公开(公告)号：US12186185B2

公开(公告)日：2025-01-07

申请号：US17863195

申请日：2022-07-12

Applicant: Edwards Lifesciences Corporation

Inventor： Dikla Kersh ,  Michael Bukin ,  Tamir S. Levi ,  Noam Nir

IPC: A61F2/24

Abstract: A prosthetic valve assembly includes a radially expandable and compressible annular frame. The frame includes a plurality of interconnected struts, which include a plurality of inner struts and a plurality of outer struts. The inner struts overlap adjacent outer struts at a plurality of pivot joints. Radial expansion or compression of the annular frame causes the inner struts to pivot relative to the outer struts at the pivot joints. The assembly also includes a valvular structure having a plurality of leaflets, each leaflet having a cusp edge portion. The assembly further includes one or more leaflet-supporting cords, each having a plurality of anchoring portions and a plurality of suspended portions, each suspended portion extending between two adjacent anchoring portions. The anchoring portions are affixed to respective anchoring features of the frame adjacent the pivot joints. The cusp edge portions of the leaflets are connected to the suspended portions.

公开(公告)号：US11883294B2

公开(公告)日：2024-01-30

申请号：US17663626

申请日：2022-05-16

Applicant: Edwards Lifesciences Corporation

Inventor： Arie Tylis ,  Nikolai Gurovich ,  Eran Goldberg ,  Boaz Manash ,  Dan Rottenberg ,  Hagar Adika ,  Tal Regev ,  Dikla Kersh ,  Danny M. Garmahi ,  Hernan Altman ,  Amir Blumenfeld

IPC: A61F2/24 ,  A61B17/04 ,  A61B17/00 ,  A61B8/08 ,  A61B8/12 ,  A61B8/00

CPC classification number: A61F2/2487 ,  A61B8/085 ,  A61B8/0883 ,  A61B8/12 ,  A61B8/42 ,  A61B17/0401 ,  A61F2/2445 ,  A61B2017/00243 ,  A61B2017/00783 ,  A61B2017/042 ,  A61B2017/0409 ,  A61B2017/0419 ,  A61B2017/0464 ,  A61F2/2466

Abstract: An anchoring system and related methods are provided for treatment of dilated hearts and of functional valve regurgitation, the system comprising one or more self-expandable or manually expandable anchors and associated devices for fixating a valve splint within the heart. For example, a spade-shaped assembly may be configured to be deployed in a right ventricle of the heart and to stabilize a puncturing instrument to puncture the septum. Various puncturing instruments may also be part of the anchoring system, including one or more of a flexible needle having a multiplicity of slits disposed along the length of the needle, a trocar catheter with a retractable head, and a catheter needle having a blunt introducer to protect nearby tissue within the heart during advancing a guidewire. A cutter catheter and puncture location catheter may also be part of the system and be used during treatment.

公开(公告)号：US11872125B2

公开(公告)日：2024-01-16

申请号：US17659577

申请日：2022-04-18

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Nikolai Gurovich ,  Michael Bukin ,  Elena Sherman ,  Tamir S. Levi ,  Ziv Yohanan ,  Gil Senesh ,  Dikla Kersh ,  Alexey Tsypenyuk ,  Waina Michelle Chu ,  Alexander Barash

IPC: A61F2/24 ,  A61F2/90

CPC classification number: A61F2/2418 ,  A61F2/2409 ,  A61F2/2433 ,  A61F2/2412 ,  A61F2/90 ,  A61F2220/0075 ,  A61F2230/0023 ,  A61F2230/0052 ,  A61F2250/0003 ,  A61F2250/0039 ,  A61F2250/0069 ,  A61F2310/00017 ,  A61F2310/00029 ,  A61F2310/00059

Abstract: A system can include a delivery catheter comprising a balloon and an implantable prosthetic heart valve. The prosthetic valve can have a plastically expandable and compressible unitary frame comprising first, second, and third rows of angled struts that define two circumferentially extending rows of diamond-shaped cells that extend continuously around the frame, and a valvular structure comprising a plurality of leaflets. A cusp edge portion of each leaflet is connected to the frame by a skirt that is connected to and disposed between the frame and the cusp edge portions of the leaflets, the skirt being connected to consecutive struts in the first, second, and third rows of struts with sutures. The compressed prosthetic heart valve can be mounted around the balloon and radially expanded to the expanded configuration with the balloon inside a patient's body.

公开(公告)号：US20230277313A1

公开(公告)日：2023-09-07

申请号：US18316942

申请日：2023-05-12

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Nikolai Gurovich ,  Michael Bukin ,  Elena Sherman ,  Tamir S. Levi ,  Ziv Yohanan ,  Gil Senesh ,  Dikla Kersh ,  Alexey Tsypenyuk ,  Waina Michelle Chu ,  Alexander Barash

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2433 ,  A61F2/2409 ,  A61F2250/0069 ,  A61F2250/0003 ,  A61F2230/0052 ,  A61F2230/0023 ,  A61F2/2412 ,  A61F2/90

Abstract: A prosthetic heart valve can include a radially expandable and compressible frame having an inflow end, an outflow end, and a plurality of struts. The prosthetic valve can further include a valvular structure comprising a plurality of leaflets, each leaflet comprising a coaptation edge portion and a cusp edge portion. The cusp edge portion of each leaflet can be folded toward the outflow end of the frame along a bending axis and a reinforcing member extends along an outflow surface of the cusp edge portion along the bending axis. The prosthetic heart valve can include a plurality of connecting skirts, each disposed between the cusp edge portion of an adjacent leaflet and the frame. First stitching secures the reinforcing member and the connecting skirts to the cusp edge portions and second stitching secures the connecting skirts to selected struts of the frame.

公开(公告)号：US20220280295A1

公开(公告)日：2022-09-08

申请号：US17750826

申请日：2022-05-23

Applicant: Edwards Lifesciences Corporation

Inventor： Anatoly Dvorsky ,  David Maimon ,  Dikla Kersh ,  Gideon Sagi

IPC: A61F2/24

Abstract: An implantable prosthetic device can include a frame that is radially expandable and compressible between a radially compressed configuration and a radially expanded configuration. The frame can include a plurality of struts, each strut comprising a first portion and a second portion separated by a deflection point. Each strut can be curved helically with respect to a first, longitudinal axis of the frame. The first portion of each strut can be curved in a first direction with respect to a first line parallel to a second axis that is perpendicular to the first, longitudinal axis of the frame, and the second portion of each strut can be curved in a second direction with respect to a second line parallel to the second axis.

公开(公告)号：US20220273438A1

公开(公告)日：2022-09-01

申请号：US17663626

申请日：2022-05-16

Applicant: Edwards Lifesciences Corporation

Inventor： Arie Tylis ,  Nikolay Gurovich ,  Eran Goldberg ,  Boaz Manash ,  Dan Rottenberg ,  Hagar Adika ,  Tal Regev ,  Dikla Kersh ,  Danny M. Garmahi ,  Hernan Altman ,  Amir Blumenfeld

IPC: A61F2/24 ,  A61B8/08 ,  A61B17/04 ,  A61B8/12 ,  A61B8/00

Abstract: An anchoring system and related methods are provided for treatment of dilated hearts and of functional valve regurgitation, the system comprising one or more self-expandable or manually expandable anchors and associated devices for fixating a valve splint within the heart. For example, a spade-shaped assembly may be configured to be deployed in a right ventricle of the heart and to stabilize a puncturing instrument to puncture the septum. Various puncturing instruments may also be part of the anchoring system, including one or more of a flexible needle having a multiplicity of slits disposed along the length of the needle, a trocar catheter with a retractable head, and a catheter needle having a blunt introducer to protect nearby tissue within the heart during advancing a guidewire. A cutter catheter and puncture location catheter may also be part of the system and be used during treatment.

公开(公告)号：US11096781B2

公开(公告)日：2021-08-24

申请号：US15664430

申请日：2017-07-31

Applicant: Edwards Lifesciences Corporation

Inventor： Nikolay Gurovich ,  Michael Bukin ,  Elena Sherman ,  Tamir S. Levi ,  Ziv Yohanan ,  Gil Senesh ,  Dikla Kersh ,  Alexey M. Tsypenyuk ,  Waina Michelle Chu ,  Alexander Barash

IPC: A61F2/24

Abstract: A prosthetic heart valve can include a radially collapsible and expandable annular frame having a plurality of struts defining openings. The prosthetic heart valve can further include a plurality of leaflets that regulate the flow of blood through the frame. The prosthetic heart valve can also include a sealing member mounted on the frame and having an inner layer and an outer layer. At least the outer layer is mounted on the outside of the frame, and the inner layer covers at least the openings in the frame between adjacent cusp portions of adjacent leaflets and the inner layer does not cover one or more openings in the frame at locations facing the outflow surfaces of the leaflets to permit retrograde blood to flow through the one or more uncovered openings in the frame and into space between the outer layer and the frame.

公开(公告)号：US10463492B2

公开(公告)日：2019-11-05

申请号：US15353657

申请日：2016-11-16

Applicant: Edwards Lifesciences Corporation

Inventor： Arie Tylis ,  Nikolay Gurovich ,  Eran Goldberg ,  Boaz Manash ,  Dan Rottenberg ,  Hagar Adika ,  Tal Regev ,  Dikla Kersh ,  Danny M Garmahi ,  Hernan Altman ,  Amir Blumenfeld

IPC: A61F2/24 ,  A61B17/04 ,  A61B8/12 ,  A61B8/00 ,  A61B8/08 ,  A61B17/00

Abstract: An anchoring system and related methods are provided for treatment of dilated hearts and of functional valve regurgitation, the system comprising one or more self-expandable or manually expandable anchors and associated devices for fixating a valve splint within the heart. For example, a spade-shaped assembly may be configured to be deployed in a right ventricle of the heart and to stabilize a puncturing instrument to puncture the septum. Various puncturing instruments may also be part of the anchoring system, including one or more of a flexible needle having a multiplicity of slits disposed along the length of the needle, a trocar catheter with a retractable head, and a catheter needle having a blunt introducer to protect nearby tissue within the heart during advancing a guidewire. A cutter catheter and puncture location catheter may also be part of the system and be used during treatment.

公开(公告)号：US20250064474A1

公开(公告)日：2025-02-27

申请号：US18940504

申请日：2024-11-07

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Yuval Kasher ,  Dikla Kersh

IPC: A61B17/32 ,  A61B17/00 ,  A61B17/3209 ,  A61B17/3211 ,  A61B18/00 ,  A61B18/14

Abstract: Exemplary transection devices for making incisions through the pericardial membrane or parietal layer of the pericardium are described. These examples share the characteristic that they are deployed intravascularly through the RAA, IVC, SVC, or via a subxiphoid approach. One example is a pericardial tissue transection device comprising an elongated body with a proximal end and a distal end and extending along a longitudinal length. An incision assembly is coupled to the distal end of the elongated body. The incision assembly comprises an incision member having first and second ends each coupled to the incision assembly and aligned with the longitudinal length of the elongate body. At least a portion of the incision member is structured to reversibly extend laterally from the elongated body.

公开(公告)号：US20240423793A1

公开(公告)日：2024-12-26

申请号：US18827555

申请日：2024-09-06

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Dikla Kersh ,  Michael Bukin ,  Tamir S. Levi ,  Noam Nir

IPC: A61F2/24

Abstract: A prosthetic valve assembly includes a radially expandable and compressible annular frame. The frame includes a plurality of interconnected struts, which include a plurality of inner struts and a plurality of outer struts. The inner struts overlap adjacent outer struts at a plurality of pivot joints. Radial expansion or compression of the annular frame causes the inner struts to pivot relative to the outer struts at the pivot joints. The assembly also includes a valvular structure having a plurality of leaflets, each leaflet having a cusp edge portion. The assembly further includes one or more leaflet-supporting cords, each having a plurality of anchoring portions and a plurality of suspended portions, each suspended portion extending between two adjacent anchoring portions. The anchoring portions are affixed to respective anchoring features of the frame adjacent the pivot joints. The cusp edge portions of the leaflets are connected to the suspended portions.