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公开(公告)号：US20110114206A1
公开(公告)日：2011-05-19
申请号：US12945793
申请日：2010-11-12
Applicant: Debjyoti Banerjee , Umberto Ulmanella , Konrad Faulstich , Aldrich N.K. Lau , Jun Xie
Inventor： Debjyoti Banerjee , Umberto Ulmanella , Konrad Faulstich , Aldrich N.K. Lau , Jun Xie
IPC: F15D1/00
CPC classification number: F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
Abstract: A diagnostic device is provided that includes a plurality of retainment regions interconnected through at least one fluid processing passageway or separated by at least one barrier. A fluid flow modulator can be provided in the fluid processing passageway if a fluid processing passageway is provided. The barrier and/or fluid flow modulator can comprise a polysaccharide, a derivative of a polysaccharide, or a combination thereof. For example, the barrier can comprise a chitosan material.
Abstract translation: 提供了一种诊断装置，其包括通过至少一个流体处理通道互连或由至少一个屏障隔开的多个保持区域。 如果提供流体处理通道，流体流动调节器可以设置在流体处理通道中。 阻隔和/或流体流动调节器可以包含多糖，多糖的衍生物或其组合。 例如，阻挡层可以包含壳聚糖材料。
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公开(公告)号：US20070014695A1
公开(公告)日：2007-01-18
申请号：US11380327
申请日：2006-04-26
Applicant: Min Yue , David Liu , Yuh-Min Chiang , Joon Mo Yang , Dennis Lehto , Charles Vann , Nigel Beard , Ian Harding , John Van Camp , Alexander Dromaretsky , Sergey Ermakov , Mark Oldham , Joy Roy , Maryam Shariati , Umberto Ulmanella
Inventor： Min Yue , David Liu , Yuh-Min Chiang , Joon Mo Yang , Dennis Lehto , Charles Vann , Nigel Beard , Ian Harding , John Van Camp , Alexander Dromaretsky , Sergey Ermakov , Mark Oldham , Joy Roy , Maryam Shariati , Umberto Ulmanella
IPC: B01L3/00
CPC classification number: C12Q1/6806 , B01J2219/00317 , B01J2219/00722 , B01L3/502707 , B01L3/502723 , B01L3/50853 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/041 , B01L2300/048 , B01L2300/0636 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/087 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0694 , G01N35/028 , Y10T436/2575
Abstract: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
Abstract translation: 用于多个分析物检测的系统和方法包括用于分配包括基底的生物样品的系统，其中所述基底包括多个样品室，用于每个样品室的样品引入通道和用于每个样品室的排气通道。 该系统可以进一步包括包含在每个样品室中并被配置用于进入基底的生物样品的核酸分析的预加载试剂和被配置为与基底接触以密封每个样品室以便基本上防止 每个样品室中包含的样品从每个样品室流出。 底物可以由检测相容和测定相容的材料构成。
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公开(公告)号：US08092664B2
公开(公告)日：2012-01-10
申请号：US12793548
申请日：2010-06-03
Applicant: Umberto Ulmanella
Inventor： Umberto Ulmanella
IPC: G01N27/453 , F16K31/02
CPC classification number: F16K99/0042 , B01L3/50273 , B01L3/502738 , B01L2200/0673 , B01L2300/0861 , B01L2400/0427 , F16K99/0001 , F16K99/0017 , F16K99/0019 , F16K2099/0084 , G05D7/0694 , Y10T137/0391 , Y10T137/212 , Y10T137/2931 , Y10T137/8593 , Y10T137/86493
Abstract: The present teachings relate to microfluidic valves and pumping systems, which may be suitable for controlling and facilitating liquid flow. Electrodes are disposed proximately to volumes containing a liquid. The liquid flow can be facilitated by electrowetting forces. Processes for controlling the flow of liquids, as well as for pumping liquids, are also disclosed.
Abstract translation: 本教导涉及微流体阀和泵送系统，其可适用于控制和促进液体流动。 电极靠近容纳液体的体积放置。 可以通过电润湿力促进液体流动。 还公开了用于控制液体流动以及泵送液体的方法。
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公开(公告)号：US20100136701A1
公开(公告)日：2010-06-03
申请号：US12627799
申请日：2009-11-30
Applicant: Debjyoti Banerjee , Konrad Faulstich , Aldrich N. K. Lau , Umberto Ulmanella , Jun Xie
Inventor： Debjyoti Banerjee , Konrad Faulstich , Aldrich N. K. Lau , Umberto Ulmanella , Jun Xie
CPC classification number: F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
Abstract: A diagnostic device is provided that includes a plurality of retainment regions, with the retainment regions that are separated by at least one dissolvable barrier. The retainment regions can be interconnected through at least one fluid processing passageway. A retainment region can include a container such as a retainment region, well, chamber, or other receptacle, or a retainment region such as a surface on which the material is retained. The retainment regions can include a reaction retainment region, one or more reagent retainment regions, each containing unreacted reagents, and a sample retainment region. A pressure-actuated valve can be positioned in each fluid processing passageway interconnecting the one or more reagent retainment regions with the respective intermediate retainment regions interposed between each of the one or more reagent retainment regions and the reaction retainment region. The dissolvable barrier can be a fluid flow modulator in the at least one fluid processing passageway.
Abstract translation: 提供了一种诊断装置，其包括多个保持区域，其中保留区域被至少一个可溶解屏障隔开。 保持区域可以通过至少一个流体处理通道相互连接。 保持区域可以包括诸如保持区域，孔，腔室或其它容器的容器，或诸如保持材料的表面的保持区域。 保留区域可以包括反应保留区域，一个或多个试剂保留区域，每个含有未反应的试剂和样品保留区域。 压力致动阀可以定位在每个流体处理通道中，其将一个或多个试剂保留区域与插入在一个或多个试剂保留区域中的每一个和反应保留区域之间的各个中间保留区域互连。 可溶解屏障可以是至少一个流体处理通道中的流体流动调节器。
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公开(公告)号：US20100133104A1
公开(公告)日：2010-06-03
申请号：US12627824
申请日：2009-11-30
Applicant: Debjyoti Banerjee , Umberto Ulmanella , Konrad Faulstich , Aldrich N. K. Lau , Jun Xie
Inventor： Debjyoti Banerjee , Umberto Ulmanella , Konrad Faulstich , Aldrich N. K. Lau , Jun Xie
CPC classification number: F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
Abstract: A diagnostic device is provided that includes a plurality of retainment regions interconnected through at least one fluid processing passageway or separated by at least one barrier. A fluid flow modulator can be provided in the fluid processing passageway if a fluid processing passageway is provided. The barrier and/or fluid flow modulator can comprise a polysaccharide, a derivative of a polysaccharide, or a combination thereof. For example, the barrier can comprise a chitosan material.
Abstract translation: 提供了诊断装置，其包括通过至少一个流体处理通道互连或由至少一个屏障隔开的多个保持区域。 如果提供流体处理通道，流体流动调节器可以设置在流体处理通道中。 阻隔和/或流体流动调节器可以包含多糖，多糖的衍生物或其组合。 例如，阻挡层可以包含壳聚糖材料。
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Patent Agency Ranking
公开(公告)号：US20060093528A1
公开(公告)日：2006-05-04
申请号：US11252821
申请日：2005-10-18
Applicant: Debjyoti Banerjee , Konrad Faulstich , Aldrich Lau , Umberto Ulmanella , Jun Xie
Inventor： Debjyoti Banerjee , Konrad Faulstich , Aldrich Lau , Umberto Ulmanella , Jun Xie
IPC: B01L3/00
CPC classification number: F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
Abstract: A diagnostic device is provided that includes a plurality of retainment regions, with the retainment regions that are separated by at least one dissolvable barrier. The retainment regions can be interconnected through at least one fluid processing passageway. A retainment region can include a container such as a retainment region, well, chamber, or other receptacle, or a retainment region such as a surface on which the material is retained. The retainment regions can include a reaction retainment region, one or more reagent retainment regions, each containing unreacted reagents, and a sample retainment region. A pressure-actuated valve can be positioned in each fluid processing passageway interconnecting the one or more reagent retainment regions with the respective intermediate retainment regions interposed between each of the one or more reagent retainment regions and the reaction retainment region. The dissolvable barrier can be a fluid flow modulator in the at least one fluid processing passageway.
Abstract translation: 提供了一种诊断装置，其包括多个保持区域，其中保留区域被至少一个可溶解屏障隔开。 保持区域可以通过至少一个流体处理通道相互连接。 保持区域可以包括诸如保持区域，孔，腔室或其它容器的容器，或诸如保持材料的表面的保持区域。 保留区域可以包括反应保留区域，一个或多个试剂保留区域，每个含有未反应的试剂和样品保留区域。 压力致动阀可以定位在每个流体处理通道中，其将一个或多个试剂保留区域与插入在一个或多个试剂保留区域中的每一个和反应保留区域之间的各个中间保留区域互连。 可溶解屏障可以是至少一个流体处理通道中的流体流动调节器。
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公开(公告)号：US20060093526A1
公开(公告)日：2006-05-04
申请号：US11252915
申请日：2005-10-18
Applicant: Konrad Faulstich , Aldrich Lau , Debjyoti Banerjee , Umberto Ulmanella , Jun Xie
Inventor： Konrad Faulstich , Aldrich Lau , Debjyoti Banerjee , Umberto Ulmanella , Jun Xie
IPC: B01L3/00
CPC classification number: F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
Abstract: A fluid processing device is provided that includes a substrate, a plurality of fluid retainment regions formed in or on the substrate, and a barrier at least partially separating two or more of the fluid retainment regions. The barrier includes a mixture of a sequestering material and a reaction component. The reaction component can be at least one of a reactant, a reagent, a catalyst, an initiator, a promoter, a cofactor, an enzyme, a salt, or a combination thereof. The sequestering material can be a porous material, a dissolvable material, or both.
Abstract translation: 提供了一种流体处理装置，其包括衬底，形成在衬底中或衬底上的多个流体保持区域，以及至少部分地分离两个或更多个流体保持区域的屏障。 屏障包括螯合材料和反应组分的混合物。 反应组分可以是反应物，试剂，催化剂，引发剂，助催化剂，辅因子，酶，盐或其组合中的至少一种。 隔离材料可以是多孔材料，可溶解材料或两者。
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公开(公告)号：US09127306B2
公开(公告)日：2015-09-08
申请号：US12372464
申请日：2009-02-17
Applicant: Vladimir I. Bashkirov , Umberto Ulmanella , Robert G. Eason , Bradford J. Taft
Inventor： Vladimir I. Bashkirov , Umberto Ulmanella , Robert G. Eason , Bradford J. Taft
CPC classification number: C12Q1/6806 , C07H1/06 , C07H21/00 , C12N15/1093 , C12Q2523/301
Abstract: Methods and kits for preparing nucleic acid fragments from a sample of purified nucleic acid are provided. Alternatively, chromatin or other long polymers can be sheared with similar methods and kits.
Abstract translation: 提供了用于从纯化的核酸样品制备核酸片段的方法和试剂盒。 或者，染色质或其他长聚合物可以用类似的方法和试剂盒进行剪切。
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公开(公告)号：US08597590B2
公开(公告)日：2013-12-03
申请号：US12789363
申请日：2010-05-27
Applicant: Min Yue , David M. Liu , Joy Roy , Yuh-Min Chiang , Joon Mo Yang , Dennis Lehto , Charles S. Vann , Nigel P. Beard , Ian A. Harding , John R. Van Camp , Alexander Dromaretsky , Sergey V. Ermakov , Mark F. Oldham , Maryam Shariati , Umberto Ulmanella
Inventor： Min Yue , David M. Liu , Joy Roy , Yuh-Min Chiang , Joon Mo Yang , Dennis Lehto , Charles S. Vann , Nigel P. Beard , Ian A. Harding , John R. Van Camp , Alexander Dromaretsky , Sergey V. Ermakov , Mark F. Oldham , Maryam Shariati , Umberto Ulmanella
IPC: G01N21/75
CPC classification number: C12Q1/6806 , B01J2219/00317 , B01J2219/00722 , B01L3/502707 , B01L3/502723 , B01L3/50853 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/041 , B01L2300/048 , B01L2300/0636 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/087 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0694 , G01N35/028 , Y10T436/2575
Abstract: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
Abstract translation: 用于多个分析物检测的系统和方法包括用于分配包括基底的生物样品的系统，其中所述基底包括多个样品室，用于每个样品室的样品引入通道和用于每个样品室的排气通道。 该系统可以进一步包括包含在每个样品室中并被配置用于进入基底的生物样品的核酸分析的预加载试剂和被配置为与基底接触以密封每个样品室以便基本上防止 每个样品室中包含的样品从每个样品室流出。 底物可以由检测相容和测定相容的材料构成。
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20.发明授权公开(公告)号：US08147770B2
公开(公告)日：2012-04-03
申请号：US12954519
申请日：2010-11-24
Applicant: Debjyoti Banerjee , Konrad Faulstich , Aldrich Lau , Umberto Ulmanella , Jun Xie
Inventor： Debjyoti Banerjee , Konrad Faulstich , Aldrich Lau , Umberto Ulmanella , Jun Xie
CPC classification number: F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
Abstract: A diagnostic device is provided that includes a plurality of retainment regions, with the retainment regions that are separated by at least one dissolvable barrier. The retainment regions can be interconnected through at least one fluid processing passageway. A retainment region can include a container such as a retainment region, well, chamber, or other receptacle, or a retainment region such as a surface on which the material is retained. The retainment regions can include a reaction retainment region, one or more reagent retainment regions, each containing unreacted reagents, and a sample retainment region. A pressure-actuated valve can be positioned in each fluid processing passageway interconnecting the one or more reagent retainment regions with the respective intermediate retainment regions interposed between each of the one or more reagent retainment regions and the reaction retainment region. The dissolvable barrier can be a fluid flow modulator in the at least one fluid processing passageway.
Abstract translation: 提供了一种诊断装置，其包括多个保持区域，其中保留区域被至少一个可溶解屏障隔开。 保持区域可以通过至少一个流体处理通道相互连接。 保持区域可以包括诸如保持区域，孔，腔室或其它容器的容器，或诸如保持材料的表面的保持区域。 保留区域可以包括反应保留区域，一个或多个试剂保留区域，每个含有未反应的试剂和样品保留区域。 压力致动阀可以定位在每个流体处理通道中，其将一个或多个试剂保留区域与插入在一个或多个试剂保留区域中的每一个和反应保留区域之间的各个中间保留区域互连。 可溶解屏障可以是至少一个流体处理通道中的流体流动调节器。
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