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1.发明授权公开(公告)号：US07838466B2
公开(公告)日：2010-11-23
申请号：US10157442
申请日：2002-05-29
Applicant: Xiaolian Gao , Xiaochuan Zhou , Erdogan Gulari
Inventor： Xiaolian Gao , Xiaochuan Zhou , Erdogan Gulari
IPC: C40B50/00
CPC classification number: C07K1/047 , B01J19/0046 , B01J2219/00434 , B01J2219/00439 , B01J2219/00497 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B82Y30/00 , C07B2200/11 , C07H21/00 , C07K1/045 , C40B40/06 , C40B40/10 , C40B40/12 , C40B50/14 , C40B60/14 , G03F7/00
Abstract: This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. In particular, the present invention provides methods and devices for selectively converting photogenerated reagent precursors to photogenerated reagents comprising a substrate comprising at least one solid surface containing a plurality of isolated reaction sites; and an optical system operably linked to the substrate comprising a light source and a computer-controlled spatial optical modulator to form an irradiation pattern, wherein the irradiation pattern selectively irradiates a plurality of reaction sites without use of a photolithographic mask. The method and apparatus of the present invention have applications in parallel synthesis of molecular sequence arrays on solid surfaces.
Abstract translation: 本发明提供了使用原位产生的光产物作为试剂或共试剂在溶液中进行化学和生物化学反应的方法和装置。 特别地，本发明提供了用于选择性地将光生试剂前体转化成光生试剂的方法和装置，所述光生试剂包含含有至少一个含有多个分离的反应位点的固体表面的底物; 以及可操作地连接到所述基板的光学系统，所述光学系统包括光源和计算机控制的空间光学调制器以形成照射图案，其中所述照射图案选择性地照射多个反应部位而不使用光刻掩模。 本发明的方法和装置具有在固体表面上并行合成分子序列阵列的应用。
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公开(公告)号：US20100055394A1
公开(公告)日：2010-03-04
申请号：US12551071
申请日：2009-08-31
Applicant: Zhishan Hua , Erdogan Gulari , Mark A. Burns , Rohit Pal , Onnop Srivannavit
Inventor： Zhishan Hua , Erdogan Gulari , Mark A. Burns , Rohit Pal , Onnop Srivannavit
CPC classification number: F16K99/0032 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2300/0819 , B01L2400/0481 , B01L2400/0655 , B01L2400/0677 , F15B15/10 , F16K99/0044 , Y10T137/0391 , Y10T137/1624 , Y10T137/1812 , Y10T137/2142 , Y10T137/218 , Y10T137/2191 , Y10T137/2196 , Y10T137/2202 , Y10T137/2218 , Y10T428/23 , Y10T428/234 , Y10T428/24322 , Y10T428/24331 , Y10T428/24612
Abstract: A microactuator may be configured by activating a source of electromagnetic radiation to heat and melt a selected set of phase-change plugs embedded in a substrate of the microactuator, pressurizing a common pressure chamber adjacent to each of the plugs to deform the melted plugs, and deactivating the source of electromagnetic radiation to cool and solidify the melted plugs.
Abstract translation: 微致动器可以通过激活电磁辐射源来加热和熔化嵌入在微致动器的衬底中的一组相变插塞，对与每个插塞相邻的公共压力室进行加压以使熔化的插头变形，以及 停用电磁辐射源以冷却和固化熔化的塞子。
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3.发明授权Method and apparatus for chemical and biochemical reactions using photo-generated reagents 有权使用光产生试剂进行化学和生化反应的方法和装置公开(公告)号：US06426184B1
公开(公告)日：2002-07-30
申请号：US09248093
申请日：1999-02-10
Applicant: Xiaolian Gao , Xiaochuan Zhou , Erdogan Gulari
Inventor： Xiaolian Gao , Xiaochuan Zhou , Erdogan Gulari
IPC: C12Q168
CPC classification number: C07K1/047 , B01J19/0046 , B01J2219/00434 , B01J2219/00439 , B01J2219/00497 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B82Y30/00 , C07B2200/11 , C07H21/00 , C07K1/045 , C40B40/06 , C40B40/10 , C40B40/12 , C40B50/14 , C40B60/14 , G03F7/00
Abstract: This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. Specifically, the method and apparatus of the present invention have applications in parallel synthesis of molecular sequence arrays on solid surfaces.
Abstract translation: 本发明提供了使用原位产生的光产物作为试剂或共试剂在溶液中进行化学和生物化学反应的方法和装置。 具体地说，本发明的方法和装置具有在固体表面上并行合成分子序列阵列的应用。
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公开(公告)号：US20100105035A1
公开(公告)日：2010-04-29
申请号：US12312686
申请日：2007-11-21
Applicant: Syed Anwar Hashsham , James M. Tiedje , Erdogan Gulari , Dieter Tourlousse , Robert Stedtfeld , Farhan Ahmad , Gregoire Seyrig , Onnop Srivannavit
Inventor： Syed Anwar Hashsham , James M. Tiedje , Erdogan Gulari , Dieter Tourlousse , Robert Stedtfeld , Farhan Ahmad , Gregoire Seyrig , Onnop Srivannavit
CPC classification number: G01N21/645
Abstract: The present invention provides compositions providing and methods using fluorescence detection device, comprising an electroluminescent light (EL) source, for measuring fluorescence in biological samples. In particularly preferred embodiments, the present invention provides an economical, battery powered and Hand-held device for detecting fluorescent light emitted from reporter molecules incorporated into DNA, RNA, proteins or other biological samples, such as a fluorescence emitting biological sample on a microarray chip. Further, a real-time hand-held PCR Analyzer device comprising an EL light source for measuring fluorescence emissions from amplified DNA is provided.
Abstract translation: 本发明提供组合物提供和使用荧光检测装置的方法，其包括用于测量生物样品中的荧光的电致发光（EL）源。 在特别优选的实施方案中，本发明提供了一种经济的电池供电和手持式装置，用于检测从结合到DNA，RNA，蛋白质或其他生物样品中的报告分子发射的荧光，例如在微阵列芯片上发射荧光的样品 。 此外，提供了包括用于测量来自扩增的DNA的荧光发射的EL光源的实时手持式PCR分析仪装置。
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5.发明授权公开(公告)号：US07491680B2
公开(公告)日：2009-02-17
申请号：US10241411
申请日：2002-09-11
Applicant: Xiaolian Gao , Xiaochuan Zhou , Erdogan Gulari
Inventor： Xiaolian Gao , Xiaochuan Zhou , Erdogan Gulari
IPC: C40B50/08
CPC classification number: C07K1/047 , B01J19/0046 , B01J2219/00434 , B01J2219/00439 , B01J2219/00497 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B82Y30/00 , C07B2200/11 , C07H21/00 , C07K1/045 , C40B40/06 , C40B40/10 , C40B40/12 , C40B50/14 , C40B60/14 , G03F7/00
Abstract: This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. In some embodiments, the present invention provides methods and devices for generating one or more selected multimers at specific reaction sites on a substrate comprising contacting the substrate with a liquid solution comprising photo-reagent precursors, isolating the reaction sites, selectively irradiating the reaction sites with a digital micromirror device, and contacting the substrate with monomers. The method and apparatus of the present invention have applications in parallel synthesis of molecular sequence arrays on solid surfaces.
Abstract translation: 本发明提供了使用原位产生的光产物作为试剂或共试剂在溶液中进行化学和生物化学反应的方法和装置。 在一些实施方案中，本发明提供用于在底物上的特定反应位点处产生一种或多种选择的多聚体的方法和装置，其包括使所述底物与包含光试剂前体的液体溶液接触，分离反应位点，用 数字微镜装置，并使基底与单体接触。 本发明的方法和装置具有在固体表面上并行合成分子序列阵列的应用。
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Patent Agency Ranking
6.发明申请DEVICE FOR CHEMICAL AND BIOCHEMICAL REACTIONS USING PHOTO-GENERATED REAGENTS 审中-公开使用照片生成试剂进行化学和生化反应的装置公开(公告)号：US20110170075A1
公开(公告)日：2011-07-14
申请号：US12949988
申请日：2010-11-19
Applicant: Xiaolian Gao , Xiaochuan Zhou , Erdogan Gulari
Inventor： Xiaolian Gao , Xiaochuan Zhou , Erdogan Gulari
IPC: G03B27/00
CPC classification number: C07K1/047 , B01J19/0046 , B01J2219/00434 , B01J2219/00439 , B01J2219/00497 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B82Y30/00 , C07B2200/11 , C07H21/00 , C07K1/045 , C40B40/06 , C40B40/10 , C40B40/12 , C40B50/14 , C40B60/14 , G03F7/00
Abstract: This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. Specifically, the method and apparatus of the present invention have applications in parallel synthesis of molecular sequence arrays on solid surfaces.
Abstract translation: 本发明提供了使用原位产生的光产物作为试剂或共试剂在溶液中进行化学和生物化学反应的方法和装置。 具体地说，本发明的方法和装置具有在固体表面上并行合成分子序列阵列的应用。
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7.发明申请公开(公告)号：US20110143964A1
公开(公告)日：2011-06-16
申请号：US10589860
申请日：2005-02-18
Applicant: Xiachuan Zhou , Erdogan Gulari , Xiaolian Gao
Inventor： Xiachuan Zhou , Erdogan Gulari , Xiaolian Gao
CPC classification number: C12Q1/686 , B01L3/5027 , B01L7/52 , B01L2200/0605 , B01L2300/0864 , B01L2300/161 , B01L2400/0406 , B01L2400/0688 , C07H21/04 , C12Q2537/143 , C12Q2565/501 , C12Q2565/629
Abstract: The present invention describes microfluidic devices that provide novel fluidic structures to facilitate the separation of fluids into isolated, pico-liter sized compartments for performing multiplexing chemical and biological reactions. Applications of the novel devices including biomolecule synthesis, polynucleotide amplification, and binding assays are also disclosed.
Abstract translation: 本发明描述了微流体装置，其提供新的流体结构以便于将流体分离成用于进行多重化学和生物反应的分离的，微微升的隔间。 还公开了包括生物分子合成，多核苷酸扩增和结合测定的新型设备的应用。
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8.发明授权公开(公告)号：US07544638B2
公开(公告)日：2009-06-09
申请号：US10340928
申请日：2003-01-13
Applicant: Xiaolian Gao , Xiaochuan Zhou , Erdogan Gulari
Inventor： Xiaolian Gao , Xiaochuan Zhou , Erdogan Gulari
IPC: C40B50/08
CPC classification number: C07K1/047 , B01J19/0046 , B01J2219/00434 , B01J2219/00439 , B01J2219/00497 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B82Y30/00 , C07B2200/11 , C07H21/00 , C07K1/045 , C40B40/06 , C40B40/10 , C40B40/12 , C40B50/14 , C40B60/14 , G03F7/00
Abstract: This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. In particular, the present invention provides methods and devices for generating a photogenerated reaction in solution on a substrate comprising generating a light beam using an optical device system comprising a light source and a computer-controlled spatial optical modulator comprising a digital micromirror device and using the spatial optical modulator to direct light to fluidly isolated reaction sites under conditions such that a photogenerated reaction takes place. The method and apparatus of the present invention have applications in parallel synthesis of molecular sequence arrays on solid surfaces.
Abstract translation: 本发明提供了使用原位产生的光产物作为试剂或共试剂在溶液中进行化学和生物化学反应的方法和装置。 特别地，本发明提供了用于在衬底上产生溶液中的光生反应的方法和装置，包括使用包括光源的光学装置系统和包括数字微镜装置的计算机控制的空间光学调制器来产生光束，并使用 空间光学调制器，以在发生光生反应的条件下将光引导到流体分离的反应位点。 本发明的方法和装置具有在固体表面上并行合成分子序列阵列的应用。
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公开(公告)号：US20070224616A1
公开(公告)日：2007-09-27
申请号：US11690368
申请日：2007-03-23
Applicant: Erdogan Gulari , Jean-Marie Rouillard , Xiaolian Gao , Xiaochuan Zhou
Inventor： Erdogan Gulari , Jean-Marie Rouillard , Xiaolian Gao , Xiaochuan Zhou
CPC classification number: B82Y30/00 , B01J19/0046 , B01J2219/00434 , B01J2219/00439 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00675 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , C40B50/18 , G01N33/54353
Abstract: A method for forming molecular sequences includes derivatizing an unconfined substrate surface with at least one linker containing a protected reactive group. The substrate is contacted with a solution containing a photogenerated reagent precursor and a buffer and/or a neutralizer. A photogenerated reagent is generated in at least a portion of the solution. The photogenerated reagent is configured to initiate the formation of at least one active region on the substrate surface. A monomer is coupled to the active region.
Abstract translation: 形成分子序列的方法包括用至少一个含有保护的反应性基团的连接体衍生无约束的底物表面。 将底物与含有光生试剂前体和缓冲剂和/或中和剂的溶液接触。 在溶液的至少一部分中产生光生试剂。 光生试剂被配置为启动在衬底表面上形成至少一个有源区。 单体与活性区连接。
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10.发明授权Catalyst for converting methane to higher hydrocarbons, including aromatic compounds 失效将甲烷转化为高级烃，包括芳族化合物的催化剂
公开(公告)号：US4952547A
公开(公告)日：1990-08-28
申请号：US223619
申请日：1988-07-25
Applicant: Ananth V. Annapragada , Erdogan Gulari
Inventor： Ananth V. Annapragada , Erdogan Gulari
IPC: B01J27/185 , C07C2/84
CPC classification number: C07C2/84 , B01J27/1853 , C07C2527/167 , C07C2527/185 , Y10S585/943
Abstract: A catalyst for use in a process for oxidatively coupling methane to C.sub.2 and other hydrocarbons, including aromatic hydrocarbons, which is an iron-phosphorus-oxide catalyst having an iron to phosphorus ratio of from 0.1:1.0 to 2.0:1.0 is used.
Abstract translation: 用于将甲烷与C2和其它烃（包括芳族烃）氧化偶联的方法中使用的催化剂，其为铁与磷比为0.1:1.0至2.0:1.0的铁 - 磷 - 氧化物催化剂。
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