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公开(公告)号：US10526287B2
公开(公告)日：2020-01-07
申请号：US15567978
申请日：2016-04-22
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Rishi G. Vaswani
IPC: C07D211/22 , C07D211/26 , C07D309/20 , C07D215/44 , C07D317/28 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D239/30 , C07C215/44 , C07D417/06 , C07D263/32 , C07D205/12 , C07D207/32 , C07D211/36 , C07D213/64 , C07D305/06 , C07C255/58 , C07C211/09 , C07C211/36 , C07C211/40 , C07C215/14 , C07C217/08 , C07C229/10 , C07C229/38 , C07C229/46 , C07C233/41 , C07C237/06 , C07C255/24 , C07C215/42 , C07C255/30 , C07D211/58 , C07D211/76 , C07D213/38 , C07D213/69 , C07D213/73 , C07D295/195 , A61P35/00
Abstract: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.
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公开(公告)号：US20180290976A1
公开(公告)日：2018-10-11
申请号：US15567978
申请日：2016-04-22
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Rishi G. Vaswani
IPC: C07D211/26 , C07D211/58 , C07C211/40 , C07D213/38 , C07C229/10 , C07D213/73 , C07C255/58 , C07D211/76 , C07D401/06 , C07C215/42 , C07C233/41 , C07C217/08 , C07C237/06 , C07D295/195 , C07C229/38 , C07C255/30 , C07D213/69 , C07D305/06
CPC classification number: C07D211/26 , A61P35/00 , C07B2200/07 , C07C211/09 , C07C211/36 , C07C211/40 , C07C215/14 , C07C215/42 , C07C215/44 , C07C217/08 , C07C229/10 , C07C229/38 , C07C229/46 , C07C233/41 , C07C237/06 , C07C255/24 , C07C255/30 , C07C255/58 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/44 , C07D205/12 , C07D207/32 , C07D211/22 , C07D211/36 , C07D211/58 , C07D211/76 , C07D213/38 , C07D213/64 , C07D213/69 , C07D213/73 , C07D215/44 , C07D239/30 , C07D263/32 , C07D295/195 , C07D305/06 , C07D309/20 , C07D317/28 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D417/06
Abstract: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.
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公开(公告)号：US09980952B2
公开(公告)日：2018-05-29
申请号：US15155749
申请日：2016-05-16
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D471/04 , A61K31/4545 , C07D401/14 , C07D401/12 , C07D417/04 , C07D487/04 , C07D417/14 , C07D405/14 , C07D409/06
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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![BENZO [C] ISOXAZOLOAZEPINE BROMODOMAIN INHIBITORS AND USES THEREOF](/abs-image/US/2015/05/28/US20150148337A1/abs.jpg.150x150.jpg)
14.发明申请BENZO [C] ISOXAZOLOAZEPINE BROMODOMAIN INHIBITORS AND USES THEREOF 有权BENZO [C] ISOXAZOLOAZEPINE BROMODOMAIN抑制剂及其用途公开(公告)号：US20150148337A1
公开(公告)日：2015-05-28
申请号：US14405209
申请日：2013-06-06
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , Michael Charles Hewitt , Victor S. Gehling , Rishi G. Vaswani
IPC: C07D498/04
CPC classification number: A61K31/55 , C07D498/04
Abstract: The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作含溴结构域蛋白质的抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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公开(公告)号：US11547695B2
公开(公告)日：2023-01-10
申请号：US17241315
申请日：2021-04-27
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Francois Brucelle , Victor S. Gehling , Avinash Khanna
IPC: C07D205/12 , C07D221/20 , A61K31/397 , A61P31/22 , A61P31/18 , A61P35/02 , A61K31/438 , A61P35/00
Abstract: Provided are novel compounds of Formula (I or Ia′): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I or Ia′), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.
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Patent Agency Ranking
公开(公告)号：US11459315B2
公开(公告)日：2022-10-04
申请号：US16762600
申请日：2018-11-08
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Jehrod B. Brenneman , Alexandre Côté , Victor S. Gehling , Avinash Khanna , Julian R. Levell , Ludivine Moine
IPC: C07D405/14 , C07D401/12 , C07D401/14 , C07D471/04
Abstract: Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compostions thereof, which are useful for treating a variety of conditions associated with methyl modifying enzymes.
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公开(公告)号：US20210230148A1
公开(公告)日：2021-07-29
申请号：US16762600
申请日：2018-11-08
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Jehrod B. Brenneman , Alexandre Côté , Victor S. Gehling , Avinash Khanna , Julian R. Levell , Ludivine Moine
IPC: C07D405/14 , C07D401/14 , C07D401/12 , C07D471/04
Abstract: Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compostions thereof, which are useful for treating a variety of conditions associated with methyl modifying enzymes.
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公开(公告)号：US10689371B2
公开(公告)日：2020-06-23
申请号：US16387851
申请日：2019-04-18
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Alexandre Côté , Victor S. Gehling , Avinash Khanna , Ludivine Moine , Jacob I. Stuckey
IPC: C07D405/14 , C07D405/12 , A61P35/00
Abstract: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.
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公开(公告)号：US20180009735A1
公开(公告)日：2018-01-11
申请号：US15658219
申请日：2017-07-24
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , James Edmund Audia , Alexandre Cote , Martin Duplessis , Victor S. Gehling , Andrew Charles Good , Jean-Christophe Harmange , Yves LeBlanc , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
IPC: C07C211/42 , C07D401/12 , A61K31/135 , A61K31/166 , C07D309/04 , C07D305/08 , C07D295/185 , C07D231/12 , C07D215/08 , C07D213/38 , C07D211/46 , C07D211/26 , C07D207/06 , C07D205/12 , C07D205/04 , C07C317/36 , C07C255/58 , C07C237/48 , C07C229/50 , C07C217/74 , A61K45/06 , A61K31/517 , A61K31/495 , A61K31/4747 , A61K31/4545 , A61K31/445 , A61K31/4406 , A61K31/437 , A61K31/4155 , A61K31/415 , A61K31/40 , A61K31/397 , A61K31/351 , A61K31/337 , A61K31/277 , A61K31/196 , C07D405/12
CPC classification number: C07C211/42 , A61K31/135 , A61K31/166 , A61K31/196 , A61K31/277 , A61K31/337 , A61K31/351 , A61K31/397 , A61K31/40 , A61K31/415 , A61K31/4155 , A61K31/437 , A61K31/4406 , A61K31/445 , A61K31/4545 , A61K31/4747 , A61K31/495 , A61K31/517 , A61K45/06 , C07C217/74 , C07C229/50 , C07C237/48 , C07C255/58 , C07C317/36 , C07C2601/02 , C07C2601/04 , C07C2603/94 , C07D205/04 , C07D205/12 , C07D207/06 , C07D211/26 , C07D211/46 , C07D211/78 , C07D213/38 , C07D215/08 , C07D231/12 , C07D295/185 , C07D305/08 , C07D309/04 , C07D401/12 , C07D405/12
Abstract: Provided herein are compounds of formula I: and salts thereof and compositions and uses thereof. The compounds are useful as inhibitors of LSD1. Also included are pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various LSD1-mediated disorders.
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公开(公告)号：US20170312262A9
公开(公告)日：2017-11-02
申请号：US15155749
申请日：2016-05-16
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: A61K31/4545 , C07D417/14 , C07D417/04 , C07D409/06 , C07D405/14 , C07D401/14 , C07D401/12 , C07D471/04 , C07D487/04
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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