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    FLAVONOID HYDROGEL
    11.
    发明申请
    FLAVONOID HYDROGEL 有权

    公开(公告)号：US20150313869A1

    公开(公告)日：2015-11-05

    申请号：US14697565

    申请日：2015-04-27

    Applicant: Agency for Science, Technology and Research

    Inventor： Motoichi Kurisawa ,  Fan Lee ,  Joo Eun Chung ,  Pui Yik Peggy Chan

    IPC: A61K31/353 ,  C12P17/06 ,  A61K31/738

    CPC classification number: A61K31/353 ,  A61K9/0024 ,  A61K31/015 ,  A61K31/05 ,  A61K31/738 ,  A61K47/61 ,  A61K47/6903 ,  A61L27/54 ,  C08J3/075 ,  C08J2397/00 ,  C12P17/06 ,  C12P19/26

    Abstract: There is provided methods for producing a hydrogel comprising conjugates of a hydrogel forming agent and a flavonoid including a method for producing a hydrogel that is capable of adhesion of cells and which comprises enzymatically cross-linked conjugates of a hydrogel forming agent and a flavonoid. There is also provided a method for producing a hydrogel comprising conjugates of a hydrogel forming agent and a flavonoid without the addition of an exogenous peroxide or peroxidase or without the addition of an exogenous peroxide. Hydrogels produced by such methods and methods of using the hydrogels are also described herein.

    Abstract translation: 提供了包含水凝胶形成剂和类黄酮的缀合物的水凝胶的方法，包括能够粘附细胞的水凝胶的制造方法，其包含水凝胶形成剂和类黄酮的酶交联的缀合物。 还提供了一种制备水凝胶的方法，其包括水凝胶形成剂和类黄酮的缀合物，而不加入外源性过氧化物酶或过氧化物酶或不加入外源过氧化物。 本文还描述了通过这些使用水凝胶的方法和方法生产的水凝胶。

    Green Tea-based Nanocomplexes for Eye Disease
    12.
    发明申请
    Green Tea-based Nanocomplexes for Eye Disease 有权

    公开(公告)号：US20240390503A1

    公开(公告)日：2024-11-28

    申请号：US18690862

    申请日：2022-08-31

    Applicant: Agency for Science, Technology and Research ,  Singapore Health Services Pte Ltd

    Inventor： Motoichi Kurisawa ,  Nunnarpas Yongvongsoontorn ,  Joo Eun Chung ,  Yasuo Yanagi

    IPC: A61K47/54 ,  A61K9/00 ,  A61K47/61 ,  A61K47/69 ,  A61P27/02

    Abstract: The present invention relates to a composition comprising a self-assembled nanocomplex, wherein the self-assembled nanocomplex comprises one or more active agent physically bound to one or more conjugate, wherein each conjugate comprises one or more flavonoid molecule and a first water-soluble polymer, and the nanocomplex is at least partially encapsulated by a second water-soluble polymer. The present invention also relates to a method of preparing the composition and uses thereof. The present invention also relates to a method of treating an eye disease caused by angiogenesis, comprising administering a composition to a subject in need thereof, wherein the composition comprises a self-assembled nanocomplex, wherein the self-assembled nanocomplex comprises an ophthalmic anti-angiogenesis drug physically bound to one or more conjugate, each conjugate comprising one or more flavonoid molecule and a first water-soluble polymer.

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