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    Apparatus and methods for self-biasing differential signaling circuitry having multimode output configurations for low voltage applications
    13.
    发明授权
    Apparatus and methods for self-biasing differential signaling circuitry having multimode output configurations for low voltage applications 有权
    具有用于低电压应用的多模输出配置的用于自偏压差动信号电路的装置和方法

    公开(公告)号：US07495477B2

    公开(公告)日：2009-02-24

    申请号：US11830897

    申请日：2007-07-31

    Applicant: Junho Cho ,  Nancy Chan ,  Ramesh Senthinathan ,  Stephen Yue ,  Richard W. Fung

    Inventor： Junho Cho ,  Nancy Chan ,  Ramesh Senthinathan ,  Stephen Yue ,  Richard W. Fung

    IPC: H03K19/094

    CPC classification number: H03K17/302 ,  H03K17/04106

    Abstract: The present disclosure relates to a differential signaling circuit including differential signaling circuitry having at least one output and one input, that can operate in multiple mode of operations while using a single, low voltage supply source. Two or more switches are included and configured to selectively couple a supply voltage to the output dependent on a mode of operation of the differential signaling circuitry. The circuit also includes a switch control biasing circuit operatively coupled to at least one of the switches and to the output of the differential signaling circuitry. The switch control biasing circuit provides a switch control biasing voltage to control a state of the switch based on a voltage level of the output. Further, a bulk biasing circuit is included and operatively coupled to the switch. The bulk biasing circuit selectively provides a bulk biasing voltage to the switch based on the voltage level of the output.

    Abstract translation: 本公开涉及一种差分信号电路，其包括具有至少一个输出和一个输入的差分信号电路，其可以在使用单个低电压电源时在多种操作模式下操作。 两个或更多个开关被包括并配置成根据差分信号电路的操作模式选择性地将电源电压耦合到输出。 电路还包括可操作地耦合到开关中的至少一个和差分信号电路的输出的开关控制偏置电路。 开关控制偏置电路提供开关控制偏置电压，以基于输出的电压电平来控制开关的状态。 此外，体积偏置电路被包括并且可操作地耦合到开关。 体积偏置电路基于输出的电压电平选择性地向开关提供体积偏置电压。

    Aza-Benzazolium Containing Cyanine Dyes
    15.
    发明申请
    Aza-Benzazolium Containing Cyanine Dyes 有权
    含有氰基染料的氮杂 - 唑烷鎓

    公开(公告)号：US20080044811A1

    公开(公告)日：2008-02-21

    申请号：US11756765

    申请日：2007-06-01

    Applicant: Richard Haugland ,  Stephen Yue

    Inventor： Richard Haugland ,  Stephen Yue

    IPC: C12Q1/70 ,  C12Q1/68 ,  G01N33/00 ,  G01N33/68

    CPC classification number: C09B23/02 ,  C12Q1/6816 ,  C12Q1/6876 ,  G01N1/30 ,  G01N27/44726 ,  G01N33/52 ,  G01N33/5308 ,  G01N33/531 ,  G01N33/582 ,  G01N33/68 ,  G01N2001/302 ,  Y10S436/80 ,  Y10T436/143333 ,  C12Q2563/173 ,  C12Q2563/107

    Abstract: Unsymmetrical cyanine dyes that incorporate an aza-benzazolium ring moiety are described, including cyanine dyes substituted by a cationic side chain, monomeric and dimeric cyanine dyes, chemically reactive cyanine dyes, and conjugates of cyanine dyes. The subject dyes are virtually non-fluorescent when diluted in aqueous solution, but exhibit bright fluorescence when associated with nucleic acid polymers such as DNA or RNA, or when associated with detergent-complexed proteins. A variety of applications are described for detection and quantitation of nucleic acids and detergent-complexed proteins in a variety of samples, including solutions, electrophoretic gels, cells, and microorganisms.

    Abstract translation: 描述了包含氮杂 - 苯并唑鎓环部分的不对称花青染料，包括由阳离子侧链取代的花青染料，单体和二聚花青染料，化学反应性花青染料和花青染料的缀合物。 当在水溶液中稀释时，受试染料实际上是非荧光的，但当与核酸聚合物如DNA或RNA相关联时或当与洗涤剂复合的蛋白质相关时，它们显示出明亮的荧光。 描述了用于检测和定量多种样品中的核酸和洗涤剂复合蛋白质的各种应用，包括溶液，电泳凝胶，细胞和微生物。

    Cyanine compounds and their application as quenching compounds
    16.
    发明授权
    Cyanine compounds and their application as quenching compounds 有权
    花青化合物及其作为淬灭化合物的应用

    公开(公告)号：US07271265B2

    公开(公告)日：2007-09-18

    申请号：US10916822

    申请日：2004-08-11

    Applicant: Rosaria Haugland ,  Ching-Ying Cheung ,  Stephen Yue

    Inventor： Rosaria Haugland ,  Ching-Ying Cheung ,  Stephen Yue

    IPC: C07D401/10 ,  C07D417/10 ,  C07D403/10

    CPC classification number: C12Q1/6876 ,  C07D209/12 ,  C07D209/14 ,  C07D209/24 ,  C07D401/04 ,  C09B23/12

    Abstract: The present invention provides methods and non-fluorescent carbocyanine quencher compounds having the general formula: Wherein the A moiety is a substituted pyridinium, unsubstituted pyridinium, substituted quinolinium, unsubstituted quinolinium, substituted benzazolium, unsubstituted benzazolium, substituted indolinium, or unsubstituted indolinium. The invention further provides luminescent donor molecule-quencher pairs and luminescent donor molecule-quencher-luminescent acceptor molecule conjugates wherein the quencher is a cyanine compound of the present invention. The energy transfer pairs are used to detect an analyte of interest in a sample.

    Abstract translation: 本发明提供了具有以下通式的方法和非荧光碳花青猝灭剂化合物：其中A部分是取代的吡啶鎓，未取代的吡啶鎓，取代的喹啉鎓，未取代的喹啉鎓，取代的苯并唑鎓，未取代的苯并咪唑鎓，取代的二氢吲哚鎓或未取代的吲哚啉鎓。 本发明还提供了发光供体分子猝灭剂对和发光供体分子 - 猝灭剂 - 发光受体分子缀合物，其中猝灭剂是本发明的花青化合物。 能量转移对用于检测样品中感兴趣的分析物。

    Apparatus and methods for self-biasing differential signaling circuitry having multimode output configurations for low voltage applications
    17.
    发明授权
    Apparatus and methods for self-biasing differential signaling circuitry having multimode output configurations for low voltage applications 有权
    具有用于低电压应用的多模输出配置的用于自偏压差动信号电路的装置和方法

    公开(公告)号：US07253663B2

    公开(公告)日：2007-08-07

    申请号：US11160243

    申请日：2005-06-15

    Applicant: Junho Cho ,  Nancy Chan ,  Ramesh Senthinathan ,  Stephen Yue ,  Richard W Fung

    Inventor： Junho Cho ,  Nancy Chan ,  Ramesh Senthinathan ,  Stephen Yue ,  Richard W Fung

    IPC: H03K19/094

    CPC classification number: H03K17/302 ,  H03K17/04106

    Abstract: The present disclosure relates to a differential signaling circuit including differential signaling circuitry having at least one output and one input, that can operate in multiple mode of operations while using a single, low voltage supply source. Two or more switches are included and configured to selectively couple a supply voltage to the output dependent on a mode of operation of the differential signaling circuitry. The circuit also includes a switch control biasing circuit operatively coupled to at least one of the switches and to the output of the differential signaling circuitry. The switch control biasing circuit provides a switch control biasing voltage to control a state of the switch based on a voltage level of the output. Further, a bulk biasing circuit is included and operatively coupled to the switch. The bulk biasing circuit selectively provides a bulk biasing voltage to the switch based on the voltage level of the output.

    Abstract translation: 本公开涉及一种差分信号电路，其包括具有至少一个输出和一个输入的差分信号电路，其可以在使用单个低电压电源时在多种操作模式下操作。 两个或更多个开关被包括并配置成根据差分信号电路的操作模式选择性地将电源电压耦合到输出。 电路还包括可操作地耦合到至少一个开关和差分信号电路的输出的开关控制偏置电路。 开关控制偏置电路提供开关控制偏置电压，以基于输出的电压电平来控制开关的状态。 此外，体积偏置电路被包括并且可操作地耦合到开关。 体积偏置电路基于输出的电压电平选择性地向开关提供体积偏置电压。

    Steel tube alloy
    19.
    发明授权
    Steel tube alloy 失效
    钢管合金

    公开(公告)号：US5226978A

    公开(公告)日：1993-07-13

    申请号：US751071

    申请日：1991-08-28

    Applicant: Patrick J. Hunt ,  John J. Jonas ,  Stephen Yue ,  George E. Ruddle

    Inventor： Patrick J. Hunt ,  John J. Jonas ,  Stephen Yue ,  George E. Ruddle

    IPC: C21D6/02 ,  C21D8/10

    CPC classification number: C21D8/10 ,  C21D6/02 ,  Y10S148/909

    Abstract: Seamless steel tubes suitable for use as grades of casing and line pipe having yield strengths in excess of 70,000 psi, without being heat treated, are made of an alloy comprising, by weight, about 0.10% to 0.18% carbon, about 1.0% to 2.0% manganese, about 0.10% to 0.16% vanadium, about 0.008% to 0.012% titanium and about 150 parts per million to 220 parts per million nitrogen, the balance comprising iron and incidental impurities. Strains are applied to the shell in a stretch reducing mill below the T.sub.nr of the steel and above the A.sub.r3 to provoke dynamic recrystallization. The nitrogen and vanadium are preferably introduced to the steel during alloying in the form of a VN alloying agent. The vanadium, titanium and nitrogen are predominantly present as vanadium nitride and titanium nitride. The steel may also comprise 0.03% to 0.05% aluminum by weight.

    Abstract translation: 适用于不经热处理的屈服强度超过70,000psi的套管和管线管等级的无缝钢管由合金制成，该合金包含重量约0.10％至0.18％的碳，约1.0％至2.0％ 约0.10％至0.16％的钒，约0.008％至0.012％的钛和约150份的百万分之一至220份/百万的氮，余量包括铁和杂质。 将菌株施加到钢的Tnr下方的拉伸还原研磨机中并在Ar 3上方引起动态再结晶。 氮和钒优选在VN合金化剂形式的合金化过程中引入钢中。 钒，钛和氮主要作为氮化钒和氮化钛存在。 钢还可以包含0.03重量％至0.05重量％的铝。

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