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公开(公告)号：US20160053296A1
公开(公告)日：2016-02-25
申请号：US14462594
申请日：2014-08-19
Applicant: General Electric Company
Inventor： Chengkun Zhang , Kenneth Roger Conway , Donald Joseph Buckley , Eugene Pauling Boden , Weston Blaine Griffin , Anshika Bajaj , Reginald Donovan Smith , Zhipeng Zhang
Abstract: A sampling assembly configured to be coupled to a sample source is provided. The sampling assembly is configured to facilitate aseptic sampling at one or more instances in time. The sampling assembly includes a first conduit having a first port and a second port, where the first port is configured to be coupled to the sample source, and where the second port is configured to be hermetically sealed. The sampling assembly further includes a plurality of sub-conduits having corresponding sub-ports, where each of the plurality of sub-conduits is operatively coupled to the first conduit at respective connection points, and where each of the sub-ports is in fluidic communication with the first conduit. Moreover, the sampling assembly includes a plurality of sampling kits, where each sampling kit of the plurality of sampling kits is operatively connected to a respective sub-port of a corresponding sub-conduit.
Abstract translation: 提供了一种被配置为耦合到采样源的采样组件。 采样组件被配置为便于在一个或多个实例的时间进行无菌取样。 采样组件包括具有第一端口和第二端口的第一导管，其中第一端口被配置为耦合到采样源，并且其中第二端口被配置为气密密封。 采样组件还包括具有对应子端口的多个子导管，其中多个子导管中的每一个在相应的连接点处可操作地耦合到第一导管，并且其中每个子端口处于流体连通 与第一个导管。 此外，采样组件包括多个采样套件，其中多个采样套件的每个采样套件可操作地连接到相应副导管的相应子端口。
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公开(公告)号：US20200231921A1
公开(公告)日：2020-07-23
申请号：US16753026
申请日：2018-10-03
Applicant: General Electric Company
Inventor： Chengkun Zhang , Kashan A. Shaikh , Weston B. Griffin , Reginald Donovan Smith
Abstract: A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.
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公开(公告)号：US10294454B2
公开(公告)日：2019-05-21
申请号：US15245584
申请日：2016-08-24
Applicant: General Electric Company
Inventor： Ernest William Kovacs , Anup Sood , Reginald Donovan Smith , Evelina Roxana Loghin , Padmaparna Chadhuri , Vandana Keskar , Chrystal Mae Chadwick , Martin James Brown
IPC: A61K38/00 , C12N5/00 , C12N5/02 , C12N5/0783 , C07K16/28
Abstract: Provided are methods and kits for activating T cells, the method comprising providing a population of T cells, adding a plurality of first agents, where the first agent comprises a T-cell activator and a first binder moiety, and adding a second agent comprising a plurality of capture oligomers, where at least a segment of at least one of the plurality of capture oligomers is capable of associating with the first binder moiety. The method further comprises incubating the population of T cells, whereby at least a portion of the population of T cells is activated.
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公开(公告)号：US10131874B2
公开(公告)日：2018-11-20
申请号：US15262644
申请日：2016-09-12
Applicant: General Electric Company
Inventor： Reginald Donovan Smith , Prameela Susarla , Slawomir Rubinsztajn , Brian David Polizzotti , Anton Beletskii
IPC: C12N5/00 , C08F293/00 , C12M1/26 , C12M1/00 , C08F8/12
Abstract: A cell culture support comprising a substrate, and a dual stimuli responsive block copolymer immobilized on the substrate, wherein the dual stimuli responsive block copolymer is both thermoresponsive and pH responsive. A method of culturing cells comprising the cell culture support having a dual stimuli responsive copolymer immobilized on a substrate, wherein the dual stimuli responsive copolymer is thermoresponsive and pH responsive; and growing the cells on the cell culture support. By lowering the temperature, cells are released from the cell culture support.
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公开(公告)号：US09920292B2
公开(公告)日：2018-03-20
申请号：US14841072
申请日：2015-08-31
Applicant: General Electric Company
Inventor： Chengkun Zhang , Reginald Donovan Smith , Kenneth Roger Conway , Anshika Bajaj
CPC classification number: C12M41/22 , C12M21/08 , C12M23/14 , C12M23/38 , C12M23/48 , C12M27/16 , C12M29/24 , C12M41/48 , C12Q3/00
Abstract: System and methods are provided for initiating a cell culture. The systems and methods include a first enclosure containing a thermal mass positioned on a surface area of a platform. The systems and methods include a second enclosure, containing a culture fluid and a gas mixture, placed on the first enclosure such that the first enclosure is positioned between the second enclosure and the platform. The systems and methods further include a cover secured on the second enclosure, and generating first thermal energy on the surface area of the platform and second thermal energy from the cover.
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Patent Agency Ranking
公开(公告)号：US20170193168A1
公开(公告)日：2017-07-06
申请号：US14984766
申请日：2015-12-30
Applicant: General Electric Company
Inventor： Nichole Lea Wood , Lynn Ann DeRose , Kunter Seref Akbay , Christopher Donald Johnson , Reginald Donovan Smith , Dolores Baksh
Abstract: The present disclosure relates to cell processing techniques. By way of example, a cell processing system may include a plurality of sample processing devices configured to process patient samples and a plurality of readers respectively associated with the plurality of sample processing devices, wherein each reader is configured to read information from tracking devices associated with respective patient samples. The system may also include a controller that uses information from the readers to provide an estimated completion time for a patient sample based on availability of the sample processing devices.
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公开(公告)号：US20160040114A1
公开(公告)日：2016-02-11
申请号：US14453683
申请日：2014-08-07
Applicant: General Electric Company
Inventor： Ying Mao , Kenneth Roger Conway , Weston Blaine Griffin , Reginald Donovan Smith , Evelina Roxana Loghin , Vandana Keskar , Chengkun Zhang , Zhipeng Zhang
CPC classification number: C12M33/00 , A01N1/0236 , A01N1/0268 , B01L7/00 , B01L2300/1827 , C12M1/26 , C12M33/04 , C12M41/12 , C12M45/20 , C12M45/22
Abstract: A coupling device configured to form a sample access assembly is provided. The sample access assembly is configured to house a sample. The coupling device includes a heating component and a separating component. Further, the separating component is configured to separate portions of first and second containers that form first and second compartments of the sample access assembly. Moreover, the heating component is configured to heat at least a portion of the sample.
Abstract translation: 提供了构造成形成样品存取组件的联接装置。 样品存取组件被配置为容纳样品。 联接装置包括加热部件和分离部件。 此外，分离部件构造成分离形成样品进入组件的第一和第二隔室的第一和第二容器的部分。 此外，加热部件构造成加热样品的至少一部分。
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公开(公告)号：US20150093739A1
公开(公告)日：2015-04-02
申请号：US14565142
申请日：2014-12-09
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Nichole Lea Wood , Reginald Donovan Smith , Hongyi Zhou , Liming Yu , Brian David Polizzotti , Peter D. Miller
IPC: G01N33/49 , C12N5/0775 , G01N1/40 , C12N5/0789
CPC classification number: G01N33/491 , A61M1/029 , B01D61/28 , B01D61/30 , B01D63/02 , B01D2313/18 , B01D2313/50 , C12N5/0647 , C12N5/0665 , G01N1/4077 , G01N2001/4083 , G01N2001/4088
Abstract: Method and systems, for processing biological material, that contain a biological material in a vessel; add an aggregating agent to the material in the vessel and allow the material to separate into two or more distinct submaterials; extract one or more of the submaterials from the vessel; automatically transport one or more of the submaterials remaining in the vessel to a filtration device; and collect a resulting target retentate into a target retentate receptacle.
Abstract translation: 用于处理在容器中含有生物材料的生物材料的方法和系统; 向容器中的材料添加聚集剂，并使材料分离成两个或更多不同的子材料; 从容器中提取一种或多种副材料; 将剩余在容器中的一种或多种副材料自动输送到过滤装置; 并将得到的目标滞留物收集到目标滞留容器中。
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公开(公告)号：US08993322B2
公开(公告)日：2015-03-31
申请号：US13776053
申请日：2013-02-25
Applicant: General Electric Company
CPC classification number: C12N5/0068 , C12M23/20 , C12M33/00 , C12N2533/32 , C12N2539/10
Abstract: Methods and kits of releasing cells are provided. The method comprises the steps of providing cultured cells on a cell culture support comprising a multi layer polyelectrolyte coating immobilized on a substrate, and releasing the cultured cells from the cell culture support by a releasing solution comprising DMSO. The kit comprises a cell culture support and a releasing solution. The releasing solution comprises DMSO.
Abstract translation: 提供了释放细胞的方法和试剂盒。 该方法包括以下步骤：在包含固定在底物上的多层聚电解质涂层的细胞培养载体上提供培养的细胞，以及通过包含DMSO的释放溶液从细胞培养支持物释放培养的细胞。 该试剂盒包括细胞培养支持物和释放溶液。 释放溶液包含DMSO。
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公开(公告)号：US11512288B2
公开(公告)日：2022-11-29
申请号：US16339077
申请日：2017-08-24
Applicant: General Electric Company
Inventor： Ernest William Kovacs , Anup Sood , Reginald Donovan Smith , Evelina Roxana Loghin , Padmaparna Chaudhuri , Vandana Keskar , Chrystal Mae Chadwick , Martin James Brown
IPC: C12N5/0783 , C07K16/28
Abstract: Provided herein are methods of activating immune cells. The method includes providing a population of immune cells and contacting the population of immune cells with a first agent and a second agent. The first agent includes an immune cell activator attached to a first binder moiety, and the second agent includes at least one capture oligomer. The at least one capture oligomer is capable of associating with the first binder moiety. Also provided are kits for activating immune cells.
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