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11.发明申请NOVEL AZACYCLYL-SUBSTITUTED ARYLDIHYDROISOQUINOLINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS 有权新乙酰胆碱取代的芳基二氢喹啉酮，其制备方法及其作为药物使用公开(公告)号：US20090264403A1
公开(公告)日：2009-10-22
申请号：US12191662
申请日：2008-08-14
申请人： Lothar SCHWINK , Siegfried STENGELIN , Matthias GOSSEL , Gerhard HESSLER , Torsten HAACK , Petra LENNIG
发明人： Lothar SCHWINK , Siegfried STENGELIN , Matthias GOSSEL , Gerhard HESSLER , Torsten HAACK , Petra LENNIG
IPC分类号： A61K31/4725 , C07D401/10 , C07D405/14 , A61K31/55
CPC分类号： A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D401/10 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The invention relates to azacyclyl-substituted aryldihydroisoquinolinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one azacyclyl-substituted aryldihydroisoquinolinone of the invention or its derivative, and the use of the azacyclyl-substituted aryidihydroisoquinolinones of the invention and their derivatives as MCH antagonists.
摘要翻译： 本发明涉及氮杂环酰基取代的芳基二氢异喹啉酮及其衍生物及其生理上耐受的盐和生理功能衍生物，其制备方法，包含至少一种本发明的氮杂环酰基取代的芳基二氢异喹啉酮或其衍生物的药物，以及使用偶氮基酰基取代的芳酰基异喹啉酮 的本发明及其衍生物作为MCH拮抗剂。
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12.发明申请Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, process for preparing them, medicaments comprising these compounds, and their use 有权芳基氨基芳基 - 烷基取代的咪唑烷-2,4-二酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US20090215728A1
公开(公告)日：2009-08-27
申请号：US12365940
申请日：2009-02-05
IPC分类号： A61K31/675 , C07D233/76 , A61K31/4174 , A61K31/4439 , C07D401/12 , C07F9/6506 , A61P3/10
CPC分类号： C07D233/72
摘要： This invention relates to arylaminoaryl-alkyl-substituted imidazolidone-2,4-diones of formula (I) and also to their physiologically tolerated salts: Wherein R, R′, R1 to R10, A, D, E, G, L and p are as defined herein. The invention also relates to processes for preparing them, pharmaceutical compositions comprising them and their therapeutic use. The compounds are suitable, for example, as anti-obesity drugs and for treating cardiometabolic syndrome.
摘要翻译： 本发明涉及式（I）的芳基氨基芳基 - 烷基取代的咪唑烷酮-2,4-二酮，也涉及其生理上耐受的盐：其中R，R'，R 1至R 10，A，D，E，G，L和p 如本文所定义。 本发明还涉及制备它们的方法，包含它们的药物组合物及其治疗用途。 该化合物例如适合作为抗肥胖药物和治疗心脏代谢综合征。
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13.发明申请NOVEL AMINOALCOHOL-SUBSTITUTED ARYLDIHYDROISOQUINOLINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS 有权新型氨基醇取代的芳基二氢喹啉酮，其制备方法及其作为药物使用公开(公告)号：US20090082391A1
公开(公告)日：2009-03-26
申请号：US12191697
申请日：2008-08-14
申请人： Lothar SCHWINK , Siegfried STENGELIN , Matthias GOSSEL , Gerhard HESSLER , Torsten HAACK , Petra LENNIG
发明人： Lothar SCHWINK , Siegfried STENGELIN , Matthias GOSSEL , Gerhard HESSLER , Torsten HAACK , Petra LENNIG
IPC分类号： A61K31/4365 , C07D495/04
CPC分类号： C07D471/04 , C07D217/24 , C07D401/12 , C07D451/06 , C07D453/02 , C07D455/06
摘要： The invention relates to aminoalcohol-substituted aryldihydroisoquinolinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one aminoalcohol-substituted aryldihydroisoquinolinone of the invention or its derivative, and the use of the aminoalcohol-substituted aryldihydroisoquinolinones of the invention and their derivatives as MCH antagonists.
摘要翻译： 本发明涉及氨基醇取代的芳基二氢异喹啉酮及其衍生物及其生理上耐受的盐和生理功能衍生物，其制备方法，包含至少一种本发明的氨基醇取代的芳基二氢异喹啉酮或其衍生物的药物，以及氨基醇取代的芳基二氢异喹啉酮的用途 的本发明及其衍生物作为MCH拮抗剂。
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14.发明申请ARYL-SUBSTITUTED HETEROCYCLES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS 有权ARYL取代的杂环化合物，其制备方法及其作为药物的用途公开(公告)号：US20080207707A1
公开(公告)日：2008-08-28
申请号：US11946286
申请日：2007-11-28
申请人： Lothar Schwink , Siegfried Stengelin , Thomas Boehme , Matthias Gossel , Gerhard Hessler , Petra Stahl
发明人： Lothar Schwink , Siegfried Stengelin , Thomas Boehme , Matthias Gossel , Gerhard Hessler , Petra Stahl
IPC分类号： A61K31/4245 , C07D271/10 , A61P3/00
CPC分类号： A61K31/4439 , A61K31/497 , A61K31/501 , A61K45/06 , A61K2300/00
摘要： The invention relates to substituted aryl-substituted heterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof, to process for their preparation and to their use as medicaments.Compounds of the formula I in which the radicals have the stated meanings, the N-oxides thereof, and the physiologically tolerated salts thereof, and process for the preparation thereof are described. The compounds bring about for example a weight reduction in mammals and are suitable for example for the prevention and treatment of obesity and diabetes.
摘要翻译： 本发明涉及取代的芳基取代的杂环及其生理上耐受的盐和生理功能衍生物，用于其制备及其作为药物的用途。 描述了其中基团具有所述含义的式I化合物，其N-氧化物及其生理上耐受的盐及其制备方法。 所述化合物例如引起哺乳动物的体重减轻，并且适合于例如预防和治疗肥胖症和糖尿病。
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15.发明申请Substituted N-aryl Heterocycles, Process For Their Preparation and Their Use As Medicaments 有权取代的N-芳基杂环，其制备方法及其用作药物公开(公告)号：US20070207991A1
公开(公告)日：2007-09-06
申请号：US11622028
申请日：2007-01-11
申请人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Thomas Boehme , Gerhard Hessler , Petra Stahl , Dirk Gretzke
发明人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Thomas Boehme , Gerhard Hessler , Petra Stahl , Dirk Gretzke
IPC分类号： A61K31/55 , A61K31/551 , A61K31/541 , A61K31/5377 , A61K31/497 , A61K31/506 , A61K31/501
CPC分类号： C07D207/26 , C07D205/04 , C07D207/14 , C07D207/16 , C07D207/34 , C07D211/58 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The invention relates to substituted N-aryl heterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof. Compounds of the formula I in which the radicals have the stated meanings the N-oxides and the physiologically tolerated salts thereof and process for the preparation thereof are described. The compounds are suitable for example as anorectic agents.
摘要翻译： 本发明涉及取代的N-芳基杂环及其生理上耐受的盐和生理功能衍生物。 描述了其中基团具有所述含义的式I的化合物，其中N-氧化物及其生理上可耐受的盐及其制备方法。 该化合物适合于例如厌食剂。
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16.发明授权Substituted diaryl heterocycles, process for their preparation and their use as medicaments 有权取代的二芳基杂环，其制备方法及其作为药物的用途公开(公告)号：US07141561B2
公开(公告)日：2006-11-28
申请号：US10626314
申请日：2003-07-24
申请人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Thomas Boehme , Gerhard Hessler , Gerard Rosse , Armin Walser
发明人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Thomas Boehme , Gerhard Hessler , Gerard Rosse , Armin Walser
IPC分类号： A61K31/397 , A61K31/415 , C07D417/10 , C07D401/10 , C07D233/02
CPC分类号： C07D233/92 , C07D209/02 , C07D233/32 , C07D233/70 , C07D233/74 , C07D233/94 , C07D243/04 , C07D249/12 , C07D401/12 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/10 , C07D409/12 , C07D417/12 , C07D487/08 , C07D491/10
摘要： This invention discloses and claims diary heterocycles of formula (I) and their pharmaceutically acceptable salts, pharmaceutical compositions thereof, and methods of using said compounds of formula (I) for the treatment or prevention of excessive weight or obesity, and for treatment of Type II diabetes, arteriosclerosis, high blood pressure, depression, anxiety, anxiety neuroses, and schizophrenia. Methods for treatment of excessive weight or obesity and for treatment of Type II diabetes with a mixture of a compound of formula I and antiobesity agents or appetite-regulating active ingredients, or with a mixture of a compound of formula I and antidiabetics or hypoglycemic active ingredients are also disclosed and claimed.
摘要翻译： 本发明公开并要求式（I）的日记杂环及其药学上可接受的盐，其药物组合物，以及使用式（I）化合物治疗或预防过度体重或肥胖以及用于治疗II型 糖尿病，动脉硬化，高血压，抑郁，焦虑，焦虑神经症和精神分裂症。 用于治疗过度体重或肥胖以及用式I化合物与抗肥胖剂或食欲调节活性成分的混合物或与式I化合物与抗糖尿病药或降血糖活性成分的混合物治疗II型糖尿病的方法 也被公开和要求保护。
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公开(公告)号：US6114322A
公开(公告)日：2000-09-05
申请号：US361530
申请日：1999-07-27
申请人： Alfons Enhsen , Eugen Falk , Heiner Glombik , Siegfried Stengelin
发明人： Alfons Enhsen , Eugen Falk , Heiner Glombik , Siegfried Stengelin
IPC分类号： C12N15/09 , A61K31/55 , A61K31/554 , A61K31/675 , A61K31/70 , A61K48/00 , A61P1/16 , A61P3/06 , A61P3/10 , A61P9/10 , A61P35/00 , C07D281/00 , C07D281/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07F9/6558 , C07H17/00 , C12N5/00 , C12N5/10 , C12N9/12 , C12N15/06 , C12N15/10 , C12N15/11 , C12N15/54 , C12N15/85 , C12P21/02 , C12R1/91
CPC分类号： C07D417/04 , C07D281/00 , C07H17/00 , Y02P20/55
摘要： The present invention is concerned with new hypolipidemic compounds, with processes and novel intermediates for their preparation, with pharmaceutical compositions containing them and with their use in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions, such as atherosclerosis.Compounds of the formula (I): ##STR1## wherein R.sup.1 to R.sup.10 and X are as defined in the Specification and useful as hypolipidemic compounds.
摘要翻译： 本发明涉及新的降血脂化合物，其制备方法和新的中间体，含有它们的药物组合物和它们在医药中的用途，特别是用于预防和治疗高脂血症病症如动脉粥样硬化。 式（I）的化合物：其中R 1至R 10和X如说明书中所定义并可用作降血脂化合物。
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18.发明授权Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament 有权螺环取代的1,3-丙二醇衍生物，其制备方法及其作为药物的用途公开(公告)号：US08859494B2
公开(公告)日：2014-10-14
申请号：US13176333
申请日：2011-07-05
申请人： Stefanie Keil , Elisabeth Defossa , Viktoria Dietrich , Siegfried Stengelin , Andreas Herling , Guido Haschke , Thomas Klabunde
发明人： Stefanie Keil , Elisabeth Defossa , Viktoria Dietrich , Siegfried Stengelin , Andreas Herling , Guido Haschke , Thomas Klabunde
IPC分类号： A61K38/28 , A61P5/50 , C07C59/72 , C07D213/64 , C07D305/06 , C07D213/65
CPC分类号： C07C59/72 , C07D213/64 , C07D213/65 , C07D305/06
摘要： The invention relates to spirocyclically substituted 1,3-propane dioxide derivatives, and to the physiologically compatible salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3, R4, R5, R6, R7, R8, A and X are each defined as specified, and the physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
摘要翻译： 本发明涉及螺环取代的1,3-丙二醇衍生物及其与生理相容的盐。 本发明涉及其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，A和X各自如上所定义的式Ⅰ化合物及其生理上相容的盐。 该化合物适用于例如治疗糖尿病。
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19.发明授权Azacyclyl-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments 有权亚烷基取代的芳基噻吩并嘧啶酮，其制备方法及其作为药物的用途公开(公告)号：US08828991B2
公开(公告)日：2014-09-09
申请号：US12191630
申请日：2008-08-14
申请人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Gerhard Hessler , Torsten Haack , Petra Lennig
发明人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Gerhard Hessler , Torsten Haack , Petra Lennig
IPC分类号： C07D495/04 , A61K31/519 , C07D403/10 , C07D239/91 , C07D491/04 , A61K31/517 , A61K31/551 , A61P3/10 , A61P3/04 , C12N9/99
CPC分类号： C07D491/04 , C07D239/91 , C07D403/10 , C07D495/04 , C12N9/99
摘要： The invention relates to azacyclyl-substituted arylthienopyrimidinones and their derivatives, of the Formula (I); and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one azacyclyl-substituted arylthienopyrimidinone according to Formula (I) or its derivative, and the use of the azacyclyl-substituted arylthienopyrimidinones according to Formula (I) and their derivatives as MCH antagonists.
摘要翻译： 本发明涉及式（I）的氮杂环酰基取代的芳基噻吩并嘧啶酮及其衍生物; 以及它们的生理学耐受的盐和生理功能衍生物及其制备方法，包含至少一种式（I）的氮杂环酰基取代的芳基噻吩并嘧啶酮或其衍生物的药物，以及根据式（I）的氮杂环酰基取代的芳基噻吩并嘧啶酮及其衍生物 作为MCH拮抗剂。
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20.发明授权Substituted indanes, method for the production thereof, and use thereof as drugs 有权取代的茚满，其制备方法及其作为药物的用途公开(公告)号：US08552199B2
公开(公告)日：2013-10-08
申请号：US13201410
申请日：2010-02-12
IPC分类号： A61K31/44 , C07D211/72
CPC分类号： C07D309/04 , C07C235/54 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D205/04 , C07D207/09 , C07D207/12 , C07D211/14 , C07D211/22 , C07D211/46 , C07D213/81 , C07D295/135 , C07D307/14 , C07D401/12 , C07D405/12 , C07D471/04
摘要： The invention relates to substituted indanes and derivatives thereof, to physiologically acceptable salts and physiologically functional derivatives thereof, to the production thereof, to drugs containing at least one substituted indane according to the invention or derivative thereof, and to the use of the substituted indanes according to the invention and to derivatives thereof as MCH antagonists.
摘要翻译： 本发明涉及取代的茚满及其衍生物，其生理上可接受的盐和生理功能衍生物，其生产方法，涉及含有至少一种本发明取代的二氢化茚或其衍生物的药物，以及根据 本发明及其衍生物作为MCH拮抗剂。
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