resonance imaging equipment, such as correlation analysis, performance test, system management and the like in the diagnosis field, by using an optimized analysis method which can be simultaneously performed using an existing ACR-MRI phantom and an MRS phantom. The fusion phantom for testing performance of magnetic resonance imaging and magnetic resonance spectroscopy of the present invention is a phantom which can enhance efficiency of time and reliability in testing performance of the magnetic resonance imaging equipment, adjust incorrect position accuracy and improve quality of images.

Abstract translation: 本发明是为了提高性能测试和质量控制的效率，其设计和制造以使用一个融合体模同时获取性能测试。 通过从图像条件和图像参数的综合结果中掌握人体MRI系统的一定程度的性能，能够同时进行磁共振成像的性能测试和预定误差范围内的磁共振波谱的性能测试。 其中将用于现有技术中的标准MRI体模的ACR-MRI模型的测试元件重新定位，并且插入配置成层的内部容器。 当获得各种图像和光谱时，它是通过改变大脑代谢物的类型和浓度进行定量测试和分析的融合体模。 用于本发明的磁共振成像和磁共振波谱测试性能的融合体模型通常可用于磁共振成像设备的多功能性能测试，如诊断中的相关分析，性能测试，系统管理等 通过使用可以使用现有ACR-MRI模型和MRS幻像同时执行的优化分析方法来实现。 用于本发明的磁共振成像和磁共振波谱的测试性能的融合体模是能够提高磁共振成像设备的性能的时间和可靠性的效率，调整不正确的位置精度和提高图像质量的幻影。