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11.发明申请GENETICALLY MODIFIED MICROORGANISMS CAPABLE OF PRODUCING BETA-GLUCANS AND METHODS FOR PRODUCING BETA-GLUCANS 有权能够生产β-葡聚糖的基因改造的微生物和用于生产β-葡聚糖的方法公开(公告)号：US20160194676A1
公开(公告)日：2016-07-07
申请号：US15074330
申请日：2016-03-18
Applicant: BASF SE , Wintershall Holding GmbH
Inventor： Beata Brockmann , Andrea Herold , Oskar Zelder , Stefan Haefner , Christian Fleck , Hartwig Schröder , Mari Granström , Julia Kristiane Schmidt
CPC classification number: C12P19/04 , C08B37/0024 , C08L5/00 , C12N9/1051 , C12N15/80 , C12P19/18 , C12Y204/01034 , Y02P20/52
Abstract: The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that the genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-β-D-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity or the use of such a polypeptide for producing β-glucans. Furthermore, the present invention relates to methods for producing β-glucans comprising the introduction of a promoter upstream of a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity thereby increasing the expression of the polynucleotide, or a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity into a microorganism being able to synthesize β-glucans.
Abstract translation: 本发明涉及能够产生β-葡聚糖的转基因微生物，其特征在于，遗传修饰的微生物过表达（i）编码具有1,3-葡聚糖合酶活性的多肽的多核苷酸和/或（ ii）与相同菌株的相应未修饰的对照微生物相比，具有1,3-葡聚糖 - D-葡聚糖合酶活性的多肽。 本发明还涉及编码具有1,3-葡萄糖 - D-葡聚糖合酶活性的多肽的多核苷酸的用途或这种多肽用于生产葡聚糖的用途。 此外，本发明涉及生产葡聚糖的方法，包括在编码具有1,3-葡萄糖-D-葡聚糖合酶活性的多肽的多核苷酸上游引入启动子，从而增加多核苷酸的表达，或 编码具有1,3-葡聚糖合酶活性的多肽的多核苷酸能够合成葡聚糖。
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12.发明申请GENETICALLY MODIFIED MICROORGANISMS CAPABLE OF PRODUCING BETA-GLUCANS AND METHODS FOR PRODUCING BETA-GLUCANS 审中-公开能够生产β-葡聚糖的基因改造的微生物和用于生产β-葡聚糖的方法公开(公告)号：US20150152453A1
公开(公告)日：2015-06-04
申请号：US14412212
申请日：2013-07-03
Applicant: BASF SE , Wintershall Holding GmbH
Inventor： Beata Brockmann , Andrea Herold , Oskar Zelder , Stefan Haefner , Christian Fleck , Hartwig Schröder , Mari Granström , Julia Kristine Schmidt
CPC classification number: C12P19/04 , C12N9/1051 , C12Y204/01034
Abstract: The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that said genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-β-D-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity or the use of such a polypeptide for producing β-glucans. Furthermore, the present invention relates to methods for producing β-glucans comprising the introduction of a promoter upstream of a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity thereby increasing the expression of said polynucleotide, or a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity into a microorganism being able to synthesize β-glucans.
Abstract translation: 本发明涉及能够产生β-葡聚糖的转基因微生物，其特征在于所述遗传修饰的微生物过表达（i）编码具有1,3-葡聚糖合酶活性的多肽的多核苷酸和/或（ ii）与相同菌株的相应未修饰的对照微生物相比，具有1,3-葡聚糖 - D-葡聚糖合酶活性的多肽。 本发明还涉及编码具有1,3-葡萄糖 - D-葡聚糖合酶活性的多肽的多核苷酸的用途或这种多肽用于生产葡聚糖的用途。 此外，本发明涉及生产葡聚糖的方法，包括在编码具有1,3-葡萄糖-D-葡聚糖合酶活性的多肽的多核苷酸上游引入启动子，从而增加所述多核苷酸的表达，或 编码具有1,3-葡聚糖合酶活性的多肽的多核苷酸能够合成葡聚糖。
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13.发明申请公开(公告)号：US20140127764A1
公开(公告)日：2014-05-08
申请号：US14150206
申请日：2014-01-08
Applicant: BASF SE
Inventor： Hartwig Schröder , Stefan Haefner , Gregory Von Abendroth , Rajan Hollmann , Aline Raddatz , Hansgeorg Ernst , Hans Gurski
IPC: C12P7/46
CPC classification number: C12P7/46 , C12N1/32 , C12N9/1029 , C12R1/01 , C12Y203/01054
Abstract: The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.
Abstract translation: 本发明涉及能够利用甘油作为发酵生产琥珀酸的碳源的细菌菌株，其中所述菌株被遗传修饰，使得它们包含其内源性丙酮酸 - 甲酸裂解酶活性的失调，以及 涉及通过利用这种微生物生产有机酸，特别是琥珀酸的方法。 本发明还涉及通过阳离子交换层析对所生产的有机酸的下游加工。
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公开(公告)号：US20130108738A1
公开(公告)日：2013-05-02
申请号：US13689958
申请日：2012-11-30
Applicant: BASF SE
Inventor： Stefan Haefner , Annegret Welzel , Robert Thummer
IPC: C12N9/16
CPC classification number: C12N9/16 , C07K2319/21
Abstract: The invention relates to a synthetic phytase with elevated thermostability, elevated stability to acids at pH 2, elevated stability to pepsin and with a broadened active pH range, and to an isolated nucleic acid sequence coding for a synthetic phytase and to the use of the phytase in an animal feed for reducing the phosphate content in the slurry and to animal feed additives and animal feeds comprising the synthetic phytase.
Abstract translation: 本发明涉及具有升高的热稳定性的合成植酸酶，在pH2下对酸的稳定性升高，对胃蛋白酶的稳定性升高，并且具有扩大的活性pH范围，以及编码合成植酸酶的分离的核酸序列和植酸酶的使用 在用于降低浆料中的磷酸盐含量的动物饲料和包含合成植酸酶的动物饲料添加剂和动物饲料中。
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公开(公告)号：US10993446B2
公开(公告)日：2021-05-04
申请号：US16079255
申请日：2017-02-15
Applicant: BASF SE
Inventor： Cristina Pop , Adrienne Huston Davenport , Michael Liszka , Xuqiu Tan , Andreas Funke , Jochen Kutscher , Michael Seitter , Stefan Haefner
Abstract: Lipase enzymes and methods of using the lipases in a baking for improving the volume, stability, tolerance of a baked product and/or reducing and reducing or eliminating the use of DATEM.
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Patent Agency Ranking
公开(公告)号：US20200308235A1
公开(公告)日：2020-10-01
申请号：US15779595
申请日：2016-12-02
Applicant: BASF SE
Inventor： Stefan Haefner , Andreas Thywissen , Holger Hartmann , Nico Boehmer
Abstract: The present invention relates to a method of producing a recombinant polypeptide a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 2 (CLR2) and to express said recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR2 and the use of this filamentous fungus in the production of a recombinant polypeptide.
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公开(公告)号：US10287558B2
公开(公告)日：2019-05-14
申请号：US15116669
申请日：2015-02-02
Applicant: BASF SE
Inventor： Joanna Martyna Krawczyk , Stefan Haefner , Hartwig Schröder , Esther Dantas Costa , Oskar Zelder , Gregory Von Abendroth , Christoph Wittmann , René Stellmacher , Judith Becker , Anna Lange , Benjamin J. Lyons , Thomas J. Lyons , Eudes De Crecy , Ewa Hughes
Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the pykA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.
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公开(公告)号：US20180354999A1
公开(公告)日：2018-12-13
申请号：US15779646
申请日：2016-12-02
Applicant: BASF SE
Inventor： Stefan Haefner , Andreas Thywissen , Holger Hartmann , Nico Boehmer
CPC classification number: C07K14/37 , C12N1/14 , C12N9/2437 , C12N15/01 , C12N15/80 , C12P19/14 , C12P21/00 , C12P21/02 , C12Q1/34
Abstract: The present invention relates to a method of producing a recombinant polypeptide in a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 1 (CLR1) and to express the recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR1 and to the use of this filamentous fungus in the production of a recombinant polypeptide.
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公开(公告)号：US09932612B2
公开(公告)日：2018-04-03
申请号：US14676317
申请日：2015-04-01
Applicant: BASF SE
Inventor： Hartwig Schröder , Stefan Haefner , Gregory Von Abendroth , Rajan Hollmann , Aline Raddatz , Hansgeorg Ernst , Hans Gurski
CPC classification number: C12P7/46 , C12N1/32 , C12N9/1029 , C12R1/01 , C12Y203/01054
Abstract: The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.
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公开(公告)号：US20170166937A1
公开(公告)日：2017-06-15
申请号：US15116896
申请日：2015-05-02
Applicant: BASF SE
Inventor： Joanna Martyna Krawczyk , Stefan Haefner , Hartwig Schröder , Esther Dantas Costa , Oskar Zelder , Gregory Von Abendroth
IPC: C12P7/46
CPC classification number: C12P7/46 , C07K14/285 , C12N1/20 , C12N15/52
Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the fruA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.
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