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    Methods of transforming a basic shape element of a character
    12.
    发明授权
    Methods of transforming a basic shape element of a character 失效
    转换字符的基本形状元素的方法

    公开(公告)号：US6157750A

    公开(公告)日：2000-12-05

    申请号：US829387

    申请日：1997-03-31

    申请人： Hyeong In Choi ,  Nam Sook Wee ,  Kyung Hwan Park ,  Sung Jin Lee ,  Sung Woo Choi ,  Hwan Pyo Moon ,  Seung Won Song ,  Myung Joo Baek ,  Jin Young Kim ,  Shin Hae Tahk ,  Hyun Joo Choi ,  Hal Lan Yang ,  Jeong Han Kim

    发明人： Hyeong In Choi ,  Nam Sook Wee ,  Kyung Hwan Park ,  Sung Jin Lee ,  Sung Woo Choi ,  Hwan Pyo Moon ,  Seung Won Song ,  Myung Joo Baek ,  Jin Young Kim ,  Shin Hae Tahk ,  Hyun Joo Choi ,  Hal Lan Yang ,  Jeong Han Kim

    IPC分类号： G06F3/12 ,  G06F3/14 ,  G06T3/40 ,  G09G5/24 ,  G06K9/32

    CPC分类号： G06T3/0093

    摘要： The present invention relates to an outline font. The purpose lies in supplying a transforming and rendering method in the shape where the important form of the shape, such as the thickness of the stroke, will be maintained from the basic shape, and at the same time the whole size of the shape can be fitted into a given bounding box. The present invention supplies the transformation method of a handwriting font including searching for the medial axis of a given element, obtaining contact points by using maximal inscribed circles with the medial axis and points of the medial axis as a center, and applying the information about the medial axis points and the contact points in case of a transformation of the element in the transformation method of handwriting where a given element can be optionally transformed in sizes in order to achieve the purpose. The present invention enables the transformation of the shape. In resizing the given element from the box surrounding element to the box where the new element is placed, the important form of the shape, such as the thickness of the stroke, is maintained, and at the same time the size of the whole is transformed in accordance with the optionally given box.

    摘要翻译： 本发明涉及一种轮廓字体。 目的在于提供一种形状的变形和渲染方法，其中形状的重要形状（例如笔划的厚度）将从基本形状保持，并且同时形状的整体尺寸可以是 装入给定的边界框。 本发明提供了一种手写字体的变换方法，包括搜索给定元素的中轴，通过使用具有中间轴的最大内切圆和中间轴的点作为中心来获得接触点，并且应用关于 在笔迹的变换方法中的元素的变换的情况下的中间轴点和接触点，其中给定元素可以可选地在尺寸上变换以实现目的。 本发明能够实现形状的变换。 在将给定元素从包围元素的大小调整到放置新元素的框中时，保持形状的重要形式（例如笔画的厚度），同时整体的大小被变换 按照任意给定的方框。

    Systems and methods for particle detection
    14.
    发明授权
    Systems and methods for particle detection 有权
    粒子检测系统和方法

    公开(公告)号：US09012830B2

    公开(公告)日：2015-04-21

    申请号：US13460170

    申请日：2012-04-30

    申请人： Jiangang Zhu ,  Sahin Kaya Ozdemir ,  Lan Yang

    发明人： Jiangang Zhu ,  Sahin Kaya Ozdemir ,  Lan Yang

    IPC分类号： G01J9/00 ,  G01N21/17 ,  G01N21/77 ,  B82Y35/00

    CPC分类号： G01N21/7746 ,  B82Y35/00 ,  Y10S977/88

    摘要： A particle detection system is provided. The particle detection system includes at least one tapered optical fiber, a light source configured to transmit light through the at least one tapered optical fiber, a photodetector configured to measure a characteristic of the light being transmitted through the at least one optical fiber, and a computing device coupled to the photodetector and configured to determine whether a nanoparticle is present within an evanescent field of the at least one tapered optical fiber based on the measured light characteristic.

    摘要翻译： 提供了一种粒子检测系统。 粒子检测系统包括至少一个锥形光纤，被配置为通过至少一个锥形光纤透射光的光源，被配置为测量透过至少一个光纤的光的特性的光电检测器，以及 耦合到所述光电检测器并且被配置为基于所测量的光特性来确定纳米颗粒是否存在于所述至少一个锥形光纤的消逝场内。

    QUINAZOLINE DERIVATIVE, COMPOSITION HAVING THE DERIVATIVE, AND USE OF THE DERIVATIVE IN PREPARING MEDICAMENT
    15.
    发明申请
    QUINAZOLINE DERIVATIVE, COMPOSITION HAVING THE DERIVATIVE, AND USE OF THE DERIVATIVE IN PREPARING MEDICAMENT 有权
    喹啉衍生物，具有衍生物的组合物，以及衍生物在制备药物中的用途

    公开(公告)号：US20150080392A1

    公开(公告)日：2015-03-19

    申请号：US14234326

    申请日：2012-07-21

    申请人： Shulong Wang ,  Jian Cai ,  Qiufu Ge ,  Dianwu Guo ,  Lan Yang ,  Binnan Huang ,  Zhenhua Liu ,  Zhonghua Peng ,  Ximing Shen ,  Feiyu Feng

    发明人： Shulong Wang ,  Jian Cai ,  Qiufu Ge ,  Dianwu Guo ,  Lan Yang ,  Binnan Huang ,  Zhenhua Liu ,  Zhonghua Peng ,  Ximing Shen ,  Feiyu Feng

    IPC分类号： C07D417/04 ,  C07D403/14 ,  C07D405/04

    CPC分类号： C07D417/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14

    摘要： A class of quinazoline derivatives or pharmaceutically acceptable salts or solvates thereof with novel structures is provided; meanwhile, a pharmaceutical composition comprising a pharmaceutically effective amount of said quinazoline derivatives or pharmaceutically acceptable salts or solvates thereof, and pharmaceutically acceptable excipients or additives is also provided. By modifying and transforming the quinazoline and screening of the transformed compounds on the activity of tyrosine kinase inhibition, most of the compounds have been found to possess inhibitory activity against one or several of EGFR, VEGFR-2, c-erbB-2, c-erbB-4, c-met, tie-2, PDGFR, c-src, lck, Zap70 and fyn kinases. The present invention has the advantages of reasonable design, broad source of and easy access to the raw materials, simple and easy operation of the preparation methods, mild reaction conditions, high yield of the products and being beneficial for industrial-scale production.

    摘要翻译： 提供了一类具有新颖结构的喹唑啉衍生物或其药学上可接受的盐或溶剂合物; 同时，还提供了包含药学上有效量的所述喹唑啉衍生物或其药学上可接受的盐或溶剂合物以及药学上可接受的赋形剂或添加剂的药物组合物。 通过修饰和转化喹唑啉和筛选转化的化合物对酪氨酸激酶抑制的活性，已经发现大多数化合物具有对EGFR，VEGFR-2，c-erbB-2，c- erbB-4，c-met，tie-2，PDGFR，c-src，lck，Zap70和fyn激酶。 本发明设计合理，原料来源广泛，易于获得原料，操作简便，制备方法简单，反应条件温和，产品收率高，有利于工业规模生产。

    Anti-fuses on semiconductor fins
    16.
    发明授权
    Anti-fuses on semiconductor fins 有权
    半导体鳍片上的防熔丝

    公开(公告)号：US08742457B2

    公开(公告)日：2014-06-03

    申请号：US13328944

    申请日：2011-12-16

    申请人： Hsiao-Lan Yang

    发明人： Hsiao-Lan Yang

    IPC分类号： H01L23/525

    CPC分类号： H01L27/11206 ,  H01L21/76895 ,  H01L21/823431 ,  H01L21/823475 ,  H01L23/5252 ,  H01L27/101 ,  H01L27/115 ,  H01L29/66484 ,  H01L29/66795 ,  H01L2924/0002 ,  H01L2924/00

    摘要： A device includes a substrate, isolation regions at a surface of the substrate, and a semiconductor region over a top surface of the isolation regions. A conductive feature is disposed over the top surface of the isolation regions, wherein the conductive feature is adjacent to the semiconductor region. A dielectric material is disposed between the conductive feature and the semiconductor region. The dielectric material, the conductive feature, and the semiconductor region form an anti-fuse.

    摘要翻译： 一种器件包括衬底，衬底表面处的隔离区域以及隔离区域顶表面上的半导体区域。 导电特征设置在隔离区的顶表面上，其中导电特征与半导体区相邻。 介电材料设置在导电特征和半导体区域之间。 电介质材料，导电特征和半导体区域形成反熔丝。

    Human antibodies that bind mesothelin, and uses thereof
    19.
    发明授权
    Human antibodies that bind mesothelin, and uses thereof 有权
    结合间皮素的人抗体及其用途

    公开(公告)号：US08268970B2

    公开(公告)日：2012-09-18

    申请号：US12681215

    申请日：2008-09-29

    申请人： Jonathan A. Terrett ,  Sarah L. Pogue ,  Kristopher Toy ,  Lan Yang ,  Chetana Rao-Naik ,  Bingliang Chen

    发明人： Jonathan A. Terrett ,  Sarah L. Pogue ,  Kristopher Toy ,  Lan Yang ,  Chetana Rao-Naik ,  Bingliang Chen

    IPC分类号： C07K16/00 ,  C12P21/08

    CPC分类号： C07K16/30 ,  A61K39/39558 ,  A61K47/6857 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/80 ,  C07K2317/92 ,  A61K2300/00

    摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure.

    摘要翻译： 本公开提供以高亲和力特别是人单克隆抗体特异性结合间皮素的分离的单克隆抗体。 优选地，所述抗体结合人间皮素。 在某些实施方案中，抗体能够内化成表达间皮素的细胞或能够介导抗原依赖性细胞毒性。 本发明还提供可以抑制间皮素与卵巢癌抗原CA125的结合的抗间皮素抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了抗体 - 配偶体分子缀合物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了用于检测间皮素的方法，以及使用本公开的抗间皮素抗体治疗癌症的方法，例如间皮瘤，胰腺癌和卵巢癌。

    Anti-CTLA-4 antibodies with reduced blocking of binding of CTLA-4 to B7 and uses thereof
    20.
    发明授权
    Anti-CTLA-4 antibodies with reduced blocking of binding of CTLA-4 to B7 and uses thereof 有权
    具有降低的CTLA-4与B7结合的抗CTLA-4抗体及其用途

    公开(公告)号：US08263073B2

    公开(公告)日：2012-09-11

    申请号：US12866149

    申请日：2009-02-04

    申请人： Alan Korman ,  Edward L. Halk ,  Changyu Wang ,  Kent B. Thudium ,  Lan Yang ,  Kristopher Toy

    发明人： Alan Korman ,  Edward L. Halk ,  Changyu Wang ,  Kent B. Thudium ,  Lan Yang ,  Kristopher Toy

    IPC分类号： A61K39/395

    CPC分类号： C07K16/2818 ,  A61K39/3955 ,  A61K2039/55516 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

    摘要： The present invention provides isolated monoclonal antibodies that bind to CTLA-4 and that are capable of increasing the response of T cells to antigenic stimulation in vivo yet the antibodies do not substantially block the binding of CTLA-4 to B7 ligands (e.g., B7-1 and B7-2) in vitro. Thus, the antibodies of the invention demonstrate that is it possible to separate the immunostimulatory function of anti-CTLA-4 antibodies from their ability to block the binding of B7 ligands. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for increasing the response of T cells to antigenic stimulation using the antibodies of the invention, including methods for treating cancer using the antibodies of the invention.

    摘要翻译： 本发明提供了与CTLA-4结合并且能够增加T细胞对体内抗原刺激的反应的分离的单克隆抗体，但是该抗体基本上不阻断CTLA-4与B7配体的结合（例如，B7- 1和B7-2）。 因此，本发明的抗体证明可以将抗CTLA-4抗体的免疫刺激功能从其阻断B7配体结合的能力分离出来。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体增加T细胞对抗原刺激的应答的方法，包括使用本发明的抗体治疗癌症的方法。