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11.发明授权Passivated and stabilized porous mineral oxide supports and method for the preparation and use of same 失效钝化和稳定的多孔矿物氧化物载体及其制备和使用方法
公开(公告)号：US5268097A
公开(公告)日：1993-12-07
申请号：US956404
申请日：1992-10-05
Applicant: Pierre Girot , Egisto Boschetti
Inventor： Pierre Girot , Egisto Boschetti
CPC classification number: B01D15/206 , B01J20/28004 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/288 , B01J20/3204 , B01J20/321 , B01J20/327 , B01J20/3282 , B01J20/3289 , B01J39/165 , B01J39/26 , B01J41/20 , B01J2220/54 , B01J2220/58
Abstract: This invention relates generally to modified porous solid supports and processes for the preparation and use of same. In particular, passivated porous mineral oxide supports are disclosed that are stabilized against leaching under harsh environmental conditions by the application of a thin, protective polymeric coating atop their porous surfaces and that are characterized by a reversible high sorptive capacity substantially unaccompanied by non-specific adsorption of or interaction with biomolecules. Passivation is achieved by the use of a passivation mixture comprising a main monomer, a passivating monomer that is different from the main monomer, and a crosslinking agent, which mixture upon polymerization results in the substantial elimination of the undesirable non-specific interaction between biomolecules and the protective polymeric coating on the surfaces of the mineral oxide matrix.
Abstract translation: 本发明一般涉及改性多孔固体载体及其制备和使用方法。 特别地，公开了钝化的多孔无机氧化物载体，其在恶劣的环境条件下通过在其多孔表面顶上施加薄的保护性聚合物涂层而稳定化，并且其特征在于基本上不伴随非特异性吸附的可逆的高吸附能力 或与生物分子相互作用。 通过使用包含主单体，不同于主单体的钝化单体和交联剂的钝化混合物来实现钝化，该聚合物上的该混合物导致基本上消除生物分子与生物分子之间不合需要的非特异性相互作用 矿物氧化物基体表面上的保护性聚合物涂层。
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12.发明授权Chromatographic material for the absorption of proteins at physiological ionic strength 有权用于在生理离子强度下吸收蛋白质的色谱材料公开(公告)号：US08021889B2
公开(公告)日：2011-09-20
申请号：US10583509
申请日：2005-01-14
Applicant: Egisto Boschetti , Pierre Girot
Inventor： Egisto Boschetti , Pierre Girot
CPC classification number: B01J39/26 , B01D15/327 , B01D15/361 , B01D15/362 , B01J20/289 , B01J20/3242 , B01J20/3285 , B01J41/20 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01J2219/0074 , B01J2220/54 , C07K1/16 , C07K1/18 , G01N30/02 , G01N33/54353 , G01N2035/00158 , Y10S435/803
Abstract: Ion exchange and hydrophobic interaction chromatographic materials are constructed by tethering a terminal binding functionality to a solid support via a hydrophobic linker. The backbone of the linker typically comprises sulfur-containing moieties. Suitable terminal binding functionalities are tertiary amines, quaternary ammonium salts, or hydrophobic groups. These chromatographic materials possess both hydrophobic and ionic character under the conditions prescribed for their use. The separation of proteins from crude mixtures at physiological ionic strength can be accomplished with a chromatographic material of this type by applying pH or ionic strength gradients, thereby effecting protein adsorption and desorption.
Abstract translation: 离子交换和疏水相互作用层析材料是通过一个疏水性接头将末端结合官能团连接到固体支持物构成的。 接头的骨架通常包含含硫部分。 合适的末端结合官能团是叔胺，季铵盐或疏水基团。 这些色谱材料在规定的条件下具有疏水性和离子性。 通过施加pH或离子强度梯度，可以用这种类型的色谱材料在生理离子强度下从粗混合物中分离蛋白质，从而进行蛋白质吸附和解吸。
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13.发明申请Chromatographic material for the absorption of proteins at physiological ionic strength 有权用于在生理离子强度下吸收蛋白质的色谱材料公开(公告)号：US20070151910A1
公开(公告)日：2007-07-05
申请号：US10583509
申请日：2005-01-14
Applicant: Egisto Boschetti , Pierre Girot
Inventor： Egisto Boschetti , Pierre Girot
IPC: B01D15/08
CPC classification number: B01J39/26 , B01D15/327 , B01D15/361 , B01D15/362 , B01J20/289 , B01J20/3242 , B01J20/3285 , B01J41/20 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01J2219/0074 , B01J2220/54 , C07K1/16 , C07K1/18 , G01N30/02 , G01N33/54353 , G01N2035/00158 , Y10S435/803
Abstract: Ion exchange and hydrophobic interaction chromatographic materials are constructed by tethering a terminal binding functionality to a solid support via a hydrophobic linker. The backbone of the linker typically comprises sulfur-containing moieties. Suitable terminal binding functionalities are tertiary amines, quaternary ammonium salts, or hydrophobic groups. These chromatographic materials possess both hydrophobic and ionic character under the conditions prescribed for their use. The separation of proteins from crude mixtures at physiological ionic strength can be accomplished with a chromatographic material of this type by applying pH or ionic strength gradients, thereby effecting protein adsorption and desorption.
Abstract translation: 离子交换和疏水相互作用层析材料是通过一个疏水性接头将末端结合官能团连接到固体支持物构成的。 接头的骨架通常包含含硫部分。 合适的末端结合官能团是叔胺，季铵盐或疏水基团。 这些色谱材料在规定的条件下具有疏水性和离子性。 通过施加pH或离子强度梯度，可以用这种类型的色谱材料在生理离子强度下从粗混合物中分离蛋白质，从而进行蛋白质吸附和解吸。
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14.发明授权Passivated porous polymer supports and methods for the preparation and use of same 失效钝化多孔聚合物载体及其制备和使用方法
公开(公告)号：US6045697A
公开(公告)日：2000-04-04
申请号：US200884
申请日：1998-11-30
Applicant: Pierre Girot , Egisto Boschetti
Inventor： Pierre Girot , Egisto Boschetti
CPC classification number: B01D15/08 , B01D15/20 , B01J20/28004 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/288 , B01J20/3204 , B01J20/321 , B01J20/327 , B01J20/3282 , B01J20/3289 , B01J39/26 , B01J41/20 , B01J2220/54 , B01J2220/58
Abstract: This invention relates generally to modified porous solid supports and processes for the preparation and use of same. In particular, passivated porous supports are disclosed which are characterized by a reversible high sorptive capacity substantially unaccompanied by non-specific adsorption of or interaction with biomolecules. Passivation is achieved by use of a passivation mixture comprising a main monomer, a passivating agent comprising polyethyleneimine, and a crosslinking agent, which mixture upon polymerization results in the substantial elimination of the undesirable non-specific interaction with biomolecules.
Abstract translation: 本发明一般涉及改性多孔固体载体及其制备和使用方法。 特别地，公开了钝化多孔载体，其特征在于基本上不伴随生物分子的非特异性吸附或相互作用的可逆高吸附能力。 通过使用包含主单体，包含聚乙烯亚胺的钝化剂和交联剂的钝化混合物来实现钝化，该聚合物上的该混合物导致基本上消除了与生物分子的不期望的非特异性相互作用。
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15.发明授权Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same 失效用于治疗性血管闭塞的微球和含有其的可注射溶液
公开(公告)号：US5648100A
公开(公告)日：1997-07-15
申请号：US471303
申请日：1995-06-06
Applicant: Egisto Boschetti , Michel Brouard , Ludovic Drouet , Pierre Girot , Alexandre Laurent , Michel Wassef
Inventor： Egisto Boschetti , Michel Brouard , Ludovic Drouet , Pierre Girot , Alexandre Laurent , Michel Wassef
IPC: A61K9/50 , A61K9/16 , A61K31/715 , A61K31/726 , A61K31/78 , A61K38/00 , A61K38/16 , A61K38/17 , A61K49/00 , A61L24/06 , A61P9/00 , A61K9/14
CPC classification number: A61L24/06 , A61K9/1676 , A61L2400/06 , A61L2430/36
Abstract: The present invention concerns the use of microspheres for therapeutic embolization consisting of a hydrophilic acrylic copolymer coated with a cell adhesion promoter.
Abstract translation: 本发明涉及微球用于治疗栓塞的用途，其由涂覆有细胞粘附促进剂的亲水丙烯酸共聚物组成。
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Patent Agency Ranking16.发明授权Passivated porous polymer supports and methods for the preparation and use of same 失效钝化多孔聚合物载体及其制备和使用方法
公开(公告)号：US5445732A
公开(公告)日：1995-08-29
申请号：US254625
申请日：1994-06-06
Applicant: Pierre Girot , Egisto Boschetti
Inventor： Pierre Girot , Egisto Boschetti
CPC classification number: B01D15/20 , B01J20/28004 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/288 , B01J20/3204 , B01J20/321 , B01J20/327 , B01J20/3282 , B01J20/3289 , B01J39/165 , B01D15/3804 , B01J2220/54 , B01J2220/58
Abstract: This invention relates generally to modified porous solid supports and processes for the preparation and use of same. In particular, passivated porous polymeric supports are disclosed which are characterized by a reversible high sorptive capacity substantially unaccompanied by non-specific adsorption of or interaction with biomolecules. Passivation is achieved by use of a passivation mixture comprising a main monomer, a passivating monomer that is different from the main monomer, and a crosslinking agent, which mixture upon polymerization results in the substantial elimination of the undesirable non-specific interaction with biomolecules.
Abstract translation: 本发明一般涉及改性多孔固体载体及其制备和使用方法。 特别地，公开了钝化的多孔聚合物载体，其特征在于基本上不伴随生物分子的非特异性吸附或相互作用的可逆的高吸附能力。 通过使用包含主单体，不同于主单体的钝化单体和交联剂的钝化混合物实现钝化，该聚合物上的该混合物导致基本上消除了与生物分子的不期望的非特异性相互作用。
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17.发明授权Composite polymers and their preparation which are useful in liquid chromatography 失效复合聚合物及其在液相色谱中有用的制备
公开(公告)号：US5075371A
公开(公告)日：1991-12-24
申请号：US619822
申请日：1990-11-29
Applicant: Egisto Boschetti , Pierre Girot
Inventor： Egisto Boschetti , Pierre Girot
IPC: B01J20/281 , B01D15/08 , B01J20/26 , B01J20/285 , B01J41/08 , C08F2/44 , C08K3/36 , C08L33/00 , C08L33/04 , G01N30/88
CPC classification number: C08K3/36 , B01D15/08 , B01J20/26 , C08F2/44 , Y10S524/903
Abstract: A homogeneous composite polymer containing, in an interpenetrated form, 20% to 80% by weight of silica and 80% to 20% by weight of a three-dimensional crosslinked acrylic, vinyl and/or allyl copolymer comprising, in a copolymerized form, 98% to 70% by weight of at least one monofunctional acrylic, vinyl or allyl monomer and 2% to 30% by weight of a difunctional acrylic or allyl crosslinking monomer is useful in liquid chromatography.
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18.发明授权Composite polymers, their preparation and their use in liquid chromatography 失效复合聚合物，其制备及其在液相色谱中的应用
公开(公告)号：US5053135A
公开(公告)日：1991-10-01
申请号：US521988
申请日：1990-05-11
Applicant: Egisto Boschetti , Pierre Girot
Inventor： Egisto Boschetti , Pierre Girot
IPC: B01J20/281 , B01D15/08 , B01J20/26 , B01J20/285 , B01J41/08 , C08F2/44 , C08K3/36 , C08L33/00 , C08L33/04 , G01N30/88
CPC classification number: C08K3/36 , B01D15/08 , B01J20/26 , C08F2/44 , Y10S524/903
Abstract: A homogeneous composite polymer containing, in an interpenetrated form, 20% to 80% by weight of silica and 80% to 20% by weight of a three-dimensional crosslinked acrylic, vinyl and/or allyl copolymer comprising, in a copolymerized form, 98% to 70% by weight of at least one monofunctional acrylic, vinyl or allyl monomer and 2 % to 30% by weight of a difunctional acrylic or allyl crosslinking monomer is useful in liquid chromatography.
Abstract translation: 一种均匀的复合聚合物，其以相互渗透的形式包含20重量％至80重量％的二氧化硅和80重量％至20重量％的三维交联的丙烯酸，乙烯基和/或烯丙基共聚物，其以共聚形式包含98 至少一种单官能丙烯酸，乙烯基或烯丙基单体的重量百分比至70％，双官能丙烯酸或烯丙基交联单体的重量百分比为2％至30％可用于液相色谱。
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19.发明申请Separation of proteins based on isoelectric point using solid-phase buffers 审中-公开使用固相缓冲液分离基于等电点的蛋白质公开(公告)号：US20070039891A1
公开(公告)日：2007-02-22
申请号：US11493923
申请日：2006-07-27
Applicant: Egisto Boschetti , Pier Righetti , Pierre Girot , Frederic Fortis
Inventor： Egisto Boschetti , Pier Righetti , Pierre Girot , Frederic Fortis
IPC: B01D15/08
CPC classification number: B01D15/362 , B01D15/1871 , B01D15/36 , B01D15/363 , B01J20/28033 , B01J39/26 , B01J41/20 , B01J47/018 , B01J2220/603 , B01J2220/82 , C07K1/18 , G01N30/461
Abstract: Proteins can be separated from mixtures, based on their pI values, through the use of a series of chromatographic materials, each comprising a solid buffer and an ion exchange resin. Each solid buffer generates a stable pH, such that passing proteins possess a net charge and can be separated by means of an appropriate ion exchanger. In this fashion, proteins from complex biological fluids can be separated for identification and study.
Abstract translation: 通过使用一系列色谱材料，每种包含固体缓冲液和离子交换树脂，蛋白质可以基于其pI值与混合物分离。 每个固体缓冲液产生稳定的pH，使得通过的蛋白质具有净电荷并且可以通过合适的离子交换剂分离。 以这种方式，可以分离来自复杂生物流体的蛋白质进行鉴定和研究。
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20.发明授权Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates 失效使用在高流速下具有高动态吸附容量的复合色谱介质从稀溶液中分离分子
公开(公告)号：US5906747A
公开(公告)日：1999-05-25
申请号：US556313
申请日：1995-11-13
Applicant: Jonathan L. Coffman , Pierre Girot , Egisto Boschetti
Inventor： Jonathan L. Coffman , Pierre Girot , Egisto Boschetti
CPC classification number: B01D15/08 , B01D15/361 , C07K1/18
Abstract: This invention relates generally to modified porous solid chromatographic media and processes for the preparation and use of same. In particular, chromatographic media of porous mineral oxide, polymeric, or polymer-coated mineral oxide supports are disclosed which are characterized by a reversible high sorptive capacity and high intraparticle mass transfer rates. In order to prevent non-specific adsorption of or interaction with biomolecules, these supports may be passivated by use of a passivation mixture comprising a main monomer, a passivating monomer, and a crosslinking agent, which mixture upon polymerization results in substantial elimination of the undesirable non-specific interaction with biomolecules.
Abstract translation: 本发明一般涉及改性多孔固体色谱介质及其制备和使用方法。 特别地，公开了多孔矿物氧化物，聚合物或聚合物涂覆的矿物氧化物载体的色谱介质，其特征在于可逆的高吸附能力和高的颗粒内传质速率。 为了防止非特异性吸附或与生物分子的相互作用，这些载体可以通过使用包含主单体，钝化单体和交联剂的钝化混合物进行钝化，该聚合物上的该混合物导致基本上不需要的 与生物分子的非特异性相互作用。
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