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公开(公告)号：US12190206B2
公开(公告)日：2025-01-07
申请号：US18300644
申请日：2023-04-14
Inventor： Gil Semo , Ziv Aqua , Oded Melamed , Dan Charash , Serge Rosenblum , Barak Dayan
Abstract: A quantum computing system, method and computer readable medium involve a vacuum enclosure for sustaining a vacuum below 10−3 millibar, optical resonators tuned to a resonance of an alkali atom, and a trapping laser for maintaining the alkali atom within a mode of the optical resonators. An atom excitation laser induces photon emissions, a plurality of waveguides couple photons to and from the optical resonators, and a plurality of detectors detect a presence or absence of an atom-resonator coupling. A processor receives output signals from the detectors and controls optical switches for switching between two or more of the plurality of waveguides.
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公开(公告)号：US20240402165A1
公开(公告)日：2024-12-05
申请号：US18688809
申请日：2022-09-05
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Ulyana SHIMANOVICH , Aleksei V. SOLOMONOV , Alexander TESLER
IPC: G01N33/543
Abstract: This invention provides nanostructures comprising a base. and nano-protrusions attached to the base. The invention further provides arrays of such nanostructures on substrates. Also provided by this invention are analysis and catalysis. separation and purification systems and methods. comprising or making use of the novel nanostructures. Particles and films comprising nano-protrusions are included in this invention as well.
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公开(公告)号：US20240368790A1
公开(公告)日：2024-11-07
申请号：US18686465
申请日：2022-08-31
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Igor LUBOMIRSKY , Valery KAPLAN
Abstract: Provided herein is an apparatus for electrolytic atomic hydrogen decrepitation and methods of use thereof.
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公开(公告)号：US20240352538A1
公开(公告)日：2024-10-24
申请号：US18764250
申请日：2024-07-04
Applicant: Yeda Research and Development Co. Ltd. , SeqLL Inc.
Inventor： Efrat SHEMA-YAACOBY , Erez NIR , Vadim FEDYUK , Ekaterina ANDREISHCHEVA , Daniel JONES , Abhijeet SHINDE
IPC: C12Q1/6886 , C12Q1/6804
CPC classification number: C12Q1/6886 , C12Q1/6804 , C12Q2600/156
Abstract: A method of analyzing nucleosomes is provided. The method comprising: (a) isolating a plurality of nucleosome molecules from a biological sample; (b) enzymatically linking adenine nucleotides to free DNA ends of the plurality of nucleosome molecules, wherein at least a portion of the adenine nucleotides comprises a label, such that the plurality of nucleosome molecules become attached to a labeled poly(A) tail; (c) hybridizing the plurality of nucleosome molecules attached to the labeled poly(A) tail to a solid support coated with poly(T); and (d) imaging the solid support, whereby the plurality of nucleosome molecules are visualized.
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公开(公告)号：US20240301368A1
公开(公告)日：2024-09-12
申请号：US18672113
申请日：2024-05-23
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Sarel FLEISHMAN , Shiran BARBER-ZUCKER
CPC classification number: C12N9/0065 , C12N15/81 , C12P7/10 , C12Y111/01007
Abstract: Recombinant peroxidase enzymes are disclosed having mutations that increase yield when expressed in yeast cells as compared to their corresponding wild-type peroxidase enzyme. Methods of generating are also disclosed as well as uses thereof.
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Patent Agency Ranking
公开(公告)号：US20240263202A1
公开(公告)日：2024-08-08
申请号：US18436233
申请日：2024-02-08
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Asaph AHARONI , Guy POLTURAK
IPC: C12P13/22 , A23L3/3463 , A23L3/3526 , A23L3/3544 , A23L5/46 , C07K14/415 , C12N9/02 , C12N9/12 , C12P13/04 , C12P17/12 , C12P19/02
CPC classification number: C12P13/225 , A23L3/3463 , A23L3/3526 , A23L3/3544 , A23L5/46 , C07K14/415 , C12N9/0083 , C12N9/1205 , C12P13/04 , C12P17/12 , C12P19/02 , C12Y207/01095 , A23V2002/00
Abstract: The invention provides recombinant polynucleotides comprising a nucleic acid encoding a CYP76AD6 or related gene and their use for producing L-DOPA from tyrosine and treating dopamine-responsive disorders, such as Parkinson's Disease. The invention also provides recombinant polynucleotides comprising a nucleic acid encoding a CYP76AD1 and/or CYP76AD6, a nucleic acid encoding a DOPA 4,5-dioxygenase (DOD) enzyme, such as Beta vulgaris DODA1, and, in some cases, a nucleic acid encoding betalain related glucosyltransferase, such as M. jalapa gene cyclo-DOPA 5-O-glucosyltransferase (cDOPA5GT), and their use for producing betalains. Finally, the invention provides chimeric polypeptides, expression vectors, cells, compositions, and organisms, including plants, and their uses in various methods of the invention.
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公开(公告)号：US20240239886A1
公开(公告)日：2024-07-18
申请号：US18432214
申请日：2024-02-05
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Ido AMIT , Chamutal BORNSTEIN-OVITS , Adam YALIN , Adi MOSHE , Oren BARBOY , Assaf WEINER , Yonatan KATZENELENBOGEN , Diego JAITIN , Fadi SHEBAN
CPC classification number: C07K16/2803 , A61K35/17 , A61K39/4611 , A61K39/4631 , A61K39/464411 , A61K45/06 , A61K47/642 , A61P35/00 , A61P37/04 , A61K2039/505 , C07K2317/565 , C07K2317/71
Abstract: Provided are antibodies to TREM2 and Gpnmb. Also provided are compositions comprising the antibodies and methods of using same.
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公开(公告)号：US20240228521A1
公开(公告)日：2024-07-11
申请号：US18554795
申请日：2022-04-14
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： David SPERANDIO , Helena SHOMAR MONNGES , Eugene J. EISENBERG , Arthur MACHLENKIN
IPC: C07F9/6561 , A61K31/675
CPC classification number: C07F9/6561 , A61K31/675
Abstract: Disclosed herein are 3, 4-didehydro- and 3′-deoxy-3, 4-didehydro-compounds, and pharmaceutical compositions thereof. The 3, 4-didehydro- and 3′-deoxy-3, 4-didehydro-compounds, and pharmaceutical compositions thereof may be used in methods of treating diseases including virus-induced diseases, cancer, autoimmune diseases, immune disorders, and bacterial-associated diseases or infections, or combinations thereof. Examples of viral-induced diseases include viral infections by RNA or DNA viruses, for example SARS-CoV-2, EBV, and BKV.
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19.发明公开公开(公告)号：US20240165027A1
公开(公告)日：2024-05-23
申请号：US18424973
申请日：2024-01-29
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Jacob KLEIN , Ronit GOLDBERG , Jasmine SEROR
IPC: A61K9/127 , A61K9/00 , A61K9/08 , A61K31/728 , A61K31/77 , A61K31/79 , A61K47/10 , A61K47/32 , A61K47/36 , B65D35/00 , B65D75/36
CPC classification number: A61K9/127 , A61K9/0048 , A61K9/08 , A61K31/728 , A61K31/77 , A61K31/79 , A61K47/10 , A61K47/32 , A61K47/36 , B65D35/00 , B65D75/36
Abstract: Formulations (e.g., solutions) comprising one or more water-soluble polymer(s), liposomes, and an aqueous carrier, are provided. The provided solutions are useful for rinsing, and/or immersing therein, a contact lens and/or in the treatment of ocular discomfort, for example, an ocular discomfort associated with a contact lens. Also provided are kits comprising the solution and a contact lens; articles-of-manufacturing comprising the solution and configured for dispending the solution; and methods utilizing the solution.
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公开(公告)号：US11983607B2
公开(公告)日：2024-05-14
申请号：US18300629
申请日：2023-04-14
Inventor： Gil Semo , Ziv Aqua , Oded Melamed , Dan Charash , Serge Rosenblum , Barak Dayan
Abstract: A quantum computing system, method and computer readable storage medium involve tuning a whispering-gallery mode optical resonator to support a resonance frequency associated with a transition frequency of an atom. Operation of a laser is controlled to cause the atom to be trapped adjacent the optical resonator and within the evanescent field portion. Based on an atom presence signal from an optical atom presence detector, an indication is provided that the atom is trapped adjacent the optical resonator. A frequency of a cooling laser is controlled to cool the atom, and the optical resonator is configured to define a closed loop-like mode including an evanescent field portion. The trapping laser is configured to cause the atom to be trapped adjacent the whispering-gallery mode resonator, and the cooling laser is configured to manipulate a state of the atom to thereby cool the atom.
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