公开(公告)号：US06509329B1

公开(公告)日：2003-01-21

申请号：US09893697

申请日：2001-06-29

申请人： Tatsuhiko Kodama ,  Masahiro Tamura ,  Toshiaki Oda ,  Yukiyoshi Yamazaki ,  Masahiro Nishikawa ,  Takeshi Doi ,  Yoshinori Kyotani

发明人： Tatsuhiko Kodama ,  Masahiro Tamura ,  Toshiaki Oda ,  Yukiyoshi Yamazaki ,  Masahiro Nishikawa ,  Takeshi Doi ,  Yoshinori Kyotani

IPC分类号： C07D25112

CPC分类号： C07D295/096 ,  A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61K31/551 ,  C07D213/38

摘要： A cyclic diamine compound of formula (1): wherein A is a single bond or C≡C; X and Y are individually CH or a nitrogen atom; m is 1 or 2; and n is a number of 1 to 5; an acid-addition salt thereof, or a hydrate thereof. The compound has excellent inhibitory effects on both cell adhesion and cell infiltration and is useful as a medicine for prevention or treatment of diseases such as allergy, asthma, rheumatism, arteriosclerosis and inflammation.

摘要翻译： 式（1）的环状二胺化合物：其中A是单键或C = C; X和Y分别是CH或氮原子; m为1或2; n为1〜5的数; 其酸加成盐或其水合物。 该化合物对细胞粘附和细胞浸润具有优异的抑制作用，可用作预防或治疗诸如过敏，哮喘，风湿病，动脉硬化和炎症等疾病的药物。

公开(公告)号：US06467527B1

公开(公告)日：2002-10-22

申请号：US09586760

申请日：2000-06-05

申请人： Kohei Kubota ,  Koichi Satoh ,  Masaru Yamamoto ,  Yoichi Nosaka ,  Yasuhisa Goto ,  Takeshi Doi

发明人： Kohei Kubota ,  Koichi Satoh ,  Masaru Yamamoto ,  Yoichi Nosaka ,  Yasuhisa Goto ,  Takeshi Doi

IPC分类号： B22D2709

CPC分类号： B22D17/08 ,  B22D21/007

摘要： A method for die-casting a magnesium alloy comprises the step of casting a die cast product free of any hot tearing, shrinkage tearing and shrinkage cavity starting from a magnesium alloy comprising i) 1 to 10% by weight of aluminum; ii) at least one member selected from the group consisting of 0.2 to 5% by weight of a rare earth metal, 0.02 to 5% by weight of calcium and 0.2 to 10% by weight of silicon; and iii) not more than 1.5% by weight of manganese, and the balance of magnesium and inevitable impurities, using a cold chamber type die-casting machine, wherein a) the temperature of the molten magnesium alloy is maintained at 650 to 750°C.; b) the charging velocity of the molten metal is set at {fraction (1/100)} to {fraction (10/100)} second; and c) the intensified pressure after the charging is set at a level of not less than 200 kgf/cm2. Thus, a die cast product free of any hot tearing, shrinkage tearing and shrinkage cavity can be produced by appropriately specifying injection conditions, mold conditions, conditions for melting a magnesium alloy and mold plan in the cold chamber type die-casting machine, or by appropriately controlling the temperature of the molten metal from the molten metal-accommodating pot to the gate portion of the machine.

摘要翻译： 压铸镁合金的方法包括以下步骤：铸造不含任何热裂纹，收缩撕裂和收缩空腔的压铸产品，该镁合金包括：i）1至10重量％的铝; ii）选自0.2至5重量％的稀土金属，0.02至5重量％的钙和0.2至10重量％的硅中的至少一种; 和iii）使用冷室式压铸机不超过1.5重量％的锰，剩余的镁和不可避免的杂质，其中a）熔融镁合金的温度保持在650-750℃ 。 b）熔融金属的充电速度设定为{分数（1/100）}至{分数（10/100）}秒; 和c）充电后的增压压力设定在不低于200kgf / cm2的水平。 因此，通过在冷室型压铸机中适当地指定注射条件，模具条件，熔融镁合金条件和模具计划，或者由冷却室型压铸机中的模具计划，可以通过适当地指定没有任何热撕裂，收缩撕裂和收缩腔的压铸产品 适当地将熔融金属的温度从熔融金属容纳罐适当地控制到机器的浇口部分。

公开(公告)号：US5198359A

公开(公告)日：1993-03-30

申请号：US487059

申请日：1990-03-05

申请人： Tadatsugu Taniguchi ,  Masanori Hatakeyama ,  Sejiro Minamoto ,  Takeshi Kono ,  Takeshi Doi ,  Masayuki Miyasaka ,  Mitsuru Tsudo ,  Hajime Karasuyma

发明人： Tadatsugu Taniguchi ,  Masanori Hatakeyama ,  Sejiro Minamoto ,  Takeshi Kono ,  Takeshi Doi ,  Masayuki Miyasaka ,  Mitsuru Tsudo ,  Hajime Karasuyma

IPC分类号： G01N33/577 ,  A61K48/00 ,  C07K1/00 ,  C07K14/00 ,  C07K14/47 ,  C07K14/52 ,  C07K14/555 ,  C07K14/565 ,  C07K14/715 ,  C07K16/00 ,  C12N1/00 ,  C12N1/16 ,  C12N1/21 ,  C12N5/10 ,  C12N15/00 ,  C12N15/09 ,  C12N15/12 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/645 ,  C12R1/91 ,  C12N15/63 ,  C07K13/00

CPC分类号： C07K14/7155

摘要： The present invention is directed to recombinant IL-2R.mu. protein or fragments thereof, cDNA coding therefore, vectors containing this cDNA, hosts transfected by these vectors, and monocional antibodies to the encoded recombinant IL-2R.mu. protein or fragments thereof.

公开(公告)号：US08575153B2

公开(公告)日：2013-11-05

申请号：US13131561

申请日：2009-11-27

申请人： Takahiro Kitamura ,  Hajime Yamada ,  Shunji Takemura ,  Masanori Ashikawa ,  Tetsuya Ishikawa ,  Yoshiharu Miyake ,  Akiyasu Kouketsu ,  Seiichi Sato ,  Hiroyuki Ishiwata ,  Yuichiro Tabunoki ,  Manabu Shibasaki ,  Takatoshi Ozawa ,  Ryota Shigemi ,  Takeshi Doi ,  Masahiro Tamura

发明人： Takahiro Kitamura ,  Hajime Yamada ,  Shunji Takemura ,  Masanori Ashikawa ,  Tetsuya Ishikawa ,  Yoshiharu Miyake ,  Akiyasu Kouketsu ,  Seiichi Sato ,  Hiroyuki Ishiwata ,  Yuichiro Tabunoki ,  Manabu Shibasaki ,  Takatoshi Ozawa ,  Ryota Shigemi ,  Takeshi Doi ,  Masahiro Tamura

IPC分类号： A61K31/506 ,  C07D239/48

CPC分类号： C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

摘要： To provide a novel JAK3 inhibitor that is useful as a preventive and/or therapeutic agent for rejection and graft versus host disease (GvHD) in organ transplantation, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, Sjögren syndrome, Behcet's disease, type I diabetes mellitus, autoimmune thyroiditis, idiopathic thrombocytopenic purpura, ulcerative colitis, Crohn's disease, asthma, allergic rhinitis, atopic dermatitis, contact dermatitis, urticaria, eczema, psoriasis, allergic conjunctivitis, uveitis, cancer, leukemia and the like. The pyridine-3-carboxyamide derivative represented by the general formula (1): or its salt or a solvate thereof.

摘要翻译： 提供可用作器官移植，类风湿关节炎，多发性硬化症，系统性红斑狼疮，Sjögren综合征，Behcet氏病，I型糖尿病的排斥反应和宿主疾病（GvHD）的预防和/或治疗剂的新型JAK3抑制剂 过敏性甲状腺炎，特发性血小板减少性紫癜，溃疡性结肠炎，克罗恩病，哮喘，过敏性鼻炎，特应性皮炎，接触性皮炎，荨麻疹，湿疹，牛皮癣，过敏性结膜炎，葡萄膜炎，癌症，白血病等。 由通式（1）表示的吡啶-3-甲酰胺衍生物或其盐或其溶剂化物。

公开(公告)号：US07969294B2

公开(公告)日：2011-06-28

申请号：US12827167

申请日：2010-06-30

申请人： Takeshi Yamamoto ,  Aki Miake ,  Toshiya Takahashi ,  Megumi Itoh ,  Mitsukazu Okuda ,  Takeshi Doi ,  Takeo Abe

发明人： Takeshi Yamamoto ,  Aki Miake ,  Toshiya Takahashi ,  Megumi Itoh ,  Mitsukazu Okuda ,  Takeshi Doi ,  Takeo Abe

IPC分类号： B60Q1/00 ,  G08B3/00 ,  G08G1/123 ,  G01C21/00 ,  G09G5/00

CPC分类号： G01C21/36 ,  B60K35/00 ,  B60K2350/2013 ,  H04N7/181

摘要： An onboard display device includes a display section attached to an instrument panel of a vehicle. The section has a second display area and a first display area. The second display area shows at least the speed as vehicle condition images indicating the conditions of the vehicle. The first display area shows a navigation image and other secondary images. The display section measures greater in width than in height with an aspect ratio of 7:3 or greater. The aspect ratio is the width/height ratio of a display area. The onboard display device allows for a visibility-improved simultaneous display of the secondary image, such as a navigation image, and the vehicle condition image, such as a speed display, which presents information on the conditions of the vehicle.

摘要翻译： 车载显示装置包括附接到车辆的仪表板的显示部。 该部分具有第二显示区域和第一显示区域。 第二显示区域至少显示指示车辆状况的车辆状态图像的速度。 第一个显示区域显示导航图像和其他二次图像。 显示部分的宽度比高度高，纵横比为7：3或更大。 宽高比是显示区域的宽/高比。 车载显示装置允许对二次图像（例如导航图像）和诸如速度显示器的车辆状况图像的同时显示进行可见度改善，其呈现关于车辆状况的信息。

公开(公告)号：US20100222347A1

公开(公告)日：2010-09-02

申请号：US12680307

申请日：2008-09-29

申请人： Masanori Ashikawa ,  Junya Tagashira ,  Akiyasu Koketsu ,  Toshiharu Morimoto ,  Tatsuaki Nishiyama ,  Satoshi Goda ,  Masaki Yamabi ,  Takeshi Doi ,  Hiroyuki Ishiwata

发明人： Masanori Ashikawa ,  Junya Tagashira ,  Akiyasu Koketsu ,  Toshiharu Morimoto ,  Tatsuaki Nishiyama ,  Satoshi Goda ,  Masaki Yamabi ,  Takeshi Doi ,  Hiroyuki Ishiwata

IPC分类号： A61K31/5377 ,  C07D215/08 ,  A61K31/4706 ,  C07D413/12 ,  C07D215/233 ,  A61K31/47 ,  A61P7/00

CPC分类号： C07D215/48 ,  A61K31/47 ,  A61K31/4706 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  C07D215/22 ,  C07D215/44 ,  C07D413/04 ,  C07D413/12

摘要： Disclosed is a low-molecular-weight compound having an EPO production-promoting activity and/or a hemoglobin expression-enhancing activity. Specifically disclosed is an EPO production promoter and/or a hemoglobin expression enhancer comprising a 1-acyl-4-(phenoxy, benzyloxy or phenylamino)-1,2,3,4-tetrahydroquinoline derivative, more specifically a tetrahydroquinoline compound represented by the general formula (1); [wherein R1, R2, R2′, R3 and R3′ independently represent a hydrogen atom, a C1-6 alkyl group, or the like; R4, R5, R6, R7, R8, R9 and R10 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, or the like; A represents N—R11 or an oxygen atom; R11 represents a hydrogen atom, a C1-6 alkyl group, or the like; and n represents an integer of 0 or 1], a salt of the tetrahydroquinoline compound, or a solvate of the tetrahydroquinoline compound or the salt.

摘要翻译： 公开了具有EPO生产促进活性和/或血红蛋白表达增强活性的低分子量化合物。 具体公开的是EPO生产促进剂和/或血红蛋白表达增强剂，其包含1-酰基-4-（苯氧基，苄氧基或苯基氨基）-1,2,3,4-四氢喹啉衍生物，更具体地是由通式 公式1）; [其中R1，R2，R2'，R3和R3'独立地表示氢原子，C1-6烷基等; R 4，R 5，R 6，R 7，R 8，R 9和R 10独立地表示氢原子，卤素原子，C 1-6烷基等; A表示N-R11或氧原子; R 11表示氢原子，C 1-6烷基等; n表示0或1的整数]，四氢喹啉化合物的盐或四氢喹啉化合物或其盐的溶剂合物。

公开(公告)号：US20080204205A1

公开(公告)日：2008-08-28

申请号：US12103164

申请日：2008-04-15

申请人： Takeshi Yamamoto ,  Aki Miake ,  Toshiya Takahashi ,  Megumi Itoh ,  Mitsukazu Okuda ,  Takeshi Doi ,  Takeo Abe

发明人： Takeshi Yamamoto ,  Aki Miake ,  Toshiya Takahashi ,  Megumi Itoh ,  Mitsukazu Okuda ,  Takeshi Doi ,  Takeo Abe

IPC分类号： B60Q1/00

CPC分类号： G01C21/36 ,  B60K35/00 ,  B60K2370/21 ,  H04N7/181

摘要： An onboard display device in accordance with the present invention includes a display section (11) attached to an instrument panel of a vehicle. The section (11) has a second display area (11b) and a first display area (11a). The second display area (11b) shows at least the speed as vehicle condition images indicating the conditions of the vehicle. The first display area (11a) shows a navigation image and other secondary images. The display section (11) measures greater in width than in height with an aspect ratio of 7:3 or greater. The aspect ratio is the width/height ratio of a display area. The onboard display device allows for a visibility-improved simultaneous display of the secondary image, such as a navigation image, and the vehicle condition image, such as a speed display, which presents information on the conditions of the vehicle.

摘要翻译： 根据本发明的车载显示装置包括附接到车辆的仪表板的显示部分（11）。 部分（11）具有第二显示区域（11b）和第一显示区域（11a）。 第二显示区域（11b）至少示出作为指示车辆状态的车辆状态图像的速度。 第一显示区域（11a）示出导航图像和其他二次图像。 显示部分（11）的宽度比高度高，纵横比为7：3或更大。 宽高比是显示区域的宽/高比。 车载显示装置允许对二次图像（例如导航图像）和诸如速度显示器的车辆状况图像的同时显示进行可见度改善，其呈现关于车辆状况的信息。

公开(公告)号：US20070273638A1

公开(公告)日：2007-11-29

申请号：US10598090

申请日：2005-02-18

申请人： Hitoshi Nohno ,  Megumi Itoh ,  Toshiya Takahashi ,  Takeshi Yamamoto ,  Aki Miake ,  Mitsukazu Okuda ,  Takeshi Doi

发明人： Hitoshi Nohno ,  Megumi Itoh ,  Toshiya Takahashi ,  Takeshi Yamamoto ,  Aki Miake ,  Mitsukazu Okuda ,  Takeshi Doi

IPC分类号： G09G5/00

CPC分类号： B60K37/02 ,  B60K2350/1072 ,  B60K2350/1088 ,  B60K2350/2013 ,  B60R1/00 ,  B60R2300/105 ,  B60R2300/207 ,  B60R2300/302 ,  B60R2300/306 ,  B60R2300/70

摘要： A display screen of an onboard display device is disposed so that a speedometer is displayed in front of a driver of a vehicle. When a right-turn instruction is detected, a blinker is displayed and a rightward rear view image outside the vehicle is displayed on the right side of the display screen. When a left-turn instruction is detected, a blinker is displayed and a leftward rear view image outside the vehicle is displayed on the left side of the display screen. Displaying the image in different positions of the display screen according to the right or the left turn instruction facilitates an intuitive determination of a meaning of the image and makes it easier to drive the vehicle.

摘要翻译： 车载显示装置的显示画面被设置为使车速表在车辆驾驶员的前方显示。 当检测到右转指示时，显示闪烁灯，并且车辆外部的右后视图像显示在显示屏的右侧。 当检测到左转指令时，显示闪烁灯，并且在显示屏左侧显示车辆外部的左后视图。 根据右转或左转指示在显示屏的不同位置显示图像有助于直观地确定图像的含义，并且使得驾驶车辆变得更容易。

公开(公告)号：US06747833B2

公开(公告)日：2004-06-08

申请号：US09887064

申请日：2001-06-25

申请人： Masayoshi Shimokoshi ,  Takeshi Doi

发明人： Masayoshi Shimokoshi ,  Takeshi Doi

IPC分类号： G11B5596

CPC分类号： G11B5/012 ,  G11B5/5547 ,  G11B21/083

摘要： The position information of the magnetic head is generated also from the data area to improve the positioning accuracy. The magnetic disk drive has a function of oscillating the magnetic head in the radial direction in the data area at a specific frequency and a function of detecting a read signal during the execution of the oscillation function and detects position information of the magnetic head from the detected read signal. The magnetic head position control can be performed in the data area. The magnetic head position signal not dependent on the frequency of a sampling signal generated from the servo information area can be generated. This in turn improves the data recording density and allows a highly precise position control of the magnetic head, thus improving the reliability of the magnetic disk drive.

摘要翻译： 也可以从数据区域生成磁头的位置信息，以提高定位精度。 磁盘驱动器具有以特定频率在数据区域中径向振荡磁头的功能，以及在执行振荡功能期间检测读取信号的功能，并且从检测到的磁头驱动器检测磁头的位置信息 读信号。 可以在数据区域中执行磁头位置控制。 可以生成不依赖于从伺服信息区域产生的采样信号的频率的磁头位置信号。 这又提高了数据记录密度，并且允许磁头的高精度位置控制，从而提高了磁盘驱动器的可靠性。

公开(公告)号：US06573578B2

公开(公告)日：2003-06-03

申请号：US09922157

申请日：2001-08-06

申请人： Shigeharu Kimura ,  Kenji Maio ,  Takeshi Doi ,  Yoichi Tamaki ,  Takeshi Shimano

发明人： Shigeharu Kimura ,  Kenji Maio ,  Takeshi Doi ,  Yoichi Tamaki ,  Takeshi Shimano

IPC分类号： H01L2714

CPC分类号： H01L27/1443 ,  H01L31/02024

摘要： A photo semiconductor integrated circuit device has a photodiode portion and amplifier portion, each portion having a buried layer. The impurity concentration and/or depth of the buried layer for the photodiode portion is lower than that of the buried layer for the amplifier portion. As a result, the frequency band width is widened.

摘要翻译： 光半导体集成电路器件具有光电二极管部分和放大器部分，每个部分具有掩埋层。 用于光电二极管部分的掩埋层的杂质浓度和/或深度低于用于放大器部分的掩埋层的杂质浓度和/或深度。 结果，频带宽度变宽。