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    POWERED TISSUE MODIFICATION DEVICES AND METHODS
    11.
    发明申请
    POWERED TISSUE MODIFICATION DEVICES AND METHODS 审中-公开
    动力组织修改装置和方法

    公开(公告)号：US20110190772A1

    公开(公告)日：2011-08-04

    申请号：US13078376

    申请日：2011-04-01

    申请人： Vahid Saadat ,  Jeffery L. Bleich ,  Kenneth J. Michlitsch ,  John E. Ashley

    发明人： Vahid Saadat ,  Jeffery L. Bleich ,  Kenneth J. Michlitsch ,  John E. Ashley

    IPC分类号： A61B17/56

    CPC分类号： A61B17/1659 ,  A61B17/1671

    摘要： A device for modifying tissue in a spine may include: a shah having a proximal portion and a distal portion, the distal portion having dimensions which allow h to be passed into an epidural space of the spine and between target and non-target tissues at least one distal force application member extending from the distal portion of the shall and configured to facilitate application of at least one of anchoring force and tensioning force to the shaft; at least one movable tissue modifying member coupled with the shaft at or near its distal portion; at least one drive member coupled with the at least one tissue modifying member to activate the at least one tissue modifying member; and at least one power transmission member coupled with the at least one drive member to deliver power to the at least one drive member.

    摘要翻译： 用于修改脊柱中的组织的装置可以包括：具有近端部分和远端部分的髋部，所述远端部分具有允许h至少进入脊柱的硬膜外腔和靶和非靶组织之间的尺寸 从远端部分延伸的一个远端力施加构件应构造成便于将锚固力和张紧力中的至少一个施加到轴上; 至少一个可动组织修改构件，其在远端部分处或其附近与所述轴联接; 至少一个驱动构件与所述至少一个组织修改构件联接以激活所述至少一个组织修改构件; 以及与所述至少一个驱动构件联接的至少一个动力传递构件，以向所述至少一个驱动构件输送动力。

    Tissue modification barrier devices and methods
    12.
    发明申请
    Tissue modification barrier devices and methods 审中-公开
    组织修饰屏障装置及方法

    公开(公告)号：US20070213734A1

    公开(公告)日：2007-09-13

    申请号：US11405859

    申请日：2006-04-17

    申请人： Jeffery Bleich ,  Steven Spisak ,  Vahid Saadat ,  Ronald Leguidleguid ,  Jeffery Bleam ,  Michael Drews ,  James Yurchenco

    发明人： Jeffery Bleich ,  Steven Spisak ,  Vahid Saadat ,  Ronald Leguidleguid ,  Jeffery Bleam ,  Michael Drews ,  James Yurchenco

    IPC分类号： A61B17/16

    CPC分类号： A61B17/1659 ,  A61B17/00234 ,  A61B17/02 ,  A61B17/1671 ,  A61B17/1757 ,  A61B17/320016 ,  A61B17/32002 ,  A61B17/3421 ,  A61B2017/00261 ,  A61B2017/00867 ,  A61B2017/32006 ,  A61B2017/3488 ,  A61B2090/08021

    摘要： A method for preventing unwanted damage to tissue in a spine of a patient during a tissue modification procedure may involve: advancing at least a distal portion of at least one barrier member over at least one guide member into an epidural space of the patient's spine; positioning at least an expanded portion of the barrier member between target tissue and non-target tissue; and performing at least one tissue modification procedure on the target tissue, using at least one tissue modification device. Generally, at least part of the barrier member may be disposed between the tissue modification device and the non-target tissue to prevent unwanted damage to the non-target tissue. In various embodiments, at least part of a barrier member may be advanced through a sheath- or catheter-like delivery device and may either automatically expand or be expandable from a collapsed configuration to an expanded configuration.

    摘要翻译： 一种用于防止在组织改变过程期间对患者的脊柱中的组织的不期望的损伤的方法可以包括：使至少一个阻挡构件的至少一个阻挡构件的至少一个远端部分在至少一个引导构件上前进到患者脊柱的硬膜外腔中; 将所述阻挡构件的至少扩大部分定位在目标组织和非目标组织之间; 以及使用至少一个组织修改装置对所述靶组织进行至少一个组织修饰程序。 通常，阻挡构件的至少一部分可以设置在组织修改装置和非目标组织之间，以防止对非目标组织的不必要的损坏。 在各种实施例中，阻挡构件的至少一部分可以通过护套或导管状递送装置前进，并且可以自动地膨胀或者可以从折叠构型扩展到扩张构型。

    Devices and methods for tissue modification
    13.
    发明申请
    Devices and methods for tissue modification 有权

    公开(公告)号：US20060095059A1

    公开(公告)日：2006-05-04

    申请号：US11251199

    申请日：2005-10-15

    申请人： Jeffery Bleich ,  Edwin Hlavka ,  Vahid Saadat ,  Steven Spisak ,  David Miller ,  James Yurchenco

    发明人： Jeffery Bleich ,  Edwin Hlavka ,  Vahid Saadat ,  Steven Spisak ,  David Miller ,  James Yurchenco

    IPC分类号： A61B17/32

    CPC分类号： A61B17/320758 ,  A61B1/3135 ,  A61B17/149 ,  A61B17/1659 ,  A61B17/1671 ,  A61B17/29 ,  A61B17/320016 ,  A61B17/32002 ,  A61B17/32053 ,  A61B17/3401 ,  A61B17/3403 ,  A61B17/3421 ,  A61B17/3496 ,  A61B18/1477 ,  A61B18/1487 ,  A61B90/04 ,  A61B90/361 ,  A61B2017/00261 ,  A61B2017/00287 ,  A61B2017/003 ,  A61B2017/00867 ,  A61B2017/00907 ,  A61B2017/320004 ,  A61B2017/320044 ,  A61B2017/32006 ,  A61B2017/3445 ,  A61B2017/3447 ,  A61B2018/1407 ,  A61B2018/1425 ,  A61B2090/061 ,  A61B2090/08021 ,  A61F2/0045 ,  A61N1/0551 ,  A61N1/36017

    摘要： Methods and apparatus are provided for selective surgical removal of tissue, e.g., for enlargement of diseased spinal structures, such as impinged lateral recesses and pathologically narrowed neural foramen. In one variation, tissue may be ablated, resected, removed, or otherwise remodeled by standard small endoscopic tools delivered into the epidural space through an epidural needle. Once the sharp tip of the needle is in the epidural space, it is converted to a blunt tipped instrument for further safe advancement. A specially designed epidural catheter that is used to cover the previously sharp needle tip may also contain a fiberoptic cable. Further embodiments of the current invention include a double barreled epidural needle or other means for placement of a working channel for the placement of tools within the epidural space, beside the epidural instrument. The current invention includes specific tools that enable safe tissue modification in the epidural space, including a barrier that separates the area where tissue modification will take place from adjacent vulnerable neural and vascular structures. In one variation, a tissue abrasion device is provided including a thin belt or ribbon with an abrasive cutting surface. The device may be placed through the neural foramina of the spine and around the anterior border of a facet joint. Once properly positioned, a medical practitioner may enlarge the lateral recess and neural foramina via frictional abrasion, i.e., by sliding the abrasive surface of the ribbon across impinging tissues. A nerve stimulator optionally may be provided to reduce a risk of inadvertent neural abrasion. Additionally, safe epidural placement of the working barrier and epidural tissue modification tools may be further improved with the use of electrical nerve stimulation capabilities within the invention that, when combined with neural stimulation monitors, provide neural localization capabilities to the surgeon. The device optionally may be placed within a protective sheath that exposes the abrasive surface of the ribbon only in the area where tissue removal is desired. Furthermore, an endoscope may be incorporated into the device in order to monitor safe tissue removal. Finally, tissue remodeling within the epidural space may be ensured through the placement of compression dressings against remodeled tissue surfaces, or through the placement of tissue retention straps, belts or cables that are wrapped around and pull under tension aspects of the impinging soft tissue and bone in the posterior spinal canal.

    Delivery of biological compounds to ischemic and/or infarcted tissue
    15.
    发明授权
    Delivery of biological compounds to ischemic and/or infarcted tissue 有权
    向缺血和/或梗死组织递送生物化合物

    公开(公告)号：US08814845B2

    公开(公告)日：2014-08-26

    申请号：US13365914

    申请日：2012-02-03

    申请人： Vahid Saadat ,  Sekhar S. Rao

    发明人： Vahid Saadat ,  Sekhar S. Rao

    IPC分类号： A61M31/00

    CPC分类号： A61B1/00165 ,  A61B1/00089 ,  A61B1/00096 ,  A61B1/00147 ,  A61B1/015 ,  A61B1/05 ,  A61B1/12 ,  A61B5/0084 ,  A61B5/6882 ,  A61B5/7282 ,  A61M25/0074 ,  A61M25/0082 ,  A61M25/0084

    摘要： The delivery of biological compounds to ischemic and/or infarcted tissue are described herein where such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to a region of tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid, such as saline, can be pumped into the imaging hood until the fluid displaces any blood, thereby leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. Additionally, any number of therapeutic tools can also be passed through the deployment catheter and into the imaging hood for performing any number of procedures on the tissue for identifying, locating, and/or accessing ischemic and/or infarcted tissue.

    摘要翻译： 在本文中描述了将生物化合物递送至缺血和/或梗死组织，其中这样的系统可以包括展开导管和可展开成扩展构型的附接成像罩。 在使用中，成像罩被放置在通常填充有不透明体液如血液的体腔中的待成像组织区域附近或邻近。 半透明或透明的液体（例如盐水）可被泵送到成像罩中，直到流体移动任何血液，从而留下通过展开导管中的成像元件成像的组织的清晰区域。 此外，任何数量的治疗工具也可以通过展开导管并进入成像罩，以在组织上执行任何数量的程序，用于识别，定位和/或获取缺血和/或梗死组织。

    Tissue manipulation and securement system
    19.
    发明授权
    Tissue manipulation and securement system 有权
    组织操纵和固定系统

    公开(公告)号：US08216252B2

    公开(公告)日：2012-07-10

    申请号：US11070863

    申请日：2005-03-01

    申请人： Robert A. Vaughan ,  Cang C. Lam ,  Richard C. Ewers ,  Vahid Saadat

    发明人： Robert A. Vaughan ,  Cang C. Lam ,  Richard C. Ewers ,  Vahid Saadat

    IPC分类号： A61B17/08

    CPC分类号： A61B17/0401 ,  A61B17/0487 ,  A61B17/06066 ,  A61B17/29 ,  A61B2017/00278 ,  A61B2017/0409 ,  A61B2017/0419 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/06076 ,  A61B2017/2923 ,  A61B2017/2927 ,  A61B2017/3488

    摘要： Tissue manipulation and securement systems are described herein. A tissue manipulation assembly is pivotably coupled to the distal end of a tubular member and has a lower jaw member and an upper jaw member pivotably coupled to the lower jaw member. A reconfigurable launch tube is also pivotably coupled to the upper jaw member and is used to urge the jaw members from a low-profile configuration to an open configuration for receiving tissue. The tissue manipulation assembly may be advanced through a shape-lockable endoscopic device, a conventional endoscope, or directly by itself into a patient. A second tool can be used in combination with the tissue manipulation assembly to engage tissue and manipulate the tissue in conjunction with the tissue manipulation assembly.

    摘要翻译： 本文描述了组织操纵和固定系统。 组织操作组件可枢转地联接到管状构件的远端，并且具有下颚构件和可枢转地联接到下颚构件的上颚构件。 可重构的发射管也可枢转地联接到上钳口构件，并且用于将钳口构件从小轮廓构造推动到用于接收组织的打开构型。 组织操作组件可以通过形状可锁定内窥镜装置，常规内窥镜，或者直接自身进入患者。 第二工具可以与组织操作组件组合使用以接合组织并且与组织操作组件一起操作组织。

    POWERED TISSUE MODIFICATION DEVICES AND METHODS
    20.
    发明申请
    POWERED TISSUE MODIFICATION DEVICES AND METHODS 有权
    动力组织修改装置和方法

    公开(公告)号：US20110098708A9

    公开(公告)日：2011-04-28

    申请号：US11406486

    申请日：2006-04-17

    申请人： Vahid Saadat ,  Jeffery Bleich ,  Kenneth Michlitsch ,  John Ashley

    发明人： Vahid Saadat ,  Jeffery Bleich ,  Kenneth Michlitsch ,  John Ashley

    IPC分类号： A61B17/00

    CPC分类号： A61B17/1659 ,  A61B17/00234 ,  A61B17/02 ,  A61B17/1671 ,  A61B17/1757 ,  A61B17/320016 ,  A61B17/32002 ,  A61B17/3421 ,  A61B2017/00261 ,  A61B2017/00867 ,  A61B2017/32006 ,  A61B2017/3488 ,  A61B2090/08021

    摘要： A device for modifying tissue in a spine may include: a shaft having a proximal portion and a distal portion, the distal portion having dimensions which allow it to be passed into an epidural space of the spine and between target and non-target tissues; at least one distal force application member extending from the distal portion of the shaft and configured to facilitate application of at least one of anchoring force and tensioning force to the shaft; at least one movable tissue modifying member coupled with the shaft at or near its distal portion; at least one drive member coupled with the at least one tissue modifying member to activate the at least one tissue modifying member; and at least one power transmission member coupled with the at least one drive member to deliver power to the at least one drive member.

    摘要翻译： 用于修改脊柱中的组织的装置可以包括：具有近端部分和远侧部分的轴，所述远端部分具有允许其进入脊柱的硬膜外腔中以及靶和非靶组织之间的尺寸; 至少一个远端力施加构件，其从所述轴的远侧部分延伸并且构造成便于将锚固力和张紧力中的至少一个施加到所述轴; 至少一个可动组织修改构件，其在远端部分处或其附近与所述轴联接; 至少一个驱动构件与所述至少一个组织修改构件联接以激活所述至少一个组织修改构件; 以及与所述至少一个驱动构件联接的至少一个动力传递构件，以向所述至少一个驱动构件输送动力。