公开(公告)号：US20240342072A1

公开(公告)日：2024-10-17

申请号：US18582331

申请日：2024-02-20

Applicant: Allergan, Inc.

Inventor： Gabriel N. Njikang ,  Xiaojie Yu ,  Futian Liu ,  Nicholas J. Manesis

IPC: A61K8/73 ,  A61K8/04 ,  A61L27/20 ,  A61L27/52 ,  A61Q19/00 ,  A61Q19/08 ,  C08B37/08

CPC classification number: A61K8/735 ,  A61K8/042 ,  A61L27/20 ,  A61L27/52 ,  A61Q19/00 ,  A61Q19/08 ,  C08B37/0072 ,  A61K2800/91 ,  A61L2400/06 ,  A61L2430/34

Abstract: The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions made with a di-amine or multiamine crosslinker in the presence of a carbodiimide coupling agent.

公开(公告)号：US20200030490A1

公开(公告)日：2020-01-30

申请号：US16595481

申请日：2019-10-08

Applicant: Allergan, Inc.

Inventor： Xiaojie Yu ,  Nicholas J. Manesis ,  Jacob Pollock

IPC: A61L27/24 ,  A61L27/52 ,  A61K8/73 ,  A61Q19/08 ,  A61K8/04 ,  A61L27/26 ,  A61L27/36

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

公开(公告)号：US20180303742A1

公开(公告)日：2018-10-25

申请号：US16024559

申请日：2018-06-29

Applicant: Allergan, Inc.

Inventor： Elizabeta Pavlovic ,  Monica A. Serban ,  Xiaojie Yu ,  Nicholas J. Manesis

IPC: A61K8/64 ,  A61Q19/08 ,  A61L27/20 ,  C08H1/00 ,  C08B37/08 ,  A61K8/73 ,  C08J3/24 ,  C08L89/00 ,  C08J3/075 ,  A61L27/22 ,  C08L5/08 ,  A61L27/52 ,  A61L27/36

Abstract: Compositions useful as dermal fillers and methods using such compositions to treat various skin and soft tissue conditions. The dermal fillers can comprise silk attached to hyaluronic acid using for example two cross linkers and can be used to treat of facial imperfections, facial defects, facial augmentations, breast imperfections, breast augmentations or breast reconstructions.

公开(公告)号：US09737633B2

公开(公告)日：2017-08-22

申请号：US14829201

申请日：2015-08-18

Applicant: Allergan, Inc.

Inventor： Futian Liu ,  Xiaojie Yu ,  Nicholas J. Manesis ,  Athene Wan Chie Chan

IPC: A61K8/73 ,  A61K8/67 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  A61Q19/08 ,  A61L27/20 ,  A61K47/48 ,  C08B37/08 ,  A61K8/04 ,  A61L27/52

CPC classification number: A61L27/20 ,  A61K8/042 ,  A61K8/676 ,  A61K8/735 ,  A61K47/60 ,  A61K47/61 ,  A61K2800/91 ,  A61L27/00 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/204 ,  A61L2300/402 ,  A61L2400/06 ,  A61Q19/08 ,  C08B37/0072

Abstract: Provided are injectable, hyaluronic acid-based hydrogel compositions including conjugated vitamins.

公开(公告)号：US20160361247A1

公开(公告)日：2016-12-15

申请号：US15244587

申请日：2016-08-23

Applicant: Allergan, Inc.

Inventor： Elizabeta Pavlovic ,  Monica A. Serban ,  Xiaojie Yu ,  Nicholas J. Manesis

IPC: A61K8/64 ,  A61Q19/08

CPC classification number: A61K8/64 ,  A61K8/735 ,  A61L27/20 ,  A61L27/227 ,  A61L27/3604 ,  A61L27/52 ,  A61L2400/06 ,  A61L2430/04 ,  A61L2430/34 ,  A61Q19/08 ,  C08B37/0072 ,  C08H1/00 ,  C08J3/075 ,  C08J3/246 ,  C08J2305/08 ,  C08J2489/00 ,  C08J2489/04 ,  C08L5/08 ,  C08L89/00

Abstract: Compositions useful as dermal fillers and methods using such compositions to treat various skin and soft tissue conditions. The dermal fillers can comprise silk attached to hyaluronic acid using for example two cross linkers and can be used to treat of facial imperfections, facial defects, facial augmentations, breast imperfections, breast augmentations or breast reconstructions.

Abstract translation: 可用作真皮填料的组合物和使用这种组合物治疗各种皮肤和软组织病症的方法。 真皮填料可以包括使用例如两个交联剂连接到透明质酸的丝，并可用于治疗面部缺陷，面部缺陷，面部增大，乳房缺陷，隆胸或乳房重建。

公开(公告)号：US09138309B2

公开(公告)日：2015-09-22

申请号：US13625159

申请日：2012-09-24

Applicant: Allergan, Inc.

Inventor： Futian Liu ,  Nicholas J. Manesis ,  Alexei Goraltchouk ,  Dimitrios Stroumpoulis

IPC: A61F2/12 ,  B29C41/14 ,  A61L27/56 ,  A61L27/18 ,  A61L27/50 ,  A61L27/58

CPC classification number: A61L27/18 ,  A61F2/12 ,  A61L27/50 ,  A61L27/56 ,  A61L27/58 ,  B05D2400/00 ,  B05D2518/00 ,  B29C41/14 ,  C08L83/04

Abstract: The present specification discloses porous materials, methods of forming such porous materials, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.

Abstract translation: 本说明书公开了多孔材料，形成这种多孔材料的方法，包括这种多孔材料的生物相容性可植入装置以及制造这种生物相容性可植入装置的方法。

公开(公告)号：US20140179819A1

公开(公告)日：2014-06-26

申请号：US14195762

申请日：2014-03-03

Applicant: Allergan, Inc.

Inventor： Futian Liu ,  Nicholas J. Manesis ,  Alexei Goraltchouk ,  Dimitrios Stroumpoulis

IPC: A61L27/56 ,  A61L31/14 ,  A61L31/06 ,  A61L27/18

CPC classification number: A61L27/56 ,  A61F2/12 ,  A61L27/18 ,  A61L27/34 ,  A61L31/06 ,  A61L31/146 ,  A61L2430/04 ,  C08J9/26 ,  C08J2201/046 ,  C08J2383/04 ,  C08J2467/00 ,  C08L83/04

Abstract: The present specification discloses porous materials, methods of forming such porous materials, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.

Abstract translation: 本说明书公开了多孔材料，形成这种多孔材料的方法，包括这种多孔材料的生物相容性可植入装置以及制造这种生物相容性可植入装置的方法。

公开(公告)号：US20140088702A1

公开(公告)日：2014-03-27

申请号：US14094618

申请日：2013-12-02

Applicant: Allergan, Inc.

Inventor： Nicholas J. Manesis ,  Nikhil S. Trilokekar ,  Dustin Leslie ,  Kaustubh S. Chitre

IPC: A61M29/02 ,  A61F2/12

CPC classification number: A61M29/02 ,  A61F2/12

Abstract: A tissue expander includes an elastomeric shell having an anterior inside surface and a posterior inside surface with a self-healing layer abutting only a portion of the anterior inside surface. The layer is spaced apart from the posterior inside surface while facilitating folding of the shell prior to insertion into a tissue pocket and also enabling inflation of the shell subsequent to insertion by a fluid injected between the self healing layer and posterior surface.

Abstract translation: 组织扩张器包括具有前内表面和后内表面的弹性体外壳，其中自修复层仅邻接前内表面的一部分。 该层与后内表面间隔开，同时便于在插入组织袋之前折叠壳体，并且还允许壳体在由自愈合层和后表面之间注入的流体插入之后进行充气。

公开(公告)号：US10758470B2

公开(公告)日：2020-09-01

申请号：US16024559

申请日：2018-06-29

Applicant: Allergan, Inc.

Inventor： Elizabeta Pavlovic ,  Monica A. Serban ,  Xiaojie Yu ,  Nicholas J. Manesis

IPC: A61K8/64 ,  A61Q19/08 ,  C08B37/08 ,  C08H1/00 ,  C08J3/24 ,  A61K8/73 ,  A61L27/20 ,  A61L27/36 ,  A61L27/52 ,  C08L5/08 ,  A61L27/22 ,  C08J3/075 ,  C08L89/00

Abstract: Compositions useful as dermal fillers and methods using such compositions to treat various skin and soft tissue conditions. The dermal fillers can comprise silk attached to hyaluronic acid using for example two cross linkers and can be used to treat of facial imperfections, facial defects, facial augmentations, breast imperfections, breast augmentations or breast reconstructions.

公开(公告)号：US20180214601A1

公开(公告)日：2018-08-02

申请号：US15936415

申请日：2018-03-26

Applicant: Allergan, Inc.

Inventor： Futian Liu ,  Xiaojie Yu ,  Jessamine P. Winer-Jones ,  Nicholas J. Manesis ,  Hengli Liu ,  Gabriel Njikang ,  Athene Wan Chie Chan

IPC: A61L27/20 ,  A61K31/728 ,  A61K47/61 ,  A61Q19/00 ,  A61L27/52 ,  A61Q19/08 ,  A61K8/73 ,  A61K8/67 ,  A61L27/54

CPC classification number: A61L27/20 ,  A61K8/676 ,  A61K8/735 ,  A61K31/728 ,  A61K47/61 ,  A61K2800/91 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/204 ,  A61L2300/236 ,  A61L2300/402 ,  A61L2400/06 ,  A61Q19/00 ,  A61Q19/08

Abstract: Provided are injectable, hyaluronic acid-based dermal filler compositions including conjugated vitamin C derivatives. The compositions provide for extended release of active vitamin C into tissue, promoting collagenesis and other benefits to skin.