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    IHC, Tissue Slide Fluid Exchange Disposable And System
    11.
    发明申请
    IHC, Tissue Slide Fluid Exchange Disposable And System 审中-公开
    IHC，组织滑动液体交换一次性和系统

    公开(公告)号：US20150260621A1

    公开(公告)日：2015-09-17

    申请号：US14618007

    申请日：2015-02-10

    Applicant: EMD Millipore Corporation

    Inventor： Chris Scott ,  Paul Sydlowski ,  John Doyle ,  Ryan Amara ,  Libby Kellard ,  Sara Gutierrez ,  Marc Emerick

    IPC: G01N1/31

    Abstract: Apparatus and method for Immunohistochemistry, including a slide holder assembly fixture, a slide holder, a slide holder frame, and a slide holder frame assembly adapted to be placed in communication with a driving force to draw fluid through the slide holder. The slide holder may include an injection port that allows consistent fluid delivery and recovery, while minimizing the introduction of air bubbles. The slide holder may include a reservoir that allows for filling, soaking, rinsing, flushing, uniform antibody coverage of the tissue and reduces handling time, space, and errors, and one or more sample chambers. The slide orientation in the slide holder allows for visualization of label information and tissue to confirm adequate antibody coverage. A multi-port frame allows multiple assays to be carried out concurrently, and is removable from a vacuum manifold and allows for easy transport from the vacuum manifold to an incubator/refrigerator and back.

    Abstract translation: 用于免疫组织化学的装置和方法，包括滑动支架组件夹具，滑动支架，滑动支架框架和滑动支架框架组件，其适于与驱动力连通以将流体通过滑块保持器拉动。 滑动架可以包括一个注射口，其允许一致的流体输送和回收，同时最小化气泡的引入。 载玻片保持器可以包括允许填充，浸泡，漂洗，冲洗，组织的均匀抗体覆盖并减少处理时间，空间和错误以及一个或多个样品室的储存器。 幻灯片固定器中的滑动方向允许标记信息和组织的可视化，以确认足够的抗体覆盖。 多端口框架允许多个测定同时进行，并且可从真空歧管移除，并且允许从真空歧管到培养箱/冰箱和背部的容易运输。

    REMOVAL TOOL FOR EXTRACTING A SAMPLE WELL COMB FROM ELECTROPHORETIC GELS
    12.
    发明公开
    REMOVAL TOOL FOR EXTRACTING A SAMPLE WELL COMB FROM ELECTROPHORETIC GELS 审中-公开

    公开(公告)号：US20240192166A1

    公开(公告)日：2024-06-13

    申请号：US18533928

    申请日：2023-12-08

    Applicant: EMD Millipore Corporation

    Inventor： Kurt E. Greenizen ,  Ryan Amara ,  Christopher A. Scott ,  Paul Sydlowski ,  Michael Miller ,  Kelly Wolfe

    IPC: G01N27/447

    CPC classification number: G01N27/44743

    Abstract: A removal tool for sample well combs that is configured to aid in the extraction of a sample well comb from an electrophoresis gel. The removal tool may be either removably coupled to the sample well comb or may be permanently affixed to the sample well comb in order to provide a surface/region that is more easily graspable by a user to aid in the extraction of the sample well comb. The removal tool may include one or more engagement members that may be at least partially disposed within an opening of the sample well comb to couple the removal tool to the sample well comb. The removal tool may also include a mechanism that is configured to impart extraction forces to a surface in proximity to the sample well comb to further aid in the extraction of the sample well comb.

    Device suitable for vacuum assisted filtration
    13.
    发明授权
    Device suitable for vacuum assisted filtration 有权

    公开(公告)号：US11925904B2

    公开(公告)日：2024-03-12

    申请号：US16328502

    申请日：2017-10-05

    Applicant: EMD Millipore Corporation

    Inventor： Christopher A. Scott ,  Kurt Greenizen ,  Paul Sydlowski

    IPC: B01D63/08 ,  B01D61/18 ,  B01D61/20

    CPC classification number: B01D63/087 ,  B01D61/18 ,  B01D61/20 ,  B01D2201/204

    Abstract: A funnel-less filtration device that attaches directly to a storage container such as a cell culture media bottle. The device includes a filter collar containing one or more membranes, an inlet with a coupling device for attaching the filter device to a supply of liquid to be filtered, an outlet at a lower portion of the collar, a vacuum port in the collar below the membrane(s) and a filtered vent in the collar above the membrane(s). Optionally, the device may include a filtrate reservoir attached to the outlet, preferably by a threaded connection. Optionally, the upper opening to the filter collar is selectively and removably sealed with a lid until used. The lid is then removed the filter device inverted over a storage container such as cell culture media bottle and the two are attached via the upper opening of the filter collar. The assembly is then inverted so the supply container is above the filter device. Upon subjecting the sample in the bottle to a driving force such as vacuum, the sample flows through the filtration element, and into a filtrate reservoir below the outlet of the filter collar.

    Connectors for pneumatic devices in microfluidic systems
    14.
    发明授权
    Connectors for pneumatic devices in microfluidic systems 有权

    公开(公告)号：US10737266B2

    公开(公告)日：2020-08-11

    申请号：US16351828

    申请日：2019-03-13

    Applicant: EMD Millipore Corporation

    Inventor： Terry Gaige ,  Andrew Zayac ,  Paul Sydlowski ,  Philip Lee

    IPC: G01N21/00 ,  G01N1/10 ,  B01L3/00 ,  A61J1/06 ,  C23F11/00 ,  A61L2/00 ,  C12M3/06 ,  C12M1/00 ,  G01N35/00

    Abstract: In one embodiment, a removable pneumatic connector, comprises a body having a plurality of bores passing through, each bore surrounded by a sealing member on an inner surface of the body. A plurality of gas lines may be placed within a corresponding bore. A vacuum port is disposed on the inner surface of the body, and an outer seal on the inner surface of the body surrounds the sealing members and the vacuum port. A vacuum line may be placed within the vacuum port, and configured to deliver negative pressure to the vacuum port. A vacuum holding area is created in the volume between the outer seal and each of the sealing members when the inner surface of the body is placed against a substrate. When the vacuum line is activated, a vacuum is created within the vacuum holding area, creating a positive seal between the body and the substrate.

    System And Method For Photopolymerizing Electrophoretic Gels
    20.
    发明公开
    System And Method For Photopolymerizing Electrophoretic Gels 审中-公开

    公开(公告)号：US20240309195A1

    公开(公告)日：2024-09-19

    申请号：US18578419

    申请日：2022-08-22

    Applicant: EMD Millipore Corporation

    Inventor： Kevin Wu ,  Kelly Wolfe ,  Anja Dedeo ,  Ryan Amara ,  Gerard Libby ,  Paul Sydlowski ,  Katelyn Kavanaugh ,  Trisha Bailey ,  Nathan T. Allen

    IPC: C08L33/26 ,  C08J9/28 ,  G01N27/447

    CPC classification number: C08L33/26 ,  C08J9/28 ,  G01N27/44747 ,  C08J2333/26

    Abstract: An acrylamide gel formulation for use in electrophoresis, and a system and method for electrophoretic gel casting. In some embodiments, the system comprises a UV-Vis curing light source, and an acrylamide formulation that allows a resolving gel and a stacking gel to be photopolymerized in a single step. In some embodiments, the resolving solution formulation comprises acrylamide and bis-acrylamide, Bis-Tris buffering agent, and lithium phenyl-2, 4, 6-trimethylbenzoyl-phosphinate (LAP) as a water-soluble photoinitiator, which allows the solution to be photopolymerized using UV radiation within a certain wavelength. In some embodiments, a dilution buffer formulation comprises acrylamide and bis-acrylamide, Bis-Tris buffering agent, and lithium phenyl-2, 4, 6-trimethyl-benzoyl-phosphinate (LAP). The dilution buffer may be added to the resolving solution in a selected amount in order to modify the concentration of the acrylamide to a desired concentration.

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