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公开(公告)号：US10662450B2
公开(公告)日：2020-05-26
申请号：US16344189
申请日：2018-06-29
Applicant: CJ Cheiljedang Corporation
Inventor： Hyung Joon Kim , Hyo Jin Kim , Hyun Won Bae , Hyun Ah Kim , Chang Il Seo , Ji Sun Lee , Jin Sook Chang
Abstract: An aspartokinase variant, a microorganism comprising the variant, and a method for producing an aspartate-derived L-amino acid or a homoserine derivative thereof using the microorganism.
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公开(公告)号：US10125179B2
公开(公告)日：2018-11-13
申请号：US15679679
申请日：2017-08-17
Applicant: CJ CHEILJEDANG CORPORATION
Inventor： Sol Kim , Hye Won Kim , Jin Sook Chang , In Hwa Yoo
IPC: C12N15/63 , C12N15/52 , C12N9/16 , C12N9/00 , C07K14/245 , C12P13/12 , C12P13/06 , C12N9/04 , C12N9/10 , C12P13/00
Abstract: The present invention relates to an RhtB (homoserine/homoserine lactone export transporter) protein variant having an enhanced ability to export O-phosphoserine (OPS) that is a precursor of L-cysteine, a polynucleotide encoding the protein, a vector comprising the polynucleotide, an OPS-producing microorganism comprising the protein variant, a method of producing O-phosphoserine using the microorganism, and a method for preparing cysteine or its derivatives, which comprises reacting O-phosphoserine, produced by the method above, with a sulfide in the presence of O-phosphoserine sulfhydrylase (OPSS) or a microorganism that expresses OPSS.
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公开(公告)号：US09765124B2
公开(公告)日：2017-09-19
申请号：US14890422
申请日：2014-05-09
Applicant: CJ CHEILJEDANG CORPORATION
Inventor： Sol Kim , Hye Won Kim , Jin Sook Chang , In Hwa Yoo
IPC: C07K14/245 , C12P13/12 , C12P13/00 , C12N15/63 , C12P13/06 , C12N9/04 , C12N9/10 , C12N9/16 , C12N15/52
CPC classification number: C07K14/245 , C12N9/0006 , C12N9/1096 , C12N9/16 , C12N15/52 , C12N15/63 , C12P13/005 , C12P13/06 , C12P13/12
Abstract: The present invention relates to an RhtB (homoserine/homoserine lactone export transporter) protein variant having an enhanced ability to export O-phosphoserine (OPS) that is a precursor of L-cysteine, a polynucleotide encoding the protein, a vector comprising the polynucleotide, an OPS-producing microorganism comprising the protein variant, a method of producing O-phosphoserine using the microorganism, and a method for preparing cysteine or its derivatives, which comprises reacting O-phosphoserine, produced by the method above, with a sulfide in the presence of O-phosphoserine sulfhydrylase (OPSS) or a microorganism that expresses OPSS.
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公开(公告)号：US11661616B2
公开(公告)日：2023-05-30
申请号：US16638974
申请日：2019-03-27
Applicant: CJ CHEILJEDANG CORPORATION
Inventor： Ji Yeon Lee , Jin Sook Chang , Hyung Joon Kim , Byoung Hoon Yoon , Sun Hyoung Choi , Yunjung Choi
CPC classification number: C12P13/04 , C12N1/20 , C12N9/1077 , C12N9/14 , C12N15/77 , C12P13/14 , C12Y204/02017 , C12Y306/01031 , C12N2830/55
Abstract: The present disclosure relates to a microorganism having increased glycine productivity and a method for producing a fermented composition using the microorganism, and more specifically, to a microorganism of the genus Corynebacterium having increased glycine productivity due to the introduction of a mutation in HisG, a method for preparing a fermented composition comprising glycine and glutamic acid using the microorganism of the genus Corynebacterium, and the fermented composition.
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公开(公告)号：US11066687B2
公开(公告)日：2021-07-20
申请号：US16482608
申请日：2018-08-16
Applicant: CJ CHEILJEDANG CORPORATION
Inventor： Ji Hye Lee , So-jung Park , Min Ji Baek , Jin Sook Chang , Byoung Hoon Yoon
Abstract: Provided are a variant of 5′-inosinic acid dehydrogenase, a microorganism including the same, and a method of preparing 5′-inosinic acid using the same.
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Patent Agency Ranking
16.发明授权公开(公告)号：US10344287B2
公开(公告)日：2019-07-09
申请号：US15323429
申请日：2015-06-30
Applicant: CJ CHEILJEDANG CORPORATION
Inventor： Jin Sook Chang , Ju Eun Kim , So Young Kim , Kwang Ho Na , Yong Uk Shin , Jae Min Lee , Jae Hee Lee , In Kyung Heo
IPC: C12N1/20 , C12N9/10 , C12Q1/68 , C12P17/12 , C07H21/04 , C07H21/02 , C07K1/00 , C12N15/70 , C12N15/09 , C12P17/10 , C12N9/06 , C12N15/52
Abstract: The present invention relates to a recombinant microorganism producing quinolinic acid, more particularly, a microorganism producing quinolinic acid and having attenuated activity or eliminated activity of a protein having a sequence of SEQ ID NO: 1 and a method of producing quinolinic acid by using the recombinant microorganism.
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17.发明申请公开(公告)号：US20180355389A1
公开(公告)日：2018-12-13
申请号：US15765577
申请日：2016-10-13
Applicant: CJ CHEILJEDANG CORPORATION
Inventor： Imsang Lee , Sung Kwang Son , Hyeryun Yoo , Jae Hee Lee , Joo Hee Lee , Jin Sook Chang , Jin-Geun Choi , So Young Kim , Yong Uk Shin
Abstract: The present disclosure relates to a novel O-acetylhomoserine sulfhydrylase variant, a polynucleotide encoding the same, a vector comprising the polynucleotide, a strain capable of expressing the variant, and a method for producing L-methionine using the variant.
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18.发明授权公开(公告)号：US10041098B2
公开(公告)日：2018-08-07
申请号：US14890423
申请日：2014-05-09
Applicant: CJ CHEILJEDANG CORPORATION
Inventor： Hye Won Kim , Sol Kim , Jin Sook Chang , In Hwa Yoo
IPC: C12P13/12 , C12P13/06 , C07K14/245
Abstract: The present invention relates to a novel isolated polypeptide having the ability to export O-phosphoserine (OPS) that is a precursor of L-cysteine, a vector comprising the polynucleotide, an OPS-producing microorganism having enhanced activity of the polypeptide, a method of producing OPS using the microorganism, and a method for preparing cysteine or its derivatives, which comprises reacting OPS, produced by the above method, with a sulfide in the presence of O-phosphoserine sulfhydrylase (OPSS) or a microorganism that expresses OPSS.
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19.发明申请Method for Producing Bio-Based Homoserine Lactone and Bio-Based Organic Acid from O-Acyl Homoserine Produced by Microorganisms 有权由微生物生产的O-酰基高丝氨酸生产生物基高丝氨酸内酯和生物有机酸的方法公开(公告)号：US20140296466A1
公开(公告)日：2014-10-02
申请号：US14219307
申请日：2014-03-19
Applicant: CJ Cheiljedang Corporation
Inventor： Han Won Lee , Young Lyeol Yang , So Young Kim , Yong Uk Shin , Jin Sook Chang , Hye Won Um , Young Hyoung Goh , Sung Hoo Jhon
IPC: C07C29/147 , C07D307/20 , C07C1/24 , C07D207/12 , C08F110/02 , C07C29/09 , C07D307/22 , C07D307/08
CPC classification number: C07C1/24 , C07C29/09 , C07C29/149 , C07C29/48 , C07C2529/40 , C07D207/12 , C07D307/08 , C07D307/20 , C07D307/22 , C07C11/04 , C07C31/12 , C07C31/08 , C07C31/202
Abstract: The present invention relates to a method of producing bio-based homoserine lactone and bio-based organic acid through hydrolysis of O-acyl homoserine produced by a microorganism in the presence of an acid catalyst. According to the present invention, O-acyl homoserine produced by a microorganism is used as a raw material for producing 1,4-butanediol, gamma-butyrolactone, tetrahydrofuran and the like, which are industrially highly useful. The O-acyl homoserine produced by a microorganism can substitute conventional petrochemical products, can solve environmental concerns, including the emission of pollutants and the exhaustion of natural resources, and can be continuously renewable so as not to exhaust natural resources.
Abstract translation: 本发明涉及通过在酸催化剂存在下由微生物产生的O-酰基高丝氨酸的水解生产生物基高丝氨酸内酯和生物基有机酸的方法。 根据本发明，由微生物生产的O-酰基高丝氨酸用作生产1,4-丁二醇，γ-丁内酯，四氢呋喃等的工业用高原料。 由微生物生产的O-酰基高丝氨酸可代替常规的石化产品，可以解决环境问题，包括污染物的排放和自然资源的枯竭，并可以不断更新，以免自然资源枯竭。
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公开(公告)号：US11352608B2
公开(公告)日：2022-06-07
申请号：US16466940
申请日：2019-03-08
Applicant: CJ CHEILJEDANG CORPORATION
Inventor： Sun Hyoung Choi , Jin Sook Chang , Hyung Joon Kim , Byoung Hoon Yoon , Ji Yeon Lee , Yunjung Choi
Abstract: The present disclosure relates to a novel promoter and a method for producing L-amino acids using the promoter, and more specifically, to a novel polynucleotide having promoter activity, a vector and a microorganism of the genus Corynebacterium comprising the polynucleotide, a method for producing L-amino acids using the microorganism, and a fermented composition.
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