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    Method and apparatus for imaging a sample on a device
    17.
    发明申请
    Method and apparatus for imaging a sample on a device 审中-公开

    公开(公告)号：US20050281708A1

    公开(公告)日：2005-12-22

    申请号：US11178087

    申请日：2005-07-07

    申请人： Mark Trulson ,  James Winkler ,  Maureen Cronin ,  David Stern

    发明人： Mark Trulson ,  James Winkler ,  Maureen Cronin ,  David Stern

    IPC分类号： C12M1/34 ,  G01J1/20 ,  G01N21/64 ,  G01T1/10

    CPC分类号： G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/6417 ,  G01N2021/6423

    摘要： In accordance with various embodiments of the invention, an apparatus is provided for hybridizing a nucleic acid microarray immobilized on a surface of a solid substrate. The apparatus comprises at least one assembly for securing the solid substrate during hybridization, the assembly comprising a carrier and a cover having a surface facing the carrier. The carrier and the cover can be dimensioned to receive the solid substrate between the carrier and the surface of the cover so that the surfaces of the cover and the solid substrate define a cavity. In some embodiments, the apparatus can include a fluid control module comprising a manifold, at least one liquid reservoir, at least one waste container, and a vacuum source in fluid communication with the waste container. The manifold can provide fluid communication between the liquid reservoir and the cavity and between the cavity and the waste container, and the vacuum source can provide a pressure difference between the liquid reservoir and the waste container. The apparatus can further include at least one thermal management module for controlling temperature of the nucleic acid microarray immobilized on the surface of the solid substrate, and the thermal management module thermally can contact the assembly; and a pulse valve in fluid communication with the cavity, the pulse valve adapted to agitate fluid within the cavity.

    Method and apparatus for imaging a sample on a device
    18.
    发明申请
    Method and apparatus for imaging a sample on a device 审中-公开
    用于在装置上成像样品的方法和装置

    公开(公告)号：US20050247887A1

    公开(公告)日：2005-11-10

    申请号：US11177529

    申请日：2005-07-07

    申请人： Mark Trulson ,  James Winkler ,  Maureen Cronin ,  David Stern

    发明人： Mark Trulson ,  James Winkler ,  Maureen Cronin ,  David Stern

    IPC分类号： C12M1/34 ,  G01J1/20 ,  G01N21/64 ,  G01T1/10

    CPC分类号： G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/6417 ,  G01N2021/6423

    摘要： In accordance with various embodiments of the invention, an apparatus is provided for hybridizing a nucleic acid microarray immobilized on a surface of a solid substrate. The apparatus comprises at least one assembly for securing the solid substrate during hybridization, the assembly comprising a carrier and a cover having a surface facing the carrier. The carrier and the cover can be dimensioned to receive the solid substrate between the carrier and the surface of the cover so that the surfaces of the cover and the solid substrate define a cavity. In some embodiments, the apparatus can include a fluid control module comprising a manifold, at least one liquid reservoir, at least one waste container, and a vacuum source in fluid communication with the waste container. The manifold can provide fluid communication between the liquid reservoir and the cavity and between the cavity and the waste container, and the vacuum source can provide a pressure difference between the liquid reservoir and the waste container. The apparatus can further include at least one thermal management module for controlling temperature of the nucleic acid microarray immobilized on the surface of the solid substrate, and the thermal management module thermally can contact the assembly; and a pulse valve in fluid communication with the cavity, the pulse valve adapted to agitate fluid within the cavity.

    摘要翻译： 根据本发明的各种实施方案，提供了一种用于杂交固定在固体基质表面上的核酸微阵列的装置。 该装置包括用于在杂交期间固定固体基底的至少一个组件，该组件包括载体和具有面向载体的表面的盖。 载体和盖的尺寸可以被确定为在载体和盖的表面之间接收固体基质，使得盖和固体基质的表面限定空腔。 在一些实施例中，该装置可以包括流体控制模块，其包括歧管，至少一个液体储存器，至少一个废物容器和与废物容器流体连通的真空源。 歧管可以在液体储存器和空腔之间以及空腔和废物容器之间提供流体连通，并且真空源可以在液体储存器和废物容器之间提供压力差。 该装置还可以包括至少一个用于控制固定在固体基质表面上的核酸微阵列的温度的热管理模块，并且热管理模块可热接触组件; 以及与所述空腔流体连通的脉冲阀，所述脉冲阀适于搅动所述空腔内的流体。