公开(公告)号：US06309664B1

公开(公告)日：2001-10-30

申请号：US09396535

申请日：1999-09-15

Applicant: Rajiv Mathur ,  Nadya Lawrence

Inventor： Rajiv Mathur ,  Nadya Lawrence

IPC: A61K9127

CPC classification number: A61Q17/00 ,  A61K8/14 ,  A61K8/31 ,  Y10S514/847 ,  Y10T428/2984

Abstract: A fluid preparation of petrolatum capable of being sprayed on to a surface. The preparation includes paucilamellar lipid vesicles containing the petrolatum. Preferably, petrolatum comprises about 20-30% or more of the total weight of the vesicles. Methods of protecting the skin of mammals using the fluid preparation of petrolatum are also discussed.

Abstract translation: 能够喷洒在表面上的凡士林的流体制剂。 该制剂包括含有凡士林的薄膜脂质囊泡。 优选地，凡士林含有囊泡总重量的约20-30％或更多。 还讨论了使用凡士林流体制剂保护哺乳动物皮肤的方法。

公开(公告)号：US6080211A

公开(公告)日：2000-06-27

申请号：US252546

申请日：1999-02-19

Applicant: Rajiv Mathur

Inventor： Rajiv Mathur

IPC: F02M25/00 ,  C10L1/10 ,  C10L1/12 ,  C10L1/18 ,  C10L1/182 ,  C10L1/19 ,  C10L1/24 ,  C10L1/26 ,  C10L1/32 ,  C10L10/02 ,  C10L1/14

CPC classification number: C10L10/02 ,  C10L1/10 ,  C10L1/125 ,  C10L1/1258 ,  C10L1/1266 ,  C10L1/18 ,  C10L1/1824 ,  C10L1/1857 ,  C10L1/19 ,  C10L1/1985 ,  C10L1/24 ,  C10L1/26

Abstract: Liquid energy sources, e.g., liquid fuels comprising lipid vesicles having fuel additives such as water are disclosed herein. The liquid energy sources, methods for preparation, and methods of enhancing engine performance disclosed herein employing the lipid vesicles result in enhanced fuel efficiency and/or lowered engine emissions. The invention further relates to liquid energy sources containing such additives which further comprise a polymeric dispersion assistant, which reduces the interfacial tension and coalescence of vesicles during dispersion process and storage, and thereby provide transparent looks to the liquid energy source.

公开(公告)号：US5776536A

公开(公告)日：1998-07-07

申请号：US772354

申请日：1996-12-23

Applicant: Paul A. Tremblay ,  Rajiv Mathur

Inventor： Paul A. Tremblay ,  Rajiv Mathur

IPC: A23G1/00 ,  A23G1/30 ,  A23G1/32 ,  A23G1/36 ,  A23L1/035

CPC classification number: A23G1/30 ,  A23G1/325 ,  A23G1/36 ,  Y10S426/804

Abstract: A reduced fat chocolate preparation comprising lipid vesicles is disclosed. Also disclosed is a method of manufacturing the reduced fat chocolate preparation. The chocolate has less fat than regular chocolate and a higher percentage of water.

Abstract translation: 公开了包含脂质囊泡的还原脂肪巧克力制剂。 还公开了制备减肥脂巧克力制剂的方法。 巧克力比常规巧克力的脂肪少，水分含量较高。

公开(公告)号：US5756014A

公开(公告)日：1998-05-26

申请号：US838633

申请日：1997-04-11

Applicant: Rajiv Mathur

Inventor： Rajiv Mathur

IPC: A61K8/00 ,  A61K8/11 ,  A61K8/14 ,  A61K8/34 ,  A61K8/36 ,  A61K8/37 ,  A61K8/39 ,  A61K8/40 ,  A61K8/97 ,  A61K8/98 ,  A61K9/127 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q1/06 ,  B01J13/02 ,  B01J13/06

CPC classification number: B01J13/02 ,  A61K8/14 ,  A61K8/39 ,  A61K9/1272 ,  A61Q1/06 ,  Y10T428/2984 ,  Y10T428/2985 ,  Y10T428/2989

Abstract: Lipid vesicles which remain stable at high temperatures are disclosed. The vesicles contain as a component of their lipid bilayers at least one ethoxylated alcohol having a linear C20-C50 carbon chain. Also disclosed is a method of making the vesicles. The lipid vesicles are useful in forming cosmetic and dermatologic preparations, such as lipstick, which are processed at high temperatures (e.g., at 80.degree. C. or above) during manufacture.

Abstract translation: 公开了在高温下保持稳定的脂质囊泡。 囊泡含有至少一种具有直链C20-C50碳链的乙氧基化醇作为它们的脂双层的组分。 还公开了制备囊泡的方法。 脂质囊泡可用于形成化妆品和皮肤病学制剂，例如唇膏，其在制造过程中在高温（例如，80℃或更高）下加工。

公开(公告)号：US5490985A

公开(公告)日：1996-02-13

申请号：US210645

申请日：1994-03-18

Applicant: Donald F. H. Wallach ,  Rajiv Mathur ,  Jean Philippot ,  Surendra Kumar

Inventor： Donald F. H. Wallach ,  Rajiv Mathur ,  Jean Philippot ,  Surendra Kumar

IPC: A61K9/127 ,  A61K33/10 ,  A61K31/695 ,  A61K33/06 ,  A61K33/12

CPC classification number: A61K9/1272 ,  A61K33/10

Abstract: An antacid product having extended duration of residence in the gastric and upper intestinal systems has been developed. This antacid product includes a blend of 10-70% by volume nonphospholipid lipid vesicles, with a particulate base. An antiflatulence agent may also be included. A method of providing extended duration amelioration of acid build up in the gastric and upper intestinal tract using this product is also disclosed.

Abstract translation: 已经开发了在胃和上肠系统中延长持续时间的抗酸产品。 该抗酸产品包括10-70体积％的非脂质脂质囊泡与颗粒基质的混合物。 还可以包括抗溢流剂。 还公开了使用该产品在胃和上肠道中延长持续时间改善酸积累的方法。

公开(公告)号：US5405615A

公开(公告)日：1995-04-11

申请号：US148885

申请日：1993-11-08

Applicant: Rajiv Mathur

Inventor： Rajiv Mathur

IPC: A61K8/14 ,  A61K8/92 ,  A61K9/127 ,  A61K47/06 ,  A61K47/26 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q19/08 ,  B01J13/02

CPC classification number: A61Q19/08 ,  A61K8/14 ,  A61K8/922 ,  A61K9/1272 ,  A61Q19/00 ,  A61Q5/12 ,  Y10T428/2984

Abstract: Disclosed are lipid vesicles containing a blend of amphiphiles, including sucrose distearate, in the lipid bilayers. The vesicles may have either an aqueous or oil-filled central cavity and are particularly useful for delivering dermatological, cosmetic and pharmaceutical formulations. A method of manufacture for these vesicles is also disclosed.

Abstract translation: 公开了在脂质双层中含有两亲物（包括蔗糖二硬脂酸酯）的共混物的脂质囊泡。 囊泡可以具有水或油填充的中心腔，并且特别可用于递送皮肤病学，化妆品和药物制剂。 还公开了这些囊泡的制造方法。

公开(公告)号：US06211231B1

公开(公告)日：2001-04-03

申请号：US09570995

申请日：2000-05-15

Applicant: Rajiv Mathur

Inventor： Rajiv Mathur

IPC: A61K3134

CPC classification number: A61K31/34

Abstract: The invention features a method of stabilizing free 1-ascorbic acid from oxidation by dispersing the free 1-ascorbic acid in a mixed glycol carrier and a solution containing the ascorbic acid in the mixed glycol solution. The mixed glycol carrier contains a mixture of at least propylene glycol and butylene glycol, but may contain other glycols such as polyethylene glycol, and stabilizing and solubility assisting agents as well.

Abstract translation: 本发明的特征在于通过将游离的1-抗坏血酸分散在混合的二醇载体和含有抗坏血酸的溶液在混合的二醇溶液中而使游离的1-抗坏血酸免于氧化的方法。 混合乙二醇载体含有至少丙二醇和丁二醇的混合物，但也可以含有其它二醇，如聚乙二醇，以及稳定和助溶剂。

公开(公告)号：US5219538A

公开(公告)日：1993-06-15

申请号：US662850

申请日：1991-03-01

Applicant: Sheryl L. Henderson ,  Donald F. H. Wallach ,  Rajiv Mathur

Inventor： Sheryl L. Henderson ,  Donald F. H. Wallach ,  Rajiv Mathur

IPC: A61K8/14 ,  A61K8/70 ,  A61K9/00 ,  A61K9/127 ,  A61K49/22 ,  A61Q19/00 ,  B01J13/02 ,  B01J13/20 ,  C08K9/04 ,  C08L101/00 ,  C11D17/00

CPC classification number: A61K9/0026 ,  A61K49/227 ,  A61K8/14 ,  A61K8/22 ,  A61K8/70 ,  A61K9/1272 ,  A61K9/1277 ,  A61K9/1278 ,  A61Q19/00 ,  B01J13/203 ,  C11D17/0021 ,  C11D17/0026 ,  Y10S436/829 ,  Y10S514/832 ,  Y10T428/2984

Abstract: The present invention relates to the production of lipid vesicles having a moderately volatile material such as a perfluorocarbon or a silicone oil encapsulated therein. In another aspect, lipid vesicles having a gas-filled center or core are made. The lipid vesicles having gas-filled central core are made by dehydrating vesicles having the moderately volatile liquid encapsulated in the central core. This drives off the water first, allowing the moderately volatile liquid to stabilize the vesicle structure as it dries, finally forming a central void which can refract light. The preferred vesicles of the invention are paucilamellar vesicles.

Abstract translation: 本发明涉及具有中等挥发性物质如全氟化碳或其中包封的硅油的脂质囊泡的生产。 在另一方面，制备具有充气中心或芯的脂质囊泡。 具有气体填充的中心芯的脂质囊泡通过将包含在中心核心中的中等挥发性液体的脱水囊泡制成。 这首先驱除水分，允许中等挥发性液体在干燥时稳定囊泡结构，最终形成可折射光的中心空隙。 本发明的优选囊泡是小泡囊泡。

公开(公告)号：US5164191A

公开(公告)日：1992-11-17

申请号：US654327

申请日：1991-02-12

Applicant: S. Esmail Tabibi ,  An-Cheng Chang ,  Rajiv Mathur ,  Donald F. H. Wallach

Inventor： S. Esmail Tabibi ,  An-Cheng Chang ,  Rajiv Mathur ,  Donald F. H. Wallach

IPC: A61K9/127

CPC classification number: A61K9/1272 ,  Y10T428/2984

Abstract: The present invention features a method of making lipid vesicles and the lipid vesicles themselves made from monomeric and dimeric alkyds. These alkyds are esters made as a condensation product of a first reactant having at least one free hydroxyl group and a C.sub.12 -C.sub.20 fatty acids chain and a second reactant which is an aromatic acid chloride or anhydride. Preferred first reactants are esters of polyols and C.sub.12 -C.sub.20 fatty acids, ethers of polyols and C.sub.12 -C.sub.20 fatty acids, and C.sub.12 -C.sub.20 fatty alcohols.

Abstract translation: 本发明的特征在于制备脂质囊泡的方法，脂质囊泡本身由单体和二聚醇酸树脂制成。 这些醇酸树脂是作为具有至少一个游离羟基的第一反应物和C 12 -C 20脂肪酸链和作为芳族酰氯或酸酐的第二反应物的缩合产物的酯。 优选的第一反应物是多元醇和C 12 -C 20脂肪酸的酯，多元醇和C 12 -C 20脂肪酸的醚和C 12 -C 20脂肪醇。

公开(公告)号：US07205006B2

公开(公告)日：2007-04-17

申请号：US10669416

申请日：2003-09-25

Applicant: Robert Mills ,  Rajiv Mathur ,  Nadya Lawrence

Inventor： Robert Mills ,  Rajiv Mathur ,  Nadya Lawrence

IPC: A61K51/00 ,  A61K31/74 ,  A01N65/00

CPC classification number: A61Q19/00 ,  A61K8/14 ,  A61K8/97 ,  A61K9/0014 ,  A61K9/127 ,  A61K36/29 ,  A61Q19/007

Abstract: A skin treatment composition comprising a Mahonia aquifolium extract in a liposome delivery system. The Mahonia aquifolium extract is present in the skin treatment composition in a range of from 5% to 20% by weight of the total composition. The skin treatment composition is particularly effective in the treatment of psoriasis, eczema and other dry skin conditions. The invention further provides a process for obtaining an extract of Mahonia aquifolium.

Abstract translation: 一种在脂质体递送系统中包含马鞭草提取物的皮肤处理组合物。 马鞭草提取物以总组合物的5重量％至20重量％的范围存在于皮肤处理组合物中。 皮肤治疗组合物在治疗牛皮癣，湿疹和其它干性皮肤病症中特别有效。 本发明还提供了一种获得马鞭草提取物的方法。