专利检索 ap:("Donald W. Hansen, Jr." OR "Robert W. Hamilton" OR "Barnett S. Pitzele" OR "Michael Clare") AND inv:"Barnett S. Pitzele" 第 2 页

11.

发明授权
Methods of making amidino compounds useful as nitric oxide synthase inhibitors 有权
标题翻译：制备脒基化合物可用作一氧化氮合酶抑制剂的方法

公开(公告)号：US07102013B2

公开(公告)日：2006-09-05

申请号：US10321969

申请日：2002-12-17

申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng

发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng

IPC分类号： C07D233/40 , C07C271/00 , C07C323/00

CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56

摘要： Method of making an alpha-amino acid compound having the structure of Formula 32: comprising treating under hydrolyzing conditions a hydantoin compound having the structure of Formula 33: where the substituents are described herein.

摘要翻译： 制备具有式32结构的α-氨基酸化合物的方法：包括在水解条件下处理具有结构式33的乙内酰脲化合物：其中取代基在本文中描述。

12.

发明授权
2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors 失效

公开(公告)号：US06951889B2

公开(公告)日：2005-10-04

申请号：US09953049

申请日：2001-09-15

申请人： Donald W. Hansen, Jr. , Ronald Keith Webber , Barnett S. Pitzele , James Sikorski , Mark A. Massa , Timothy J. Hagen , Margaret Grapperhaus , Lijuan Jane Wang , Arija A. Bergmanis , Steven W. Kramer , E. Ann Hallinan

发明人： Donald W. Hansen, Jr. , Ronald Keith Webber , Barnett S. Pitzele , James Sikorski , Mark A. Massa , Timothy J. Hagen , Margaret Grapperhaus , Lijuan Jane Wang , Arija A. Bergmanis , Steven W. Kramer , E. Ann Hallinan

IPC分类号： C07D265/32 , A61K31/198 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/08 , A61P21/04 , A61P25/04 , A61P25/06 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07C229/30 , C07C237/16 , C07C257/14 , C07C259/14 , C07C271/22 , C07D271/06 , C07D271/07 , C07D413/06 , C07F7/18 , A61K31/195 , C07C251/00

CPC分类号： C07D271/07 , C07B2200/07 , C07B2200/09 , C07C229/30 , C07C257/14 , C07C259/14 , C07C271/22 , C07D413/06 , C07F7/1804

摘要： The present invention relates to 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.

13.

发明授权
Pyrrolodino imidines useful as nitric oxide synthase inhibitors 失效
标题翻译：吡咯二酰亚胺可用作一氧化氮合酶抑制剂

公开(公告)号：US6043261A

公开(公告)日：2000-03-28

申请号：US199899

申请日：1998-11-25

申请人： Donald W. Hansen, Jr. , E. Ann Hallinan , Timothy J. Hagen , Steven W. Kramer , Suzanne Metz , Karen B. Peterson , Dale P. Spangler , Mihaly V. Toth , Kam F. Fok , Arija A. Bergmanis , R. Keith Webber , Mahima Trivedi , Foe S. Tjoeng , Barnett S. Pitzele

发明人： Donald W. Hansen, Jr. , E. Ann Hallinan , Timothy J. Hagen , Steven W. Kramer , Suzanne Metz , Karen B. Peterson , Dale P. Spangler , Mihaly V. Toth , Kam F. Fok , Arija A. Bergmanis , R. Keith Webber , Mahima Trivedi , Foe S. Tjoeng , Barnett S. Pitzele

IPC分类号： C07D319/06 , A61K31/045 , A61K31/12 , A61K31/15 , A61K31/165 , A61K31/19 , A61K31/35 , A61K31/351 , A61K31/357 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/42 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/451 , A61K31/55 , A61P9/00 , A61P25/00 , A61P25/30 , A61P29/00 , A61P43/00 , C07C251/44 , C07D207/22 , C07D211/72 , C07D211/76 , C07D223/10 , C07D223/12 , C07D225/02 , C07D309/06 , C07D333/16 , C07D333/20 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06 , C07D521/00 , A01W57/00

CPC分类号： C07D249/08 , C07D207/22 , C07D211/72 , C07D223/12 , C07D225/02 , C07D231/12 , C07D233/56 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06

摘要： The current invention discloses useful pyrrolodino imidine derivatives useful as nitric oxide synthase inhibitors.

摘要翻译： 本发明公开了可用作一氧化氮合酶抑制剂的有用的吡咯烷亚胺衍生物。

14.

发明授权
Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors 失效

公开(公告)号：US5981511A

公开(公告)日：1999-11-09

申请号：US813545

申请日：1997-03-05

申请人： Rolando E. Gapud , Timothy J. Hagen , Ann E. Hallinan , Donald W. Hansen, Jr. , Robert E. Manning , Suzanne Metz , Barnett S. Pitzele , Foe S. Tjoeng , Mihaly V. Toth , R. Keith Webber

发明人： Rolando E. Gapud , Timothy J. Hagen , Ann E. Hallinan , Donald W. Hansen, Jr. , Robert E. Manning , Suzanne Metz , Barnett S. Pitzele , Foe S. Tjoeng , Mihaly V. Toth , R. Keith Webber

IPC分类号： A61K31/00 , A61K31/155 , A61K31/195 , A61K31/197 , A61K31/22 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/42 , A61K31/535 , A61K31/5377 , A61K31/5395 , A61K31/55 , A61P9/00 , A61P25/04 , A61P29/00 , A61P37/00 , C07C257/14 , C07C259/14 , C07C271/22 , C07C275/16 , C07C313/28 , C07C313/34 , C07C323/60 , C07C327/22 , C07C329/02 , C07C329/06 , C07C333/04 , C07C391/00 , C07D223/12 , C07D233/54 , C07D233/56 , C07D233/76 , C07D261/08 , C07D273/02 , C07F7/08 , C07K5/068 , A01N55/00

CPC分类号： C07D233/64 , C07C257/14 , C07C259/14 , C07C275/16 , C07C313/28 , C07C323/60 , C07C327/22 , C07C329/02 , C07C329/06 , C07C333/04 , C07C391/00 , C07D223/12 , C07D261/08 , C07F7/0818

摘要： The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.

15.

发明授权
Process for the preparation of ethyl 3S-[[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-penty noate 失效
标题翻译：制备3S - [[4 - [[4-（氨基亚氨基甲基）苯基]氨基] -1,4-二氧代丁基]氨基] -4-戊酸乙酯的方法

公开(公告)号：US5631399A

公开(公告)日：1997-05-20

申请号：US647514

申请日：1996-05-14

申请人： Kevin A. Babiak , Srinivasan Babu , James R. Behling , Mark L. Boys , Kimberly J. Cain-Janicki , Wendel W. Doubleday , Payman Farid , Timothy J. Hagen , E. A. Hallinan , Donald W. Hansen, Jr. , Donald E. Korte , Kathleen T. Mc Laughlin , John R. Medich , Sean T. Nugent , Vlasdislav Orlovski , Jung M. Park , Karen B. Peterson , Daniel R. Pilipauskas , Barnett S. Pitzele , Sofya Tsymbalov , Glenn L. Stahl

发明人： Kevin A. Babiak , Srinivasan Babu , James R. Behling , Mark L. Boys , Kimberly J. Cain-Janicki , Wendel W. Doubleday , Payman Farid , Timothy J. Hagen , E. A. Hallinan , Donald W. Hansen, Jr. , Donald E. Korte , Kathleen T. Mc Laughlin , John R. Medich , Sean T. Nugent , Vlasdislav Orlovski , Jung M. Park , Karen B. Peterson , Daniel R. Pilipauskas , Barnett S. Pitzele , Sofya Tsymbalov , Glenn L. Stahl

IPC分类号： C07C227/02 , C07B61/00 , C07C227/12 , C07C227/34 , C07C229/08 , C07C257/18 , C07C229/30

CPC分类号： C07C227/12 , C07C227/34 , C07C257/18

摘要： The present invention relates to a novel process for the preparation of ethyl 3S-[[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-pentynoate and pharmaceutically acceptable acid addition salt thereof.

摘要翻译： 本发明涉及制备3S - [[4 - [[4-（氨基亚氨基甲基）苯基]氨基] -1,4-二氧代丁基]氨基] -4-戊酸乙酯及其药学上可接受的酸加成盐的新方法。

16.

发明授权
2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors 失效
标题翻译：可用作一氧化氮合酶抑制剂的2-氨基-2-烷基-4-己烯酸和己炔酸衍生物

公开(公告)号：US07005450B2

公开(公告)日：2006-02-28

申请号：US10819853

申请日：2004-04-07

申请人： Richard C. Durley , James Sikorski , Donald W. Hansen, Jr. , Michelle A. Promo , Ronald Keith Webber , Barnett S. Pitzele , Alok K. Awasthi , Alan Moormann

发明人： Richard C. Durley , James Sikorski , Donald W. Hansen, Jr. , Michelle A. Promo , Ronald Keith Webber , Barnett S. Pitzele , Alok K. Awasthi , Alan Moormann

IPC分类号： A61K31/195

CPC分类号： C07D209/48 , A61K31/198 , C07C229/30 , C07C251/08 , C07C251/16 , C07C255/30 , C07C257/14 , C07C271/22 , C07D271/07 , C07D413/06

摘要： The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.

摘要翻译： 本发明涉及2-氨基-2-烷基-4-己烯酸和己酸衍生物及其在治疗中的用途，特别是其用作一氧化氮合酶抑制剂。

17.

发明授权
2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors 失效
标题翻译：可用作一氧化氮合酶抑制剂的2-氨基-2-烷基-4-己烯酸和己炔酸衍生物

公开(公告)号：US06756406B2

公开(公告)日：2004-06-29

申请号：US09952906

申请日：2001-09-15

申请人： Richard C. Durley , James Sikorski , Donald W. Hansen, Jr. , Michelle A. Promo , Ronald Keith Webber , Barnett S. Pitzele , Alok K. Awasthi , Alan Moorman

发明人： Richard C. Durley , James Sikorski , Donald W. Hansen, Jr. , Michelle A. Promo , Ronald Keith Webber , Barnett S. Pitzele , Alok K. Awasthi , Alan Moorman

IPC分类号： C07D27106

CPC分类号： C07D209/48 , A61K31/198 , C07C229/30 , C07C251/08 , C07C251/16 , C07C255/30 , C07C257/14 , C07C271/22 , C07D271/07 , C07D413/06

摘要： The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.

摘要翻译： 本发明涉及2-氨基-2-烷基-4-己烯酸和己酸衍生物及其在治疗中的用途，特别是其用作一氧化氮合酶抑制剂。

18.

发明授权
Halogenated 2-amino-3, 4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors 失效
标题翻译：用作一氧化氮合酶抑制剂的卤化2-氨基-3,4-庚烯酸衍生物

公开(公告)号：US06586471B1

公开(公告)日：2003-07-01

申请号：US09835193

申请日：2001-04-13

申请人： Donald W. Hansen, Jr. , Barnett S. Pitzele , Ronald Keith Webber , Mihaly V. Toth , Pamela T. Manning , Alok K. Awasthi , Mahima Trivedi

发明人： Donald W. Hansen, Jr. , Barnett S. Pitzele , Ronald Keith Webber , Mihaly V. Toth , Pamela T. Manning , Alok K. Awasthi , Mahima Trivedi

IPC分类号： A61K3122

CPC分类号： C07D209/48 , C07C257/14 , C07D263/04 , C07D263/06 , C07D413/06

摘要： The present invention contains halogenated 2-amino-3,4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.

摘要翻译： 本发明包含可用作一氧化氮合酶抑制剂的卤代2-氨基-3,4-庚烯酸衍生物。