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公开(公告)号：US20160184281A1
公开(公告)日：2016-06-30
申请号：US14878836
申请日：2015-10-08
Applicant: AbbVie Inc.
Inventor： Richard F. Clark , Bryan Sorensen , Augustine T. Osuma , Robin Frey , Kenton Longenecker , George Doherty , Michael L. Curtin , Michael Michaelides , Ramzi Sweis , Marina Pliushchev , Andrew Judd , Todd Hansen , Howard R. Heyman
IPC: A61K31/437 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/55 , A61K31/5377 , A61K31/444
CPC classification number: A61K31/437 , A61K31/407 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D471/04 , C07D487/04 , A61K2300/00
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
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公开(公告)号：US09296723B2
公开(公告)日：2016-03-29
申请号：US13891363
申请日：2013-05-10
Applicant: AbbVie Inc.
Inventor： Michael L. Curtin , Kenton Longenecker , Todd M. Hansen , Richard F. Clark , Bryan Sorensen , Howard R. Heyman , Zhiqin Ji
IPC: C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , A61K45/06
CPC classification number: C07D405/14 , A61K45/06 , C07D401/14 , C07D409/14 , C07D417/14
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
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公开(公告)号：US09187472B2
公开(公告)日：2015-11-17
申请号：US13891366
申请日：2013-05-10
Applicant: AbbVie Inc.
Inventor： Richard F. Clark , Bryan Sorensen , Augustine T. Osuma , Robin Frey , Kenton Longenecker , George Doherty , Michael L. Curtin , Michael R. Michaelides , Ramzi F. Sweis , Marina A. Pliushchev , Andy Judd , Todd M. Hansen , Howard R. Heyman
IPC: C07D471/04 , C07D487/04 , A61K31/437 , A61K31/4985 , A61K45/06 , A61K31/5377 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/55 , A61K31/407
CPC classification number: A61K31/437 , A61K31/407 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D471/04 , C07D487/04 , A61K2300/00
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
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公开(公告)号：US20150141398A1
公开(公告)日：2015-05-21
申请号：US14603832
申请日：2015-01-23
Applicant: AbbVie Inc.
Inventor： Todd M. Hansen , Kenton Longenecker , Howard R. Heyman , Michael L. Curtin , Richard F. Clark , Bryan Sorensen , Zhiqin Ji , Kevin Woller , George Doherty , Robin Frey
IPC: A61K31/501 , A61K31/4545
CPC classification number: A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
Abstract translation: 公开了抑制NAMPT活性的化合物，含有该化合物的组合物和治疗其中NAMPT表达的疾病的方法。
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公开(公告)号：US20140336168A1
公开(公告)日：2014-11-13
申请号：US13891363
申请日：2013-05-10
Applicant: AbbVie Inc.
Inventor： Michael L. Curtin , Kenton Longenecker , Todd M. Hansen , Richard F. Clark , Bryan Sorensen , Howard R. Heyman , Zhiqin Ji
IPC: C07D401/14 , A61K31/4545 , C07D405/14 , C07D409/14 , A61K45/06 , A61K31/496 , A61K31/4439 , C07D417/14 , A61K31/501 , A61K31/4427 , A61K31/5377
CPC classification number: C07D405/14 , A61K45/06 , C07D401/14 , C07D409/14 , C07D417/14
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
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Patent Agency Ranking
公开(公告)号：US20130303510A1
公开(公告)日：2013-11-14
申请号：US13891357
申请日：2013-05-10
Applicant: AbbVie Inc.
Inventor： Todd M. Hansen , Kenton Longenecker , Howard R. Heyman , Michael L. Curtin , Richard F. Clark , Bryan Sorensen , Zhiqin Ji , Kevin Woller , George Doherty , Robin Frey
IPC: C07D401/14 , A61K31/4545 , A61K31/506 , C07D409/14 , A61K31/501 , C07D405/14 , A61K31/5377
CPC classification number: A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
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公开(公告)号：US09957274B2
公开(公告)日：2018-05-01
申请号：US15588398
申请日：2017-05-05
Applicant: AbbVie Inc.
Inventor： Michael R. Michaelides , Michael L. Curtin , Huan-Qiu Li , Marina A Pliushchev , Ying Wang , Hongyu H. Zhao , Richard F. Clark , Alan S. Florjancic , Zhiqin Ji , Mariazel Torrent , Ramzi F. Sweis , Anil Vasudevan , Justin D. Dietrich
IPC: C07D207/14 , A61K31/40 , C07D487/04 , C07D403/10 , C07D405/04 , C07D413/10 , C07D403/12 , C07D401/12 , C07D403/04 , C07D403/14 , C07D417/14 , C07D471/04 , C07D401/04 , C07D401/14
CPC classification number: C07D487/04 , A61K31/40 , C07D207/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D413/10 , C07D417/14 , C07D471/04
Abstract: Compounds having a structure of Formula (I): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein A1, A2, A3, A4, A5, n, and m are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various EED-related conditions or diseases, including cancer, by administration of such compounds are also provided.
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公开(公告)号：US20160168134A1
公开(公告)日：2016-06-16
申请号：US15048574
申请日：2016-02-19
Applicant: AbbVie Inc.
Inventor： Michael L. Curtin , Kenton Longenecker , Todd M. Hansen , Richard F. Clark , Bryan Sorensen , Howard R. Heyman , Zhiqin Ji
IPC: C07D405/14
CPC classification number: C07D405/14 , A61K45/06 , C07D401/14 , C07D409/14 , C07D417/14
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
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![PYRROLO [2,3-B] PYRIDINE CDK9 KINASE INHIBITORS](/abs-image/US/2016/03/03/US20160060257A1/abs.jpg.150x150.jpg)
公开(公告)号：US20160060257A1
公开(公告)日：2016-03-03
申请号：US14780018
申请日：2014-03-13
Applicant: ABBVIE INC.
Inventor： Yunsong Tong , Milan Bruncko , Richard F. Clark , Michael Curtin , Alan S. Florjancic , Robin R. Frey , Jianchun Gong , Todd M. Hansen , Zhiqin Ji , Chunqiu Lai , Anthony Mastracchio , Michael Michaelides , Juliem Miyashiro , Roberto M. Risi , Xiaohong Song , Zhi-fu Tao , Keith W. Woods , Guidong Zhu , Thomas Penning , Andrew Souers , Rajeev Goswami , Omprakash Reddy Iquturi , Madhu Babu Dabbeeru
IPC: C07D471/04 , A61K31/5377 , A61K31/437 , A61K31/4545
CPC classification number: C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K45/06 , A61K2300/00
Abstract: Disclosed are compounds of Formula (IIa), wherein R1, R2, R3A, R3B, R3C, R3D, R3E, and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (IIa).
Abstract translation: 公开了式（IIa）的化合物，其中R1，R2，R3A，R3B，R3C，R3D，R3E和R4如说明书中所定义，及其药学上可接受的盐。 这些化合物可以用作治疗包括癌症在内的疾病的药剂。 还提供了包含一种或多种式（IIa）化合物的药物组合物。
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公开(公告)号：US09193723B2
公开(公告)日：2015-11-24
申请号：US13891349
申请日：2013-05-10
Applicant: AbbVie Inc.
Inventor： Richard F. Clark , Bryan Sorensen , Augustine T. Osuma , Robin Frey , Kenton Longenecker , George Doherty , Michael L. Curtin , Michael R. Michaelides , Ramzi F. Sweis , Marina A. Pliushchev , Andy Judd , Todd M. Hansen , Howard R. Heyman
IPC: A61K31/437 , A61K31/4985 , A61K45/06 , A61K31/5377 , C07D471/04 , C07D487/04 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/55 , A61K31/407
CPC classification number: A61K31/437 , A61K31/407 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D471/04 , C07D487/04 , A61K2300/00
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
Abstract translation: 公开了抑制NAMPT活性的化合物，含有该化合物的组合物和治疗其中NAMPT表达的疾病的方法。
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