公开(公告)号：US20110230936A1

公开(公告)日：2011-09-22

申请号：US12727889

申请日：2010-03-19

申请人： Steven L. Jensen ,  Dwight E. Nelson

发明人： Steven L. Jensen ,  Dwight E. Nelson

IPC分类号： A61N1/05 ,  A61N1/00

CPC分类号： A61N1/36146 ,  A61N1/0534 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36139

摘要： This disclosure describes techniques for delivering electrical stimulation at one or more phases relative to an ongoing oscillating signal in a patient, and then mapping the response to the oscillating signal. The techniques may reduce or eliminate the oscillating signal. In one example, the disclosure is directed to a method that includes delivering a set of first electrical stimulation at a plurality of phases relative to an oscillating signal, measuring a response in the oscillating signal to the set of first electrical stimulation after delivering electrical stimulation at each respective phase of the plurality of phases, determining a phase at which to deliver second electrical stimulation based on the measured responses, and delivering the second electrical stimulation to the patient at the determined phase to produce a therapeutic effect.

摘要翻译： 本公开描述了相对于患者中正在进行的振荡信号在一个或多个相位递送电刺激的技术，然后将响应映射到振荡信号。 这些技术可以减少或消除振荡信号。 在一个示例中，本公开涉及一种方法，其包括相对于振荡信号在多个相位递送一组第一电刺激，在将电刺激传递到第一电刺激之后测量振荡信号中的响应到第一电刺激 确定基于所测量的响应来传递第二电刺激的相位，以及在确定的阶段将第二电刺激递送给患者以产生治疗效果。

公开(公告)号：US08868173B2

公开(公告)日：2014-10-21

申请号：US13446459

申请日：2012-04-13

申请人： Dwight E. Nelson ,  Rahul Agarwal ,  Steven L. Jensen ,  Rahul Gupta

发明人： Dwight E. Nelson ,  Rahul Agarwal ,  Steven L. Jensen ,  Rahul Gupta

IPC分类号： A61B5/04 ,  A61B5/0476 ,  A61N1/36 ,  A61N1/372 ,  A61B5/0496 ,  A61M5/142 ,  A61N1/05

CPC分类号： A61N1/36139 ,  A61B5/0476 ,  A61B5/0496 ,  A61M5/14276 ,  A61M2005/14208 ,  A61N1/0534 ,  A61N1/36067 ,  A61N1/36132 ,  A61N1/36153 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36185 ,  A61N1/37247

摘要： Various embodiments concern sensing a LFP signal from one or more electrodes, measuring the amplitude of the signals over a period of time, and calculating a plurality of variance values from the amplitude, wherein each of the variance values correspond to the variance of the amplitude for a different interval of time of the period of time with respect to the other variance values. Such embodiments may further include assessing the relative level of neural activation of an area of the brain based on the variance values, wherein the area of the brain is assessed to have a relatively higher level of neural activation when the variance is relatively higher and the area of the brain is assessed to have a relatively lower level of neural activation when the variance is relatively lower.

摘要翻译： 各种实施例涉及感测来自一个或多个电极的LFP信号，在一段时间内测量信号的幅度，以及从幅度计算多个方差值，其中每个方差值对应于幅度的方差 相对于其他方差值的时间段的不同时间间隔。 这样的实施方案可以进一步包括基于方差值评估脑区域的神经激活的相对水平，其中当方差相对较高时评估脑的面积具有相对较高水平的神经激活， 当方差相对较低时，脑的评估具有相对较低水平的神经激活。

公开(公告)号：US07680540B2

公开(公告)日：2010-03-16

申请号：US11194088

申请日：2005-07-29

申请人： Steven L. Jensen ,  Allen D. Almendinger ,  Christopher M. Arnett

发明人： Steven L. Jensen ,  Allen D. Almendinger ,  Christopher M. Arnett

IPC分类号： A61N1/08

CPC分类号： A61N1/37252 ,  A61N1/36007 ,  A61N1/3605 ,  A61N1/3625 ,  A61N1/37241

摘要： The disclosure relates to an electrical trial stimulator that stores multiple applications to selectively emulate the operation of different chronically implanted stimulators. Each application corresponds to a different chronically implanted stimulator. Upon selection of a particular application, the stimulator executes a set of instructions to emulate the operation of a chronically implanted stimulator that corresponds to the application. The multi-application stimulator permits a physician to select an application for stimulation therapy, and evaluate efficacy of a particular chronically implanted stimulator. In addition, the physician may select any of the other stimulation applications to emulate other stimulators. The different stimulation applications may correspond to different stimulators that deliver a similar therapy, e.g., stimulators designed to deliver spinal cord stimulation for alleviation of chronic pain. Alternatively, the applications may correspond to stimulators that deliver different types of therapy, e.g., stimulators that deliver spinal cord, deep brain, gastrointestinal, or pelvic floor stimulation.

摘要翻译： 本公开涉及一种电试验刺激器，其存储多个应用以选择性地模拟不同的长期植入的刺激器的操作。 每个应用对应于不同的长期植入的刺激器。 在选择特定应用时，刺激器执行一组指令以模拟对应于应用的长期植入的刺激器的操作。 多应用刺激器允许医师选择用于刺激治疗的应用，并评估特定的长期植入的刺激器的功效。 此外，医师可以选择任何其他刺激应用来模拟其他刺激器。 不同的刺激应用可以对应于递送类似疗法的不同刺激器，例如设计用于递送脊髓刺激以减轻慢性疼痛的刺激器。 或者，应用可以对应于递送不同类型治疗的刺激器，例如，递送脊髓，深部脑，胃肠道或盆底刺激的刺激器。

公开(公告)号：US07330754B2

公开(公告)日：2008-02-12

申请号：US10973136

申请日：2004-10-26

申请人： Steven L. Jensen

发明人： Steven L. Jensen

IPC分类号： A61N1/08

CPC分类号： A61N1/08 ,  A61N1/36071

摘要： A stream processor for an implantable medical device provides rapid computation using simple architecture and low power in which each input data sample is processed in parallel by a separate and independent central processing unit executing similar or identical kernel code consisting of the following elements. A housing contains a power source. A controller with memory coupled to the power source. A first physiological sensing apparatus and at least a second physiological sensing apparatus is coupled to the controller. A first stream processing element is coupled to the first physiological sensor and coupled to the controller. At least a second stream processing element is coupled to the second physiological sensor and coupled to the controller.

摘要翻译： 用于可植入医疗设备的流处理器使用简单的架构和低功率提供快速计算，其中每个输入数据样本由执行由以下元件组成的相似或相同的内核代码的独立和独立的中央处理单元并行处理。 外壳包含电源。 具有耦合到电源的存储器的控制器。 第一生理感测装置和至少第二生理感测装置耦合到控制器。 第一流处理元件耦合到第一生理传感器并耦合到控制器。 至少第二流处理元件耦合到第二生理传感器并且耦合到控制器。

公开(公告)号：US06878999B2

公开(公告)日：2005-04-12

申请号：US10619699

申请日：2003-07-15

申请人： Philip L. Hower ,  John Lin ,  Sameer Pendharkar ,  Steven L. Jensen

发明人： Philip L. Hower ,  John Lin ,  Sameer Pendharkar ,  Steven L. Jensen

IPC分类号： H01L23/482 ,  H01L29/06 ,  H01L29/417 ,  H01L29/45 ,  H01L29/49 ,  H01L29/73 ,  H01L29/78 ,  H01L29/76 ,  H01L29/94 ,  H01L31/062 ,  H01L31/113 ,  H01L31/119

CPC分类号： H01L29/7816 ,  H01L23/4824 ,  H01L24/05 ,  H01L24/06 ,  H01L29/0692 ,  H01L29/0696 ,  H01L29/41758 ,  H01L29/456 ,  H01L29/4933 ,  H01L29/73 ,  H01L29/7824 ,  H01L2224/04042 ,  H01L2224/05553 ,  H01L2224/48463 ,  H01L2224/4911 ,  H01L2924/1305 ,  H01L2924/13091 ,  H01L2924/14 ,  H01L2924/00

摘要： Segmented transistor devices are provided, wherein contiguous individual transistor segments extend along corresponding segment axes, in which two or more of the segment axes are at a non-zero angle with respect to one another. The segmentation of the transistor provides a high overall device aspect ratio which may be easily fit into pre-existing circuit blocks or cells in a device layout, thereby facilitating device scaling.

摘要翻译： 提供了分段晶体管器件，其中相邻的单独晶体管​​段沿着相应的分段轴线延伸，其中两个或多个分段轴线相对于彼此处于非零角度。 晶体管的分割提供了高的整体器件纵横比，其可以容易地装配到器件布局中的预先存在的电路块或单元中，从而有助于器件缩放。

公开(公告)号：US09878161B2

公开(公告)日：2018-01-30

申请号：US13446801

申请日：2012-04-13

申请人： Jianping Wu ,  Steven L. Jensen ,  Dwight E. Nelson

发明人： Jianping Wu ,  Steven L. Jensen ,  Dwight E. Nelson

IPC分类号： A61N1/00 ,  A61N1/36

CPC分类号： A61N1/36171 ,  A61N1/36067 ,  A61N1/36139

摘要： The disclosure relates to the delivery of electrical stimulation therapy to the brain of a patient, e.g., to treat or otherwise manage a patient disorder. In one example, the disclosure relates to a method comprising generating electrical stimulation via a medical device; delivering the electrical stimulation at a first frequency to a brain of a patient when the bioelectrical brain signals of the patient oscillate at a second frequency, where the second frequency corresponds to pathological brain signals of the patient, where the electrical stimulation is selected to entrain the bioeiectrical brain signals of the patient; and adjusting the delivered electrical stimulation from the first frequency to a third frequency, where adjusting the delivered electrical stimulation changes the bioelectrical brain signal oscillations to a fourth frequency different from the second frequency. The fourth frequency may correspond to an oscillation frequency of non-pathological brain signals of the patient.

公开(公告)号：US20120277820A1

公开(公告)日：2012-11-01

申请号：US13446801

申请日：2012-04-13

申请人： Jianping Wu ,  Steven L. Jensen ,  Dwight E. Nelson

发明人： Jianping Wu ,  Steven L. Jensen ,  Dwight E. Nelson

IPC分类号： A61N1/36

CPC分类号： A61N1/36171 ,  A61N1/36067 ,  A61N1/36139

摘要： The disclosure relates to the delivery of electrical stimulation therapy to the brain of a patient, e.g., to treat or otherwise manage a patient disorder. In one example, the disclosure relates to a method comprising generating electrical stimulation via a medical device; delivering the electrical stimulation at a first frequency to a brain of a patient when the bioelectrical brain signals of the patient oscillate at a second frequency, where the second frequency corresponds to pathological brain signals of the patient, where the electrical stimulation is selected to entrain the bioeiectrical brain signals of the patient; and adjusting the delivered electrical stimulation from the first frequency to a third frequency, where adjusting the delivered electrical stimulation changes the bioelectrical brain signal oscillations to a fourth frequency different from the second frequency. The fourth frequency may correspond to an oscillation frequency of non-pathological brain signals of the patient.

摘要翻译： 本公开涉及将电刺激治疗递送到患者的大脑，例如治疗或以其他方式治疗患者病症。 在一个示例中，本公开涉及一种包括经由医疗装置产生电刺激的方法; 当患者的生物电脑信号以第二频率振荡时，将第一频率的电刺激递送到患者的大脑，其中第二频率对应于患者的病理性脑信号，其中选择电刺激以夹带 患者生物大脑信号; 以及将所递送的电刺激从所述第一频率调整到第三频率，其中调节所输送的电刺激将所述生物电脑信号振荡改变到与所述第二频率不同的第四频率。 第四频率可以对应于患者的非病理性脑信号的振荡频率。

公开(公告)号：US20120271189A1

公开(公告)日：2012-10-25

申请号：US13446459

申请日：2012-04-13

申请人： Dwight E. Nelson ,  Rahul Agarwal ,  Steven L. Jensen ,  Rahul Gupta

发明人： Dwight E. Nelson ,  Rahul Agarwal ,  Steven L. Jensen ,  Rahul Gupta

IPC分类号： A61B5/0476

CPC分类号： A61N1/36139 ,  A61B5/0476 ,  A61B5/0496 ,  A61M5/14276 ,  A61M2005/14208 ,  A61N1/0534 ,  A61N1/36067 ,  A61N1/36132 ,  A61N1/36153 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36185 ,  A61N1/37247

摘要： Various embodiments concern sensing a LFP signal from one or more electrodes, measuring the amplitude of the signals over a period of time, and calculating a plurality of variance values from the amplitude, wherein each of the variance values correspond to the variance of the amplitude for a different interval of time of the period of time with respect to the other variance values. Such embodiments may further include assessing the relative level of neural activation of an area of the brain based on the variance values, wherein the area of the brain is assessed to have a relatively higher level of neural activation when the variance is relatively higher and the area of the brain is assessed to have a relatively lower level of neural activation when the variance is relatively lower.

摘要翻译： 各种实施例涉及感测来自一个或多个电极的LFP信号，在一段时间内测量信号的幅度，以及从幅度计算多个方差值，其中每个方差值对应于幅度的方差 相对于其他方差值的时间段的不同时间间隔。 这样的实施方案可以进一步包括基于方差值来评估脑区域的神经激活的相对水平，其中当方差相对较高时评估脑的面积具有相对较高水平的神经激活， 当方差相对较低时，脑的评估具有相对较低水平的神经激活。

公开(公告)号：US20120101547A1

公开(公告)日：2012-04-26

申请号：US13338751

申请日：2011-12-28

申请人： Steven L. Jensen ,  Dwight E. Nelson

发明人： Steven L. Jensen ,  Dwight E. Nelson

IPC分类号： A61N1/36

CPC分类号： A61N1/36146 ,  A61N1/0534 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36139

摘要： This disclosure describes techniques for delivering electrical stimulation at one or more phases relative to an ongoing oscillating signal in a patient, and then mapping the response to the oscillating signal. The techniques may reduce or eliminate the oscillating signal. In one example, the disclosure is directed to a method that includes delivering a set of first electrical stimulation at a plurality of phases relative to an oscillating signal, measuring a response in the oscillating signal to the set of first electrical stimulation after delivering electrical stimulation at each respective phase of the plurality of phases, determining a phase at which to deliver second electrical stimulation based on the measured responses, and delivering the second electrical stimulation to the patient at the determined phase to produce a therapeutic effect.

摘要翻译： 本公开描述了相对于患者中正在进行的振荡信号在一个或多个相位递送电刺激的技术，然后将响应映射到振荡信号。 这些技术可以减少或消除振荡信号。 在一个示例中，本公开涉及一种方法，其包括相对于振荡信号在多个相位递送一组第一电刺激，在将电刺激传递到第一电刺激之后测量振荡信号中的响应到第一电刺激 确定基于所测量的响应来传递第二电刺激的相位，以及在确定的阶段将第二电刺激递送给患者以产生治疗效果。

公开(公告)号：US08099170B2

公开(公告)日：2012-01-17

申请号：US12727889

申请日：2010-03-19

申请人： Steven L. Jensen ,  Dwight E. Nelson

发明人： Steven L. Jensen ,  Dwight E. Nelson

IPC分类号： A61N1/00

CPC分类号： A61N1/36146 ,  A61N1/0534 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36139

摘要： This disclosure describes techniques for delivering electrical stimulation at one or more phases relative to an ongoing oscillating signal in a patient, and then mapping the response to the oscillating signal. The techniques may reduce or eliminate the oscillating signal. In one example, the disclosure is directed to a method that includes delivering a set of first electrical stimulation at a plurality of phases relative to an oscillating signal, measuring a response in the oscillating signal to the set of first electrical stimulation after delivering electrical stimulation at each respective phase of the plurality of phases, determining a phase at which to deliver second electrical stimulation based on the measured responses, and delivering the second electrical stimulation to the patient at the determined phase to produce a therapeutic effect.

摘要翻译： 本公开描述了相对于患者中正在进行的振荡信号在一个或多个相位递送电刺激的技术，然后将响应映射到振荡信号。 这些技术可以减少或消除振荡信号。 在一个示例中，本公开涉及一种方法，其包括相对于振荡信号在多个相位递送一组第一电刺激，在将电刺激传递到第一电刺激之后测量振荡信号中的响应到第一电刺激 确定基于所测量的响应来传递第二电刺激的相位，以及在确定的阶段将第二电刺激递送给患者以产生治疗效果。