公开(公告)号：US10041906B2

公开(公告)日：2018-08-07

申请号：US15059093

申请日：2016-03-02

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Boaz Ran

IPC: G01N27/453 ,  G01N27/447

Abstract: Integrated electrophoresis and electroblotting systems and methods are provided. In one embodiment, a cassette includes a separation gel and a sheet adjacent to a surface of the separation gel, wherein the sheet is configured to be removed from the cassette without opening the cassette. Systems and methods are also described and illustrated.

公开(公告)号：US09933565B2

公开(公告)日：2018-04-03

申请号：US15211728

申请日：2016-07-15

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Steve Swihart ,  Evan Thrush ,  Yochanan Uri ,  Boaz Ran ,  Itay Barak ,  Kevin McDonald

IPC: G02B6/08 ,  G02B5/22 ,  G01N21/64 ,  G02B5/28 ,  G01N27/447

CPC classification number: G02B6/08 ,  G01N21/6454 ,  G01N27/44721 ,  G01N2021/6484 ,  G02B5/22 ,  G02B5/28

Abstract: Devices, systems, methods, and kits for contact imaging are provided. A contact imaging device includes an imaging sensor, a fixed fiber faceplate mechanically coupled to the imaging sensor, and an optical filtering layer mechanically coupled to the fixed fiber faceplate. The optical filtering layer can include an interference filter, an absorptive filter, and/or a removable fiber faceplate. The contact imaging device can be used to image fluorescent samples by filtering out excitation light on the basis of wavelength and/or angle of incidence.

公开(公告)号：US09829434B2

公开(公告)日：2017-11-28

申请号：US15070211

申请日：2016-03-15

Applicant: Bio-Rad Laboratories Inc.

Inventor： Yochanan Uri ,  Boaz Ran ,  Ariel G. Notcovich ,  Shay Nimri

IPC: G01N21/01 ,  G01N21/65 ,  G01N21/25 ,  G01N21/552 ,  G01N33/543 ,  G01N21/03

CPC classification number: G01N21/553 ,  G01N21/253 ,  G01N21/658 ,  G01N33/54373 ,  G01N2021/0328 ,  G01N2201/0407 ,  G01N2201/0484 ,  G01N2201/062

Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.

公开(公告)号：US09794454B2

公开(公告)日：2017-10-17

申请号：US14789717

申请日：2015-07-01

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Yochanan Uri ,  Boaz Ran ,  Itay Barak ,  Steven Swihart ,  Evan Thrush

IPC: H04N5/228 ,  H04N5/225

CPC classification number: H04N5/2252 ,  G01N21/76 ,  G01N21/763 ,  G01N2201/0221

Abstract: Provided herein are imaging cassettes for detecting a luminescent and/or radioactive signals. Such cassettes are useful in common biological assays, e.g., immunoassays, nucleotide detection assays, and other affinity assays.

公开(公告)号：US09774804B2

公开(公告)日：2017-09-26

申请号：US14563411

申请日：2014-12-08

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Boaz Ran ,  Steve Swihart ,  Evan Thrush ,  Itay Barak

IPC: H04N5/361 ,  H04N5/365

CPC classification number: H04N5/361 ,  H04N5/365

Abstract: In one application, an imaging device includes an image sensor having an array of pixels, and a mask coupled with the image sensor. The mask is configured to darken a plurality of isolated pixels or groups of pixels interspersed within the array of pixels. The imaging device also includes a processor coupled with the image sensor and configured to receive image data from the image sensor, and determine a dark current fixed pattern noise based on the image data received from the plurality of darkened pixels or groups of pixels.

公开(公告)号：US20150172526A1

公开(公告)日：2015-06-18

申请号：US14563355

申请日：2014-12-08

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Steve Swihart ,  Evan Thrush ,  Boaz Ran

IPC: H04N5/235 ,  H04N5/357 ,  H04N5/374 ,  H04N5/359 ,  H04N5/361 ,  H04N5/232

CPC classification number: H04N5/2355 ,  G01N21/272 ,  G01N21/6408 ,  G01N21/6456 ,  G01N21/76 ,  H04N5/2173 ,  H04N5/2353 ,  H04N5/35545 ,  H04N5/361 ,  H04N5/365

Abstract: Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.

Abstract translation: 本文公开的方法和数字成像装置适于在一段时间内使用来自样品的一系列短的曝光来捕获化学反应中的样本的图像。 使用数字成像设备中的图像传感器的像素阵列来捕获一系列短曝光，其被配置为执行连续的非破坏性读取操作，以从像素阵列读出样本的一组非破坏性读取图像 。 在一个实施例中，通过延迟读出直到化学反应结束或接近化学反应结束来捕获图像，以减少图像中的读取噪声。 可以连续地监视从图像传感器读出的信号，并且可以自动地或基于来自用户的命令中断图像的捕获。 然后可以在图形显示中显示捕获的图像。

公开(公告)号：US08743369B2

公开(公告)日：2014-06-03

申请号：US13966364

申请日：2013-08-14

Applicant: Bio-Rad Laboratories Inc.

Inventor： Boaz Ran ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

IPC: G01N21/55

CPC classification number: G01N21/55 ,  G01N21/553 ,  G01N2021/058

Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.

Abstract translation: 一种SPR传感器，包括薄导电层，该导电层包括形成在透明基板的表面上的至少一个导电元件，照亮导电层和基板之间的界面的光源，从该界面反射的光产生信号的光敏表面 ，形成有至少一个流动通道的流动池，所述流动通道具有由由弹性材料形成的壁和从导电层的区域限定的内腔，以及至少一个中空流体供应流量控制装置，其具有内腔和孔口连通 与其流明。 通过迫使流量控制装置的一端通过弹性材料使得流体通道与流动控制装置的内腔之间能够进行流体流动，使得孔口与流动通道内腔连通。