公开(公告)号：US20130011691A1

公开(公告)日：2013-01-10

申请号：US13581799

申请日：2010-09-08

Applicant: Jianming Ruan ,  Jianquan Xie ,  Yunfeng Jie ,  Zhiqiang Wang ,  Hua Feng ,  Chao You ,  Qi Pang ,  Jian Zhou ,  Lei Ye ,  Bin Liu ,  Yazhuo Zhang

Inventor： Jianming Ruan ,  Jianquan Xie ,  Yunfeng Jie ,  Zhiqiang Wang ,  Hua Feng ,  Chao You ,  Qi Pang ,  Jian Zhou ,  Lei Ye ,  Bin Liu ,  Yazhuo Zhang

IPC: B22F3/11 ,  B32B3/26

CPC classification number: A61L27/56 ,  A61L27/047 ,  A61L2400/08 ,  B22F3/1137 ,  B22F3/1146 ,  B22F2003/248 ,  B22F2998/10 ,  B22F2999/00 ,  Y10T428/12153 ,  B22F1/0074 ,  B22F3/1021 ,  B22F2201/20

Abstract: A porous tantalum used for medical implantation is provided, which includes a foam structure with three-dimensional interconnecting pores and produced by: mixing a solution made by organic binder and dispersant and tantalum powder to form tantalum slurry, casting the tantalum slurry into a organic foam body through impregnation until the pores of the organic foam body are filled, drying the impregnated organic foam body with the tantalum slurry to remove the dispersant, degreasing the dried organic foam body to separate the organic binder and the organic foam body from the dried tantalum slurry in a protective environment of inert gas, vacuum sintering the dried tantalum slurry to obtain a porous sintered body, and vacuum annealing then treating the porous sintered body with normal post-treatments to obtain the porous tantalum. Accordingly, the porous tantalum has well-distributed interconnecting pores and sintering neck structures resulting in good mechanical properties, and especially good ductility.

Abstract translation: 提供用于医学植入的多孔钽，其包括具有三维互连孔的泡沫结构，其通过以下方式制备：将由有机粘合剂制成的溶液和分散剂和钽粉末混合以形成钽浆料，将钽浆料浇铸成有机泡沫 通过浸渍直到有机泡沫体的孔被填充，用钽浆料干燥浸渍的有机泡沫体以除去分散剂，将干燥的有机泡沫体脱脂以将有机粘合剂和有机泡沫体与干燥的钽浆料分离 在惰性气体的保护环境中，真空烧结干燥的钽浆料，得到多孔烧结体，真空退火，然后用正常后处理处理多孔烧结体，得到多孔钽。 因此，多孔钽具有良好分布的互连孔和烧结颈结构，导致良好的机械性能，特别是良好的延展性。

公开(公告)号：US20120321591A1

公开(公告)日：2012-12-20

申请号：US13595250

申请日：2012-08-27

Applicant: Venkata Ramana Doppalapudi ,  Jing-Yu Lai ,  Bin Liu ,  Dingguo Liu ,  Joel Desharnais ,  Abhijit Suresh Bhat ,  Yanwen Fu ,  Bryan Douglas Oates ,  Gang Chen ,  Curt William Bradshaw

Inventor： Venkata Ramana Doppalapudi ,  Jing-Yu Lai ,  Bin Liu ,  Dingguo Liu ,  Joel Desharnais ,  Abhijit Suresh Bhat ,  Yanwen Fu ,  Bryan Douglas Oates ,  Gang Chen ,  Curt William Bradshaw

IPC: A61K38/18 ,  A61P35/00 ,  A61P19/02 ,  A61P9/12 ,  A61P13/12 ,  A61K38/21 ,  A61P27/06 ,  A61K39/395 ,  A61K33/36 ,  A61K38/50 ,  A61K33/24 ,  A61P27/02 ,  A61P17/06

CPC classification number: A61K47/48215 ,  A61K47/48246 ,  A61K47/48415 ,  A61K47/48507 ,  A61K47/60 ,  A61K47/64 ,  A61K47/6811 ,  A61K47/6835 ,  C07K14/71

Abstract: The present invention provides various uses of VEGF binding peptides, including methods to treat disorders associated with abnormal angiogenesis. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules

Abstract translation: 本发明提供VEGF结合肽的各种用途，包括治疗与异常血管生成相关的疾病的方法。 此外，本发明提供了与单独的抗体和其它抗血管生成分子结合的VEGF肽

公开(公告)号：US20120190125A1

公开(公告)日：2012-07-26

申请号：US13498985

申请日：2010-09-28

Applicant: Bin Liu ,  Kanyi Pu

Inventor： Bin Liu ,  Kanyi Pu

IPC: G01N21/76 ,  C07F7/21

CPC classification number: C07F7/21 ,  B82Y15/00 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1014 ,  C09K2211/1051 ,  G01N33/54386 ,  G01N33/582 ,  G01N33/588

Abstract: This invention includes a compound represented by the following structural formula (I) or an acceptable salt thereof.

Abstract translation: 本发明包括由下列结构式（I）表示的化合物或其可接受的盐。

公开(公告)号：US20110295854A1

公开(公告)日：2011-12-01

申请号：US12788407

申请日：2010-05-27

Applicant: Laura Chiticariu ,  Bin Liu ,  Frederick R. Reiss

Inventor： Laura Chiticariu ,  Bin Liu ,  Frederick R. Reiss

IPC: G06F17/30

CPC classification number: G06F17/30616

Abstract: A method and system for automatically refining information extraction (IE) rules. A provenance graph for IE rules on a set of test documents is determined. The provenance graph indicates a sequence of evaluations of the IE rules that generates an output of each operator of the IE rules. Based on the provenance graph, high-level rule changes (HLCs) of the IE rules are determined. Low-level rule changes (LLCs) of the IE rules are determined to specify how to implement the HLCs. Each LLC specifies changing an operator's structure or inserting a new operator in between two operators. Based on how the LLCs affect the IE rules and previously received correct results of applying the rules on the test documents, a ranked list of the LLCs is determined. The IE rules are refined based on the ranked list.

Abstract translation: 一种自动提炼信息提取（IE）规则的方法和系统。 确定一组测试文件上的IE规则的原始图。 来源图表示生成IE规则的每个运算符的输出的IE规则的评估序列。 根据来源图，确定IE规则的高级规则变更（HLC）。 确定IE规则的低级规则更改（LLC）以指定如何实现HLC。 每个LLC指定更改操作员的结构或在两个操作符之间插入一个新的操作符。 根据LLC如何影响IE规则，并且先前收到在测试文档上应用规则的正确结果，确定LLC的排名列表。 IE规则根据排名列表进行细化。

公开(公告)号：US20110151888A1

公开(公告)日：2011-06-23

申请号：US12686623

申请日：2010-01-13

Applicant: Mark Hahm ,  Wei Luo ,  Thirunathan Sutharsan ,  Andrew du Preez ,  Bin Liu ,  Jun Wu ,  Severine Catreux-Erceg ,  Shuangquan Wang

Inventor： Mark Hahm ,  Wei Luo ,  Thirunathan Sutharsan ,  Andrew du Preez ,  Bin Liu ,  Jun Wu ,  Severine Catreux-Erceg ,  Shuangquan Wang

IPC: H04W72/04 ,  H04B7/08

CPC classification number: H04B1/71075 ,  H04B1/7115 ,  H04B1/712 ,  H04B2201/70702

Abstract: Aspects of a method and system for a programmable interference suppression module may include receiving a communication signal comprising one or more desired signal, and one or more undesired signals. The communication signal may be utilized to generate estimated channel state information. The estimated channel state information may be formatted for use in interference suppression. A reduced interference signal may be generated from a delayed version of said communications signal and the estimated channel state information, wherein the one or more undesired signals may be attenuated. The reduced interference signal may be formatted for post-processing. The desired signals may comprise WCDMA and/or HSDPA signals, and the undesired signals may be inter-cell and/or intra-cell interference. Further processing may comprise HSDPA processing and/or RAKE finger processing. The communication signal may be a Universal Mobile Telecommunication System (UMTS) compliant signal.

Abstract translation: 用于可编程干扰抑制模块的方法和系统的方面可以包括接收包括一个或多个期望信号的通信信号以及一个或多个不需要的信号。 通信信号可用于产生估计的信道状态信息。 估计的信道状态信息可以被格式化以用于干扰抑制。 可以从所述通信信号的延迟版本和所估计的信道状态信息产生减小的干扰信号，其中所述一个或多个不需要的信号可以被衰减。 减小的干扰信号可以被格式化用于后处理。 期望的信号可以包括WCDMA和/或HSDPA信号，并且不期望的信号可以是小区间和/或小区内干扰。 进一步的处理可以包括HSDPA处理和/或RAKE手指处理。 通信信号可以是符合通用移动通信系统（UMTS）的信号。

公开(公告)号：US07912503B2

公开(公告)日：2011-03-22

申请号：US11952152

申请日：2007-12-07

Applicant: Eric Chang ,  David Dehghan ,  Stanley Sun ,  Bin Liu

Inventor： Eric Chang ,  David Dehghan ,  Stanley Sun ,  Bin Liu

IPC: H04B1/38

CPC classification number: H04M1/72527

Abstract: A universal smart interface and peripheral management system for portable devices such as mobile phones. The smart system includes a connector interface that connects peripherals to a phone and/or personal digital assistant (PDA), through the smart system. The smart system includes a cradle for receiving a cell phone and interfacing the phone to external systems such as peripherals, networks and other systems through a USB hub and other suitable connector interfaces. The peripheral devices to which the smart system can interface include, but are not limited to, large displays (e.g., television), external monitors, input devices such as mice and keyboards, external storage devices, and networks (wired and/or wireless). The smart system also facilitates connectivity to large display systems such as TVs, computer displays and monitors.

Abstract translation: 通用智能接口和便携式设备（如手机）的外设管理系统。 智能系统包括通过智能系统将外围设备连接到电话和/或个人数字助理（PDA）的连接器接口。 该智能系统包括用于接收蜂窝电话并通过USB集线器和其他合适的连接器接口将电话与诸如外围设备，网络和其他系统的外部系统接口的支架。 智能系统可以接口的外围设备包括但不限于大型显示​​器（例如电视机），外部监视器，诸如鼠标和键盘的输入设备，外部存储设备和网络（有线和/或无线） 。 智能系统还有助于连接大型显示系统，如电视机，电脑显示器和显示器。

公开(公告)号：US07741479B2

公开(公告)日：2010-06-22

申请号：US11295638

申请日：2005-12-07

Applicant: Enrique Luis Michelotti ,  Eric Bruce Springman ,  Duyan Nguyen ,  Rupa S. Shetty ,  Younghee Lee ,  Kristofer Kent Moffett ,  Jennifer Lee Ludington ,  Ted Tsutomis Fujimoto ,  Zenon D. Konteatis ,  Bin Liu ,  Frank Hollinger ,  Bruce D. Dorsey

Inventor： Enrique Luis Michelotti ,  Eric Bruce Springman ,  Duyan Nguyen ,  Rupa S. Shetty ,  Younghee Lee ,  Kristofer Kent Moffett ,  Jennifer Lee Ludington ,  Ted Tsutomis Fujimoto ,  Zenon D. Konteatis ,  Bin Liu ,  Frank Hollinger ,  Bruce D. Dorsey

IPC: C07D273/06

CPC classification number: C07D333/38 ,  C07D231/40 ,  C07D243/08 ,  C07D277/48 ,  C07D277/56 ,  C07D295/192 ,  C07D333/36 ,  C07D403/06 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14 ,  C07D495/04

Abstract: The present invention is directed to a compound having the formula wherein R1, R2, G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases such as MAP kinases, in particular p38 kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease. The present invention is also directed to a method of treating or preventing a protein kinase-mediated condition.

Abstract translation: 本发明涉及具有下式的化合物：其中R1，R2，G和Q如本文所定义。 本发明的化合物可用作蛋白激酶如MAP激酶，特别是p38激酶的抑制剂。 本发明还涉及包含根据上式的化合物的组合物。 本文所述的化合物和组合物可用于治疗和预防炎性疾病或疾病。 本发明还涉及治疗或预防蛋白激酶介导的病症的方法。

公开(公告)号：US07487271B2

公开(公告)日：2009-02-03

申请号：US11233597

申请日：2005-09-22

Applicant: Charbel Khawand ,  Jean Khawand ,  Bin Liu

Inventor： Charbel Khawand ,  Jean Khawand ,  Bin Liu

IPC: G06F3/00 ,  G06F12/00 ,  G06F15/00

CPC classification number: G06F9/5016

Abstract: A multiprocessor system (100) for sharing memory has a memory (102), and two or more processors (104). The processors are programmed to establish (202) memory buffer pools between the processors, and for each memory buffer pool, establish (204) an array of buffer pointers that point to corresponding memory buffers. The processors are further programmed to, for each array of buffer pointers, establish (206) a consumption pointer for the processor owning the memory buffer pool, and a release pointer for another processor sharing said memory buffer pool, each pointer initially pointing to a predetermined location of the array, and adjust (208-236) the consumption and release pointers according to buffers consumed and released.

Abstract translation: 用于共享存储器的多处理器系统（100）具有存储器（102）和两个或更多个处理器（104）。 处理器被编程为在处理器之间建立（202）存储器缓冲池，并且对于每个存储器缓冲池，建立指向相应存储器缓冲器的缓冲器指针阵列（204）。 处理器进一步被编程为对于每个缓冲器指针阵列，建立（206）用于处理器拥有存储器缓冲池的消耗指针，以及用于共享所述存储器缓冲池的另一个处理器的释放指针，每个指针最初指向预定的 阵列的位置，并根据消耗和释放的缓冲区调整（208-236）消耗和释放指针。

公开(公告)号：US20090023475A1

公开(公告)日：2009-01-22

申请号：US11952152

申请日：2007-12-07

Applicant: Eric Chang ,  David Dehghan ,  Stanley Sun ,  Bin Liu

Inventor： Eric Chang ,  David Dehghan ,  Stanley Sun ,  Bin Liu

IPC: H04B1/38

CPC classification number: H04M1/72527

Abstract: A universal smart interface and peripheral management system for portable devices such as mobile phones. The smart system includes a connector interface that connects peripherals to a phone and/or personal digital assistant (PDA), through the smart system. The smart system includes a cradle for receiving a cell phone and interfacing the phone to external systems such as peripherals, networks and other systems through a USB hub and other suitable connector interfaces. The peripheral devices to which the smart system can interface include, but are not limited to, large displays (e.g., television), external monitors, input devices such as mice and keyboards, external storage devices, and networks (wired and/or wireless). The smart system also facilitates connectivity to large display systems such as TVs, computer displays and monitors.

Abstract translation: 通用智能接口和便携式设备（如手机）的外设管理系统。 智能系统包括通过智能系统将外围设备连接到电话和/或个人数字助理（PDA）的连接器接口。 该智能系统包括用于接收蜂窝电话并通过USB集线器和其他合适的连接器接口将电话与诸如外围设备，网络和其他系统的外部系统接口的支架。 智能系统可以接口的外围设备包括但不限于大型显示​​器（例如电视机），外部监视器，诸如鼠标和键盘的输入设备，外部存储设备和网络（有线和/或无线） 。 智能系统还有助于连接大型显示系统，如电视机，电脑显示器和显示器。

公开(公告)号：US07279477B2

公开(公告)日：2007-10-09

申请号：US10466926

申请日：2002-01-22

Applicant: Thomas Arrhenius ,  Mi Chen ,  Jie Fei Cheng ,  Yujin Huang ,  Alex Michael Nadzan ,  Sovouthy Tith ,  David Mark Wallace ,  Bin Liu ,  Masahiro Nishimoto ,  Gary D. Lopaschuk ,  Jason R. Dyck

Inventor： Thomas Arrhenius ,  Mi Chen ,  Jie Fei Cheng ,  Yujin Huang ,  Alex Michael Nadzan ,  Sovouthy Tith ,  David Mark Wallace ,  Bin Liu ,  Masahiro Nishimoto ,  Gary D. Lopaschuk ,  Jason R. Dyck

IPC: A61K31/5375 ,  C07D265/30

CPC classification number: C07D231/06 ,  A61K31/16 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/44 ,  A61K31/5375 ,  C07C33/46 ,  C07C257/22 ,  C07C279/18 ,  C07C307/10 ,  C07C335/18 ,  C07D231/14 ,  C07D233/64 ,  C07D233/90 ,  C07D261/04 ,  C07D261/08 ,  C07D261/14 ,  C07D261/18 ,  C07D295/13 ,  C07D295/194 ,  C07D295/21 ,  C07D295/215 ,  C07D295/32 ,  C07D307/52 ,  C07D401/12 ,  C07F9/247 ,  C07F9/4021

Abstract: The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.

Abstract translation: 本发明涉及新型化合物（I），其前药和药学上可接受的盐以及含有这样的化合物的药物组合物，其可用于治疗某些代谢疾病和通过抑制酶丙二酰辅酶A脱羧酶（丙二酰 - CoA脱羧酶，MCD）。 特别地，本发明涉及通过抑制丙二酰辅酶A脱羧酶来预防，治疗和治疗心血管疾病，糖尿病，酸中毒，癌症和肥胖的化合物和组合物和方法。