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公开(公告)号：US09758492B2
公开(公告)日：2017-09-12
申请号：US14914184
申请日：2014-08-26
Applicant: Bristol-Myers Squibb Company
Inventor： Jay A. Markwalder , Steven P. Seitz , James Aaron Balog , Audris Huang , Sunil Kumar Mandal , Shefali Srivastava , David K. Williams , Libing Chen
IPC: C07D257/04 , A61K31/17 , A61K31/18 , A61K31/381 , A61K31/41 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/451 , A61K31/4709 , A61K31/497 , A61K31/50 , A61K31/506 , A61K31/5375 , A61K45/06 , C07D211/14 , C07D237/20 , C07D333/38 , C07D401/10 , C07D407/12 , C07D417/12 , C07D403/12 , C07D309/14 , C07D215/06 , C07D231/12 , C07D333/10 , C07D401/12 , C07D409/12 , C07D411/12 , C07D413/12 , C07D277/22 , C07C275/42 , C07C311/05 , C07C311/09 , C07C317/44 , C07B59/00
CPC classification number: C07D257/04 , A61K31/17 , A61K31/18 , A61K31/381 , A61K31/41 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/451 , A61K31/4709 , A61K31/497 , A61K31/50 , A61K31/506 , A61K31/5375 , A61K45/06 , C07B59/002 , C07C275/42 , C07C311/05 , C07C311/09 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D211/14 , C07D215/06 , C07D231/12 , C07D237/20 , C07D277/22 , C07D309/14 , C07D333/10 , C07D333/38 , C07D401/10 , C07D401/12 , C07D403/12 , C07D407/12 , C07D409/12 , C07D411/12 , C07D413/12 , C07D417/12
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention.
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公开(公告)号：US09738630B2
公开(公告)日：2017-08-22
申请号：US15037081
申请日：2014-11-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kyoung S. Kim , Liping Zhang , Ashok Vinayak Purandare , Steven P. Seitz
IPC: C07D405/12 , C07D401/14 , C07D413/14 , A61K31/4725 , C07D407/14 , C07D417/14 , A61K45/06 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D405/14
CPC classification number: C07D405/12 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D417/14 , Y02A50/411 , Y02A50/414 , A61K2300/00
Abstract: There are disclosed compounds that are inhibitors of EZH2, pharmaceutical compositions containing said compounds and methods of treating hyperproliferative, inflammatory, infectious, and immunoregulatory disorders and diseases, utilizing the compounds of the invention.
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公开(公告)号：US20160200674A1
公开(公告)日：2016-07-14
申请号：US14914184
申请日：2014-08-26
Applicant: Bristol-Myers Squibb Company
Inventor： Jay A. Markwalder , Steven P. Seitz , James Aaron Balog , Audris Huang , Sunil Kumar Mandal , Shefali Srivastava , David K. Williams , Libing Chen
IPC: C07C275/42 , A61K31/41 , A61K45/06 , C07C311/09 , A61K31/18 , A61K31/17 , C07D417/12 , A61K31/427 , C07D333/38 , A61K31/381 , C07D401/10 , A61K31/4439 , C07D407/12 , C07D211/14 , A61K31/451 , C07D403/12 , A61K31/506 , C07D413/12 , A61K31/422 , A61K31/497 , A61K31/4709 , C07D237/20 , A61K31/50 , A61K31/5375 , C07D257/04
CPC classification number: C07D257/04 , A61K31/17 , A61K31/18 , A61K31/381 , A61K31/41 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/451 , A61K31/4709 , A61K31/497 , A61K31/50 , A61K31/506 , A61K31/5375 , A61K45/06 , C07B59/002 , C07C275/42 , C07C311/05 , C07C311/09 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D211/14 , C07D215/06 , C07D231/12 , C07D237/20 , C07D277/22 , C07D309/14 , C07D333/10 , C07D333/38 , C07D401/10 , C07D401/12 , C07D403/12 , C07D407/12 , C07D409/12 , C07D411/12 , C07D413/12 , C07D417/12
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention.
Abstract translation: 公开了调节或抑制吲哚胺2,3-双加氧酶（IDO）的酶活性的化合物，含有所述化合物的药物组合物和治疗增殖性疾病的方法，例如癌症，病毒感染和/或自身免疫疾病，其利用 发明。
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公开(公告)号：US11447449B2
公开(公告)日：2022-09-20
申请号：US16959487
申请日：2019-01-03
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Steven P. Seitz , David K. Williams , Murugaiah Andappan Murugaiah Subbaiah
IPC: C07C275/42 , C07K16/28
Abstract: The present invention provides a compound of formula (II): an inhibitor of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases. Its prodrugs are disclosed.
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公开(公告)号：US20200069646A1
公开(公告)日：2020-03-05
申请号：US16555634
申请日：2019-08-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Steven P. Seitz , Susheel Jethanand Nara , Saumya Roy , Srinivasan Thangathirupathy , Soodamani Thangavel , Ramesh Kumar Sistla
IPC: A61K31/415 , C07C275/42 , C07D231/12 , C07D401/12 , C07D403/12 , C07D261/08 , C07D277/22 , C07D285/08 , C07D211/60 , C07D317/50 , C07D307/36 , C07D333/54 , C07D231/56 , C07D221/22 , C07D471/04 , C07D487/04 , A61K31/17 , A61K31/4439 , A61K31/506 , A61K31/42 , A61K31/426 , A61K31/433 , A61K31/357 , A61K31/341 , A61K31/381 , A61K31/5377
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the disclosure.
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Patent Agency Ranking
公开(公告)号：US09822103B2
公开(公告)日：2017-11-21
申请号：US15037066
申请日：2014-11-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Steven P. Seitz , Jay A. Markwalder , Ashok Vinayak Purandare
IPC: A61K31/4427 , C07D405/12 , C07D405/14 , C07D413/14 , A61K31/443 , A61K31/444 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06
CPC classification number: C07D405/12 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14 , C07D413/14
Abstract: There are disclosed compounds that are inhibitors of EZH2, pharmaceutical compositions containing said compounds and methods of treating hyperproliferative, inflammatory, infectious, and immunoregulatory disorders and diseases utilizing the compounds of the invention.
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公开(公告)号：US09790169B2
公开(公告)日：2017-10-17
申请号：US15088211
申请日：2016-04-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Emily Charlotte Cherney , Weiwei Guo , Audris Huang , Jay A. Markwalder , Steven P. Seitz , Weifang Shan , David K. Williams , Natesan Murugesan , Susheel Jethanand Nara , Saumya Roy , Soodamani Thangavel , Ramesh Kumar Sistla , Srinivas Cheruku , Srinivasan Thangathirupathy , Yadagiri Kanyaboina , Nagalakshmi Pulicharla
IPC: C07C229/42 , A61K31/17 , A61K31/196 , A61K31/277 , A61K31/351 , A61K31/382 , A61K31/397 , A61K31/428 , A61K31/437 , A61K31/445 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K39/395 , C07C255/58 , C07C275/40 , C07D205/04 , C07D211/14 , C07D239/47 , C07D265/36 , C07D277/64 , C07D295/155 , C07D309/04 , C07D335/02 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D309/14 , C07D407/12 , C07D487/08 , C07D265/30 , C07D207/08 , C07D211/08 , C07D307/22 , C07C255/57 , C07C235/38 , C07C235/56
CPC classification number: C07C275/40 , A61K31/17 , A61K31/196 , A61K31/277 , A61K31/351 , A61K31/382 , A61K31/397 , A61K31/428 , A61K31/437 , A61K31/445 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K39/3955 , A61K39/39558 , A61K45/06 , C07C229/42 , C07C233/81 , C07C235/38 , C07C235/56 , C07C255/57 , C07C255/58 , C07C275/30 , C07C275/42 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/08 , C07D211/14 , C07D239/34 , C07D239/47 , C07D265/30 , C07D265/36 , C07D277/64 , C07D295/155 , C07D307/22 , C07D309/04 , C07D309/14 , C07D317/46 , C07D335/02 , C07D401/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US20170231999A1
公开(公告)日：2017-08-17
申请号：US15584818
申请日：2017-05-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Emily Charlotte Cherney , Weiwei Guo , Audris Huang , Jay A. Markwalder , Steven P. Seitz , Weifang Shan , David K. Williams , Natesan Murugesan , Susheel Jethanand Nara , Saumya Roy , Soodamani Thangavel , Ramesh Kumar Sistla , Srinivas Cheruku , Srinivasan Thangathirupathy , Yadagiri Kanyaboina , Nagalakshmi Pulicharla
IPC: A61K31/538 , A61K31/17 , A61K31/196 , A61K31/277 , A61K31/351 , A61K31/382 , A61K31/397 , A61K31/428 , A61K31/437 , A61K31/445 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5375 , A61K31/5377 , A61K39/395 , A61K45/06
CPC classification number: C07C275/40 , A61K31/17 , A61K31/196 , A61K31/277 , A61K31/351 , A61K31/382 , A61K31/397 , A61K31/428 , A61K31/437 , A61K31/445 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K39/3955 , A61K39/39558 , A61K45/06 , C07C229/42 , C07C233/81 , C07C235/38 , C07C235/56 , C07C255/57 , C07C255/58 , C07C275/30 , C07C275/42 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/08 , C07D211/14 , C07D239/34 , C07D239/47 , C07D265/30 , C07D265/36 , C07D277/64 , C07D295/155 , C07D307/22 , C07D309/04 , C07D309/14 , C07D317/46 , C07D335/02 , C07D401/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US09675571B2
公开(公告)日：2017-06-13
申请号：US14776035
申请日：2014-03-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Audris Huang , Bin Chen , Libing Chen , Steven P. Seitz , Amy C. Hart , Jay A. Markwalder
IPC: A61K31/135 , A61K31/196 , C07C255/44 , C07C255/57 , C07D213/84 , C07C275/42 , C07D317/66 , C07C311/51 , C07D239/42 , C07D241/42 , C07D257/04 , C07D261/08 , C07C233/55 , C07D261/14 , C07C235/38 , C07D271/12 , C07D213/56 , A61K31/18 , A61K31/216 , A61K31/27 , A61K31/36 , A61K31/41 , A61K31/42 , A61K31/4245 , A61K31/44 , A61K31/498 , A61K31/505 , A61K45/06 , A61N5/10 , C07C69/743 , C07C271/28 , C07C311/47 , C07D213/75
CPC classification number: A61K31/196 , A61K31/18 , A61K31/216 , A61K31/27 , A61K31/36 , A61K31/41 , A61K31/42 , A61K31/4245 , A61K31/44 , A61K31/498 , A61K31/505 , A61K45/06 , A61N5/10 , C07B2200/07 , C07C69/743 , C07C233/55 , C07C235/38 , C07C255/44 , C07C255/57 , C07C271/28 , C07C275/42 , C07C311/47 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/02 , C07C2602/08 , C07C2602/14 , C07C2602/42 , C07D213/56 , C07D213/75 , C07D213/84 , C07D239/42 , C07D241/42 , C07D257/04 , C07D261/08 , C07D261/14 , C07D271/12 , C07D317/66 , Y02A50/411 , Y02A50/414
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US20160297805A1
公开(公告)日：2016-10-13
申请号：US15037066
申请日：2014-11-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Steven P. Seitz , Jay A. Markwalder , Ashok Vinayak Purandare
IPC: C07D405/12 , A61K45/06 , A61K31/5377 , A61K31/4427 , A61K31/496 , A61K31/444 , A61K31/506 , A61K31/443 , C07D405/14
CPC classification number: C07D405/12 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14 , C07D413/14
Abstract: There are disclosed compounds that are inhibitors of EZH2, pharmaceutical compositions containing said compounds and methods of treating hyperproliferative, inflammatory, infectious, and immunoregulatory disorders and diseases utilizing the compounds of the invention.
Abstract translation: 公开了作为EZH2抑制剂的化合物，含有所述化合物的药物组合物以及利用本发明化合物治疗过度增殖，炎性，感染性和免疫调节性疾病和疾病的方法。
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