公开(公告)号：US20120201897A1

公开(公告)日：2012-08-09

申请号：US13502116

申请日：2009-11-17

Applicant: Hyun-Shin Park ,  Ji-Chul Yu ,  Ju-Hee Park ,  Jang-Hoon Kim ,  Hun Kim ,  Sae-Bom Lee ,  Jae-Deog Jang ,  Cheong-Ho Jang

Inventor： Hyun-Shin Park ,  Ji-Chul Yu ,  Ju-Hee Park ,  Jang-Hoon Kim ,  Hun Kim ,  Sae-Bom Lee ,  Jae-Deog Jang ,  Cheong-Ho Jang

IPC: A61K35/16 ,  A61P43/00

CPC classification number: A61L27/3616 ,  A61K35/16 ,  A61K38/39 ,  A61L27/24 ,  A61L27/38 ,  A61K2300/00

Abstract: The present invention relates to a composition for cartilaginous tissue repair and to a production method therefor. The present invention comprises the steps of: (a) dissolving freeze-dried fibrinogen in an aprotinin solution; (b) dissolving freeze-dried thrombin in a stabilizing solution; (c) mixing an enriched collagen solution with thrombin and the stabilizing solution; and installing the fibrinogen solution (a) to one side of a dual kit and the solution (c) containing the collagen to the other side, and then mixing and injecting into damaged cartilaginous tissue. In the present invention, which is constituted as described above, biomaterials such as collagen and fibrin are mixed so as to allow damaged cartilaginous tissue to be repaired to a state allowing transplantation onto the tissue, and efficient regeneration is induced, thereby making it possible to reduce surgery-related stress on people and animals while inducing relatively rapid and efficient cartilage repair and regeneration.

Abstract translation: 本发明涉及一种用于软骨组织修复的组合物及其制备方法。 本发明包括以下步骤：（a）将冷冻干燥的纤维蛋白原溶解在抑肽酶溶液中; （b）将冻干凝血酶溶解在稳定溶液中; （c）将富集的胶原溶液与凝血酶和稳定溶液混合; 并将纤维蛋白原溶液（a）安装在双重试剂盒的一侧和将胶原蛋白溶液（c）另一侧，然后混合并注入损伤的软骨组织中。 在如上所述构成的本发明中，混合了诸如胶原和纤维蛋白等生物材料，以便使损伤的软骨组织被修复到允许移植到组织上的状态，从而可以有效地再生， 减少对人和动物的手术相关压力，同时诱导相对快速和有效的软骨修复和再生。

公开(公告)号：US20110111032A1

公开(公告)日：2011-05-12

申请号：US13003157

申请日：2008-07-23

Applicant: Jae-Deog Jang ,  Hun Kim ,  Ji-Chul Yu ,  Se-Geun Yeo ,  Tae-Hyoung Kim ,  Hyun-Shin Park ,  Seon-Ae Kim ,  Jang-Hoon Kim ,  Seong-Soo Kim

Inventor： Jae-Deog Jang ,  Hun Kim ,  Ji-Chul Yu ,  Se-Geun Yeo ,  Tae-Hyoung Kim ,  Hyun-Shin Park ,  Seon-Ae Kim ,  Jang-Hoon Kim ,  Seong-Soo Kim

IPC: A61K9/14 ,  A61K35/12 ,  A61P19/00

CPC classification number: A61L27/24 ,  A61L27/12 ,  A61L27/3804 ,  A61L27/3847 ,  A61L27/46 ,  A61L27/52 ,  A61L27/56

Abstract: Disclosed herein is a method for preparing a collagen gel composition for bone regeneration comprising collecting bone marrow from animal tissues and isolating nucleated cells from the bone marrow; and mixing the nucleated cells and a bio-matrix composed of type I collagen and apatite.

Abstract translation: 本文公开了一种制备用于骨再生的胶原凝胶组合物的方法，包括从动物组织收集骨髓并从骨髓中分离有核细胞; 并将有核细胞和由I型胶原和磷灰石组成的生物基质混合。

公开(公告)号：US20050005431A1

公开(公告)日：2005-01-13

申请号：US10753633

申请日：2004-01-07

Applicant: Young-sam Koo ,  Si-chul Yu ,  Jae-an Lee

Inventor： Young-sam Koo ,  Si-chul Yu ,  Jae-an Lee

IPC: B05D5/00 ,  H01M2/16 ,  H01M10/04 ,  H01M10/0525 ,  H01M10/0565 ,  H01M10/36

CPC classification number: H01M10/0525 ,  H01M2/1653 ,  H01M10/0565 ,  H01M2300/0082 ,  H01M2300/0085 ,  Y10T29/4911 ,  Y10T29/49115

Abstract: The present invention relates to a method of making a polymeric porous separation membrane for a lithium ion polymer battery, the method comprising: providing a porous polyolefin membrane and a polymer solution of the concentration of 1-20 weight % in an organic solvent fabricated by dissolving in an organic solvent a polymer compound that is stable in an electrolyte containing a lithium salt and can be gelled in the electrolyte, at the temperature of 10-40° C.; and fabricating a polymeric porous separation membrane by coating the polymeric porous polyolefin membrane with the polymer solution. Thus, the porous separation membrane for a lithium ion polymer battery is fabricated by using the polymer solution fabricated at the low temperatures of 10-40° C., and the size of the pores of the coated is proper, so that the containing capacity of the electrolyte and the ion conductivity are good. Further gelling at low pressure is enabled and cohesive force to the electrodes is improved. In the lithium ion battery containing the porous separation membrane, the gelling is accomplished at atmospheric pressure or at low pressure for a few hours, so that problems caused by gelling for a short period at high pressure and high temperature such as the non uniform gelling of the battery, the deformation of the separation membrane and the weakened cohesion can be avoided. Moreover, the high-rate discharge, the cycle life becomes excellent.

Abstract translation: 本发明涉及一种制备用于锂离子聚合物电池的聚合物多孔分离膜的方法，该方法包括：在通过溶解制备的有机溶剂中提供浓度为1-20重量％的多孔聚烯烃膜和聚合物溶液 在有机溶剂中，在含有锂盐的电解质中稳定且可在电解质中凝胶化的聚合物化合物，温度为10-40℃; 以及通过用聚合物溶液涂覆聚合物多孔聚烯烃膜来制造聚合物多孔分离膜。 因此，通过使用在10-40℃的低温下制造的聚合物溶液制造用于锂离子聚合物电池的多孔分离膜，并且涂覆的孔的尺寸是适当的，使得 电解质和离子电导率都很好。 能够进一步在低压下凝胶化，并提高对电极的内聚力。 在含有多孔分离膜的锂离子电池中，胶凝在大气压或低压下进行数小时，因此在高压高温下凝胶化的问题，如非均匀胶凝 可以避免电池，分离膜的变形和弱化的内聚力。 此外，高倍率放电，循环寿命变得优异。

公开(公告)号：US09023318B2

公开(公告)日：2015-05-05

申请号：US13849646

申请日：2013-03-25

Applicant: Gang Chen ,  Umesh B. Gangadharmath ,  Dhanalakshmi Kasi ,  Harmuth C. Kolb ,  Changhui Liu ,  Anjana Sinha ,  Anna Katrin Szardenings ,  Joseph C. Walsh ,  Eric Wang ,  Chul Yu ,  Wei Zhang ,  Klaus Kopka ,  Guenter Haufe ,  Michael Schaefers ,  Verena Hugenberg ,  Stefan Wagner ,  Sven Hermann ,  Hans-Joerg Breyholz ,  Andreas Faust

Inventor： Gang Chen ,  Umesh B. Gangadharmath ,  Dhanalakshmi Kasi ,  Harmuth C. Kolb ,  Changhui Liu ,  Anjana Sinha ,  Anna Katrin Szardenings ,  Joseph C. Walsh ,  Eric Wang ,  Chul Yu ,  Wei Zhang ,  Klaus Kopka ,  Guenter Haufe ,  Michael Schaefers ,  Verena Hugenberg ,  Stefan Wagner ,  Sven Hermann ,  Hans-Joerg Breyholz ,  Andreas Faust

IPC: A61K51/00 ,  A61M36/14 ,  C07D403/14 ,  C07D405/14 ,  C07D249/04 ,  C07D309/12 ,  C07D213/42

CPC classification number: C07D403/14 ,  C07D213/42 ,  C07D249/04 ,  C07D309/12 ,  C07D405/14

Abstract: Novel compounds and pharmaceutical compositions having MMP inhibitory activity are disclosed, which have been found to be particularly useful in the prevention, treatment and diagnostic imaging of diseases associated with an unpaired activity of MMP, amongst others MMP-2, MMP-8, MMP-9 and/or MMP-13 to name a few. The compounds of the present invention are useful for the prevention, the treatment and the in vivo diagnostic imaging of a range of disease states (inflammatory, malignant and degenerative diseases) where specific matrix metalloproteinases are known to be involved.

Abstract translation: 已经公开了具有MMP抑制活性的新型化合物和药物组合物，其已经被发现特别可用于预防，治疗和诊断成像与MMP的非配对活性相关的疾病，其中MMP-2，MMP-8，MMP- 9和/或MMP-13等等。 本发明的化合物可用于预防，治疗和体内诊断成像的一系列疾病状态（炎性，恶性和退行性疾病），其中已知特定的基质金属蛋白酶涉及。

公开(公告)号：US09011929B2

公开(公告)日：2015-04-21

申请号：US13502116

申请日：2009-11-17

Applicant: Hyun-Shin Park ,  Ji-Chul Yu ,  Ju-Hee Park ,  Jang-Hoon Kim ,  Hun Kim ,  Sae-Bom Lee ,  Jae-Deog Jang ,  Cheong-Ho Jang

Inventor： Hyun-Shin Park ,  Ji-Chul Yu ,  Ju-Hee Park ,  Jang-Hoon Kim ,  Hun Kim ,  Sae-Bom Lee ,  Jae-Deog Jang ,  Cheong-Ho Jang

IPC: A61K35/16 ,  A61K38/39 ,  A61L27/36 ,  A61L27/24 ,  A61L27/38

CPC classification number: A61L27/3616 ,  A61K35/16 ,  A61K38/39 ,  A61L27/24 ,  A61L27/38 ,  A61K2300/00

Abstract: The present invention relates to a composition for cartilaginous tissue repair and to a production method therefor. The present invention comprises the steps of: (a) dissolving freeze-dried fibrinogen in an aprotinin solution; (b) dissolving freeze-dried thrombin in a stabilizing solution; (c) mixing an enriched collagen solution with thrombin and the stabilizing solution; and installing the fibrinogen solution (a) to one side of a dual kit and the solution (c) containing the collagen to the other side, and then mixing and injecting into damaged cartilaginous tissue. In the present invention, which is constituted as described above, biomaterials such as collagen and fibrin are mixed so as to allow damaged cartilaginous tissue to be repaired to a state allowing transplantation onto the tissue, and efficient regeneration is induced, thereby making it possible to reduce surgery-related stress on people and animals while inducing relatively rapid and efficient cartilage repair and regeneration.

Abstract translation: 本发明涉及一种用于软骨组织修复的组合物及其制备方法。 本发明包括以下步骤：（a）将冷冻干燥的纤维蛋白原溶解在抑肽酶溶液中; （b）将冻干凝血酶溶解在稳定溶液中; （c）将富集的胶原溶液与凝血酶和稳定溶液混合; 并将纤维蛋白原溶液（a）安装在双重试剂盒的一侧和将胶原蛋白溶液（c）另一侧，然后混合并注入损伤的软骨组织中。 在如上所述构成的本发明中，混合了诸如胶原和纤维蛋白等生物材料，以便使损伤的软骨组织被修复到允许移植到组织上的状态，从而可以有效地再生， 减少对人和动物的手术相关压力，同时诱导相对快速和有效的软骨修复和再生。

公开(公告)号：US20130287746A1

公开(公告)日：2013-10-31

申请号：US13979807

申请日：2011-02-17

Applicant: Ji Chul Yu ,  Se Ken Yeo ,  Tai Hyoung Kim ,  Dong Sam Shu ,  Cheong Ho Chang

Inventor： Ji Chul Yu ,  Se Ken Yeo ,  Tai Hyoung Kim ,  Dong Sam Shu ,  Cheong Ho Chang

IPC: C07K1/113 ,  A61L27/36 ,  A61L27/24 ,  C07K14/78

CPC classification number: C07K1/113 ,  A61K8/0212 ,  A61K8/65 ,  A61K47/42 ,  A61K2800/81 ,  A61L15/325 ,  A61L15/42 ,  A61L27/24 ,  A61L27/3604 ,  A61L27/38 ,  A61L27/50 ,  A61L27/52 ,  A61L27/60 ,  A61Q19/00 ,  C07K14/78

Abstract: The present invention relates to radiation cross-linked collagen gel, and a preparation method and usage method thereof. To this end, the present invention comprises a cross-linked collagen material made by irradiating liquid collagen with radioactive rays, wherein the concentration of said collagen is specifically 0.1-10% (W/V), and the radiation dose (dose rate×time) is 0.1-40 kGy on the basis of 1 kGy/hr. The present invention configured as above can prepare a formulated collagen gel using a physical cross-linking method instead of a chemical cross-linking method, specifically carries out the formulation by mixing biocompatible materials, and provides a method capable of using a cross-linked collagen hydrogel in wound dressings, graft materials, cell cultures and the like. Therefore, the present invention provides an industrially convenient and safe preparation method, thereby instilling a good image to a customer by greatly improving the quality and confidence in the products.

Abstract translation: 本发明涉及辐射交联胶原凝胶及其制备方法及其使用方法。 为此，本发明包括通过用放射线照射液体胶原物制成的交联胶原材料，其中所述胶原蛋白的浓度特别是0.1-10％（W / V），辐射剂量（剂量率×时间 ）基于1kGy / hr为0.1-40kGy。 如上构造的本发明可以使用物理交联法代替化学交联法制备配制的胶原凝胶，特别是通过混合生物相容性材料进行制剂，并提供能够使用交联胶原蛋白 伤口敷料中的水凝胶，移植材料，细胞培养物等。 因此，本发明提供了工业上方便和安全的制备方法，从而通过大大提高产品的质量和信心向顾客灌注良好的形象。

公开(公告)号：US20130217887A1

公开(公告)日：2013-08-22

申请号：US13849646

申请日：2013-03-25

Applicant: Gang Chen ,  Umesh B. Gangadharmath ,  Dhanalakshmi Kasi ,  Harmuth C. Kolb ,  Changhui Liu ,  Anjana Sinha ,  Anna Katrin Szardenings ,  Joseph C. Walsh ,  Eric Wang ,  Chul Yu ,  Wei Zhang ,  Klaus Kopka ,  Guenter Haufe ,  Michael Schaefers ,  Verena Hugenberg ,  Stefan Wagner ,  Sven Hermann ,  Hans-Joerg Breyholz ,  Andreas Faust

Inventor： Gang Chen ,  Umesh B. Gangadharmath ,  Dhanalakshmi Kasi ,  Harmuth C. Kolb ,  Changhui Liu ,  Anjana Sinha ,  Anna Katrin Szardenings ,  Joseph C. Walsh ,  Eric Wang ,  Chul Yu ,  Wei Zhang ,  Klaus Kopka ,  Guenter Haufe ,  Michael Schaefers ,  Verena Hugenberg ,  Stefan Wagner ,  Sven Hermann ,  Hans-Joerg Breyholz ,  Andreas Faust

IPC: C07D403/14 ,  C07D249/04 ,  C07D405/14

CPC classification number: C07D403/14 ,  C07D213/42 ,  C07D249/04 ,  C07D309/12 ,  C07D405/14

Abstract: Novel compounds and pharmaceutical compositions having MMP inhibitory activity are disclosed, which have been found to be particularly useful in the prevention, treatment and diagnostic imaging of diseases associated with an unpaired activity of MMP, amongst others MMP-2, MMP-8, MMP-9 and/or MMP-13 to name a few. The compounds of the present invention are useful for the prevention, the treatment and the in vivo diagnostic imaging of a range of disease states (inflammatory, malignant and degenerative diseases) where specific matrix metalloproteinases are known to be involved.

Abstract translation: 已经公开了具有MMP抑制活性的新型化合物和药物组合物，其已经被发现特别可用于预防，治疗和诊断成像与MMP的非配对活性相关的疾病，其中MMP-2，MMP-8，MMP- 9和/或MMP-13等等。 本发明的化合物可用于预防，治疗和体内诊断成像的一系列疾病状态（炎性，恶性和退行性疾病），其中已知特定的基质金属蛋白酶涉及。

公开(公告)号：US08491869B2

公开(公告)日：2013-07-23

申请号：US12661777

申请日：2010-03-23

Applicant: Umesh B. Gangadharmath ,  Hartmuth C. Kolb ,  Peter J. H. Scott ,  Joseph C. Walsh ,  Wei Zhang ,  Anna Katrin Szardenings ,  Anjana Sinha ,  Gang Chen ,  Eric Wang ,  Vani P. Mocharia ,  Chul Yu ,  Changhui Liu ,  Daniel Kurt Cashion ,  Dhanalakshmi Kasi

Inventor： Umesh B. Gangadharmath ,  Hartmuth C. Kolb ,  Peter J. H. Scott ,  Joseph C. Walsh ,  Wei Zhang ,  Anna Katrin Szardenings ,  Anjana Sinha ,  Gang Chen ,  Eric Wang ,  Vani P. Mocharia ,  Chul Yu ,  Changhui Liu ,  Daniel Kurt Cashion ,  Dhanalakshmi Kasi

IPC: A61K51/00 ,  A61M36/14

CPC classification number: A61K51/0455 ,  A61K51/04 ,  A61K51/0453 ,  A61K51/0459 ,  A61K51/0463 ,  C07B59/002 ,  C07D215/06 ,  C07D235/14 ,  C07D277/62 ,  C07D401/04 ,  C07D403/06 ,  C07D413/10 ,  C07D413/14 ,  C07D487/04

Abstract: Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering ti a patient in need compounds of formula (I) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formula (I) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.

Abstract translation: 式（I）的成像剂和用于检测神经障碍的方法包括给予需要能够结合tau蛋白和β-淀粉样肽的式（I）化合物的化合物。 本发明还涉及成像Abeta和tau聚集体的方法，包括引入可检测量的包含放射性标记的式（I）化合物的药物制剂，并检测患者中与淀粉样蛋白沉积物和/或tau蛋白相关的标记化合物。 这些方法和组合使得临床前诊断和监测AD和其他神经障碍的进展。

公开(公告)号：US20120207736A1

公开(公告)日：2012-08-16

申请号：US13503228

申请日：2009-12-03

Applicant: Cheong-Ho Jang ,  Ji-Chul Yu ,  Sae-Bom Lee ,  Hyun-Shin Park ,  Hyun-Jo Kim ,  Jae-Deog Jang ,  Se-Ken Yeo ,  Ju-Hee Park ,  Seok-Jung Kim

Inventor： Cheong-Ho Jang ,  Ji-Chul Yu ,  Sae-Bom Lee ,  Hyun-Shin Park ,  Hyun-Jo Kim ,  Jae-Deog Jang ,  Se-Ken Yeo ,  Ju-Hee Park ,  Seok-Jung Kim

IPC: A61K38/48 ,  A61P19/00

CPC classification number: A61L27/26 ,  A61F2002/30766 ,  A61L2400/06 ,  A61L2430/06 ,  C08L89/06

Abstract: The present invention relates to a composition for cartilaginous tissue repair and to a production method therefor. The present invention comprises the steps of: (a) dissolving freeze-dried fibrinogen in an aprotinin solution; (b) dissolving freeze-dried thrombin in a stabilizing solution; (c) mixing an enriched collagen solution with thrombin and the stabilizing solution; and installing the fibrinogen solution (a) to one side of a dual kit and the solution (c) containing the collagen to the other side, and then mixing and injecting into damaged cartilaginous tissue. In the present invention, which is constituted as described above, biomaterials such as collagen and fibrin are mixed so as to allow damaged cartilaginous tissue to be repaired to a state allowing transplantation onto the tissue, and efficient regeneration is induced, thereby making it possible to reduce surgery-related stress on people and animals while inducing relatively rapid and efficient cartilage repair and regeneration.

Abstract translation: 本发明涉及一种用于软骨组织修复的组合物及其制备方法。 本发明包括以下步骤：（a）将冷冻干燥的纤维蛋白原溶解在抑肽酶溶液中; （b）将冻干凝血酶溶解在稳定溶液中; （c）将富集的胶原溶液与凝血酶和稳定溶液混合; 并将纤维蛋白原溶液（a）安装在双重试剂盒的一侧和将胶原蛋白溶液（c）另一侧，然后混合并注入损伤的软骨组织中。 在如上所述构成的本发明中，混合了诸如胶原和纤维蛋白等生物材料，以便将损伤的软骨组织修复到允许移植到组织上的状态，从而可以有效地再生， 减少对人和动物的手术相关压力，同时诱导相对快速和有效的软骨修复和再生。

公开(公告)号：US20050060458A1

公开(公告)日：2005-03-17

申请号：US10885657

申请日：2004-07-08

Applicant: In-chul Yu

Inventor： In-chul Yu

IPC: G06F12/00 ,  G06F9/46 ,  G06F9/52 ,  G06F13/36 ,  G06F15/16 ,  G06F13/14 ,  G06F13/38

CPC classification number: G06F13/4269

Abstract: The present invention provides a method and apparatus enabling multiple CPU systems to independently access a shared device, each of the multiple CPU systems having data I/O lines, a reset line, a clock line and the like without requiring an additional switching logic or circuit. The method of sharing the device among multiple CPU systems according to an embodiment of the present invention comprises setting interfaces of all the systems to a floating state, determining the status of a PIO indicating whether it is possible to access the device, and the status of the PIO to an access-disable state. The method of sharing the device among multiple CPU systems further comprises changing the status of an interface of a first system, which intends to access the device, so that communications can be made between the first system and the device, and transmitting and receiving data between the first system and the device.

Abstract translation: 本发明提供一种能够使多个CPU系统独立地访问共享设备的方法和装置，所述多个CPU系统中的每一个具有数据I / O线，复位线，时钟线等，而不需要额外的开关逻辑或电路 。 根据本发明的实施例，在多个CPU系统之间共享设备的方法包括将所有系统的接口设置为浮置状态，确定指示是否可以访问设备的PIO的状态，以及 PIO进入访问禁用状态。 在多个CPU系统之间共享设备的方法还包括改变第一系统的接口的状态，该第一系统的接口意图访问该设备，使得可以在第一系统和设备之间进行通信，以及在第一系统和设备之间发送和接收数据 第一个系统和设备。