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128 条记录 (耗时 0.058 秒)

    Devices, systems, and methods for reshaping a heat valve annulus
    12.
    发明申请
    Devices, systems, and methods for reshaping a heat valve annulus 有权
    用于重新形成热阀环的装置，系统和方法

    公开(公告)号：US20090306622A1

    公开(公告)日：2009-12-10

    申请号：US12462956

    申请日：2009-08-12

    申请人： Timothy R. Machold ,  David A. Rahdert ,  John A. Macoviak ,  Robert T. Chang ,  Rick A. Soss

    发明人： Timothy R. Machold ,  David A. Rahdert ,  John A. Macoviak ,  Robert T. Chang ,  Rick A. Soss

    IPC分类号： A61M31/00 ,  A61F2/24

    CPC分类号： A61F2/2418 ,  A61B2017/00243 ,  A61F2/2445 ,  A61F2/2454 ,  A61F2/2466 ,  A61F2220/0016

    摘要： Devices, systems, and methods employ an implant that is sized and configured to attach to the annulus of a dysfunctional heart valve annulus. In use, the implant extends across the major axis of the annulus above and/or along the valve annulus. The implant reshapes the major axis dimension and/or other surrounding anatomic structures. The implant restores to the heart valve annulus and leaflets a more functional anatomic shape and tension. The more functional anatomic shape and tension are conducive to coaptation of the leaflets during systole, which, in turn, reduces regurgitation. The implant improves function to the valve, without surgically cinching, resecting, and/or fixing in position large portions of a dilated annulus, or without the surgical fixation of ring-like structures.

    摘要翻译： 装置，系统和方法采用尺寸和构造成附着到功能障碍性心脏瓣膜环的环的植入物。 在使用中，植入物跨过瓣膜环上方和/或沿着瓣膜环的环的长轴延伸。 植入物重塑长轴尺寸和/或其他周围的解剖结构。 植入物恢复到心脏瓣膜环，并具有更多功能的解剖形状和张力。 更多功能的解剖形状和张力有利于收缩期间传单的接合，这反过来又降低了反流。 植入物可以改善瓣膜的功能，而无需外科手术收紧，切除和/或固定在扩张的环的大部分位置，或无环状结构的手术固定。

    Use of intravascular hypothermia during angioplasty procedures
    13.
    发明授权
    Use of intravascular hypothermia during angioplasty procedures 有权
    在血管成形术过程中使用血管内低温

    公开(公告)号：US07510569B2

    公开(公告)日：2009-03-31

    申请号：US10933979

    申请日：2004-09-02

    申请人： Michael W. Dae ,  Wade A. Keller ,  Timothy R. Machold

    发明人： Michael W. Dae ,  Wade A. Keller ,  Timothy R. Machold

    IPC分类号： A61F7/12

    CPC分类号： A61F7/12 ,  A61F7/123 ,  A61F2007/0056 ,  A61F2007/0076 ,  A61F2007/126 ,  A61M25/1002

    摘要： Methods and apparatus for preventing myocardial infarction, or lessening the size/severity of an evolving myocardial infarction, by cooling at least the affected area of the myocardium using an intravascular heat exchange catheter. The heat exchange catheter may be inserted into the vasculature (e.g., a vein) and advanced to a position wherein a heat exchanger on the catheter is located in or near the heart (e.g., within the vena cava near the patient's heart). Thereafter, the heat exchange catheter is used to cool the myocardium (or the entire body of the patient) to a temperature that effectively lessens the metabolic rate and/or oxygen consumption of the ischemic myocardial cells or otherwise protects the ischemic myocardium from undergoing irreversible damage or infarction.

    摘要翻译： 通过使用血管内热交换导管至少冷却至少心肌的受影响区域来预防心肌梗死或减轻心肌梗死的大小/严重程度的方法和装置。 热交换导管可以插入脉管系统（例如静脉）中并且前进到导管上的热交换器位于心脏中或附近（例如在患者心脏附近的腔静脉内）的位置。 此后，热交换导管用于将心肌（或患者的整个身体）冷却到有效降低缺血心肌细胞的代谢率和/或氧消耗的温度，或以其它方式保护缺血心肌免受不可逆损伤 或梗死。

    Heat exchange catheter with discrete heat exchange elements
    16.
    发明授权
    Heat exchange catheter with discrete heat exchange elements 有权

    公开(公告)号：US06702840B2

    公开(公告)日：2004-03-09

    申请号：US09907799

    申请日：2001-07-18

    申请人： Wade E. Keller ,  Timothy R. Machold ,  Mark A. Saab

    发明人： Wade E. Keller ,  Timothy R. Machold ,  Mark A. Saab

    IPC分类号： A61F700

    CPC分类号： A61F7/12 ,  A61F2007/126

    摘要： A catheter for exchanging heat with a body fluid is disclosed. The catheter includes a main shaft and a heat exchange region having a plurality of heat exchange elements each having a length and opposed ends. Each of the elements is attached on at least one of its ends to the shaft and disposed so that when inserted in a fluid body cavity having body fluid therein, the body fluid may circumferentially surround each heat exchange element along a portion of the length of the heat exchange element. The catheter includes a fluid circulation path therein, which desirably includes the hollow lumen within each of heat exchange elements. The heat exchange elements may be connected at two points along the shaft using manifolds that are in fluid communication with fluid flow paths within the shaft. Alternatively, the heat exchange elements may be connected at only one point and be permitted to float in a proximal or distal direction with respect to the catheter. The heat exchange region may be formed on a distal portion of the catheter, or may be formed along the entire length thereof. In the former configuration, an insulating member, such as a balloon, may be provided along the shaft proximal to the heat exchange region. Ribs may be provided on each heat exchange element to disrupt flow therearound and increase heat exchange. Each of the heat exchange elements may be non-circular in cross-section, and may extend in an undulating path with respect to the catheter shaft.

    Method of controlling body temperature while reducing shivering
    17.
    发明授权
    Method of controlling body temperature while reducing shivering 有权
    减少发抖的方法来控制体温

    公开(公告)号：US06702839B1

    公开(公告)日：2004-03-09

    申请号：US10137741

    申请日：2002-05-02

    申请人： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

    发明人： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

    IPC分类号： A61F700

    CPC分类号： A61M25/00 ,  A61B2017/00084 ,  A61F7/123 ,  A61F2007/0056 ,  A61F2007/0295 ,  A61F2007/126 ,  A61M2205/36

    摘要： A method and apparatus for lowering the body temperature of a patient while reducing shivering by using a heat exchange device in combination with an &agr;2-adrenoreceptor agonist, a non-opiod analgesic monoamine uptake inhibitor or neuropeptide that temporarily reduces shivering. The devices disclosed include a catheter having a heat exchange balloon thereon with heat exchange fluid circulating through the interior of the balloon. The heat exchange balloon is placed in the vasculature of a patient, and heat exchange fluid at a temperature other than the temperature of the blood in the vasculature is circulated through the interior of the balloon to add or remove heat from the blood of the patient. Various &agr;2-adrenoreceptor agonist &agr;2-adrenoreceptor agonists, non-opiod analgesic monoamine uptake inhibitors and neuropeptides are disclosed including dexmedetomidine, nefopam, neurotensin and anticonvulsant medications and pharmaceutically acceptable salts thereof. A control system for the control of the patient's temperature is disclosed for controlling the patient's temperature in conjunction with administering the &agr;2-adrenoreceptor agonist, non-opiod analgesic monoamine uptake inhibitor or neuropeptide.

    摘要翻译： 一种用于降低患者体温的方法和装置，同时通过使用热交换装置与α2-肾上腺素受体激动剂，非阿片类镇痛单胺摄取抑制剂或神经肽暂时减轻发抖相结合来减轻发抖。 所公开的装置包括具有热交换球囊的导管，其中热交换流体循环通过气囊的内部。 将热交换球放置在患者的脉管系统中，并且在脉管系统中除血液温度以外的温度下的热交换流体循环通过气囊的内部以从患者的血液中添加或除去热量。 公开了各种α2-肾上腺素受体激动剂α2-肾上腺素受体激动剂，非阿片类镇痛单胺摄取抑制剂和神经肽，包括右美托咪定，奈福泮，神经降压素和抗惊厥药物及其药学上可接受的盐。 公开了用于控制患者体温的控制系统，用于与施用α2-肾上腺素受体激动剂，非阿片类镇痛单胺摄取抑制剂或神经肽一起控制患者的温度。