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公开(公告)号：US20180099002A1
公开(公告)日：2018-04-12
申请号：US15834052
申请日：2017-12-06
Applicant: The Board of Regents of the University of Texas System , The Board of Trustees of the University of Illinois
Inventor： Paul J. HERGENROTHER , David A. BOOTHMAN , Joseph S. BAIR , Lifen CAO , Jinming GAO , Xiumei HUANG , Xiuquan LUO , Xinpeng MA , Zachary R. MOORE , Elizabeth I. PARKINSON
IPC: A61K31/706 , A61K31/4745 , A61K31/4738 , A61K31/131 , A61K45/06 , C12Q1/6886 , A61K31/353
Abstract: The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective legality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1.
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公开(公告)号：US09932564B2
公开(公告)日：2018-04-03
申请号：US15122695
申请日：2015-02-27
Inventor： Demetrius Matassov , Rodion V. Gorchakov , Stefan Hamm , Rebecca Nowak , Robert L. Seymour , John H. Eldridge , Robert B. Tesh , David K. Clarke , Theresa E. Latham , Scott Weaver , Farooq Nasar
CPC classification number: C12N7/00 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/545 , C12N15/86 , C12N2740/16071 , C12N2740/16234 , C12N2760/20221 , C12N2760/20222 , C12N2760/20243 , C12N2760/20262 , C12N2760/20271 , C12N2770/36134 , C12N2770/36171 , Y02A50/383
Abstract: Certain embodiments are directed to recombinant vesiculovirus encoding a heterologous polynucleotide and methods of using the same.
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公开(公告)号：US20180086829A1
公开(公告)日：2018-03-29
申请号：US15696972
申请日：2017-09-06
Inventor： Chengcheng ZHANG , Mi DENG , Wei XIONG , Zhiqiang AN , Ningyan ZHANG , Xun GUI , Junke ZHENG
IPC: C07K16/28 , C07K16/30 , A61P35/02 , A61K45/06 , A61K39/395 , G01N33/574
CPC classification number: C07K16/2803 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61P35/02 , C07K16/3061 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C12N15/1138 , C12N2310/14 , C12N2310/531 , G01N33/57426 , G01N33/57492 , G01N2333/70503
Abstract: The present disclosure is directed to antibodies binding to LILRBs and methods of detecting and treating cancer therewith.
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公开(公告)号：US20180085733A1
公开(公告)日：2018-03-29
申请号：US15560570
申请日：2016-03-23
Inventor： Banglin CHEN , Tong-Liang HU
CPC classification number: B01J20/226 , B01D53/02 , B01D2253/204 , B01D2256/24 , B01D2257/7022 , B01J20/28011 , B01J20/28057 , B01J20/28069 , C07C7/12 , C07F1/08 , C07F3/02 , C07F15/025 , C07F15/065
Abstract: A metal-organic framework (MOF) and uses thereof are provided herein, including MOF comprising a repeat unit of the formula [ML], wherein L is a ligand of the following formula: and M is a divalent metal such as copper. The MOFs provided herein may be used in the separation of two or more gaseous molecules from each other. In some embodiments, the gaseous molecules are ethylene and acetylene.
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185.发明授权公开(公告)号：US09926340B2
公开(公告)日：2018-03-27
申请号：US15088561
申请日：2016-04-01
Applicant: The Board of Regents of the University of Texas System , Biolog Life Science Institute Forschungslabor und Biochemica-Vertrieb GmbH , Cornell University
Inventor： W. Lee Kraus , Bryan A. Gibson , Frank Schwede , Hening Lin
IPC: G01N33/573 , C07H21/02 , C12Q1/48
CPC classification number: C07H21/02 , C12Q1/48 , G01N2333/91142 , G01N2440/40 , G01N2458/00
Abstract: The present disclosure provides NAD analogs of the formula: wherein R1, n, and X1 are defined herein, useful for the identification of PARP target proteins and the amino acid sequence wherein the ribose group is attached to the target protein. Also, provided herein are methods of identifying target protein and amino acid sequences. Additionally, the present disclosure provides methods of identifying DNA sequences associated with specific chromatin proteins.
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Patent Agency Ranking
公开(公告)号：US20180057888A1
公开(公告)日：2018-03-01
申请号：US15557608
申请日：2016-03-08
Inventor： David A. BOOTHMAN , Edward A. MOTEA , Praveen PATIDAR , Julio MORALES
IPC: C12Q1/68 , C12N15/113 , A61N5/10
CPC classification number: C12Q1/6886 , A61N5/10 , C12N15/1137 , C12N2310/14 , C12N2310/531 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Y204/0203 , G01N33/574 , G01N2333/4703 , G01N2800/52 , G01N2800/56
Abstract: The present disclosure is directed to methods of detecting KUB5/HERA expression levels, copy number and mutation status, particularly in cancer cells. The methods permit physicians to tailor therapies to subject having certain genotypes/phenotypes, and to exclude therapies unlikely to be effective.
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公开(公告)号：US09890216B2
公开(公告)日：2018-02-13
申请号：US14437544
申请日：2013-08-30
Inventor： George Georgiou , William Kelton , Nishant Mehta
CPC classification number: C07K16/2863 , A61K47/6849 , C07K16/00 , C07K16/30 , C07K16/32 , C07K2317/52 , C07K2317/524 , C07K2317/56 , C07K2317/66 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/92
Abstract: Antibody Fc polypeptides are provided that efficiently bind to both Fcγ and Fcα receptors. In certain aspects, a Fc polypeptide comprises a chimeric IgG CH2 domain having a α1 loop from IgA and an IgA CH3 domain. Recombinant antibodies comprising Fc polypeptides of the embodiments and methods for making and using such antibodies are likewise provided.
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公开(公告)号：US20180022730A1
公开(公告)日：2018-01-25
申请号：US15521107
申请日：2015-10-21
Applicant: The Board of Regents of the University of Texas System , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Inventor： Rolf A. BREKKEN , Ke DING , Xiaomei REN , Zhengchao TU , Zhen WANG , Kristina Y. AGUILERA
IPC: C07D401/14 , A61K45/06 , A61K31/337 , C07D401/04 , A61K31/4725
CPC classification number: C07D401/14 , A61K31/337 , A61K31/4725 , A61K31/7068 , A61K45/06 , A61K2300/00 , C07D401/04
Abstract: Compounds of formula (I), their pharmaceutically acceptable salts and stereoisomers thereof, as well as application in effectively inhibiting the enzymatic activity of discoidin domain receptor 1 and can be used as new therapeutic agents for preventing and treating e.g. inflammation, liver fibrosis, kidney fibrosis, lung fibrosis, skin scar, atherosclerosis, and cancer. The compound of formula I is: wherein the variables are as defined herein.
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189.发明申请公开(公告)号：US20180015030A1
公开(公告)日：2018-01-18
申请号：US15585980
申请日：2017-05-03
Inventor： Christopher C. CAPELLI , Phillip C. PHAN , Allen W. BURTON
Abstract: The present invention provides methods for reducing pain in a subject in need of such pain reduction by delivering, e.g., intrathecally or epidurally, a volatile anesthetic dissolved in a solution comprising an extractive solvent, e.g., DMSO or NMP, in an amount effective to reduce pain. Chronic or acute pain may be treated, or the anesthetic may be delivered as a regional anesthesia to a subject to anesthetize a portion the subject prior to a surgery. In certain embodiments, isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, or mixtures thereof may be used. Dosing regimens including a one-time administration, continuous and/or periodic administration are contemplated.
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公开(公告)号：US09853809B2
公开(公告)日：2017-12-26
申请号：US15087422
申请日：2016-03-31
Inventor： Benito R. Fernández , José R. Capriles-Grané , Michael D. Bryant , John W. Hall , Carlos A. García
CPC classification number: H04L9/001 , G06F1/04 , H03B5/1259 , H03B28/00 , H03B29/00 , H03K3/84 , H04L2209/12
Abstract: Described herein is a combination of mixed-signal hardware and software that is capable or realizing hybrid chaotic oscillators that can be tuned digitally. This includes the type/class of chaotic oscillator, initial conditions, nonlinear elements, thresholds, nonlinear event surfaces, delays, etc. At the same time, tunable methods of how to use the chaotic oscillator information to encrypt and decrypt both analog and digital information is presented. This will make the secure information not vulnerable by digital information compromises or hardware breach.
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