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11.发明申请公开(公告)号：US20050191688A1
公开(公告)日：2005-09-01
申请号：US11075231
申请日：2005-03-07
Applicant: Sergey Selifonov , Willem Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip Patten , Jeremy Minshull
Inventor： Sergey Selifonov , Willem Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip Patten , Jeremy Minshull
IPC: A61K39/00 , C07K14/16 , C07K14/505 , C07K14/535 , C12N9/16 , C12N15/10 , C12N15/11 , G06F19/00 , C12Q1/68 , G01N33/48 , G01N33/50
CPC classification number: C12N15/1031 , A61K39/00 , C07K14/005 , C07K14/505 , C07K14/535 , C12N9/16 , C12N15/1027 , C12N15/11 , C12N2740/16122
Abstract: “In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
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公开(公告)号：US06379964B1
公开(公告)日：2002-04-30
申请号：US09354922
申请日：1999-07-15
Applicant: Stephen del Cardayre , Matthew Tobin , Willem P. C. Stemmer , Jeremy Minshull
Inventor： Stephen del Cardayre , Matthew Tobin , Willem P. C. Stemmer , Jeremy Minshull
IPC: C12N1500
CPC classification number: A01H1/00 , A01K2217/05 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12Q1/6811
Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
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公开(公告)号：US08030051B2
公开(公告)日：2011-10-04
申请号：US11581946
申请日：2006-10-16
Applicant: Svetlana Balatskaya , Birthe Borup , Ranjini Chatterjee , Ish Dhawan , Richard J. Fox , Kenneth W. Mitchell , Emily C. Mundorff , Les Partridge , Matthew Tobin
Inventor： Svetlana Balatskaya , Birthe Borup , Ranjini Chatterjee , Ish Dhawan , Richard J. Fox , Kenneth W. Mitchell , Emily C. Mundorff , Les Partridge , Matthew Tobin
Abstract: The present disclosure relates generally to polypeptides having improved alanine 2,3-aminomutase (AAM) activity, the polynucleotides encoding the AAM polypeptides, and expression vectors and host cells for expressing the AAM polypeptides.
Abstract translation: 本公开一般涉及具有改进的丙氨酸2,3-氨基变位酶（AAM）活性的多肽，编码AAM多肽的多核苷酸，以及用于表达AAM多肽的表达载体和宿主细胞。
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公开(公告)号：US07957912B2
公开(公告)日：2011-06-07
申请号：US12557463
申请日：2009-09-10
Applicant: Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
Inventor： Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
CPC classification number: G06F19/16 , B01J2219/007 , C40B50/02 , G06F19/14 , G06F19/18 , G06F19/22 , G06F19/24
Abstract: In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided. One disclosed method involves identifying and producing a polypeptide. The method may involve (a) receiving data identifying sequences of two or more parental polypeptides or parental nucleic acids that encode the polypeptides; (b) selecting one or more cross-over sites on the sequences thereby defining one or more recombinant polypeptides or recombinant nucleic acids; (c) selecting at least one of the recombinant polypeptides or recombinant nucleic acids; (d) recombining one or more oligonucleotides, at least one of which has a sequence matching some or all of that of the recombinant polypeptides or recombinant nucleic acids selected in (c); (e) selecting at least some of the recombined oligonucleotides produced in (d); and (f) producing a polypeptide encoded by the selected nucleic acid.
Abstract translation: 在硅胶核酸重组方法中，提供了利用遗传算子和通过计算机改组方法制备的文库的相关综合系统。 一种公开的方法涉及鉴定和产生多肽。 该方法可以包括（a）接收识别编码多肽的两个或多个亲本多肽或亲本核酸的序列的数据; （b）在序列上选择一个或多个交叉位点，从而限定一个或多个重组多肽或重组核酸; （c）选择至少一种重组多肽或重组核酸; （d）重组一种或多种寡核苷酸，其中至少一种具有与（c）中选择的重组多肽或重组核酸的部分或全部相匹配的序列; （e）选择（d）中产生的至少一些重组寡核苷酸; 和（f）产生由所选择的核酸编码的多肽。
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15.发明申请METHODS FOR IDENTIFYING SETS OF OLIGONUCLEOTIDES FOR USE IN AN IN VITRO RECOMBINATION PROCEDURE 有权用于鉴定体外重组程序中使用寡核苷酸的方法公开(公告)号：US20100056385A1
公开(公告)日：2010-03-04
申请号：US12557463
申请日：2009-09-10
Applicant: Sergey A. Selifonov , Willem P.C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
Inventor： Sergey A. Selifonov , Willem P.C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
IPC: C40B30/02
CPC classification number: G06F19/16 , B01J2219/007 , C40B50/02 , G06F19/14 , G06F19/18 , G06F19/22 , G06F19/24
Abstract: In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
Abstract translation: 在硅胶核酸重组方法中，提供了利用遗传算子和通过计算机改组方法制备的文库的相关综合系统。
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Patent Agency Ranking
16.发明申请公开(公告)号：US20080050782A1
公开(公告)日：2008-02-28
申请号：US11975638
申请日：2007-10-18
Applicant: Sergey Selifonov , Willem Stemmer , Claes Gustafsson , Matthew Tobin , Stephen Cardayre , Phillip Patten , Jeremy Minshull , Lorraine Giver
Inventor： Sergey Selifonov , Willem Stemmer , Claes Gustafsson , Matthew Tobin , Stephen Cardayre , Phillip Patten , Jeremy Minshull , Lorraine Giver
CPC classification number: G06F19/16 , B01J2219/007 , C40B50/02 , G06F19/14 , G06F19/18 , G06F19/22 , G06F19/24
Abstract: In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
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17.发明申请公开(公告)号：US20080015116A1
公开(公告)日：2008-01-17
申请号：US11677505
申请日：2007-02-21
Applicant: Steven Bass , S. Davis , Phillip Patten , Matthew Tobin , Jeremy Minshull , Mark Welch , Claus Gustafsson , Brian Carr , Stephane Jenne , Sun Raillard , Andreas Crameri , Willem Stemmer , Robin Emig , Pascal Longschamp , Stanley Goldman , Lorraine Giver , Joseph Affholter
Inventor： Steven Bass , S. Davis , Phillip Patten , Matthew Tobin , Jeremy Minshull , Mark Welch , Claus Gustafsson , Brian Carr , Stephane Jenne , Sun Raillard , Andreas Crameri , Willem Stemmer , Robin Emig , Pascal Longschamp , Stanley Goldman , Lorraine Giver , Joseph Affholter
IPC: C40B60/04
CPC classification number: C12N15/1031 , B01J19/0046 , B01J2219/00378 , B01J2219/00585 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/00722 , B82Y30/00 , C12N15/1027 , C40B60/04 , G06F19/18 , Y02A90/22
Abstract: Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.
Abstract translation: 提供了用于多样化生成和筛选的集成系统和方法。 该系统使用普通液体和阵列处理组分来提供核酸多样化，转录，翻译，产物筛选和随后的多样化反应。
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18.发明申请公开(公告)号：US20070026446A1
公开(公告)日：2007-02-01
申请号：US11506215
申请日：2006-08-17
Applicant: Stephen del Cardayre , Matthew Tobin , Willem Stemmer , Jon Ness , Jeremy Minshull , Phillip Patten , Venkiteswaran Subramanian , Linda Castle , Claus Krebber , Steven Bass , Ying-Xin Zhang , Tony Cox , Gjalt Huisman , Ling Yuan , Joseph Affholter
Inventor： Stephen del Cardayre , Matthew Tobin , Willem Stemmer , Jon Ness , Jeremy Minshull , Phillip Patten , Venkiteswaran Subramanian , Linda Castle , Claus Krebber , Steven Bass , Ying-Xin Zhang , Tony Cox , Gjalt Huisman , Ling Yuan , Joseph Affholter
CPC classification number: C12R1/465 , A01K2267/02 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12N15/90 , C12P17/162 , C12Q1/6811 , C12Q1/6827
Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
Abstract translation: 本发明提供了采用迭代循环重组和选择/筛选全细胞和生物体以获得所需性质的方法的方法。 这些性质的实例包括增加的重组原性，基因组拷贝数以及蛋白质和次级代谢物的表达和/或分泌能力。
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19.发明授权公开(公告)号：US06716631B1
公开(公告)日：2004-04-06
申请号：US09516695
申请日：2000-03-01
Applicant: Stephen delCardayre , Matthew Tobin , William P. C. Stemmer , Jon E. Ness , Jeremy Minshull , Phillip Patten
Inventor： Stephen delCardayre , Matthew Tobin , William P. C. Stemmer , Jon E. Ness , Jeremy Minshull , Phillip Patten
IPC: C12N1500
CPC classification number: C12N15/102 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12P17/162 , C12Q1/68 , C12Q1/6811 , C12Q1/6827 , C12R1/465
Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
Abstract translation: 本发明提供了采用迭代循环重组和选择/筛选全细胞和生物体以获得所需性质的方法的方法。 这些性质的实例包括增加的重组原性，基因组拷贝数以及蛋白质和次级代谢物的表达和/或分泌能力。
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20.发明授权公开(公告)号：US08014961B2
公开(公告)日：2011-09-06
申请号：US11677505
申请日：2007-02-21
Applicant: Steven H. Bass , Simon Christopher Davis , Phillip A. Patten , Matthew Tobin , Jeremy S. Minshull , Mark Welch , Claus Gustafsson , Brian Carr , Stephan J. Jenne , Sun Ai Raillard , Andreas Crameri , Willem P. C. Stemmer , Robin Emig , Pascal Longchamp , Stanley Goldman , Lorraine J. Giver , Joseph A. Affholter
Inventor： Steven H. Bass , Simon Christopher Davis , Phillip A. Patten , Matthew Tobin , Jeremy S. Minshull , Mark Welch , Claus Gustafsson , Brian Carr , Stephan J. Jenne , Sun Ai Raillard , Andreas Crameri , Willem P. C. Stemmer , Robin Emig , Pascal Longchamp , Stanley Goldman , Lorraine J. Giver , Joseph A. Affholter
IPC: G01N33/48
CPC classification number: C12N15/1031 , B01J19/0046 , B01J2219/00378 , B01J2219/00585 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/00722 , B82Y30/00 , C12N15/1027 , C40B60/04 , G06F19/18 , Y02A90/22
Abstract: Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.
Abstract translation: 提供了用于多样化生成和筛选的集成系统和方法。 该系统使用普通液体和阵列处理组分来提供核酸多样化，转录，翻译，产物筛选和随后的多样化反应。
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