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11.发明授权Topical application of immixture of ascorbic acid + ascorbic acid compounds for augmenting the synthesis of epidermal ceramides 有权局部应用抗坏血酸+抗坏血酸化合物，以增强表皮神经酰胺的合成公开(公告)号：US06774114B2
公开(公告)日：2004-08-10
申请号：US10425608
申请日：2003-04-30
Applicant: Isabelle Castiel , Corinne Ferraris , Armelle Lavalle-Bouchard
Inventor： Isabelle Castiel , Corinne Ferraris , Armelle Lavalle-Bouchard
IPC: A01N4304
CPC classification number: A61Q19/00 , A61K8/676 , A61K2800/59 , A61Q17/00 , A61Q19/08
Abstract: Synergistic immixtures of ascorbic acid with at least one monosaccharide ester of ascorbic acid and/or at least one metal salt of phosphorylated ascorbic acid more effectively increase the synthesis of epidermal ceramides in human skin, especially types IV to VII ceramides, as well as improve the barrier function, moisture content and/or suppleness/surface appearance of the skin and which otherwise combat/prevent intrinsic aging thereof and are useful for the treatment of dermatitis.
Abstract translation: 抗坏血酸与抗坏血酸和/或至少一种磷酸化抗坏血酸金属盐的至少一种单糖酯的协同增效更有效地增加人皮肤特别是IV型至VII型神经酰胺类中表皮神经酰胺的合成，以及改善 屏障功能，水分含量和/或皮肤的柔软性/表面外观，否则会抵抗/防止其内在老化，并且可用于治疗皮炎。
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公开(公告)号：US10238897B2
公开(公告)日：2019-03-26
申请号：US12200417
申请日：2008-08-28
Applicant: Isabelle Castiel , Lionel Breton , Audrey Gueniche
Inventor： Isabelle Castiel , Lionel Breton , Audrey Gueniche
Abstract: Cosmetic use of an effective amount of at least one lysate of at least one microorganism of the genus Bifidobacterium species and/or a fraction thereof, for preventing and/or treating a skin disorder in the case of sensitive skin.
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13.发明授权Cosmetic and therapeutic use of proteins of DJ-1 type for treating skin dryness 有权DJ-1型蛋白质的化妆和治疗用途，用于治疗皮肤干燥公开(公告)号：US09295711B2
公开(公告)日：2016-03-29
申请号：US13130710
申请日：2009-11-19
Applicant: Dominique Bernard , Lucie Simonetti , Isabelle Castiel
Inventor： Dominique Bernard , Lucie Simonetti , Isabelle Castiel
CPC classification number: A61K38/1709 , A61K8/64 , A61Q19/007
Abstract: The present invention relates to the use, especially the cosmetic and/or therapeutic use, of the protein DJ-1, of polypeptides derived from this protein or of analogs thereof, of a nucleic acid sequence coding for such a polypeptide or of a modulator of the activity, stability or expression of such a polypeptide, especially for preventing and/or treating the signs of skin dryness. The invention also relates to the use of the protein DJ-1, of polypeptides derived from this protein or of analogs thereof or of a nucleic acid sequence coding for such a polypeptide, as a marker for evaluating the state of dryness of an epithelium.
Abstract translation: 本发明涉及编码这种多肽或调节剂的核酸序列的衍生自该蛋白质或其类似物的多肽的蛋白质DJ-1的使用，特别是化妆品和/或治疗用途 这种多肽的活性，稳定性或表达，特别是用于预防和/或治疗皮肤干燥症状。 本发明还涉及蛋白质DJ-1来自该蛋白质或其类似物的多肽或编码这种多肽的核酸序列作为评价上皮干燥状态的标记物的用途。
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公开(公告)号：US09265719B2
公开(公告)日：2016-02-23
申请号：US12659597
申请日：2010-03-15
Applicant: Isabelle Castiel , Audrey Gueniche
Inventor： Isabelle Castiel , Audrey Gueniche
IPC: A61K8/02 , A61K8/99 , A61K35/74 , A61K9/68 , A61K9/00 , A61K9/48 , A61K9/28 , A61P17/14 , A61Q5/02 , A61Q5/06 , A61Q5/10 , A61Q5/12 , A61Q11/00 , A61Q5/00 , A61Q19/00
CPC classification number: A61K8/99 , A61K8/0216 , A61K8/0229 , A61K2800/88 , A61K2800/92 , A61Q5/006 , A61Q19/00
Abstract: The present invention relates to a use of an effective amount of at least one probiotic microorganism and/or a fraction thereof and/or a metabolite thereof for preventing and/or treating dandruff disorders of the scalp, as well as a cosmetic process for preventing and/or treating a dandruff condition including the administration a first cosmetic active agent and of at least a second cosmetic active agent, topically, the said first and second cosmetic active agents being formulated in separate compositions, the first cosmetic active agent being chosen from probiotic microorganisms, and mixtures thereof, and the second cosmetic active agent being chosen from antidandruff active agents.
Abstract translation: 本发明涉及有效量的至少一种益生菌微生物和/或其部分和/或其代谢物用于预防和/或治疗头皮的头皮屑病的用途，以及用于预防和/ /或治疗包括施用第一美容活性剂和至少第二化妆用活性剂的头皮屑状况，所述第一和第二美容活性剂局部地配制在分开的组合物中，所述第一美容活性剂选自益生菌微生物 ，及其混合物，第二化妆品活性剂选自去头皮屑活性剂。
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公开(公告)号：US09176144B2
公开(公告)日：2015-11-03
申请号：US12515198
申请日：2007-11-16
Applicant: Mark Donovan , Dominique Bernard , Isabelle Castiel , Veronique Chaussade
Inventor： Mark Donovan , Dominique Bernard , Isabelle Castiel , Veronique Chaussade
IPC: G01N33/53 , G01N33/68 , A61K8/60 , A61K8/66 , A61Q19/00 , A61Q19/08 , C12N5/071 , C12Q1/68 , G01N33/50 , A61K38/46
CPC classification number: G01N33/6881 , A61K8/606 , A61K8/66 , A61K38/465 , A61Q19/007 , A61Q19/08 , C12N5/0629 , C12N2501/70 , C12Q1/6883 , C12Q2600/158 , C12Y301/2601 , G01N33/5082 , G01N33/6893 , G01N2333/922 , G01N2500/00 , G01N2800/20
Abstract: The present invention relates to the use, in cosmetics and in therapeutics, of at least one antimicrobial protein belonging to the ribonuclease family, ribonuclease 7, or of polypeptides derived from said protein, notably as a marker for evaluating the condition of the epidermis. It further relates to the use of at least one polypeptide according to the invention, of at least one nucleic acid sequence coding for a polypeptide according to the invention, or of at least one agent that modulates the expression or the activity, notably biological, of said polypeptide or of its interaction with an element of the extracellular matrix, for the preparation of compositions intended for the prevention and/or treatment of skin disorders.
Abstract translation: 本发明涉及在化妆品和治疗学中至少一种属于核糖核酸酶家族的抗微生物蛋白质，核糖核酸酶7或衍生自所述蛋白质的多肽，特别是用作评估表皮条件的标记物。 本发明进一步涉及至少一种根据本发明的多肽的至少一种编码本发明多肽的核酸序列或至少一种调节表达或活性，特别是生物学活性的试剂 所述多肽或其与细胞外基质的元件的相互作用，用于制备旨在预防和/或治疗皮肤病症的组合物。
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Patent Agency Ranking
公开(公告)号：US08951775B2
公开(公告)日：2015-02-10
申请号：US13056344
申请日：2009-07-23
Applicant: Isabelle Castiel , Audrey Gueniche
Inventor： Isabelle Castiel , Audrey Gueniche
CPC classification number: A61Q19/008 , A61K8/99 , A61Q19/00 , Y10S514/859 , Y10S514/864
Abstract: The present invention relates to the cosmetic use of an effective amount of at least one probiotic microorganism and/or a fraction thereof and/or a metabolite thereof, as an agent for treating and/or preventing oily skin or skin with an oily tendency and the associated skin disorders.
Abstract translation: 本发明涉及有效量的至少一种益生菌微生物和/或其部分和/或其代谢物作为用于治疗和/或预防油性皮肤或皮肤的药物的油性倾向的化妆品用途， 相关皮肤病。
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公开(公告)号：US08932579B2
公开(公告)日：2015-01-13
申请号：US12513631
申请日：2007-11-06
Applicant: Vanessa Crespy , Isabelle Castiel , Rachid Bel-Rhlid , Nicolas Page , Thomas Raab
Inventor： Vanessa Crespy , Isabelle Castiel , Rachid Bel-Rhlid , Nicolas Page , Thomas Raab
CPC classification number: A61K35/747 , A23L5/00 , A23L7/00 , A23L31/00 , A23L33/10 , A23L33/105 , A23L33/125 , A23L33/135 , A23L33/14 , A23V2002/00 , A61K31/216 , A61K35/745 , A61K36/53 , A61K38/465 , A61K2300/00 , A23V2250/2132 , A23V2200/3204 , A23V2250/21
Abstract: The present invention relates to compositions of rosmarinic acid or its derivatives and to the use of a hydrolytic enzyme or of microorganism containing or producing hydrolytic enzymes in these compositions. The invention also pertains to methods for improving the biological effects of the rosemary extracts and for administering such compositions to a human or animal subject for improving the skin, coat, hair or health of the subject.
Abstract translation: 本发明涉及迷迭香酸或其衍生物的组合物以及在这些组合物中含有或产生水解酶的水解酶或微生物的用途。 本发明还涉及用于改善迷迭香提取物的生物学作用并将这些组合物给予人或动物受试者以改善受试者的皮肤，外套，毛发或健康的方法。
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公开(公告)号：US20100216707A1
公开(公告)日：2010-08-26
申请号：US12602246
申请日：2008-06-20
Applicant: Dominique Bernard , Isabelle Castiel , Lucie Simonetti
Inventor： Dominique Bernard , Isabelle Castiel , Lucie Simonetti
CPC classification number: G01N33/92 , A61K8/64 , A61K38/1709 , A61Q17/00 , A61Q19/08 , C07K14/775 , G01N2500/04 , G01N2500/10
Abstract: The subject of the present invention is the use, in particular the cosmetic and/or therapeutic use, of the apolipoprotein D, of polypeptides derived from this protein or of analogues thereof, of a nucleic sequence encoding such a polypeptide or of an agent modulating the activity or of the expression of such a polypeptide, in particular for stimulating terminal epithelial differentiation. The invention also relates to the use of the protein apolipoprotein D, of polypeptides derived from this protein or of analogues thereof, or of a nucleic sequence encoding such a polypeptide as a marker for evaluating the state of the epidermis.
Abstract translation: 本发明的主题是使用来自该蛋白质或其类似物的多肽的载脂蛋白D的化妆品和/或治疗用途，编码这种多肽的核酸序列或调节 活性或这种多肽的表达，特别是用于刺激末端上皮分化。 本发明还涉及来自该蛋白质或其类似物的多肽的蛋白质载脂蛋白D或编码这种多肽的核酸序列作为评估表皮状态的标记物的用途。
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19.发明申请公开(公告)号：US20090060962A1
公开(公告)日：2009-03-05
申请号：US12200426
申请日：2008-08-28
Applicant: Isabelle CASTIEL , Lionel BRETON , Audrey GUENICHE
Inventor： Isabelle CASTIEL , Lionel BRETON , Audrey GUENICHE
CPC classification number: A61Q19/007 , A61K8/99
Abstract: Cosmetic use of an effective amount of a lysate of at least one microorganism of the genus Bifidobacterium species and/or one of its fractions in treating and/or preventing dryness and/or associated disorders of a keratinous substance.
Abstract translation: 化妆品使用有效量的双歧杆菌属物种和/或其部分之一的至少一种微生物的裂解物处理和/或预防角质形成物的干燥和/或相关疾病。
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公开(公告)号：US06596695B2
公开(公告)日：2003-07-22
申请号：US09828881
申请日：2001-04-10
Applicant: Isabelle Castiel , Corinne Ferraris , Armelle LaValle-Bouchard
Inventor： Isabelle Castiel , Corinne Ferraris , Armelle LaValle-Bouchard
IPC: A61K3170
CPC classification number: A61Q19/00 , A61K8/676 , A61K2800/59 , A61Q17/00 , A61Q19/08
Abstract: Synergistic immixtures of ascorbic acid with at least one monosaccharide ester of ascorbic acid and/or at least one metal salt of phosphorylated ascorbic acid more effectively increase the synthesis of epidermal ceramides in human skin, especially types IV to VII ceramides, as well as improve the barrier function, moisture content and/or suppleness/surface appearance of the skin and which otherwise combat/prevent intrinsic aging thereof and are useful for the treatment of dermatitis.
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