公开(公告)号：US08765454B2

公开(公告)日：2014-07-01

申请号：US10589860

申请日：2005-02-18

Applicant: Xiaochuan Zhou ,  Xiaollan Gao ,  Erdogan Gulari

Inventor： Xiaochuan Zhou ,  Xiaollan Gao ,  Erdogan Gulari

IPC: C12Q1/68 ,  C12M1/34 ,  B01L3/00

CPC classification number: C12Q1/686 ,  B01L3/5027 ,  B01L7/52 ,  B01L2200/0605 ,  B01L2300/0864 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/0688 ,  C07H21/04 ,  C12Q2537/143 ,  C12Q2565/501 ,  C12Q2565/629

Abstract: The present invention describes microfluidic devices that provide novel fluidic structures to facilitate the separation of fluids into isolated, pico-liter sized compartments for performing multiplexing chemical and biological reactions. Applications of the novel devices including biomolecule synthesis, polynucleotide amplification, and binding assays are also disclosed.

Abstract translation: 本发明描述了微流体装置，其提供新的流体结构以便于将流体分离成用于进行多重化学和生物反应的分离的，微微升的隔间。 还公开了包括生物分子合成，多核苷酸扩增和结合测定的新型设备的应用。

公开(公告)号：US08551599B2

公开(公告)日：2013-10-08

申请号：US12551071

申请日：2009-08-31

Applicant: Zhishan Hua ,  Erdogan Gulari ,  Mark A. Burns ,  Rohit Pal ,  Onnop Srivannavit

Inventor： Zhishan Hua ,  Erdogan Gulari ,  Mark A. Burns ,  Rohit Pal ,  Onnop Srivannavit

IPC: B32B3/24 ,  B32B3/26 ,  F16K7/12 ,  F16K7/17 ,  F16K31/02 ,  F16K31/126 ,  B81C1/00

CPC classification number: F16K99/0032 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2300/0819 ,  B01L2400/0481 ,  B01L2400/0655 ,  B01L2400/0677 ,  F15B15/10 ,  F16K99/0044 ,  Y10T137/0391 ,  Y10T137/1624 ,  Y10T137/1812 ,  Y10T137/2142 ,  Y10T137/218 ,  Y10T137/2191 ,  Y10T137/2196 ,  Y10T137/2202 ,  Y10T137/2218 ,  Y10T428/23 ,  Y10T428/234 ,  Y10T428/24322 ,  Y10T428/24331 ,  Y10T428/24612

Abstract: A microactuator may be configured by activating a source of electromagnetic radiation to heat and melt a selected set of phase-change plugs embedded in a substrate of the microactuator, pressurizing a common pressure chamber adjacent to each of the plugs to deform the melted plugs, and deactivating the source of electromagnetic radiation to cool and solidify the melted plugs.

公开(公告)号：US20080318806A1

公开(公告)日：2008-12-25

申请号：US10340928

申请日：2003-01-13

Applicant: Xiaolian Gao ,  Xiaochuan Zhou ,  Erdogan Gulari

Inventor： Xiaolian Gao ,  Xiaochuan Zhou ,  Erdogan Gulari

IPC: C40B40/04 ,  G02F1/13

CPC classification number: C07K1/047 ,  B01J19/0046 ,  B01J2219/00434 ,  B01J2219/00439 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00689 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B82Y30/00 ,  C07B2200/11 ,  C07H21/00 ,  C07K1/045 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B50/14 ,  C40B60/14 ,  G03F7/00

Abstract: This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. In particular, the present invention provides methods and devices for generating a photogenerated reaction in solution on a substrate comprising generating a light beam using an optical device system comprising a light source and a computer-controlled spatial optical modulator comprising a digital micromirror device and using the spatial optical modulator to direct light to fluidly isolated reaction sites under conditions such that a photogenerated reaction takes place. The method and apparatus of the present invention have applications in parallel synthesis of molecular sequence arrays on solid surfaces.

Abstract translation: 本发明提供了使用原位产生的光产物作为试剂或共试剂在溶液中进行化学和生物化学反应的方法和装置。 特别地，本发明提供了用于在衬底上产生溶液中的光生反应的方法和装置，包括使用包括光源的光学装置系统和包括数字微镜装置的计算机控制的空间光学调制器来产生光束，并使用 空间光学调制器，以在发生光生反应的条件下将光引导到流体分离的反应位点。 本发明的方法和装置具有在固体表面上并行合成分子序列阵列的应用。