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公开(公告)号：US20110300104A1
公开(公告)日：2011-12-08
申请号：US13152377
申请日：2011-06-03
申请人： Yao-Ling Qiu , Ce Wang , Hui Cao , Xiaowen Peng , Datong Tang , Yat Sun Or
发明人： Yao-Ling Qiu , Ce Wang , Hui Cao , Xiaowen Peng , Datong Tang , Yat Sun Or
IPC分类号： A61K31/4178 , A61K31/4439 , A61K31/5377 , A61K31/496 , A61K31/427 , C12N7/06 , A61P31/14 , A61K39/00 , A61K38/21 , A61K38/19 , A61K31/7056 , C07D491/107 , A61K31/422
CPC分类号： A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K31/7056 , A61K38/21 , A61K45/06 , C12N2770/24211 , A61K2300/00
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the Hepatitis C Virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the Hepatitis C Virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译： 本发明公开了式（I）化合物或其药学上可接受的盐，酯或前药：其抑制含RNA病毒，特别是丙型肝炎病毒（HCV）。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
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公开(公告)号：US20060252710A1
公开(公告)日：2006-11-09
申请号：US11122251
申请日：2005-05-04
申请人： Guoqiang Wang , Ly Phan , Yat Or , Yao-Ling Qiu , Deqiang Niu , Yulin Peng , Marina Busuyek , Yanchun Wang , Suanne Nakajima
发明人： Guoqiang Wang , Ly Phan , Yat Or , Yao-Ling Qiu , Deqiang Niu , Yulin Peng , Marina Busuyek , Yanchun Wang , Suanne Nakajima
IPC分类号： C07H17/08 , A61K31/7052
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes processes by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US20100226882A1
公开(公告)日：2010-09-09
申请号：US12707190
申请日：2010-02-17
申请人： Yat Sun Or , Xiaowen Peng , Ce Wang , Lu Ying , Datong Tang , Yao-Ling Qiu
发明人： Yat Sun Or , Xiaowen Peng , Ce Wang , Lu Ying , Datong Tang , Yao-Ling Qiu
IPC分类号： A61K38/21 , C07D233/64 , A61K31/4178 , C07D401/14 , A61K31/444 , A61K31/4545 , C07D413/14 , A61K31/5377 , C07D241/04 , A61K31/497 , C07D277/593 , A61K31/427 , C07D263/38 , A61K31/422 , C07D257/04 , A61K31/41 , C07D215/12 , A61K31/4709 , C07D277/64 , A61K31/428 , C07D239/42 , A61K31/506 , C07D221/06 , A61K31/473 , A61K39/29 , A61P31/18 , A61P31/22 , C12N7/00
CPC分类号： C07D403/14 , A61K31/41 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/428 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/473 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K38/21 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D495/04 , C07D498/04 , C07F9/65583 , C12N2770/24211 , A61K2300/00
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译： 本发明公开了式（I）化合物或其药学上可接受的盐，酯或前药：其抑制含RNA病毒，特别是丙型肝炎病毒（HCV）。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
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公开(公告)号：US08609648B2
公开(公告)日：2013-12-17
申请号：US12816171
申请日：2010-06-15
申请人： Yat Sun Or , Lu Ying , Xiaowen Peng , Datong Tang , Ce Wang , Yao-Ling Qiu
发明人： Yat Sun Or , Lu Ying , Xiaowen Peng , Datong Tang , Ce Wang , Yao-Ling Qiu
IPC分类号： A01N43/42 , A01N43/00 , A61K31/00 , A61K31/535 , C07D513/02 , C07D515/02 , C07D267/02 , C07D281/02 , C07D291/08 , C07D413/00
CPC分类号： C07F9/6561 , A61K31/437 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/675 , A61K31/7056 , A61K38/00 , A61K45/06 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00 , A61K2300/00
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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公开(公告)号：US20110008288A1
公开(公告)日：2011-01-13
申请号：US12816171
申请日：2010-06-15
申请人： Yat Sun Or , Lu Ying , Xiaowen Peng , Datong Tang , Ce Wang , Yao-Ling Qiu
发明人： Yat Sun Or , Lu Ying , Xiaowen Peng , Datong Tang , Ce Wang , Yao-Ling Qiu
IPC分类号： A61K31/437 , C07D471/04 , C07F9/6561 , C07D498/04 , C07D513/04 , A61K31/5377 , A61K31/496 , A61K31/675 , A61K31/4709 , A61K31/506 , A61K39/00 , A61K38/21 , A61K31/7056 , A61P31/14 , C12N7/04
CPC分类号： C07F9/6561 , A61K31/437 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/675 , A61K31/7056 , A61K38/00 , A61K45/06 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00 , A61K2300/00
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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公开(公告)号：US08778938B2
公开(公告)日：2014-07-15
申请号：US13152377
申请日：2011-06-03
申请人： Yao-Ling Qiu , Ce Wang , Hui Cao , Xiaowen Peng , Datong Tang , Yat Sun Or
发明人： Yao-Ling Qiu , Ce Wang , Hui Cao , Xiaowen Peng , Datong Tang , Yat Sun Or
IPC分类号： A61K31/397 , A61K31/5377 , A61K31/495 , A61K31/506 , A61K31/443 , A61K31/4525 , A61K31/47 , A61K31/41 , A61K31/4178 , A61K31/4196 , A61K31/422 , A61K31/42 , A61K31/4245 , A61K31/427 , A61K31/428 , C07D273/01 , C07D239/24 , C07D241/04 , C07D221/20 , C07D277/60 , C07D277/20 , C07D263/02 , C07D263/30 , C07D261/20 , C07D257/02 , C07D233/54
CPC分类号： A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K31/7056 , A61K38/21 , A61K45/06 , C12N2770/24211 , A61K2300/00
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the Hepatitis C Virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the Hepatitis C Virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译： 本发明公开了式（I）化合物或其药学上可接受的盐，酯或前药：其抑制含RNA病毒，特别是丙型肝炎病毒（HCV）。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
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公开(公告)号：US08420686B2
公开(公告)日：2013-04-16
申请号：US12707190
申请日：2010-02-17
申请人： Yat Sun Or , Xiaowen Peng , Ce Wang , Lu Ying , Datong Tang , Yao-Ling Qiu
发明人： Yat Sun Or , Xiaowen Peng , Ce Wang , Lu Ying , Datong Tang , Yao-Ling Qiu
IPC分类号： A61K31/4178 , C07D403/10 , C07D403/12
CPC分类号： C07D403/14 , A61K31/41 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/428 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/473 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K38/21 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D495/04 , C07D498/04 , C07F9/65583 , C12N2770/24211 , A61K2300/00
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译： 本发明公开了式（I）化合物或其药学上可接受的盐，酯或前药：其抑制含RNA病毒，特别是丙型肝炎病毒（HCV）。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
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公开(公告)号：US20090118506A1
公开(公告)日：2009-05-07
申请号：US12212596
申请日：2008-09-17
申请人： IN JONG KIM , Tongzhu Liu , Yao-Ling Qiu , Guoqiang Wang , Jiang Long , Heejin Kim , Yanchun Wang , Ly Tam Phan , Yat Sun Or
发明人： IN JONG KIM , Tongzhu Liu , Yao-Ling Qiu , Guoqiang Wang , Jiang Long , Heejin Kim , Yanchun Wang , Ly Tam Phan , Yat Sun Or
IPC分类号： C07D405/14 , C07D417/14 , C07D413/14 , C07D401/14
CPC分类号： C07H17/08 , C07D213/69 , C07D213/80 , C07D309/40 , C07D498/12
摘要： The present invention discloses compounds of formula I, II or, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I，II或其药学上可接受的盐，酯或前药的化合物：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US07273853B2
公开(公告)日：2007-09-25
申请号：US11042720
申请日：2005-01-25
申请人： Yat Sun Or , Guoqiang Wang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
发明人： Yat Sun Or , Guoqiang Wang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
CPC分类号： C07H17/08 , A61K31/7052 , A61K45/06 , Y02A50/401 , Y02A50/478 , A61K2300/00
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US07064110B2
公开(公告)日：2006-06-20
申请号：US10717290
申请日：2003-11-19
申请人： Yat Sun Or , Wang Guoqiang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
发明人： Yat Sun Or , Wang Guoqiang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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